Prof Christina Mitchell - Researcher Profile

Christina Mitchell

Address

Faculty of Medicine, Nursing & Health Sciences
Monash University, Clayton

Contact Details

Email: Christina.Mitchell@monash.edu


Biography

Professor Christina Mitchell trained as a physician scientist specialising in clinical haematology. She received a degree in Medicine from Melbourne University and consultant training in Haematology at the Alfred Hospital, Melbourne. She graduated with a Fellowship from the Royal Australian College of Physicians and also a Fellowship in Pathology. She obtained a Ph.D. from Monash University and her post-doctoral studies were undertaken in the field of intracellular signalling at Washington University Medical School, St Louis, USA. In 1991 she returned to Australia and became an independent investigator at the Department of Medicine, Box Hill Hospital. In 1999 she was appointed Professor and Head of the Department of Biochemistry and Molecular Biology, Monash University, while also conducting research on the newly emerging family of enzymes, inositol polyphosphate 5-phosphatases, negative regulators of PI3-kinase signalling.

The major research direction of her group is to characterise the metabolic pathways that regulate phosphoinositide signalling in human cancer.

Her group was among the first to purify and clone the 5-phosphatases and to delineate the substrates for these important enzymes in cancer. More recently her group has investigated the functional role of inositol polyphosphate 3- and 4-phosphatases in various cell systems and human disease. In 2006 Prof. Mitchell became Head of the School of Biomedical Sciences at Monash University, which is the largest of the Schools within the Faculty of Medicine. In 2011 she was promoted to the prestigious position of Dean of Medicine at Monash University.

She has presented the group’s work at many national meetings and as an invited symposium and/or plenary speaker at international meetings, including Keystone meeting, “Lipid signalling molecules”, USA, 2002; Japanese Lipid Signalling meeting, 2004; Biochemical Society Annual Symposium, "The Cell Biology of Inositol Lipids and Phosphates", Birmingham, UK, 2006; FEBS advanced course in Lipid Signalling Pathways in Italy, 2007. In 2012 she was one of three organisers of a conference on Inositide signaling hosted by the New York Academy of Sciences, New York, USA. She was also invited (fully funded) to speak at the “22nd IUBMB and 37th FEBS Conference”, which was held in Seville, Spain in 2012. Prof. Mitchell has received funding from the Australian Research Council (ARC), National Health and Medical Research Council of Australia (NHMRC), Muscular Dystrophy Association (USA), Cancer Council Victoria, Diabetes Australia Research Trust and National Heart Foundation.


In addition, Prof. Mitchell serves on the Organising Committee for the Hunter Cell Biology Conference and the Scientific Advisory Board of the Peter MacCallum Research Institute.

 
Prof. Mitchell has published over 100 papers and received numerous awards. In 1998 she was awarded the Monash Vice-Chancellor's Award for Distinguished Post-graduate Supervision. In 2003 she was awarded the Dean's Prize for Excellence in Research in the Medical Faculty at Monash University. In 2008 Prof. Mitchell was made a Sir John Monash Distinguished Professor, one of only 5 appointees in the last 20 years and only woman, and was also a recipient of a Monash University 50th Anniversary Research Award in the same year.

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Keywords

Cancer, Cancer Biology, Muscular Dystrophy, Phosphoinositide signalling, signal transduction, , gene knockout

Qualifications

POSTDOCTORATE
Institution: Washington University School of Medicine
Year awarded: 1990
DOCTOR OF PHILOSOPHY (PHD)
Institution: Monash University
Year awarded: 1987
FRACP
Institution: Royal Australasian College of Physicians
Year awarded: 1987
FRCPA
Institution: Royal Australasian College of Pathologists
Year awarded: 1987
BACHELOR OF MEDICINE, BACHELOR OF SURGERY (MBBS)
Institution: University of Melbourne
Year awarded: 1978

Publications

Book Chapters

Hakim, S., Bertucci, M.C., Conduit, S.E., Vuong, D.L., Mitchell, C.A., 2012, Inositol polyphosphate phosphatases in human disease, in Current Topics In Microbiology And Immunology [P], eds M Falasca, Springer Science+Business Media, USA, pp. 247-314.

