Dr Michael Hickey - Researcher Profile

Michael Hickey

Address

Faculty of Medicine, Nursing & Health Sciences
Monash University, Clayton

Biography

The up and downside of white blood cells 

Associate Professor Michael Hickey says leukocytes, or white blood cells, are both the good and bad guys of our immune system. While these cells are critical to our ability to recognise and fight infections, they are also responsible for some of our most debilitating inflammatory diseases, including rheumatoid arthritis, asthma and multiple sclerosis. Michael is researching how leukocytes enter inflamed tissues, which could lead to a better understanding of inflammatory diseases.

 

Leukocytes circulate in the blood vessels and find their way into our tissue when they detect signs of infection or tissue damage. Inflammatory diseases occur when this response starts to fight against us. This happens because our white blood cells incorrectly recognise part of our body as foreign, enter the tissue and attack it, or when a normal inflammatory response is not ‘switched off’. Michael examines the process whereby the cells stick to blood vessel walls in order to leave the bloodstream and enter the inflammatory site. His laboratory uses special microscopes to examine this process.

“We investigate how they get out of those blood vessels and what molecules are involved,” Michael says. “It sounds simple but it’s very diverse because the mechanisms of this process can be different in the brain, kidney, joints and the skin. So I visualise this process in specific tissues with the aim of understanding how the process varies between different tissues,” he says.

Inflammation is a common aspect of many conditions. As such Michael’s research covers a wide range of diseases. Two of his focuses involve relatively unexplored areas of white blood cell migration into the kidneys and skin.

“There’s a part of the kidney that filters the blood and has quite a unique blood vessel structure, but it can also be a target of a life-threatening inflammatory disease,” Michael says. “We’re trying to work out why leukocytes are attracted to that part of the kidney and what they do when they get there. We’ve discovered some unique aspects of how this part of the kidney gets targeted. We’re one of the few labs in the world using microscopy to look specifically at this part of the kidney.

“We’ve also done quite a lot of work in the skin,” he says. “We’ve been studying a very rare kind of white blood cell that tries to turn inflammation off. We’re studying the process of how they get into the skin and what they do when they get there.” 

Michael’s team also has Heart Foundation funding to explore the effect of inflammation on blood vessels. 

“This study examines the basic biology of the human endothelial cell, which is a blood vessel lining cell. We’re studying the molecular control of what makes a blood vessel a ‘sticky surface’ for white blood cells to attach to. That’s a focus for the Heart Foundation because it relates to the response to heart attack and stroke, conditions which stem from blockage of blood flow. When blood starts flowing again, inflammation and white blood cell accumulation can affect tissues in these conditions. This causes more damage in the affected area, which can make the problem worse.”

 

Qualifications

DOCTOR OF PHILOSOPHY
Institution: University of Melbourne
Year awarded: 1996
SCIENCE (HONS)
Institution: University of Melbourne
Year awarded: 1987

Publications

Book Chapters

Kitching, A.R., Kuligowski, M.P., Hickey, M.J., 2009, In vivo imaging of leukocyte recruitment to glomeruli in mice using intravital microscopy, in Kidney Research: Experimental Protocols, eds Tim D. Hewitson and Gavin J. Becker, Humana Press, United States, pp. 109-117.

Kubes, P., Hickey, M.J., 2003, Leukocyte adhesion mechanisms in chronic inflammatory disease, in Molecular Basis for Microcirculatory Disorders, eds Geert W. Schmid-Sch??nbein and D.Neil Granger, Springer-Verlag, Paris, France, pp. 73-87.

Journal Articles

Yang, Y.H., Song, W., Deane, J.A., Kao, W., Ooi, J., Ngo, D., Kitching, A.R., Morand, E.F., Hickey, M.J., 2013, Deficiency of annexin A1 in CD4+ T cells exacerbates T cell-dependent inflammation, Journal Of Immunology [P], vol 90, issue 3, American Association of Immunologists, United States, pp. 997-1007.

Devi, S., Li, A., Westhorpe, C.L., Lo, C.Y., Abeynaike, L., Snelgrove, S.L., Hall, P.H., Sobey, C.G., Kitching, A.R., Hickey, M.J., 2013, Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus, Nature Medicine [P], vol 19, issue 1, Nature Publishing Group, United States, pp. 107-112.

