Dr Jillian Broadbear - Researcher Profile

Biography

Jillian is a senior lecturer in the Faculty of Medicine, Nursing & Health Sciences at Monash University.  Her teaching and research focuses on the neurobiology and behaviour of mood disorder and substance abuse. 

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Keywords

addiction, drug abuse, behaviour, endocrinology,, mood disorder, pain medicine, novel treatments

Qualifications

Graduate Certificate of Higher Education

Institution: Monash University

Year awarded: 2008

PhD (Psychology)

Institution: University of Michigan

Year awarded: 1999

Master of Biopsychology

Institution: University of Michigan

Year awarded: 1996

Bachelor of Science

Institution: Monash University

Year awarded: 1988

Publications

Journal Articles

Ogeil, R.P., Wilson Rajaratnam, S.M., Broadbear, J.H., 2012, Disturbed sleep in ecstasy users reported by partners/roommates, Australian and New Zealand Journal of Psychiatry [E], vol 46, issue 6, Sage Publications Ltd., Australia, pp. 587-588.

Ogeil, R.P., Wilson Rajaratnam, S.M., Broadbear, J.H., 2012, Ecstasy and sleep disturbance: progress towards elucidating a role for the circadian system, Sleep and Biological Rhythm [P], vol 10, issue 1, Wiley-Blackwell Publishing Asia, Australia, pp. 3-13.

Moynihan, H.A., Derrick, I., Broadbear, J.H., Greedy, B.M., Aceto, M.D., Harris, L.S., Purington, L., Thomas, M.P., Woods, J.H., Traynor, J.R., Husbands, S.M., Lewis, J.W., 2012, Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversible (Mu) opioid receptor antagonist effects, Journal of Medicinal Chemistry [P], vol 55, issue 22, American Chemical Society, United States, pp. 9868-9874.

Ogeil, R.P., Kennaway, D.J., Salkeld, M.D., Wilson Rajaratnam, S.M., Broadbear, J.H., 2012, MDMA induces Per1, Per2 and c-fos gene expression in rat suprachiasmatic nuclei, Psychopharmacology [P], vol 220, issue 4, Springer, Germany, pp. 835-843.

Mak, P., Broussard, C., Vacy, K., Broadbear, J.H., 2012, Modulation of anxiety behavior in the elevated plus maze using peptidic oxytocin and vasopressin receptor ligands in the rat , Journal of Psychopharmacology [P], vol 26, issue 4, Sage Publications Ltd, United Kingdom, pp. 532-542.

Broadbear, J., Tunstall, B., Beringer, K., 2011, Are females more sensitive to MDMA-related discriminative stimuli?, The Open Addiction Journal [E], vol 4, issue special issue, Bentham Open, Netherlands, pp. 10-11.

Ogeil, R., Wilson Rajaratnam, S., Broadbear, J., 2011, Assessing sleep disturbance in ecstasy users: A questionnaire study, The Open Addiction Journal [E], vol 4, issue special issue, Bentham Open, Netherlands, pp. 32-33.

Ogeil, R., Wilson Rajaratnam, S., Phillips, J., Redman, J., Broadbear, J., 2011, Ecstasy use and self-reported disturbances in sleep, Human Psychopharmacology-Clinical And Experimental [P], vol 26, issue 7, John Wiley & Sons Ltd, UK, pp. 508-516.

Smithies, V., Broadbear, J., 2011, Evaluating the contribution of serotonin receptor subtypes and ‘binge’ 3,4-methylenedioxymethamphetamine (MDMA) exposure to the discriminative stimulus effects of MDMA in rats, The Open Addiction Journal [E], vol 4, issue special issue, Bentham Open, Netherlands, pp. 55-56.

Broadbear, J., Parrott, A., 2011, Second International MDMA 'Ecstasy' Conference in Australasia: Monash University, Melbourne Australia, The Open Addiction Journal [E], vol 4, Bentham Open, Netherlands, pp. 1-2.

Ogeil, R., Rajaratnam, S.M.W., Redman, J., Broadbear, J., 2010, Acute MDMA administration alters the distribution and circadian rhythm of wheel running activity in the rat, Brain Research [P], vol 1359, issue C, Elsevier BV, Netherlands, pp. 128-136.

