Dr Lina Wang - Researcher Profile

Biography

Lina works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

PHD ON MICROBIOLOGY

Institution: Monash University

Year awarded: 2001

MASTER ON ENVIROMENTAL MICROBIOLOGY

Institution: Chinese Academy of Preventive Medicine, Beijing, China

Year awarded: 1992

BACHELOR ON ENVIROMENTAL SCIENCE AND ENGINEERING

Institution: Tsinghua University, Beijing, China

Year awarded: 1989

Publications

Book Chapters

Topolska, A.E., Wang, L., Black, C.G., Coppel, R.L., 2004, Merozoite Cell Biology, in Malaria Parasites, eds A P Waters and C J Janse, Caister Academic Press, Norfolk England, pp. 365-444.

Wang, L., Coppel, R.L., 2002, Triton x-114 Phase Partitioning for Antigen Characterization, in Malaria Methods and Protocols, eds Denise L Doolan, Humana Press Inc., Totowa USA, pp. 581-585.

Journal Articles

Ma, C.W.C., Wang, L., Webster, D.E., Campbell, A.E., Coppel, R.L., 2012, Production, characterisation and immunogenicity of a plant-made Plasmodium antigen - the 19 kDa C-terminal fragment of Plasmodium yoelii merozoite surface protein 1, Applied Microbiology And Biotechnology [P], vol 94, issue 1, Springer, Germany, pp. 151-161.

De Silva, H.D., Saleh, S.M., Kovacevic, S., Wang, L., Black, C.G., Plebanski, M., Coppel, R.L., 2011, The antibody response to Plasmodium falciparum Merozoite Surface Protein 4: Comparative assessment of specificity and growth inhibitory antibody activity to infection-acquired and immunization-induced epitopes, Malaria Journal [P], vol 10, issue Art. No: 266, BioMed Central Ltd, UK, pp. 1-12.

Wang, L., Ma, C.W.C., Coppel, R.L., 2010, Alternative approaches to vaccine delivery, Human Vaccines [P], vol 6, issue 1, Landes Bioscience, USA, pp. 133-138.

Logan, G.J., Wang, L., Zheng, M., Coppel, R.L., Alexander, I.E., 2010, Antigen fusion with C3d3 augments or inhibits humoral immunity to AAV genetic vaccines in a transgene-dependent manner, Immunology And Cell Biology [P], vol 88, Nature Publishing Group, UK , Australia, pp. 228-232.

Ma, C., Harrison, P.F., Wang, L., Coppel, R.L., 2010, Automated estimation of parasitaemia of Plasmodium yoelii-infected mice by digital image analysis of Giemsa-stained thin blood smears, Malaria Journal [P], vol 9, issue Art. No: 348, BioMed Central Ltd, UK, pp. 1-9.

Murhandarwati, E.E.H., Wang, L., De Silva, H.D., Ma, C.W.C., Plebanski, M., Black, C.G., Coppel, R.L., 2010, Growth-inhibitory antibodies are not necessary for protective immunity to malaria infection, Infection And Immunity [P], vol 78, American Society for Microbiology, USA, pp. 680-687.

Liu, S., Danquah, M.K., Forde, G., Ma, C.W.C., Wang, L., Coppel, R.L., 2010, Microparticle-mediated gene delivery for the enhanced expression of a 19-kDa fragment of merozoite surface protein 1 of Plasmodium falciparum, Biotechnology Progress [P], vol 26, Wiley-Blackwell Publishing, Inc., USA, pp. 257-262.

Bracho, G., Zayas, C., Wang, L., Coppel, R.L., Perez, O., Petrovsky, N., 2009, AFCo1, a meningococcal B-derived cochleate adjuvant, strongly enhances antibody and T-cell immunity against Plasmodium falciparum merozoite surface protein 4 and 5, Malaria Journal, vol 8, issue 35, BioMed Central Ltd., UK, pp. 1-10.

Logan, G.J., Wang, L., Zheng, M., Ginn, S.L., Coppel, R.L., Alexander, I.E., 2009, Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules, Gene Therapy, vol 16, issue 2, Nature Publishing Group, UK, pp. 200-210.

Murhandarwati, E.E.H., Wang, L., Black, C.G., Nhan, D.H., Richie, T.L., Coppel, R.L., 2009, Inhibitory antibodies specific for the 19-kilodalton fragment of merozoite surface protein 1 do not correlate with delayed appearance of infection with Plasmodium falciparum in semi-immune individuals in Vietnam, Infection And Immunity [P], vol 77, issue 10, American Society for Microbiology, USA, pp. 4510-4517.

Morahan, B.J., Wang, L., Coppel, R.L., 2009, No TRAP, no invasion, Trends in Parasitology, vol 25, Elsevier Ltd., United Kingdom, pp. 77-84.

