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Prof Jamie Rossjohn - Researcher Profile

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Address

Department of Biochemistry & Molecular Biology
Faculty of Medicine, Nursing & Health Sciences, Clayton

Profile
Summary
Qualifications
Publications
Supervisions

Biography

Professor Jamie Rossjohn's research is centred on understanding the basis of infection and immunity, specifically host recognition, responses developed by the pathogen and drug design to modulate and/or counteract these events.

He is currently an NHMRC Australia Fellow (2011-2016)

Professor Rossjohn's research team and collaborators have provided seminal insight into the pathogenesis of infectious human diseases, adaptive and innate immunity and autoimmunity, publishing more than 200 research papers including generalist journals such as Nature, Science, Cell and PNAS, as well as top-tier journals in this area: Nature Immunology, Nature Reviews Immunology, Nature Reviews Drug Discovery, Immunity and Journal of Experimental Medicine.

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Qualifications

DOCTOR OF PHILOSOPHY: Institution: Bath University; Year awarded: 1994

Publications

Book Chapters

McCluskey, J., Gras, S., Bharadwaj, M., Kjer-Nielsen, L., Macdonald, W.A., Saunders, P.M., Rossjohn, J., 2010, HLA Molecules of the Major Histocompatibility Complex, in The HLA Complex in Biology and Medicine: A Resource Book, eds NK Mehra, DK Agencies (P) Ltd, India, pp. 86-118.

Polekhina, G., Feil, S., Tang, J., Rossjohn, J., Giddings, K., Tweten, R., Parker, M., 2006, Comparative three-dimensional structure of cholesterol-dependent cytolysins, in The comprehensive sourcebook of Bacterial Protein Toxins, eds Joseph E. Alouf & Michel R. Popoff, Academic Press, United States, pp. 659-670.

Prescott, M., Battad, J., Wilmann, P.G., Rossjohn, J., Devenish, R.J., 2006, Recent advances in all-protein chromophore technology, in Biotechnology Annual Review, Volume 12, eds M Raafat El-Gewely, Elsevier, Netherlands, pp. 31-66.

Rossjohn, J., Tweeten, R.K., Rood, J.I., Parker, M.W., 1999, Perfringolysin O, in The Comprehensive Sourcebook of Bacterial Protein Toxins, Academic Press, London UK, pp. 496-510.

Journal Articles

Sanderson, J.P., Brennan, P.J., Mansour, S., Matulis, G., Patel, O.G., Lissin, N., Godfrey, D.I., Kawahara, K., Rossjohn, J., Brenner, M.B., Gadola, S.D., 2013, CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant natural killer T (iNKT) cells, European Journal Of Immunology [P], vol 43, issue 3, Wiley - V C H Verlag GmbH & Co, KGaA, Germany, pp. 815-825.

Illing, P.T., Vivian, J.P., Purcell, A.W., Rossjohn, J., McCluskey, J., 2013, Human leukocyte antigen-associated drug hypersensitivity, Current Opinion in Immunology [P], vol 25, issue 1, Elsevier Ltd * Current Opinion Journals, UK, pp. 81-89.

Gapin, L., Godfrey, D.I., Rossjohn, J., 2013, Natural Killer T cell obsession with self-antigens, Current Opinion in Immunology [P], vol E-pub, Elsevier Ltd * Current Opinion Journals, UK, pp. 1-6.

Ekeruche-Makinde, J., Miles, J.J., Van Den Berg, H.A., Skowera, A., Cole, D.K., Dolton, G., Schauenburg, A.J., Tan, M.P., Pentier, J., Llewellyn-Lacey, S., Miles, K.M., Bulek, A.M., Clement, M., Williams, T., Trimby, A., Bailey, M., Rizkallah, P.J., Rossjohn, J., Peakman, M., Price, D.A., Burrows, S.R., Sewell, A.K., Wooldridge, L., 2013, Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement, Blood [P], vol 121, issue 7, American Society of Hematoloty, USA, pp. 1112-1123.

Heatley, S.L., Pietra, G., Lin, J., Widjaja, J.M., Harpur, C.M., Lester, S., Rossjohn, J., Szer, J., Schwarer, A., Bradstock, K.F., Bardy, P., Mingari, M., Moretta, L., Sullivan, L.C., Brooks, A., 2013, Polymorphism in human cytomegalovirus UL40 impacts on recognition of HLA-E by natural killer cells, Journal Of Biological Chemistry [P], vol E-pub, American Society for Biochemistry and Molecular Biology Inc, USA, pp. 1-23.

Tatituri, R.V., Watts, G.F., Bhowruth, V., Barton, N., Rothchild, A., Hsu, F., Almeida, C.F., Cox, L.R., Eggeling, L., Cardell, S.L., Rossjohn, J., Godfrey, D.I., Behar, S.M., Besra, G.S., Brenner, M.B., Brigl, M., 2013, Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 110, issue 5, National Academy of Sciences, USA, pp. 1827-1832.

Battad, J., Traore, D.A., Byres, E., Rossjohn, J., Devenish, R.J., Olsen, S., Wilce, M.C., Prescott, M., 2012, A Green Fluorescent Protein Containing a QFG Tri-Peptide Chromophore: Optical Properties and X-Ray Crystal Structure, PLoS ONE [P], vol 7, issue 10, Public Library of Science, USA, pp. e47331.1-e47331.14.

Zeng, L., Sullivan, L.C., Vivian, J.P., Walpole, N.G., Harpur, C.M., Rossjohn, J., Clements, C.S., Brooks, A.G., 2012, A structural basis for antigen presentation by the MHC class Ib molecule, Qa-1b, Journal Of Immunology [P], vol 188, issue 1, American Association of Immunologists, USA, pp. 302-310.

Gras, S., Wilmann, P., Chen, Z., Abd Halim, N., Liu, Y.C., Kjer-Nielsen, L., Purcell, A.W., Burrows, S.R., McCluskey, J., Rossjohn, J., 2012, A structural basis for varied alphabeta TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule, Journal Of Immunology [P], vol 188, issue 1, American Association of Immunologists, USA, pp. 311-321.

Gras, S., Burrows, S.R., Turner, S.J., Sewell, A.K., McCluskey, J., Rossjohn, J., 2012, A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned, Immunological Reviews [P], vol 250, issue 1, Wiley-Blackwell Publishing Inc., USA, pp. 61-81.

Broughton, S.E., Petersen, J., Theodossis, A., Scally, S.W., Loh, K.L., Thompson, A., van Bergen, J., Kooy-Winkelaar, Y., Henderson, K.N., Beddoe, T.C., Tye-Din, J.A., Mannering, S.I., Purcell, A.W., McCluskey, J., Anderson, R.P., Koning, F., Reid, H.H., Rossjohn, J., 2012, Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease, Immunity [P], vol 37, issue 4, Cell Press, USA, pp. 611-621.

Lahoud, M.H., Ahmet, F., Zhang, J., Meuter, S., Policheni, A.N., Kitsoulis, S., Lee, C., O'Keeffe, M., Sullivan, L.C., Brooks, A.G., Berry, R., Rossjohn, J., Mintern, J.D., Vega-Ramos, J., Villadangos, J.A., Nicola, N.A., Nussenzweig, M.C., Stacey, K.J., Shortman, K., Heath, W.R., Caminschi, I., 2012, DEC-205 is a cell surface receptor for CpG oligonucleotides, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 109, issue 40, National Academy of Sciences, USA, pp. 16270-16275.