Tan Hoong Yu, J., Ludeman, J.P., Wedderburn, J., Canals, M., Hall, P.H., Butler, S.J., Taleski, D., Christopoulos, A., Hickey, M.J., Payne, R.J., Stone, M.J., 2013, Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1), Journal Of Biological Chemistry [P], vol E-pub, American Society for Biochemistry and Molecular Biology Inc, USA, pp. 1-23.

Deane, J., Abeynaike, L., Norman, M., Wee, J., Kitching, A., Kubes, P., Hickey, M., 2012, Endogenous regulatory T cells adhere in inflamed dermal vessels via ICAM-1: association with regulation of effector leukocyte adhesion, Journal Of Immunology [P], vol 188, issue 5, American Association of Immunologists, United States, pp. 2179-2188.

Cheng, Q., Hoi, A., Hickey, M., Morand, E., 2012, Lymphocytes from systemic lupus erythematosus patients display increased spreading on VCAM-1, an effect associated with active renal involvement, Lupus [P], vol 21, issue 6, Sage Publications Ltd, United Kingdom, pp. 632-641.

Seyed-Razavi, Y., Hickey, M.J., Kuffova, L., McMenamin, P.G., Chinnery, H.R., 2012, Membrane nanotubes in myeloid cells in the adult mouse cornea represent a novel mode of immune cell interaction, Immunology And Cell Biology [P], vol 91, issue 1, Nature Publishing Group, UK, pp. 89-95.

Sun, W., Abeynaike, L., Escarbe, S., Smith, C., Pitson, S., Hickey, M., Bonder, C., 2012, Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent, American Journal Of Pathology [P], vol 180, issue 4, Elsevier Inc., United States, pp. 1740-1750.

Snelgrove, S., Kausman, J., Lo, C., Lo, C., Ooi, J.D., Coates, P., Hickey, M., Holdsworth, S., Kurts, C., Engel, D., Kitching, A., 2012, Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis, American Journal Of Pathology [P], vol 180, issue 1, Elsevier Inc., United States, pp. 91-103.

Ooi, J., Chang, J., Hickey, M.J., Borza, D., Fugger, L., Holdsworth, S.R., Kitching, A.R., 2012, The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 109, issue 39, National Academy of Sciences, United Statess, pp. E2615-E2624.

Stanley, A., de Labastida Rivera, F., Haque, A., Sheel, M., Zhou, Y., Amante, F., Bunn, P., Randall, L., Pfeffer, K., Scheu, S., Hickey, M., Saunders, B., Ware, C., Hill, G., Tamada, K., Kaye, P., Engwerda, C., 2011, Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection, Plos Pathogens [P], vol 7, issue 10, Public Library of Science, United States, p. e1002279.

Wong, C.H.Y., Abeynaike, L., Crack, P., Hickey, M., 2011, Divergent roles of Glutathione Peroxidase-1 (Gpx1) in regulation of leukocyte-endothelial cell interactions in the inflamed cerebral microvasculature, Microcirculation [P], vol 18, issue 1, John Wiley & Sons Ltd, United Kingdom, pp. 12-23.

Ooi, J., Snelgrove, S., Engel, D., Hochheiser, K., Ludwig-Portugall, I., Nozaki, Y., O'Sullivan, K., Hickey, M., Holdsworth, S., Kurts, C., Kitching, A., 2011, Endogenous foxp3{+} T-regulatory cells suppress anti-glomerular basement membrane nephritis, Kidney International [P], vol 79, issue 9, Nature Publishing Group, United Kingdom, United States, pp. 977-986.

Straub, A., Krajewski, S., Hohmann, J., Westein, E., Jia, F., Bassler, N., Selan, C., Kurz, J., Wendel, H., Dezfouli, S., Yuan, Y., Nandurkar, H., Jackson, S., Hickey, M., Peter, K., 2011, Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target, Arteriosclerosis Thrombosis And Vascular Biology [P], vol 31, issue 7, Lippincott Williams & Wilkins, USA, pp. 1607-1616.