Liu, S., Danquah, M.K., Ho, J., Ma, C.W.C., Wang, L., Coppel, R.L., Forde, G., 2009, Preparation and characterization of poly(lactic-co-glycolic acid) microparticles containing DNA molecules encoding a malaria vaccine candidate, Journal of Chemical Technology and Biotechnology [P], vol 84, issue 5, John Wiley & Sons Ltd, England, pp. 782-788.

Webster, D.E., Wang, L., Mulcair, M., Ma, C., Santi, L., Mason, H., Wesselingh, S.L., Coppel, R.L., 2009, Production and characterization of an orally immunogenic Plasmodium antigen in plants using a virus-based expression system, Plant Biotechnology Journal [P], vol 7, Blackwell Publishing Ltd, USA, pp. 846-855.

Murhandarwati, E.E.H., Black, C.G., Wang, L., Weisman, S., de Koning-Ward, T.F., Baird, J.K., Tjitra, E., Richie, T.L., Crabb, B.S., Coppel, R.L., 2008, Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections, The Journal of Infectious Diseases, vol 198, issue 8, University of Chicago Press, USA, pp. 1212-1218.

Kats, L., Wang, L., Murhandarwati, E.E.H., Mitri, K., Black, C.G., Coppel, R.L., 2008, Active immunisation with RAMA does not provide protective immunity against Plasmodium yoelii challenge despite its association with protective responses in endemic populations, Vaccine, vol 26, issue 26, Elsevier Ltd., United Kingdom, pp. 3261-3267.

Wang, L., Webster, D., Campbell, A.E., Dry, I.B., Wesselingh, S.L., Coppel, R.L., 2008, Immunogenicity of Plasmodium yoelii merozoite surface protein 4/5 produced in transgenic plants, International Journal of Parasitology, vol 38, Pergamon-Elsevier Science Ltd, Oxford England UK, pp. 103-110.

Wang, L., Coppel, R.L., 2008, Oral vaccine delivery: can it protect against non-mucosal pathogens?, Expert Review of Vaccines, vol 7, issue 6, Expert Reviews Ltd., United Kingdom, pp. 729-738.

Danquah, M.K., Liu, S., Ho, J., Wang, L., Coppel, R.L., Forde, G., 2008, Rapid production of a plasmid DNA encoding a malaria vaccine candidate via amino-functionalized poly(GMA-co-EDMA) monolith, AIChE Journal, vol 54, issue 11, Wiley, USA, pp. 2990-2998.

Logan, G.J., Wang, L., Zheng, M., Cunningham, S.C., Coppel, R.L., Alexander, I.E., 2007, AAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection, Vaccine, vol 25, Elsevier Ltd, UK, pp. 1014-1022.

Eisen, D.P., Wang, L., Jouin, H., Murhandarwati, E.E.H., Black, C.G., Mercereau-Puijalon, O., Coppel, R.L., 2007, Antibodies elicited in adults by a primary Plasmodium falciparum blood-stage infection recognize different epitopes compared with immune individuals, Malaria Journal, vol 6, issue 86, Biomed Central Ltd, London England UK, pp. 1-9.

Wang, L., Kedzierski, L., Schofield, L., Coppel, R.L., 2005, Influence of glycosylphosphatidylinositol anchorage on the efficacy of DNA vaccines encoding Plasmodium yoelii merozoite surface protein 4/5, Vaccine, vol 23, issue 32, Elsevier, Kidlington England, pp. 4120-4127.

Black, C.G., Wu, T., Wang, L., Topolska, A.E., Coppel, R.L., 2005, MSP8 is a non-essential merozoite surface protein in Plasmodium falciparum, Molecular & Biochemical Parasitology, vol 144, issue 1, Elsevier, The Netherlands, pp. 27-35.

Black, C.G., Wang, L., Topolska, A.E., Finkelstein, D.I., Horne, M.K., Thomas, A., Mohandas, N., Coppel, R.L., 2004, Merozoite surface proteins 4 and 5 of Plasmodium knowlesi have differing cellular localisation and association with lipid rafts, Molecular & Biochemical Parasitology, vol 138, issue 1, Elsevier, Amsterdam The Netherlands, pp. 153-158.

Wang, L., Goschnick, M.W., Coppel, R.L., 2004, Oral immunization with a combination of Plasmodium yoelii merozoite surface proteins 1 and 4/5 enhances protection against lethal malaria challenge, Infection and Immunity, vol 72, issue 10, American Society for Microbiology, Washington USA, pp. 6172-6175.

Wang, L., Webster, D., Wesselingh, S., Coppel, R.L., 2004, Orally delivered malaria vaccines: not too hard to swallow, Expert Opinion on Biological Therapy, vol 4, issue 10, Ashley Publications Ltd, London England, pp. 1585-1594.

Black, C.G., Wang, L., Wu, T., Coppel, R.L., 2003, Apical location of a novel EGF-like domain-containing protein of Plasmodium falciparum, Molecular & Biochemical Parasitology, vol 127, issue 1, Elsevier Science BV, Amsterdam The Netherlands, pp. 59-68.