Maloveste, S.M., Chen, D., Gostick, E., Vivian, J.P., Plishka, R.J., Iyengar, R., Kruthers, R.L., Buckler-White, A., Brooks, A.G., Rossjohn, J., Price, D.A., Lafont, B.A., 2012, Degenerate recognition of MHC class I molecules with Bw4 and Bw6 motifs by a killer cell Ig-like receptor 3DL expressed by Macaque NK cells, Journal Of Immunology [P], vol 189, issue 9, American Association of Immunologists, USA, pp. 4338-4348.

Smith, C., Elhassen, D., Gras, S., Wynn, K.K., Dasari, V., Tellam, J., Tey, S., Liu, Y.C., Rossjohn, J., Burrows, S.R., Khanna, R., 2012, Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8(+)T cells, Blood [P], vol 120, issue 16, American Society of Hematology, USA, pp. 3237-3245.

Wun, K.S., Ross, F., Patel, O.G., Besra, G.S., Porcelli, S.A., Richardson, S.K., Keshipeddy, S., Howell, A.R., Godfrey, D.I., Rossjohn, J., 2012, Human and mouse type I natural killer T cell antigen receptors exhibit different fine specificities for CD1d-antigen complex, Journal Of Biological Chemistry [P], vol 287, issue 46, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 39139-39148.

Illing, P.T., Vivian, J.P., Dudek, N.L., Kostenko, L., Chen, Z., Bharadwaj, M., Miles, J.J., Kjer-Nielsen, L., Gras, S., Williamson, N.A., Burrows, S.R., Purcell, A.W., Rossjohn, J., McCluskey, J., 2012, Immune self-reactivity triggered by drug-modified HLA-peptide repertoire, Nature [P], vol 486, issue 7404, Nature Publishing Group, UK, pp. 554-558.

Chen, A.T., Cornberg, M., Gras, S., Guillonneau, C., Rossjohn, J., Trees, A., Emonet, S., de la Torre, J.C., Welsh, R.M., Selin, L.K., 2012, Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope, PLoS Pathogens [E], vol 8, issue 4 (Art. ID: e1002633), Public Library of Science, USA, pp. 1-12.

Kjer-Nielsen, L., Patel, O.G., Corbett, A.J., Le Nours, J., Meehan, B., Liu, L., Bhati, M., Chen, Z., Kostenko, L., Reantragoon, R., Williamson, N.A., Purcell, A.W., Dudek, N.L., McConville, M.J., O'Hair, R.A., Khairallah, G.N., Godfrey, D.I., Fairlie, D.P., Rossjohn, J., McCluskey, J., 2012, MR1 presents microbial vitamin B metabolites to MAIT cells, Nature [P], vol 491, issue 7426, Nature Publishing Group, UK, pp. 717-723.

Rossjohn, J., Pellicci, D.G., Patel, O.G., Gapin, L., Godfrey, D.I., 2012, Recognition of CD1d-restricted antigens by natural killer T cells, Nature Reviews Immunology [P], vol 12, issue 12, Nature Publishing Group, UK, pp. 845-857.

Patel, O.G., Pellicci, D.G., Gras, S., Sandoval Romero, M.L., Uldrich, A.P., Mallevaey, T., Clarke, A.J., Le Nours, J., Theodossis, A., Cardell, S.L., Gapin, L., Godfrey, D.I., Rossjohn, J., 2012, Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor, Nature Immunology [P], vol 13, issue 9, Nature Publishing Group, USA, pp. 857-863.

Andrews, D.M., Sullivan, L.C., Baschuk, N., Chan, C., Berry, R., Cotterell, C.L., Lin, J., Halse, H., Watt, S.V., Poursine-Laurent, J., Wang, C., Scalzo, A.A., Yokoyama, W.M., Rossjohn, J., Brooks, A.G., Smyth, M.J., 2012, Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells, Nature Immunology [P], vol 13, issue 12, Nature Publishing Group, USA, pp. 1171-1177.

Bulek, A.M., Cole, D.K., Skowera, A., Dolton, G., Gras, S., Madura, F., Fuller, A., Miles, J.J., Gostick, E., Price, D.A., Drijfhout, J.W., Knight, R.R., Huang, G.C., Lissin, N., Molloy, P.E., Wooldridge, L., Jakobsen, B.K., Rossjohn, J., Peakman, M., Rizkallah, P.J., Sewell, A.K., 2012, Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes, Nature Immunology [P], vol 13, issue 3, Nature Publishing Group, USA, pp. 283-289.

Reantragoon, R., Kjer-Nielsen, L., Patel, O.G., Chen, Z., Illing, P.T., Bhati, M., Kostenko, L., Bharadwaj, M., Meehan, B., Hansen, T.H., Godfrey, D.I., Rossjohn, J., McCluskey, J., 2012, Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor, Journal of Experimental Medicine [P], vol 209, issue 4, Rockefeller University Press, USA, pp. 761-774.

Liu, Y.C., Chen, Z., Burrows, S.R., Purcell, A.W., McCluskey, J., Rossjohn, J., Gras, S., 2012, The energetic basis underpinning T-cell receptor recognition of a super-bulged peptide bound to a major histocompatibility complex class I molecule, Journal Of Biological Chemistry [P], vol 287, issue 15, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 12267-12276.

Brennan, R.M., Petersen, J., Neller, M.A., Miles, J.J., Burrows, J.M., Smith, C., McCluskey, J., Khanna, R., Rossjohn, J., Burrows, S.R., 2012, The impact of a large and frequent deletion in the human TCR � locus on antiviral immunity, Journal Of Immunology [P], vol 188, issue 6, American Association of Immunologists, USA, pp. 2742-2748.

Mallevaey, T., Clarke, A.J., Scott-Browne, J.P., Young, M.H., Roisman, L.C., Pellicci, D.G., Patel, O., Vivian, J.P., Matsuda, J.L., McCluskey, J., Godfrey, D.I., Marrack, P., Rossjohn, J., Gapin, L., 2011, A molecular basis for NKT cell recognition of CD1d-self-antigen, Immunity [P], vol 34, issue 3, Cell Press, USA, pp. 315-326.

Wun, K., Cameron, G., Patel, O., Pang, S.S., Pellicci, D.G., Sullivan, L.C., Keshipeddy, S., Young, M.H., Uldrich, A.P., Thakur, M.S., Richardson, S.K., Howell, A.R., Illarionov, P.A., Brooks, A.G., Besra, G.S., McCluskey, J., Gapin, L., Porcelli, S.A., Godfrey, D.I., Rossjohn, J., 2011, A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells, Immunity [P], vol 34, issue 3, Cell Press, USA, pp. 327-339.

Uldrich, A., Patel, O., Cameron, G., Pellicci, D., Day, E., Sullivan, L., Kyparissoudis, K., Kjer-Nielsen, L., Vivian, J., Cao, B., Brooks, A., Williams, S., Illarionov, P., Besra, G., Turner, S., Porcelli, S., McCluskey, J., Smyth, M., Rossjohn, J., Godfrey, D., 2011, A semi-invariant V{alpha}10{+} T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties, Nature Immunology [P], vol 12, issue 7, Nature Publishing Group, USA, pp. 616-623.