Hickey, M., 2011, MPO and neutrophils: a magnetic attraction, Blood [P], vol 117, issue 4, American Society of Hematology, United States, pp. 1103-1104.

Fan, H., Hall, P., Santos, L., Gregory, J.L., Fingerle-Rowson, G., Bucala, R., Morand, E., Hickey, M., 2011, Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase, Journal Of Immunology [P], vol 186, issue 8, American Association of Immunologists, USA, pp. 4915-4924.

Santos, L., Fan, H., Hall, P., Ngo, D., Mackay, C., Fingerle-Rowson, G., Bucala, R., Hickey, M., Morand, E., 2011, Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice, Arthritis & Rheumatism-Arthritis Care & Research [P], vol 63, issue 4, John Wiley & Sons, Inc., USA, pp. 960-970.

Cheng, Q., McKeown, S.J., Santos, L.L., Santiago, F.S., Kachigian, L.M., Morand, E.F., Hickey, M.J., 2010, Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules, Journal Of Immunology [P], vol 185, issue 2, American Association of Immunologists, United States, pp. 1238-1247.

Devi, S., Kuligowski, M.P., Kwan, R.Y.Q., Westein, E., Jackson, S., Kitching, A.R., Hickey, M.J., 2010, Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway., American Journal Of Pathology [P], vol 177, issue 3, American Society for Investigative Pathology, United States, pp. 1131-1142.

Kuligowski, M.P., Kwan, R., Lo, C., Wong, C., James, W.G.M., Bourges, D., Ooi, J.D., Abeynaike, L., Hall, P.H., Kitching, A.R., Hickey, M.J., 2009, Antimyeloperoxidase antibodies rapidly induce alpha4-integrin-dependent glomerular neutrophil adhesion, Blood [P], vol 113, issue 25, American Society of Hematology, United States, pp. 6485-6494.

Nie, C.Q., Bernard, N.J., Norman, M.U., Amante, F., Lundie, R.J., Crabb, B.S., Heath, W.R., Engwerda, C.R., Hickey, M.J., Schofield, L., Hansen, D., 2009, IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection, Plos Pathogens [P], vol 5, issue 4 (e1000369), Public Library of Science, United States, pp. 1-16.

Gregory, J.L., Hall, P.H., Leech, M.T., Morand, E.F., Hickey, M.J., 2009, Independent roles of macrophage migration inhibitory factor and endogenous, but not exogenous glucocorticoids in regulating leukocyte trafficking, Microcirculation [P], vol 16, issue 8, John Wiley & Sons Ltd, United Kingdom, pp. 735-748.

Hickey, M.J., Kubes, P., 2009, Intravascular immunity: The host-pathogen encounter in blood vessels, Nature Reviews Immunology [P], vol 9, issue 5, Nature Publishing Group, United Kingdom, pp. 364-375.

Deane, J.A., Hickey, M.J., 2009, Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging., Expert Reviews in Molecular Medicine [P], vol 11, issue e25, Cambridge University Press, United Kingdom, pp. 1-21.

Eyles, J.L., Hickey, M.J., Norman, M.U., Croker, B.A., Roberts, A.W., Drake, S.F., James, W.G.M., Metcalf, D., Campbell, I.K., Wicks, I., 2008, A key role for G-CSF induced neutrophil production and trafficking during inflammatory arthritis, Blood [P], vol 112, issue 13, American Society of Hematology, USA, pp. 5193-5201.

Wong, C.H.Y., Bozinovski, S., Hertzog, P.J., Hickey, M.J., Crack, P.J., 2008, Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion, Journal of Neurochemistry, vol 107, issue 1, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 241-252.

Norman, M.U., James, W.G.M., Hickey, M.J., 2008, Differential roles of ICAM-1 and VCAM-1 in leukocyte-endothelial cell interactions in skin and brain of MRL/faslpr mice, Journal of Leukocyte Biology [P], vol 84, issue 1, Federation of American Societies for Experimental Biology, United States, pp. 68-76.

Ayoub, S., Hickey, M.J., Morand, E.F., 2008, Mechanisms of disease: macrophage migration inhibitory factor in SLE, RA and atherosclerosis, Nature Clinical Practice Rheumatology, vol 4, issue 2, Nature Publishing Group, United States, pp. 98-105.