Wang, L., Mohandas, N., Thomas, A., Coppel, R.L., 2003, Detection of detergent-resistant membranes in asexual blood-stage parasites of Plasmodium falciparum, Molecular & Biochemical Parasitology, vol 130, issue 2, Elsevier BV, Amsterdam The Netherlands, pp. 149-153.

Wang, L., Crouch, L., Richie, T.L., Nhan, D.H., Coppel, R.L., 2003, Naturally acquired antibody responses to the components of the Plasmodium falciparum merozoite surface protein 1 complex, Parasite Immunology, vol 25, issue 8/9, Blackwell Publishing Ltd, Oxford England, pp. 403-412.

Wang, L., Kedzierski, L., Wesselingh, S.L., Coppel, R.L., 2003, Oral immunization with a recombinant malaria protein induces conformational antibodies and protects mice against lethal malaria, Infection and Immunity, vol 71, issue 5, American Society for Microbiology, Washington USA, pp. 2356-2364.

Wang, L., Marshall, V.M., Coppel, R.L., 2002, Limited polymorphism of the vaccine dandidate merozoite surface protein 4 of Plasmodium faciparum, Molecular & Biochemical Parasitology, vol 120, Elsevier, Science, Amsterdam Netherlands, pp. 301-303.

Weisman, S., Wang, L., Billman-Jacobe, H., Nhan, D.H., Richie, T.L., Coppel, R.L., 2001, Antibody responses to infections with strains of plasmodium falciparum expressing diverse forms of merozoite surface protein 2, Infection and immunity, vol 69, issue 2, American Society for Microbiology, Washington DC USA, pp. 959-967.

Wang, L., Menting, J.G.T., Black, C.G., Stowers, A., Kaslow, D.C., Hoffman, S.L., Coppel, R.L., 2001, Differences in epitope recognition, isotype and titer of antisera to Plasmodium falciparum merozoite surface protein 4 raised by different modes of DNA or protein immunization, Vaccine, vol 19, Elsevier Science Ltd, Oxford England, pp. 816-824.

Black, C.G., Wu, T., Wang, L., Hibbs, A.R., Coppel, R.L., 2001, Merozoite surface protein 8 of Plasmodium falciparum contains two epidermal growth factor-like domains, Molecular & Biochemical Parasitology, vol 114, Elsevier, Amsterdam The Netherlands, pp. 217-226.

Wang, L., Richie, T.L., Stowers, A., Nhan, D.H., Coppel, R.L., 2001, Naturally acquired antibody responses to plasmodium falciparum merozoite surface protein 4 in a population living in an area of endemicity in Vietnam, Infection and Immunity, vol 69, issue 7, American Society for Microbiology, Washington DC USA, pp. 4390-4397.

Wang, L., Menting, J.G.T., Stowers, A., Charoenvit, Y., Sacci Jr, J.B., Coppel, R.L., 2000, Antigens cross reactive with Plasmodium falciparum merozoite surface protein 4 are found in pre-erythrocytic and sexual stages, Molecular and Biochemical Parasitology, vol 109, Elsevier Science BV, Amsterdam Netherlands, pp. 189-194.

Black, C.G., Wang, L., Hibbs, A.R., Werner, E.B., Coppel, R.L., 1999, Identification of the "Plasmodium chabaudi" homologue of merozoite surface proteins 4 and 5 of "Plasmodium falciparum", Infection and Immunity, vol 67 issue 5, American Society for Microbiology, Washington USA, pp. 2075-2081.

Wu, T., Black, C.G., Wang, L., Hibbs, A.R., Coppel, R.L., 1999, Lack of sequence diversity in the gene encoding merozoite surface protein 5 of "Plasmodium falciparum", Molecular and Biochemical Parasitology, vol 103, Elsevier Science BV, Amsterdam Netherlands, pp. 243-250.

Wang, L., Black, C.G., Marshall, V.M., Coppel, R.L., 1999, Structural and antigenic properties of merozoite surface protein 4 of "Plasmodium falciparum", Infection and Immunity, vol 67 issue 5, Americal Society for Microbiology, Washington USA, pp. 2193-2200.

Marshall, V.M., Silva, A., Foley, M., Cranmer, S., Wang, L., McColl, D.J., Kemp, D.J., Coppel, R.L., 1997, A second merozoite surface protein (MSP-4) of Plasmodium falciparum that contains an epidermal growth factor-like domain, Infection and Immunity, vol 65, American Society for Microbiology, Washington DC, pp. 4460-4467.

Conference Proceedings

Wang, L., Ma, C.W.C., Webster, D.E., Wesselingh, S.L., Coppel, R.L., 2009, Examination of novel strategies for the production and delivery of malaria vaccines, Symposium 7: Cancer: From genes to therapy, April 24-27, The Australia Chinese Association for Biomedical Sciences Inc., Australia, p. 194.