Denton, A., Wesselingh, R., Gras, S., Guillonneau, C., Olson, M.R., Mintern, J.D., Zeng, W., Jackson, D.C., Rossjohn, J., Hodgkin, P.D., Doherty, P.C., Turner, S.J., 2011, Affinity thresholds for naive CD8{+} CTL activation by peptides and engineered influenza A viruses, Journal Of Immunology [P], vol 187, issue 11, American Association of Immunologists, USA, pp. 5733-5744.

Miles, J.J., Thammanichanond, D., Moneer, S., Nivarthi, U.K., Kjer-Nielsen, L., Tracy, S.L., Aitken, C.K., Brennan, R.M., Zeng, W., Marquart, L., Jackson, D., Burrows, S.R., Bowden, D.S., Torresi, J., Hellard, M., Rossjohn, J., McCluskey, J., Bharadwaj, M., 2011, Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection, Journal Of Immunology [P], vol 186, issue 2, American Association of Immunologists, USA, pp. 901-912.

Godfrey, D., Pellicci, D., Rossjohn, J., 2011, Beta-testing NKT cell self-reactivity, Nature Immunology [P], vol 12, issue 12, Nature Publishing Group, USA, pp. 1135-1137.

Bharadwaj, M., Illing, P., Theodossis, A., Purcell, A.W., Rossjohn, J., McCluskey, J., 2011, Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex, Annual Review Of Pharmacology And Toxicology [P], vol E, Annual Reviews, USA, pp. 1-31.

Iglesias, M., Almeida, J., Fastenackels, S., van Bockel, D., Hashimoto, M., Venturi, V., Gostick, E., Urrutia, A., Wooldridge, L., Clement, M., Gras, S., Wilmann, P., Autran, B., Moris, A., Rossjohn, J., Davenport, M., Takiguchi, M., Brander, C., Douek, D., Kelleher, A., Price, D., Appay, V., 2011, Escape from highly effective public CD8+ T-cell clonotypes by HIV, Blood [P], vol 118, issue 8, American Society of Hematology, USA, pp. 2138-2149.

Don Paul, C., Traore, D., Byres, E., Rossjohn, J., Devenish, R., Kiss, C., Bradbury, A., Wilce, M., Prescott, M., 2011, Expression, purification, crystallization and preliminary X-ray analysis of eCGP123, an extremely stable monomeric green fluorescent protein with reversible photoswitching properties, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 67, issue 10, Wiley-Blackwell Publishing, Inc., USA, pp. 1266-1268.

Beddoe, T.C., Brooks, A.G., Rossjohn, J., 2011, How opposites attract, Immunology And Cell Biology [P], vol 89, issue 2, Nature Publishing Group, UK, pp. 163-164.

Berry, R., Chen, Z., McCluskey, J., Rossjohn, J., 2011, Insight into the basis of autonomous immunoreceptor activation, Trends In Immunology [P], vol 32, issue 4, Elsevier Ltd, UK, pp. 165-170.

Vivian, J.P., Duncan, R.C., Berry, R., O'Connor, G.M., Reid, H.H., Beddoe, T.C., Gras, S., Saunders, P.M., Olshina, M.A., Widjaja, J.M., Harpur, C.M., Lin, J., Maloveste, S.M., Price, D.A., Lafont, B.A., McVicar, D.W., Clements, C.S., Brooks, A.G., Rossjohn, J., 2011, Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B, Nature [P], vol 479, issue 7373, Nature Publishing Group, UK, pp. 401-405.

Patel, O., Cameron, G., Pellicci, D., Liu, Z., Byun, H., Beddoe, T., McCluskey, J., Franck, R., Castano, A., Harrak, Y., Llebaria, A., Bittman, R., Porcelli, S., Godfrey, D., Rossjohn, J., 2011, NKT TCR recognition of CD1d-a-C-galactosylceramide, Journal Of Immunology [P], vol 187, issue 9, The American Association of Immunologists, Inc., USA, pp. 4705-4713.

Godfrey, D., Rossjohn, J., 2011, New ways to turn on NKT cells, Journal of Experimental Medicine [P], vol 208, issue 6, Rockefeller University Press, USA, pp. 1121-1125.

Kostenko, L., Kjer-Nielsen, L., Nicholson, I., Hudson, F., Lucas, A., Foley, B., Chen, K., Lynch, K., Nguyen, J., Wu, A., Tait, B., Holdsworth, R., Mallal, S., Rossjohn, J., Bharadwaj, M., McCluskey, J., 2011, Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensitivity, Tissue Antigens [P], vol 78, issue 1, Wiley-Blackwell Publishing, Inc., USA, pp. 11-20.

Pellicci, D., Clarke, A., Patel, O., Mallevaey, T., Beddoe, T., Le Nours, J., Uldrich, A., McCluskey, J., Besra, G., Porcelli, S., Gapin, L., Godfrey, D., Rossjohn, J., 2011, Recognition of beta-linked self glycolipids mediated by natural killer T cell antigen receptors, Nature Immunology [P], vol 12, issue 9, Nature Publishing Group, USA, pp. 827-833.

Day, E., Guillonneau, C., Gras, S., La Gruta, N., Vignali, D., Doherty, P., Purcell, A., Rossjohn, J., Turner, S., 2011, Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 108, issue 23, National Academy of Sciences, USA, pp. 9536-9541.

Gras, S., Kjer-Nielsen, L., Chen, Z., Rossjohn, J., McCluskey, J., 2011, The structural bases of direct T-cell allorecognition: Implications for T-cell-mediated transplant rejection, Immunology And Cell Biology [P], vol 89, issue 3, Nature Publishing Group, UK, Australia, pp. 388-395.

D'Orsogna, L.J.A., Roelen, D.L., van der Meer-Prins, E.M., van der Pol, P., Franke-van Dijk, M.E., Eikmans, M., Anholts, J., Rossjohn, J., McCluskey, J., Mulder, A., van Kooten, C., Doxiadis, I.I., Claas, F.H., 2011, Tissue specificity of cross-reactive allogeneic responses by EBV EBNA3A-specific memory T cells, Transplantation [P], vol 91, issue 5, Lippincott Williams & Wilkins, USA, Canada, pp. 494-500.

Patel, O.G., Pellicci, D.G., Uldrich, A.P., Sullivan, L.C., Bhati, M., McKnight, M.A., Richardson, S.K., Howell, A.R., Mallevaey, T., Zhang, J., Bedel, R., Besra, G., Brooks, A.G., Kjer-Nielsen, L., McCluskey, J., Porcelli, S.A., Gapin, L., Rossjohn, J., Godfrey, D.I., 2011, Vbeta2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 108, issue 47, National Academy of Sciences, USA, pp. 19007-19012.

Turner, S., Rossjohn, J., 2011, alphabeta T cell receptors come out swinging, Immunity [P], vol 35, issue 5, Cell Press, USA, pp. 660-662.

Gras, S., Chen, Z., Miles, J.J., Liu, Y.C., Bell, M.J., Sullivan, L.C., Kjer-Nielsen, L., Brennan, R.M., Burrows, J.M., Neller, M.A., Khanna, R., Purcell, A.W., Brooks, A.G., McCluskey, J., Rossjohn, J., Burrows, S.R., 2010, Allelic polymorphism in the T cell receptor and its impact on immune responses, Journal of Experimental Medicine [P], vol 207, issue 7, Rockefeller University Press, USA, pp. 1555-1567.