Hickey, M.J., Kwan, R., Awad, M.M., Kennedy, C.L., Young, L.F., Hall, P.H., Cordner, L.M., Lyras, D., Emmins, J.J., Rood, J.I., 2008, Molecular and cellular basis of microvascular perfusion deficits induced by clostridium perfringens and clostridium septicum, P L o S Pathogens, vol 4, issue 4, Public Library of Science, United States, pp. 1-9.

Woollard, K., Suhartoyo, A., Harris, E.E., Eisenhardt, S.U., Jackson, S., Peter, K., Dart, A.M., Hickey, M.J., Chin-Dusting, J.P., 2008, Pathophysiological levels of soluble P-selectin mediate adhesion of leukocytes to the endothelium through Mac-1 activation, Circulation Research, vol 103, issue 10, Lippincott Williams & Wilkins, United States, pp. 1128-1138.

Kitching, A.R., Holdsworth, S.R., Hickey, M.J., 2008, Targeting leukocytes in immune glomerular diseases, Current Medicinal Chemistry, vol 15, issue 5, Bentham Science Publishers Ltd., Netherlands, pp. 448-458.

Apostolopoulos, J., Hickey, M.J., Sharma, L., Davenport, P.R., Moussa, L., James, W.G.M., Gregory, J.L., Kitching, A.R., Li, M., Tipping, P.G., 2008, The cytoplasmic domain of tissue factor in macrophages augments cutaneous delayed-type hypersensitivity, Journal of Leukocyte Biology, vol 83, issue 4, Federation of American Societies for Experimental Biology, United States, pp. 902-911.

Hickey, M.J., Kubes, P., 2007, COMMENT: Does Angiotensin-II link arteries and monocytes?, Blood, vol 110, issue 8, American Society of Hematology, USA, pp. 2785-2786.

Yipp, B.G., Hickey, M.J., Andonegui, G., Murray, A.G., Looareesuwan, S., Kubes, P., Ho, M., 2007, Differential roles of CD36, ICAM-1, and p-selectin in Plasmodium falciparum cytoadherence in vivo, Microcirculation, vol 14, issue 6, Informa Healthcare USA Inc, USA, pp. 593-602.

Lister, K.J., James, W.G.M., Hickey, M.J., 2007, Immune Complexes Mediate Rapid Alterations in Microvascular Permeability: Roles for Neutrophils, Complement, and Platelets, Microcirculation, vol 14, issue 7, Informa Healthcare USA Inc, USA, pp. 709-722.

Bernhagen, J., Krohn, R., Hongqi, L., Gregory, J., Zernecke, A., Koenen, R., Dewor, M., Georgiev, I., Schober, A., Leng, L., Kooistra, T., Fingerle-Rowson, G., Ghezzi, P., Kleemann, R., McColl, S.R., Bucala, R., Hickey, M.J., Weber, C., 2007, MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment, Nature Medicine, vol 13, issue 5, Nature Publishing Group, USA, pp. 587-596.

Sasmono, R.T., Ehrnsperger, A., Cronau, S.L., Ravasi, T., Kandane, R.K., Hickey, M.J., Cook, A.D., Himes, S.R., Hamilton, J.A., Hume, D.A., 2007, Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1, Journal of Leukocyte Biology, vol 82, issue 1, Federation of American Societies for Experimental Biology, USA, pp. 111-123.

Ruth, A., Kitching, A.R., Kwan, R.Q., Odobasic, D., Ooi, J.D.K., Timoshanko, J.R., Hickey, M.J., Holdsworth, S.R., 2006, Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis, Journal of the American Society of Nephrology, vol 17, issue 7, Lippincott Williams & Wilkins, USA, pp. 1940-1949.

James, W.G.M., Hutchinson, P.E., Bullard, D.C., Hickey, M.J., 2006, Cerebral leucocyte infiltration in lupus-prone MRL/MpJ-faslpr mice - roles of intercellular adhesion molecule-1 and P-selectin, Clinical and Experimental Immunology, vol 144, issue 2, Blackwell Publishing, London England, pp. 299-308.

