Mrs Magdaline Costa - Researcher Profile

Biography

Magdaline works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 2005

Publications

Journal Articles

Costa, M., Sourris, K., Lim, S.M., Yu, Q.C., Hirst, C.E., Parkington, H.C., Jameson, V.J., Dear, A.E., Liu, H.B., Micallef, S.J., Koutsis, K., Elefanty, A.G., Stanley, E., 2013, Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization, Stem Cell Research [P], vol 10, issue 1, Elsevier BV, The Netherlands, pp. 103-117.

Yu, Q.C., Hirst, C.E., Costa, M., Ng, E.S.S., Schiesser, J.V., Gertow, K.A., Stanley, E.G., Elefanty, A.G., 2012, APELIN promotes hematopoiesis from human embryonic stem cells, Blood [P], vol 119, issue 26, American Society of Hematology, USA, pp. 6243-6254.

Davis, R.P.F., Grandela, C., Sourris, K., Hatzistavrou, T., Dottori, M., Elefanty, A.G., Stanley, E., Costa, M., 2009, Generation of human embryonic stem cell reporter knock-in lines by homologous recombination, Current Protocols in Stem Cell Biology [P], issue Unit 5B.1, John Wiley & Sons, Inc., USA, pp. 1-34.

Davis, R.P.F., Costa, M., Grandela, C., Holland, A.M., Hatzistavrou, T., Micallef, S.J., Li, X., Goulburn, A., Azzola, L., Elefanty, A.G., Stanley, E., 2008, A protocol for removal of antibiotic resistance cassettes from human embryonic stem cells genetically modified by homologous recombination or transgenesis, Nature Protocols, vol 3, issue 10, Nature Publishing Group, UK, pp. 1550-1558.

Costa, M., Sourris, K., Hatzistavrou, T., Elefanty, A.G., Stanley, E., 2008, Expansion of human embryonic stem cells in vitro, Current Protocols in Stem Cell Biology, issue IC.1, John Wiley & Sons Inc, USA, pp. C1.1-C1.7.

Davis, R.P.F., Ng, E., Costa, M., Mossman, A.K., Sourris, K., Elefanty, A.G., Stanley, E., 2008, Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors, Blood, vol 111, American Society of Hematology, Washington, DC, USA, pp. 1876-1884.

Costa, M., Dottori, M., Sourris, K., Jamshidi, P., Hatzistavrou, T., Davis, R.P.F., Azzola, L., Jackson, S., Lim, S.M., Pera, M.F., Elefanty, A.G., Stanley, E., 2007, A method for genetic modification of human embryonic stem cells using electroporation, Nature Protocols, vol 2, issue 4, Nature Publishing Group, UK, pp. 792-796.

Lux, W., Klobeck, H., Daniel, P.B., Costa, M., Medcalf, R.L., Schleuning, W., 2005, In vivo and in vitro analysis of the human tissue-type plasminogen activator gene promoter in neuroblastomal cell lines: Evidence for a functional upstream kappaB element, Journal of Thrombosis and Haemostasis, vol 3, Blackwell Publishing, Oxford England, pp. 1009-1017.

Costa, M., Dottori, M., Ng, E., Hawes, S.M., Sourris, K., Jamshidi, P., Pera, M.F., Elefanty, A.G., Stanley, E., 2005, The hESC line Envy expresses high levels of GFP in all differentiated progeny, Nature Methods, vol 2, issue 4, Nature Publishing Group, London UK, pp. 259-260.

Costa, M., Medcalf, R., 2001, Ectopic expression of the cAMP-responsive element binding protein inhibits phorbol ester-mediated induction of tissue-type plasminogen activator gene expression, European Journal of Biochemistry, vol 268, Blackwell Science Ltd, Oxford England, pp. 987-996.

Costa, M., Grant, P., Rice, G., Futers, S., Medcalf, R., 2001, Human endothelial cell-derived nuclear proteins that recognise polymorphic DNA elements in the von Willebrand factor gene promoter include YY1, Thrombosis and Haemostasis, vol 86, issue 2, Schattauer GMBH Verlag Medizin Naturwissenschaften, Stuttgart Germany, pp. 672-679.

Costa, M., Shen, Y.O., Medcalf, R.L., 2000, Overexpression of a dominant negative CREB protein in HT-1080 cells selectively disrupts plaminogen activator inhibitor type 2 but not tissue-type plasminogen activator gene expression, FEBS Letters, vol 482, Elsevier Science BV, Amsterdam Netherlands, pp. 75-80.

Costa, M., Shen, Y.O., Maurer, F., Medcalf, R.L., 1998, Transcriptional regulation of the tissue-type plasminogen activator gene in human endothelial cells: identification of nuclear factors that recognise functional elements in the tissue-type plasminogen-actovator gene promotoer, Euro. J. Biochem, vol 258, FEBS, Europe, pp. 123-131.

Dear, A.E., Costa, M., Medcalf, R.L., 1997, Urokinase-mediated transactivation of the plasminogen activator inhibitor type 2 (PAI-2) gene promoter in HT-1080 calles utilises AP-1 binding sites and potentiates phorbol ester-mediated induction of endogenous PAI-2 mRNA, FEBS Letters, vol 402, Elsevier Science, Amsterdam Netherlands, pp. 265-272.

Costa, M., Medcalf, R.L., 1996, Differential Binding of cAMP-responsive-element(CRE)-binding Protein-1 and Activating Transcription Factor-2 to a CRE-Like Element in the Human Tissue-Type Plasminogen Activator (t-PA) Gene Promoter Correlates with Opposite Regulation of t-PA by Phor, FEBS Journal [E], vol 237, issue 3, Wiley-Blackwell Publishing Ltd, UK, pp. 532-538.

Postgraduate Research Supervisions

Completed Supervision

Student:

Mossman, A.

Program of Study:

Studies on the function of the mammalian Mixl1 homeobox gene. (PHD) 2007.

Supervisors:

Elefanty, A (Joint-Co), Stanley, E (Joint), Costa, M (Associate), Pereira, L (Associate).