Semmling, V., Lukacs-Kornek, V., Thaiss, C.A., Quast, T., Hochheiser, K., Panzer, U., Rossjohn, J., Perlmutter, P., Cao, J., Godfrey, D.I., Savage, P.B., Knolle, P.A., Kolanus, W., Forster, I., Kurts, C., 2010, Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs, Nature Immunology [P], vol 11, issue 4, Nature Publishing Group, USA, pp. 313-320.

Godfrey, D.I., Pellicci, D.G., Patel, O., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J., 2010, Antigen recognition by CD1d-restricted NKT T cell receptors, Seminars In Immunology [P], vol 22, issue 2, Academic Press, UK, pp. 61-67.

Tye-Din, J.A., Stewart, J.A., Dromey, J.A., Beissbarth, T., van Heel, D.A., Tatham, A., Henderson, K., Mannering, S.I., Gianfrani, C., Jewell, D.P., Hill, A.V., McCluskey, J., Rossjohn, J., Anderson, R.P., 2010, Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease, Science Translational Medicine [P], vol 2, issue Art. No: 41ra51, American Association for the Advancement of Science, USA, pp. 1-14.

Theodossis, A., Guillonneau, C., Welland, A.D., Ely, L.K., Clements, C.S., Williamson, N.A., Webb, A.I., Wilce, J.A., Mulder, R.J., Dunstone, M.A., Doherty, P.C., McCluskey, J., Purcell, A.W., Turner, S.J., Rossjohn, J., 2010, Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 107, issue 12, National Academy of Sciences, USA, pp. 5534-5539.

Gras, S., Kedzierski, L., Valkenburg, S.A., Laurie, K.L., Liu, Y.C., Denholm, J.T., Richards, M.J., Rimmelzwaan, G.F., Kelso, A., Doherty, P.C., Turner, S.J., Rossjohn, J., Kedzierska, K., 2010, Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 107, issue 28, National Academy of Sciences, USA, pp. 12599-12604.

Vivian, J., Riedmaier, P., Ge, H., Le Nours, J., Sansom, F.M., Wilce, M.C.J., Byres, E., Dias, M., Schmidberger, J., Cowan, P.J., d'Apice, A.J., Hartland, E.L., Rossjohn, J., Beddoe, T.C., 2010, Crystal Structure of a Legionella pneumophila Ecto -Triphosphate Diphosphohydrolase, A Structural and Functional Homolog of the Eukaryotic NTPDases, Structure [P], vol 18, issue 2, Cell Press, USA, pp. 228-238.

Scoble, J.A., McAlister, A.D., Fulton, Z.J., Troy, S.T., Byres, E., Vivian, J., Brammananth, R., Wilce, M.C.J., Le Nours, J., Zaker-Tabrizi, L., Coppel, R.L., Crellin, P., Rossjohn, J., Beddoe, T.C., 2010, Crystal structure and comparative functional analyses of a Mycobacterium aldo-keto reductase, Journal of Molecular Biology [P], vol 398, issue 1, Academic Press, UK, pp. 26-39.

Godfrey, D.I., Rossjohn, J., McCluskey, J., 2010, Fighting infection with your MAITs, Nature Immunology [P], vol 11, issue 8, Nature Publishing Group, USA, pp. 693-695.

Burrows, S.R., Chen, Z., Archbold, J.K., Tynan, F.E., Beddoe, T.C., Kjer-Nielsen, L., Miles, J.J., Khanna, R., Moss, D.J., Liu, Y.C., Gras, S., Kostenko, L., Brennan, R.M., Clements, C.S., Brooks, A.G., Purcell, A.W., McCluskey, J., Rossjohn, J., 2010, Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 107, issue 23, National Academy of Sciences, USA, pp. 10608-10613.

Valkenburg, S.A., Gras, S., Guillonneau, C., La Gruta, N.L., Thomas, P.G., Purcell, A.W., Rossjohn, J., Doherty, P.C., Turner, S.J., Kedzierska, K., 2010, Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold, Plos Pathogens [P], vol 6, issue 8 (e1001039), Public Library of Science, USA, pp. 1-15.

Beddoe, T.C., Paton, A.W., Le Nours, J., Rossjohn, J., Paton, J.C., 2010, Structure, biological functions and applications of the AB5 toxins, Trends In Biochemical Sciences [P], vol 35, issue 7, Elsevier Ltd, UK, Switzerland, pp. 411-418.

Crellin, P., Vivian, J., Scoble, J.A., Chow, F.M., West, N.P., Brammananth, R., Proellocks, N.I., Shahine, A.E., Le Nours, J., Wilce, M.C., Britton, W.J., Coppel, R.L., Rossjohn, J., Beddoe, T.C., 2010, Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability, Journal Of Biological Chemistry [P], vol 285, issue 39, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 30050-30060.

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Olsen, S., Prescott, M., Wilmann, P.G., Battad, J., Rossjohn, J., Smith, S.C., 2006, Determination of chromophore charge states in the low pH color transition of the fluorescent protein Rtms5H146S via time-dependent DFT, Chemical Physics Letters, vol 420, issue 4-6, Elsevier, Amsterdam The Netherlands, pp. 507-511.

Ely, L.K., Beddoe, T.C., Clements, C.S., Matthews, J.M., Purcell, A.W., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J., 2006, Disparate thermodynamics governing T cell receptor-MHC-1 interactions implicate extrinsic factors in guiding MHC restriction, Proceedings of the National Academy of Sciences of the United States of America, vol 103, issue 17, National Academy of Sciences, Washington USA, pp. 6641-6646.

Burrows, S.R., Rossjohn, J., McCluskey, J., 2006, Have we cut ourselves too short in mapping CTL epitopes?, Trends in Immunology, vol 27, issue 1, Elsevier, Kidlington England, pp. 11-16.

Marland, Z., Beddoe, T.C., Zaker-Tabrizi, L., Lucet, I., Brammananth, R., Whisstock, J.C., Wilce, M.C.J., Coppel, R.L., Crellin, P.K., Rossjohn, J., 2006, Hijacking of a substrate-binding protein scaffold for use in mycobacterial cell wall biosynthesis, Journal of Molecular Biology, vol 359, issue 4, Academic Press Ltd Elsevier Science Ltd, London UK, pp. 983-997.

Amin, A.A., Faux, N.G., Fenalti, G., Williams, G.N., Bernadou, A., Daglish, B., Keefe, K., Middleton, S., Rae, J., Tetis, K., Law, R.H.P., Fulton, K.F., Rossjohn, J., Whisstock, J.C., Buckle, A.M., 2006, Managing and mining protein crystallization data, Proteins: Structure Function, and Bioinformatics, vol 62, issue 1, Wiley-Liss, Hoboken USA, pp. 4-7.

Clements, C.S., Dunstone, M.A., Macdonald, W.A., McCluskey, J., Rossjohn, J., 2006, Specificity on a knife-edge: The alphabeta T cell receptor, Current Opinion in Structural Biology, vol 16, issue 6, Current Biology Ltd, London UK, pp. 787-795.

Hoare, H.L., Sullivan, L.C., Pietra, G., Clements, C.S., Lee, E.J., Ely, L.K., Beddoe, T.C., Falco, M., Kjer-Nielsen, L., Reid, H.H., McCluskey, J., Moretta, L., Rossjohn, J., Brooks, A.G., 2006, Structural basis for a major histocompatibility complex class Ib-restricted T cell response, Nature Immunology, vol 7, issue 3, Nature Publishing Group, New York USA, pp. 256-264.