He, X., Schoeb, T.R., Panoskaltsis-Mortari, A., Zinn, K.R., Kesterson, R.A., Zhang, J., Samuel, S., Hicks, M.J., Hickey, M.J., Bullard, D.C., 2006, Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC Chemokine Ligand 2 in lupus-prone mice, Journal of Immunology, vol 177, issue 12, American Association of Immunologists, United States, pp. 8748-8756.

Lister, K., Hickey, M.J., 2006, Immune complexes alter cerebral microvessel permeability: roles of complement and leukocyte adhesion, American Journal of Physiology: Heart and Circulatory Physiology, vol 291, issue 2, American Physiological Society, USA, pp. 694-704.

Goschnick, M.W., Lau, L., Wee, J.L., Liu, Y.S., Hogarth, P.M., Robb, L.M., Hickey, M.J., Wright, M.D., Jackson, D.E., 2006, Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice, Blood, vol 108, issue 6, American Society of Hematology, Washington USA, pp. 1911-1918.

Kuligowski, M.P., Kitching, A.R., Hickey, M.J., 2006, Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin in the absence of rolling, The Journal of Immunology, vol 176, issue 11, American Association of Immunologists, USA, pp. 6991-6999.

Hoi, A., Hickey, M.J., Hall, P.H., Yamana, J., O'Sullivan, K., Santos, L.L., James, W.G.M., Kitching, A.R., Morand, E.F., 2006, Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice, Journal of Immunology, vol 177, issue 8, American Association of Immunologists, Bethesda USA, pp. 5687-5696.

Gregory, J., Morand, E.F., McKeown, S.J., Ralph, J., Hall, P.H., Yang, Y.H., McColl, S.R., Hickey, M.J., 2006, Macrophage migration inhibitory factor induces macrophage recruitment via CC chemokine ligand 2, The Journal of Immunology, vol 177, issue 11, The American Association of Immunologists, Inc., USA, pp. 8072-8079.

Norman, M.U., Hickey, M.J., 2005, Mechanisms of lymphocyte migration in autoimmune disease, Tissue Antigens, vol 66, issue 3, Blackwell Munksgaard, Denmark, pp. 163-172.

Norman, M.U., Lister, K.J., Yang, Y.H., Issekutz, A., Hickey, M.J., 2005, TNF regulates leukocyte-endothelial cell interactions and microvascular dysfunction during immune complex-mediated inflammation, British Journal of Pharmacology, vol 144, issue 2, Nature Publishing Group, UK, pp. 265-274.

Gregory, J., Leech, M.T., David, J.R., Yang, Y.H., Dacumos, A., Hickey, M.J., 2004, Reduced Leukocyte-Endothelial Cell Interactions in the Inflamed Microcirculation of Macrophage Migration Inhibitory Factor-Deficient Mice, Arthritis & Rheumatism, vol 50, issue 9, Wiley-Liss, USA, pp. 3023-3034.

Kerfoot, S.M., Long, E.M., Hickey, M.J., Andonegui, G., Lapointe, B.M., Zanardo, R.C.O., Bonder, C.S., James, W.G., Robbins, S.M., Kubes, P., 2004, TLR4 Contributes to Disease-inducing Mechanisms Resulting in Central Nervous System Autoimmune Disease, The Journal of Immunology, vol 173, issue 11, The American Association of immunologists, Inc, USA, pp. 7070-7079.

Sharma, L., Melis, E., Hickey, M.J., Clyne, C.D., Erlich, J., Khachigian, L.M., Davenport, P.R., Morand, E.F., Carmeliet, P., Tipping, P.G., 2004, The Cytoplasmic Domain of Tissue Factor Contributes to Leukocyte Recruitment and Death in Endotoxemia, American Journal of Pathology, vol 165, issue 1, American Society for Investigative Pathology, USA, pp. 331-340.

Hickey, M.J., 2003, Alterations in leucocyte trafficking in lupus-prone mice: an examination of the MRL/faslpr mouse, Immunology and Cell Biology, vol 81, Blackwell Publishing Asia, Carlton Vic Australia, pp. 390-396.