Chaviaras, S., Mak, P., Ralph, D., Krishnan, L., Broadbear, J., 2010, Assessing the antidepressant-like effects of carbetocin, an oxytocin agonist, using a modification of the forced swimming test, Psychopharmacology [P], vol 210, issue 1, Spinger, Germany, pp. 35-43.

Broadbear, J., Tunstall, B., Beringer, K., 2010, Examining the role of oxytocin in the interoceptive effects of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') using a drug discrimination paradigm in the rat, Addiction Biology [P], vol 16, Wiley-Blackwell Publishing Ltd, United Kingdom, pp. 202-214.

Nieland, N.P.R., Rennison, D., Broadbear, J.H., Purington, L., Woods, J.H., Traynor, J.R., Lewis, J.W., Husbands, S.M., 2009, 14beta-Arylpropiolylamino-17-cyclopropylmethyl-7,8-dihydronormorphinones and related opioids. Further examples of pseudoirreversible micro opioid receptor antagonists, Journal of Medicinal Chemistry [P], vol 52, American Chemical Society, USA, pp. 6926-6930.

Moynihan, H., Jales, A., Greedy, B., Rennison, D., Broadbear, J., Purington, L., Traynor, J., Woods, J., Lewis, J., Husbands, S., 2009, 14beta-O-Cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity, Journal of Medicinal Chemistry [P], vol 52, issue 6, American Chemical Society, USA, pp. 1553-1557.

Parrott, A.C., Broadbear, J.H., Bruno, R.B., Degenhardt, L., Morefield, K., Scholey, A.B., 2009, MDMA: Neurohormonal, neurocognitive, and psychobiological aspects of recreational ecstasy, The Open Addiction Journal [E], vol 2, Bentham Open, Netherlands, pp. 24-27.

Allott, K.A., Canny, B.J., Broadbear, J.H., Stepto, N.K., Murphy, B., Redman, J.R., 2009, Neuroendocrine and subjective responses to pharmacological challenge with citalopram: A controlled study in male and female ecstasy/MDMA users, Journal of Psychopharmacology, vol 23, issue 7, Sage Science Press, United Kingdom, pp. 759-774.

Gurtman, C.G., Broadbear, J.H., Redman, J.R., 2008, Effects of modafinil on simulator driving and self-assessment of driving following sleep deprivation, Human Psychopharmacology: Clinical and Experimental, vol 23, issue 8, John Wiley & Sons Ltd., UK, pp. 681-692.

Broadbear, J.H., 2006, Corticotropin-releasing hormone in nonhuman primates., Frontiers in Bioscience, vol 11, issue 1, Frontiers in Bioscience Inc, Manhasset NY USA, pp. 2303-2335.

Nieland, N.P.R., Moynihan, H.A., Carrington, S., Broadbear, J.H., Woods, J.H., Traynor, J.R., Husbands, S.M., Lewis, J.W., 2006, Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones, Journal of Medicinal Chemistry, vol 49, American Chemical Society, Washington USA, pp. 5333-5338.

Husbands, S.M., Neilan, C.L., Broadbear, J.H., Grundt, P., Breeden, S., Aceto, M.D., Woods, J.H., Lewis, J.W., Traynor, J.R., 2005, BU74, a complex oripavine derivative with potent kappa opioid receptor agonism and delayed opioid antagonism, European Journal of Pharmacology, vol 509, Elsevier, Amsterdam The Netherlands, pp. 117-125.

Broadbear, J.H., Pierce, B.N., Clarke, I.J., Canny, B.J., 2005, Role of sex and sex steroids in mediating pituitary-adrenal responses to acute buspirone treatment in sheep, Journal of Neuroendocrinology, vol 17, issue 12, Blackwell Publishing Ltd, UK, pp. 804-810.

Broadbear, J.H., Winger, G., Woods, J.H., 2005, Self-administration of methohexital, midazolam and ethanol: effects on the pituitary-adrenal axis in rhesus monkeys, Psychopharmacology, vol 178, issue 1, Springer, New York USA, pp. 83-91.

Broadbear, J.H., Nguyen, T., Clarke, I.J., Canny, B.J., 2004, Antidepressants, sex steroids and pituitary-adrenal response in sheep, Psychopharmacology, vol 175, issue 2, Springer-Verlag, New York USA, pp. 247-255.