Turner, S.J., Doherty, P., McCluskey, J., Rossjohn, J., 2006, Structural determinants of T-cell receptor bias in immunity, Nature Reviews Immunology, vol 6, issue 12, Nature Publishing Group, London UK, pp. 883-894.

Miles, J.J., Borg, N.A., Brennan, R.M., Tynan, F.E., Kjer-Nielsen, L., Silins, S.L., Bell, M.J., Burrows, J.M., McCluskey, J., Rossjohn, J., Burrows, S.R., 2006, TCRalpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope, Journal of Immunology, vol 177, issue 10, The American Association of Immunologists, Bethesda USA, pp. 6804-6814.

Wilmann, P.G., Turcic, K., Battad, J.M., Wilce, M.C.J., Devenish, R.J., Prescott, M., Rossjohn, J., 2006, The 1.7 angstrom crystal structure of Dronpa: A photoswitchable green fluorescent protein, Journal of Molecular Biology, vol 364, issue 2, Academic Press Ltd Elsevier Science Ltd, London England, pp. 213-224.

Wilmann, P., Battad, J., Beddoe, T.C., Olsen, S., Dove, S., Devenish, R.J., Rossjohn, J., Prescott, M., 2006, The 2.0 A crystal structure of a pocilloporin at pH 3.5: The structural basis for the linkage between color transition and halide binding, Photochemistry & Photobiology, vol 82, issue 2, American Society for Photobiology, Augusta USA, pp. 359-366.

Wilmann, P.G., Battad, J., Beddoe, T.C., Olsen, S., Smith, S.C., Dove, S., Devenish, R.J., Rossjohn, J., Prescott, M., 2006, The 2.0 angstrom crystal structure of a pocilloporin at pH 3.5: The structural basis for the linkage between color transition and halide binding, Photochemistry & Photobiology, vol 82, issue 2, American Society for Photobiology, Augusta USA, pp. 359-366.

Wilmann, P.G., Battad, J., Petersen, J., Wilce, M.C.J., Dove, S., Devenish, R.J., Prescott, M., Rossjohn, J., 2006, The 2.1 angstrom crystal structure of copGFP, a representative member of the copepod clade within the green fluorescent protein superfamily, Journal of Molecular Biology, vol 359, issue 4, Academic Press Ltd Elsevier Science Ltd, London UK, pp. 890-900.

Clements, C.S., Kjer-Nielsen, L., Kostenko, L., McCluskey, J., Rossjohn, J., 2006, The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt, Acta Crystallographica, vol 62, issue 1, Blackwell Publishing, Oxford England, pp. 70-73.

Lucet, I.S., Fantino, E., Styles, M., Bamert, R.S., Patel, O.G., Broughton, S.E., Walter, M., Burns, C.J., Treutlein, H., Wilks, A.F., Rossjohn, J., 2006, The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor, Blood, vol 107, issue 20 September 2005, American Society of Hematology, Washington DC USA, pp. 176-183.

Bushell, S.R., Bottomley, S.P., Rossjohn, J., Beddoe, T.C., 2006, Tracking the unfolding pathway of a multirepeat protein via tryptophan scanning: Evidence of localized instability in the mitochondrial import receptor Tom70, The Journal of Biological Chemistry, vol 281, issue 34, American Society for Biochemistry and Molecular Biology, Inc, Bethesda USA, pp. 24345-24350.

Williamson, N.A., Rossjohn, J., Purcell, A.W., 2006, Tumors reveal their secrets to cytotoxic T cells, Proceedings of the National Academy of Sciences of the United States of America, vol 103, issue 40, National Academy of Sciences, Washington USA, pp. 14649-14650.

Adams, V.M., Lucet, I., Tynan, F.E., Chiarezza, M., Howarth, P., Kim, J., Rossjohn, J., Lyras, D., Rood, J.I., 2006, Two distinct regions of the large serine recombinase TnpX are required for DNA binding and biological function, Molecular Microbiology, vol 60, issue 3, Blackwell Publishing, UK, pp. 591-601.

McGowan, S., Buckle, A.M., Irving, J.A., Ong, P.C., Bashtannyk-Puhalovich, T.A., Kan, W., Henderson, K., Bulynko, Y.A., Popova, E.Y., Smith, A.I., Bottomley, S.P., Rossjohn, J., Grigoryev, S.A., Pike, R.N., Whisstock, J.C., 2006, X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation, The EMBO Journal, vol 25, issue 13, Nature Publishing Group, New York USA, pp. 3144-3155.

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Bushell, S.R., Beddoe, T.C., Perugini, M.A., Bottomley, S.P., Rossjohn, J., 2005, A structural and functional characterization of Tom70: a receptor of the mitochondrial import machinery, Febs Journal, vol 272, Blackwell Publishing, Oxford England, p. 365.

Ely, L.K., Green, K.J., Beddoe, T.C., Clements, C.S., Miles, J.J., Bottomley, S.P., Zernich, D., Kjer-Nielsen, L., Purcell, A.W., McCluskey, J., Rossjohn, J., Burrows, S.R., 2005, Antagonism of antiviral and allogeneic activity of a human public ctl clonotype by a single altered peptide ligand: Implications for allograft rejection, Journal of Immunology, vol 174, issue 9, American Association of Immunologists, Bethesda USA, pp. 5593-5601.

Godfrey, D.I., McCluskey, J., Rossjohn, J., 2005, CD1d antigen presentation: treats for NKT cells, Nature Immunology, vol 6, issue 8, Nature Publishing Group, New York USA, pp. 754-756.

Miles, J.J., Elhassen, D., Borg, N.A., Silins, S.L., Tynan, F.E., Burrows, J.M., Purcell, A.W., Kjer-Nielsen, L., Rossjohn, J., Burrows, S.R., McCluskey, J., 2005, CTL recognition of a bulged viral peptide involves biased TCR selection, Journal of Immunology, vol 175, issue 6, American Association of Immunologists, Bethesda USA, pp. 3826-3834.

Clements, C.S., Kjer-Nielsen, L., Kostenko, L., Hoare, H.L., Dunstone, M.A., Moses, E.K., Freed, K., Brooks, A.G., Rossjohn, J., McCluskey, J., 2005, Crystal structure of HLA-G: A nonclassical MHC class I molecule expressed at the fetal-maternal interface, Proceedings of the National Academy of Sciences of the United States of America, vol 102, issue 9, National Academy of Sciences, Washington USA, pp. 3360-3365.

Marland, Z., Beddoe, T.C., Zaker-Tabrizi, L., Coppel, R.L., Crellin, P., Rossjohn, J., 2005, Expression, purification, crystallization and preliminary X-ray diffraction analysis of an essential lipoprotein implicated in cell-wall biosynthesis in Mycobacteria, Acta Crystallographica, vol 61, issue 12, Blackwell Publishing, Oxford England, pp. 1081-1083.

Tynan, F.E., Borg, N., Miles, J.J., Beddoe, T.C., El-Hassen, D., Silins, S.L., van Zuylen, W.J., Purcell, A.W., Kjer-Nielsen, L., McCluskey, J., Burrows, S.R., Rossjohn, J., 2005, High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I: implications for T-Cell receptor engagement and T-cell immunodominance, Journal of Biological Chemistry, vol 280, issue 25, American Society for Biochemistry and Molecular Biology Inc., Bethesda USA, pp. 23900-23909.