James, W.G., Bullard, D.C., Hickey, M.J., 2003, Critical role of the alpha4 integrin/VCAM-1 pathway in cerebral leukocyte trafficking in lupus-prone MRL/faslpr mice, The Journal of Immunology, vol 170, issue 1 (1 January), American Association of Immunologists, Bethesda USA, pp. 520-527.

Norman, M.U., Lew, R., Smith, A.I., Hickey, M.J., 2003, Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature, American Journal of Physiology - Heart and Circulatory Physiology, vol 284, issue 6, American Physiological Society, Bethesda USA, pp. 1942-1948.

Norman, M.U., Van de Velde, N.C., Timoshanko, J.R., Issekutz, A., Hickey, M.J., 2003, Overlapping roles of endothelial selectins and vascular cell adhesion molecule-1 in immune complex-induced leukocyte recruitment in the cremasteric microvasculature, American Journal of Pathology, vol 163, issue 4, American Society for Investigative Pathology, Inc., Bethesda USA, pp. 1491-1503.

Hickey, M.J., Sihota, E., Amrani, A., Santamaria, P., Zbytnuik, L.D., Ng, E.S.M., Ho, W., Sharkey, K.A., Kubes, P., 2002, Inducible nitric oxide synthase (iNOS) in endotoxemia: chimeric mice reveal different cellular sources in various tissues, FASEB, vol 16, issue 9, Federation American Society Experimental Biology, Bethesda MD USA, pp. 1141-1143.

Hickey, M.J., Bullard, D.C., Issekutz, A., James, W.G., 2002, Leukocyte-Endothelial Cell Interactions Are Enhanced in Dermal Postcapillary Venules of MRL/fas1pr (Lupus-Prone) Mice: Roles of P- and E-Sectin, Journal of Immunology, vol 168, American Association of Immunologists, Bethesda MD USA, pp. 4728-4736.

Norman, M., Smith, A.I., Hickey, M.J., 2002, Metalloendopeptidases EC 3.4.24.15 and EC 3.4.24.16: potential roles in vascular physiology, Letters in Peptide Science, vol 8, Kluwer/ESCOM, Netherlands, pp. 195-199.

Carvalho-Tavares, J., Hickey, M.J., Hutchinson, J., Michaud, J., Sutcliffe, I.T., Kubes, P., 2000, A role for platelets and endothelial selectins in tumor necrosis factor-induced leukocyte recruitment in the brain microvasculature, Circulation Research, vol 87, issue 12, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1141-1148.

Postgraduate Research Supervisions

Current Supervision

Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Mechanisms of T-cell recruitment in dermal inflammation.
Supervisors:
Hickey, M (Main), Deane, J (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Mechanisms of regulatory T cell recruitment and migration in contact sensitivity.
Supervisors:
Hickey, M (Main), Deane, J (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Regulatory T Cell Function in Contact Sensitivity.
Supervisors:
Hickey, M (Main), Deane, J (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Studies of neutrophil behaviour and function in vivo.
Supervisors:
Lieschke, G (Main), Hickey, M (Associate).

Completed Supervision

Student:
Devi, S.
Program of Study:
Mechanisms of glomerular leukocyte trafficking. (PHD) 2011.
Supervisors:
Hickey, M (Main).
Student:
Gregory, J.
Program of Study:
Macrophage migration inhibitory factor and leukocyte recruitment. (PHD) 2007.
Supervisors:
Hickey, M (Main).
Student:
Hoi, A.
Program of Study:
The role of macrophage migration inhibitory factor in the pathogenesis of systemic lupus erythematosus. (PHD) 2010.
Supervisors:
Hickey, M (Joint), Morand, E (Joint-Co).
Student:
Kuligowski, M.
Program of Study:
Mechanisms of leukocyte recruitment to the glomerulus. (PHD) 2007.
Supervisors:
Hickey, M (Main), Kitching, A (Joint).
Student:
Lister, K.
Program of Study:
The mechanisms of immune complex-mediated inflammation in the cerebral and skeletal muscle microvasculature. (PHD) 2006.
Supervisors:
Hickey, M (Main).
Student:
Wong, C.
Program of Study:
Oxidative stress and the cerebral microvasculature: a role for glutathione peroxidase-1. (PHD) 2008.
Supervisors:
Hertzog, P (Joint), Hickey, M (Joint-Co).