Broadbear, J.H., Winger, G., Rivier, J., Rice, K.C., Woods, J.H., 2004, Corticotropin-releasing hormone antagonists, astressin B and antalarmin: differing profiles of activity in rhesus monkeys, Neuropsychopharmacology, vol 29, Nature Publishing Group, USA, pp. 1112-1121.

Williams, K.L., Broadbear, J.H., Woods, J.H., 2004, Noncontingent and response-contingent intravenous ethanol attenuates the effect of naltrexone on hypothalamic-pituitary-adrenal activity in rhesus monkeys, Alcoholism-Clinical And Experimental Research, vol 28, issue 4, Lippincott Williams & Wilkins, Philadelphia, pp. 566-571.

Broadbear, J.H., Winger, G., Woods, J.H., 2004, Self-administration of fentanyl, cocaine and ketamine: effects on the pituitary-adrenal Axis in rhesus monkeys, Psychopharmacology, vol 176, Springer, New York USA, pp. 398-406.

Broadbear, J.H., Hutton, L.C., Clarke, I.J., Canny, B.J., 2004, Sex differences in the pituitary-adrenal response following acute antidepressant treatment in sheep, Psychopharmacology, vol 171, Springer-Verlag, New York USA, pp. 450-457.

Broadbear, J.H., Winger, G., Rice, K.C., Woods, J.H., 2002, Antalarmin, a putative CRH-RI antagonist, has transient reinforcing effects in rhesus monkeys, Psychopharmacology, vol 164, Springer-Verlag, New York USA, pp. 268-276.

Broadbear, J., Derrick, I., Husbands, S., Traynor, J., Woods, J., Lewis, J., 2000, Cinnamoyl derivatives of 7alpha-Amino- and 7alpha-(Aminomethyl)-N-(cyclopropylmethyl)-6,14-endo-ethanotetrahydronororipavines are high-potency opioid antagonists, Helvetica Chimica Acta [P], vol 83, Verlag Helvetica Chimica Acta, Switzerland, pp. 3122-3130.

Broadbear, J.H., Sumpter, T.L., Burke, T.F., Husbands, S.M., Lewis, J., Woods, J.H., Traynor, J.R., 2000, Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, -funaltrexamine, and -chlornaltrexamine, Journal of Pharmacology and Experimental Therapeutics, vol 294, issue 3, American Society for Pharmacology and Experimental Therapeutics, Bethesda USA, pp. 933-940.

Conference Proceedings

Beringer, K., Broadbear, J.H., 2008, Oxytocin as a mediator of the unique interoceptive effects of 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") in the rat, Proceedings of the 43rd APS Annual Conference, 23 September to 27 September 2008, The Australian Psychological Society, Melbourne, pp. 31-35.

Other

Abdulwadud, O.A., Clavisi, O., Parkhill, A., King, S.T., Broadbear, J.H., Dalton, A., 2005, Prostate specific antigen (PSA) near patient testing for diagnosis and management of prostate cancer, Commonwealth of Australia, Australia, p. 1.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Memory, sleep and mood - The impact of MDMA/Ecstasy use..

Supervisors:

Broadbear, J (Joint-co), Conduit, R (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The efficacy of ketamine in Normalising pain and responsiveness to opioids in chronic pain: a clinical and preclinical investigation.

Supervisors:

Broadbear, J (Main).

Program of Study:

(MASTER'S BY RESEARCH).

Thesis Title:

The role of Oxytocin in Social Cognition.

Supervisors:

Broadbear, J (Main), Boon, W (Associate).

Completed Supervision

Student:

Allott, K.

Program of Study:

Harm reduction, serotonergic effects and sex differences associated with the use of ecstasy/3,4-methylenedioxymethamphetamine (MDMA). (PHD) 2007.

Supervisors:

Redman, J (Main), Canny, B (Associate), Broadbear, J (Associate), Stepto, N (Associate).

Student:

Gurtman, C.

Program of Study:

Effects of modafinil on simulator driving, mood and neurocognitive performance following sleep deprivation. (PHD) 2008.

Supervisors:

Redman, J (Main), Broadbear, J (Associate).

Student:

Ogeil, R.

Program of Study:

MDMA: effects on sleep and the circadian system. (PHD) 2011.

Supervisors:

Broadbear, J (Main), Rajaratnam, S (Associate).