Lucet, I.S., Tynan, F.E., Adams, V.M., Rossjohn, J., Lyras, D., Rood, J.I., 2005, Identification of the structural and functional domains of the large serine recombinase TnpX from Clostridium perfringens, The Journal of Biological Chemistry, vol 280, issue 4, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 2503-2511.

Turner, S.J., Kedzierska, K., Komodromou, H., La Gruta, N.L., Dunstone, M.A., Webb, A.I., Webby, R., Walden, H., Xie, W., McCluskey, J., Purcell, A.W., Rossjohn, J., Doherty, P.C., 2005, Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations, Nature Immunology, vol 6, issue 4, Nature Publishing Group, New York USA, pp. 382-389.

Ely, L.K., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J., 2005, Structural studies on the alphabeta T-cell receptor, IUBMB Life, vol 57, issue 8, Taylor & Francis Inc., Philadelphia USA, pp. 575-582.

Webb, A.I., Dunstone, M.A., Williamson, N.A., Price, J.D., de Kauwe, A., Chen, W., Oakley, A.J., Perlmutter, P., McCluskey, J., Aguilar, M., Rossjohn, J., Purcell, A.W., 2005, T cell determinants incorporating beta-amino acid residues are protease resistant and remain immunogenic in vivo, Journal of Immunology, vol 175, issue 6, American Association of Immunologists, Bethesda USA, pp. 3810-3818.

Tynan, F.E., Burrows, S.R., Buckle, A.M., Clements, C.S., Borg, N.A., Miles, J.J., Beddoe, T.C., Whisstock, J.C., Wilce, M.C.J., Silins, S.L., Burrows, J.M., Kjer-Nielsen, L., Kostenko, L., Purcell, A.W., McCluskey, J., Rossjohn, J., 2005, T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide, Nature Immunology, vol 6, issue 11, Nature Publishing Group, New York USA, pp. 1114-1122.

Wilmann, P.G., Petersen, J., Pettikiriarachchi, A., Buckle, A.M., Smith, S.C., Olsen, S., Perugini, M.A., Devenish, R.J., Prescott, M., Rossjohn, J., 2005, The 2.1 Angstrom Crystal Structure of the Far-red Fluorescent Protein HcRed: Inherent Conformational Flexibility of the Chromophore, Journal of Molecular Biology, vol 349, issue 1, Academic Press Ltd Elsevier Science Ltd, London England, pp. 223-237.

Borg, N.A., Ely, L.K., Beddoe, T.C., Macdonald, W.A., Reid, H.H., Clements, C.S., Purcell, A.W., Kjer-Nielsen, L., Miles, J.J., Burrows, S.R., McCluskey, J., Rossjohn, J., 2005, The CDR3 regions of an Immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition, Nature Immunology, vol 6, issue 2, Nature Publishing Group, New York USA, pp. 171-180.

Fulton, K.F., Buckle, A.M., Cabrita, L.D., Irving, J.A., Butcher, R.E., Smith, A.I., Reeve, S.B., Lesk, A.M., Bottomley, S.P., Rossjohn, J., Whisstock, J.C., 2005, The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition, Journal of Biological Chemistry, vol 280, issue 9, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 8435-8442.

Law, R.H.P., Irving, J.A., Buckle, A.M., Ruzyla, K., Buzza, M.S., Bashtannyk-Puhalovich, T.A., Beddoe, T.C., Nguyen, K., Worrall, M.D., Bottomley, S.P., Bird, P.I., Rossjohn, J., Whisstock, J.C., 2005, The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix, Journal of Biological Chemistry, vol 280, issue 23, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 22356-22364.

Tynan, F.E., Elhassen, D., Purcell, A.W., Burrows, J.M., Borg, N.A., Miles, J.J., Williamson, N.A., Green, K.J., Tellam, J., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J., Burrows, S.R., 2005, The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation, The Journal of Experimental Medicine, vol 202, issue 9, Rockefeller University Press, New York USA, pp. 1249-1260.

Mannering, S.I., Harrison, L.C., Williamson, N.A., Morris, J.S., Thearle, D.J., Jensen, K.P., Kay, T.W., Rossjohn, J., Falk, B.A., Nepom, G.T., Purcell, A.W., 2005, The insulin A-chain epitope recognized by human T cells is posttranslationally modified, Journal of Experimental Medicine, vol 202, issue 9, Rockefeller University Press, New York USA, pp. 1191-1197.

Horvath, A.J., Irving, J.A., Rossjohn, J., Law, R.H.P., Bottomley, S.P., Quinsey, N.S., Pike, R.N., Coughlin, P.B., Whisstock, J., 2005, The murine orthologue of human antichymotrypsin: a structural paradigm for CLADE A3 serpins, Journal of Biological Chemistry, vol 280, issue 52, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 43168-43178.

Wilmann, P.G., Petersen, J., Devenish, R.J., Prescott, M., Rossjohn, J., 2005, Variations on the GFP chromophore: A polypeptide fragmentation within the chromophore revealed in the 2.1-Angstrom crystal structure of a nonfluorescent chromoprotein from Anemonia sulcata, The Journal of Biological Chemistry, vol 280, issue 4, American Society of Biochemistry & Molecular Biology Inc, Bethesda, MD, USA, pp. 2401-2404.

Beddoe, T.C., Bushell, S.R., Perugini, M.A., Lithgow, T., Mulhern, T.D., Bottomley, S.P., Rossjohn, J., 2004, A biophysical analysis of the tetratricopeptide repeat-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable, and unfolds via a multistate pathway, Journal of Biological Chemistry, vol 279, issue 45, The American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 46448-46454.

Pereira, J.J., Meyer, T., Docherty, S.E., Reid, H.H., Marshall, J., Thompson, E.W., Rossjohn, J., Price, J.T., 2004, Bimolecular interaction of Insulin-Like Growth Factor (IGF) binding Protein-2 with 3 negatively modulates IGF-I-Mediated migration and tumor growth, Cancer Research, vol 64, issue 3, American Association of Cancer Research, Philadelphia USA, pp. 977-984.

Kjer-Nielsen, L., Dunstone, M.A., Kostenko, L., Ely, L.K., Beddoe, T.C., Mifsud, N.A., Purcell, A.W., Brooks, A.G., McCluskey, J., Rossjohn, J., 2004, Crystal structure of the human T cell receptor CD3 heterodimer complexed to the therapeutic mAb OKT3, Proceeedings of the National Academy of Sciences of the United Stated of America, vol 101, issue 20, National Academy of Sciences, Washington USA, pp. 7675-7680.

Webb, A.I., Dunstone, M.A., Chen, W., Aguilar, M.I., Chen, Q., Jackson, H., Chang, L., Kjer-Nielsen, L., Beddoe, T.C., McCluskey, J., Rossjohn, J., Purcell, A.W., 2004, Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogue, The Journal of Biological Chemistry, vol 279, issue 22, American Society for Biochemistry and Molecular Biology Inc., Bethesda USA, pp. 23438-23446.

Zernich, D., Purcell, A.W., Macdonald, W.A., Kjer-Nielsen, L., Ely, L.K., Laham, N., Crockford, T., Mifsud, N.A., Bharadwaj, M., Chang, L., Tait, B.D., Holdsworth, R., Brooks, A.G., Bottomley, S.P., Beddoe, T.C., Peh, C.A., Rossjohn, J., McCluskey, J., 2004, Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion, The Journal of Experimental Medicine, vol 200, issue 1, Rockerfeller University Press, New York USA, pp. 13-24.

McCluskey, J., Rossjohn, J., Purcell, A.W., 2004, TAP genes and immunity, Current Opinion in Immunology, vol 16, issue 5, Current Biology Ltd, London UK, pp. 651-659.

Melton, J.A., Parker, M.W., Rossjohn, J., Buckley, J.T., Tweten, R.K., 2004, The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin, The Journal of Biological Chemistry, vol 279, issue 14, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 14315-14322.

Dunstone, M.A., Kjer-Nielsen, L., Kostenko, L., Purcell, A.W., Brooks, A.G., Rossjohn, J., McCluskey, J., 2004, The production and purification of the human T-cell receptors, the CD3and CD3heterodimers: Complex formation and crystallization with OKT3, a therapeutic monoclonal antibody, Acta Crystallographica Section D - Biological Crystallography, vol 60, issue 8, Blackwell Munksgaard, Copenhagen Denmark, pp. 1425-1428.

Webb, A.I., Borg, N.A., Dunstone, M.A., Kjer-Nielsen, L., Beddoe, T.C., McCluskey, J., Carbone, F.R., Bottomley, S.P., Aguilar, M.I., Purcell, A.W., Rossjohn, J., 2004, The structure of H-2Kb and Kbm8 complexed to a herpes simplex virus determinant: evidence for a conformational switch that governs T cell repertoire selection and viral resistance, The Journal of Immunology, vol 173, issue 1, American Association of Immunologists, Bethesda USA, pp. 402-409.

Macdonald, W.A., Purcell, A.W., Mifsud, N.A., Ely, L.K., Williams, D.S., Chang, L., Gorman, J.J., Clements, C.S., Kjer-Nielsen, L., Koelle, D.M., Burrows, S.R., Tait, B.D., Holdsworth, R., Brooks, A.G., Lovrecz, G.O., Lu, L., Rossjohn, J., McCluskey, J., 2003, A naturally selected dimorphism within the HLA-B44 supertype alters Class I structure, peptide repertoire, and T cell recognition, Journal of Experiemental Medicine, vol 198, issue 5, Rockefeller University Press, New York USA, pp. 679-691.

Kjer-Nielsen, L., Clements, C.S., Purcell, A.W., Brooks, A.G., Whisstock, J.C., Burrows, S.R., McCluskey, J., Rossjohn, J., 2003, A structural basis for the selection of dominant T cell receptors in antiviral immunity, Immunity, vol 18, issue 1, Cell Press, Cambridge USA, pp. 53-64.

Micaloni, C., Kong, G.K., Mazzetti, A.P., Nuccetelli, M., Antonini, G., Stella, L., McKinstry, W.J., Polekhina, G., Rossjohn, J., Federici, G., Ricci, G., Parker, M.W., Lo Bello, M., 2003, Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences, Journal of Molecular Biology [P], vol 325, issue 1, Academic Press Ltd Elsevier Science Ltd, London, England, pp. 111-122.

Irving, J.A., Cabrita, L.D., Rossjohn, J., Pike, R.N., Bottomley, S.P., Whisstock, J.C., 2003, The 1.5 crystal structure of a prokaryote serpin: controlling conformational change in a heated environment, Structure, vol 11, issue 4, Cell Press, Cambridge USA, pp. 387-397.

Petersen, J., Wilmann, P.G., Beddoe, T.C., Oakley, A.J., Devenish, R.J., Prescott, M., Rossjohn, J., 2003, The 2.0- crystal structure of eqFP611, a far red fluorescent protein from the sea anemone Entacmaea quadricolor, Journal of Biological Chemistry, vol 278, issue 45, American Society for Biochemistry and Molecular Biology Inc., Bethesda USA, pp. 44626-44631.

Prescott, M., Ling, M., Beddoe, T.C., Oakley, A.J., Dove, S., Hoegh-Guldberg, O., Devenish, R.J., Rossjohn, J., 2003, The 2.2 crystal structure of a pocilloporin pigment reveals a nonplanar chromophore conformation, Structure, vol 11, issue 3, Cell Press, Cambridge USA, pp. 275-284.

Clements, C.S., Reid, H.H., Beddoe, T.C., Tynan, F.E., Perugini, M., Johns, T.G., Bernard, C.C.A., Rossjohn, J., 2003, The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis, Proceedings of the National Academy of Sciences of the United States of America, vol 100, issue 19, National Academy of Sciences, Washington USA, pp. 11059-11064.

Beddoe, T.C., Ling, M., Dove, S., Hoegh-Guldberg, O., Devenish, R.J., Prescott, M., Rossjohn, J., 2003, The production, purification and crystallization of a pocilloporin pigment from a reef-forming coral, Acta Crystallography Section D-BIological Crystallography, vol 59, Blackwell Munksgaard, Copenhagen Denmark, pp. 597-599.

Macdonald, W., Williams, D.S., Gorman, J.J., Kjer-Nielsen, L., Brooks, A.G., McCluskey, J., Rossjohn, J., Purcell, A.W., 2002, Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant form of each complex, FEBS Letters, vol 527, issue 1-3, Elsevier Science BV, Amsterdam Netherlands, pp. 27-32.

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Conference Proceedings

Theodossis, A., Ruiz-Gomez, G., Gibb, A., Welland, A.D., Jones, P., Fairlie, D.P., Rossjohn, J., 2012, Shedding light on MHC class I antigen loading: a UV-labile peptide ligand approach, Shedding light on MHC class I antigen loading: a UV-labile peptide ligand approach, 25-27 April 2012, Pergamon, UK, p. 33.

Kjer-Nielsen, L., Beddoe, T.C., Kostenko, L., Clements, C.S., Williamson, N.A., Besra, G.S., Reid, H.H., Bharadwaj, M., Godfrey, D.I., McCluskey, J., Rossjohn, J., 2005, A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1D-mediated antigen recognition, Tissue Antigens, 29 November 2005 - 3rd December 2005, Blackwell Publishing, Oxford England, p. 365.

Tynan, F.E., Burrows, S.R., Buckle, A.M., Clements, C.S., Borg, N., Beddoe, T.C., Whisstock, J.C., Wilce, M.C.J., Silins, S.L., Burrows, J.M., Kjer-Nielsen, L., Kostenko, L., Purcell, A.W., McCluskey, J., Rossjohn, J., 2005, A super-bulged epitope and single amino acid polymorphism identify critical features for T cell recognition, Tissue Antigens, 29 November 2005 - 3rd December 2005, Blackwell Publishing, Oxford England, p. 571.

Webb, A.I., Dunstone, M.A., Aguilar, M.I., Rossjohn, J., Purcell, A.W., 2005, Engineering protease resistance into T cell epitopes improves bioavailability of vaccine components, Tissue Antigens, 29 November 2005 - 3rd December 2005, Blackwell Publishing, Oxford England, p. 586.

Miles, J.J., Borg, N., Tynan, F.E., Kjer-Nielsen, L., Elhassen, D., Silins, S.L., Burrows, J.M., Brennan, R.M., Purcell, A.W., McCluskey, J., Rossjohn, J., 2005, Predicting the human T cell receptor choice before viral infection; Facts learnt from primary infection, Tissue Antigens, 29 November 2005 - 3rd December 2005, Blackwell Publishing, Oxford England, p. 493.

Hoare, H.L., Sullivan, L.C., Pietra, G., Clements, C.S., Beddoe, T.C., Kjer-Nielsen, L., Reid, H.H., McCluskey, J., Moretta, L., Rossjohn, J., 2005, Recognition of the non-classical MHC class I molecule, HLA-E, by the adaptive immune system, Tissue Antigens, 29 November 2005 - 3rd December 2005, Blackwell Publishing, Oxford England, p. 443.

Archbold, J.K., Macdonald, W.A., Purcell, A.W., McCluskey, J., Rossjohn, J., 2005, The crystal structure of HLA-B*5701: Implications for abacavir hypersensitivity, Tissue Antigens, 29 November 2005 - 3rd December 2005, Blackwell Publishing, Oxford England, pp. 351-352.

La Gruta, N.L., Webb, A.I., Dunstone, M.A., Doherty, P.C., Purcell, A.W., Rossjohn, J., Turner, S.J., 2005, The relationship between peptide-MHC class I structures and the TCR repertoire diversity of influenza a virus specific CD8+T cells, Tissue Antigens, 29 November 2005 - 3rd December 2005, Blackwell Publishing, Oxford England, pp. 570-571.

Henderson, K., Rossjohn, J., McCluskey, J., 2005, The structural and functional importance of deamidation of the dominant gliadin epitope in HLA-DQ8 associated Celiac disease, Tissue Antigens, 29 November 2005 - 3rd December 2005, Blackwell Publishing, Oxford England, p. 441.

Rossjohn, J., Feil, S.C., Wilce, M., Sexton, J.L., Spithill, T.W., Parker, M.W., 1998, Crystallization, structural determination and analysis of a novel parasite vaccine candidate - Fasciola hepatica glutathion e S - transferase, Proceedings, 23rd Annual Lorne Conference on Protein Structure and Function, Lorne 8-12 February 1998, Lorne Protein Workshop Inc, Melbourne Vic Australia, p. C-66.

Parker, M.W., Rossjohn, J., Oakley, A.J., Polekhina, G., McKinstry, W.J., Feil, S.C., Lo Bello, M., Di Ilio, C., Spithill, T.W., Board, P.G., 1998, Evolution of functional diversity - structural studies of an enzyme superfamily, Proceedings of the Australian Society for Biochemistry and Molecular Biology, Adelaide 28 September - 1 October 1998, Aust Soc for Biochemistry & Molecular Biology, Kent Town SA, pp. S-22-03-s-22-03.

Other

Rossjohn, J., 2011, New cell type offers new hope, Monash University News and Events, Monash University, Australia.

Pang, S.S., Berry, R., Chen, Z., Kjer-Nielsen, L., Perugini, M.A., King, G.F., Wang, C., Chew, S.H., La Gruta, N.L., Williams, N.K., Beddoe, T.C., Tiganis, T., Cowieson, N.P., Godfrey, D.I., Purcell, A.W., Wilce, M.C., McCluskey, J., Rossjohn, J., 2010, Crucial link in immune development and regulation unearthed, Quality control mechanism that must take place for our immune system, Monash University, Clayton, Vic, Australia.

Rossjohn, J., Beddoe, T.C., Dunstone, M.A., Ely, L.K., McCluskey, J., Kjer-Nielsen, L., Kostenko, L., Purcell, A.W., 2004, Crystal structure of CD3ϵgammaad;/OKT3 complex, Australia.

Aguilar, M., Perlmutter, P., Purcell, A.W., Webb, A.I., Rossjohn, J., 2002, A method of modulating cellular activity and molecules for use therein, Australia.

Postgraduate Research Supervisions

Current Supervision

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Elucidating the role of NKT Cells in Asthma.
Supervisors:: Rossjohn, J (Main).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Natural killer T cell recognition of lipid-based antigens.
Supervisors:: Rossjohn, J (Main), Patel, O (Associate).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Structural and biophysical investigations into super-bulged antigen and its recognition by T cell receptors..
Supervisors:: Rossjohn, J (Main), Gras, S (Associate).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Structural basis for citrullination dependent rheumatoid arthritis.
Supervisors:: Rossjohn, J (Main), Reid, H (Associate).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Structural insights into the recognition of CD1d-restricted self antigens by the Natural Killer T cell T cell antigen Receptor.
Supervisors:: Rossjohn, J (Main).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Structure function of mycolic acid biosynthesis in Mycobacterium tuberculosis.
Supervisors:: Rossjohn, J (Main), Beddoe, T (Associate).

Completed Supervision

Student:: Archbold, J.
Program of Study:: Structural insights into T cell specificity and alloreactivity. (PHD) 2008.
Supervisors:: Rossjohn, J (Main), Macdonald, W (Associate).
Student:: Broughton, S.
Program of Study:: Structural insights into the CD4+ T cell response to the alpha1-gliadin peptide in celiac disease. (PHD) 2010.
Supervisors:: Rossjohn, J (Main), Reid, H (Associate).
Student:: Bushell, S.
Program of Study:: Adaptability and flexibility in natural tetratricopeptide repeat models. (PHD) 2007.
Supervisors:: Devenish, R (Joint), Rossjohn, J (Joint-Co).
Student:: Ely, L.
Program of Study:: A structural investigation into T-cell receptor allorecognition. (PHD) 2005.
Supervisors:: Devenish, R (Joint), Rossjohn, J (Joint-Co).
Student:: Fulton, Z.
Program of Study:: A structural investigation into mycobacterial cell wall biosynthesis proteins. (PHD) 2008.
Supervisors:: Coppel, R (Joint), Rossjohn, J (Joint-Co).
Student:: Henderson, K.
Program of Study:: A structural and functional investigation into celiac disease. (PHD) 2008.
Supervisors:: Rossjohn, J (Main), Mccluskey, J (External).
Student:: Hoare, H.
Program of Study:: Structural basis for the recognition of Human Leukocyte Antigen-E by Natural Killer cell and T cell receptors. (PHD) 2008.
Supervisors:: Devenish, R (Joint), Rossjohn, J (Joint-Co).
Student:: Shahine, A.
Program of Study:: Protein crystallography for TB. 2009.
Supervisors:: Rossjohn, J (Main), Beddoe, T (Associate).
Student:: Tynan, F.
Program of Study:: . 2002.
Supervisors:: Rossjohn, J (Main).
Student:: Tynan, F.
Program of Study:: T cell receptor recognition of pMHC-I molecules: a structural investigation of lengthy, bulging epitopes and MHC polymorphisms. (PHD) 2007.
Supervisors:: Rossjohn, J (Main), Devenish, R (Associate), Mccluskey, J (External).
Student:: Walpole, N.
Program of Study:: Structural investigation of human class Ib Major Histocompatibility Complex molecules in innate and adaptive immunity. (PHD) 2012.
Supervisors:: Clements, C (Joint), Rossjohn, J (Joint-Co).
Student:: Wilmann, P.
Program of Study:: A structural investigation into the green fluorescent protein-like superfamily. (PHD) 2006.
Supervisors:: Rossjohn, J (Main), Devenish, R (Associate), Prescott, M (Associate).
Student:: Wun, K.
Program of Study:: Structural insights into the natural killer T cell receptor specificity and CD1d-glycolipid recognition. (PHD) 2011.
Supervisors:: Rossjohn, J (Main).
Student:: Xu, A.
Program of Study:: . 2010.
Supervisors:: Rossjohn, J (Main), Reid, H (Associate).