Dyson, J.M., Fedele, C.G., Davies, E.M., Becanovic, J., Mitchell, C.A., 2012, Phosphoinositide phosphatases: just as important as the kinases, in Phosphoinositides I: Enzymes of Synthesis and Degradation, eds T Balla,M Wymann & JD York, Springer Science+Business Media, USA, pp. 215-279.

Davies, E.M., Sheffield, D.A., Tibarewal, P., Fedele, C.G., Mitchell, C.A., Leslie, N.R., 2012, The PTEN and myotubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease, in Phosphoinositides I: Enzymes of Synthesis and Degradation, eds T. Balla, M. Wymann, & J.D. York, Springer Science+Business Media, USA, pp. 281-336.

Ooms, L.M., Dyson, J.M., Kong, A.M., Mitchell, C.A., 2009, Analysis of phosphatidylinositol 3,4,5 trisphosphate 5-phosphatase activity by in vitro and in vivo assays, in Lipid Signaling Protocols, eds B Larijani, R Woscholski, C A rosser, Humana Press, USA, pp. 223-239.

Campbell, J.K., Brown, S., Munday, A.D., Mitchell, C.A., 2000, The role of the phosphoinositide-derived second messenger molecules in platelet activatiuon, in Platelets, Thrombosis and the Vessel Wall, eds MC Berndt, Harwood Academic Publishers, The Netherlands, pp. 127-148.

Journal Articles

Shields, B.J., Wiede, F., Gurzov, E., Wee, K.T.B., Hauser, C., Zhu, H., Molloy, T.J., O'Toole, S.A., Daly, R.J., Sutherland, R.L., Mitchell, C.A., McLean, C.A., Tiganis, T., 2013, TCPTP regulates SFK and STAT3 signalling and is lost in triple negative breast cancers, Molecular and Cellular Biology [P], vol 33, issue 3, American Society for Microbiology, USA, pp. 557-570.

Layton, M.J., Saad, M., Church, N., Pearson, R.B., Mitchell, C.A., Phillips, W.A., 2012, Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity , BMC Biochemistry [P], vol 13, issue 1 (Art. No.:30), BioMed Central Ltd, UK, pp. 1-9.

Friedrich, F.W., Wilding, B.R., Reischmann, S., Crocini, C., Lang, P., Charron, P., Muller, O.J., McGrath, M.J., Vollert, I., Hansen, A., Linke, W.A., Hengstenberg, C., Bonne, G., Morner, S., Wichter, T., Madeira, H., Arbustini, E., Eschenhagen, T., Mitchell, C.A., Isnard, R., Carrier, L., 2012, Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy, Human Molecular Genetics [P], vol 21, issue 14, Oxford University Press, UK, pp. 3237-3254.

Rynkiewicz, N., Liu, T., Balamatsias, D., Mitchell, C., 2012, INPP4A/INPP4B and P-Rex proteins: Related but different?, Advances In Enzyme Regulation [P], vol 52, issue 1, Elsevier BV, Netherlands, pp. 265-279.

Conduit, S.E., Dyson, J.M., Mitchell, C.A., 2012, Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathies, FEBS Letters [P], vol 586, issue 18, Elsevier BV, Netherlands, pp. 2846-2857.

Johnson, J.F., Hall, T.E., Dyson, J.M., Sonntag, C., Ayers, K.L., Berger, S., Gautier, P., Mitchell, C.A., Hollway, G.E., Currie, P.D., 2012, Scube activity is necessary for Hedgehog signal transduction in vivo, Developmental Biology [P], vol 368, issue 2, Academic Press, USA, pp. 193-202.

Tilkorn, D.J., Davies, E., Keramidaris, E., Dingle, A.M., Gerrand, Y., Taylor, C.J., Han, X.L., Palmer, J.A., Penington, A.J., Mitchell, C.A., Morrison, W.A., Dusting, G.J., Mitchell, G.M., 2012, The in vitro preconditioning of myoblasts to enhance subsequent survival in an in vivo tissue engineering chamber model, Biomaterials [P], vol 33, issue 15, Elsevier BV, The Netherlands, pp. 3868-3879.

Manji, S.S.M., Williams, L.L., Miller, K.A., Ooms, L.M., Bahlo, M., Mitchell, C.A., Dahl, H.M., 2011, A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart, PLoS ONE [P], vol 6, issue 3, Public Library of Science, USA, pp. e17607.1-e17607.11.

Nguyen, N., Maxwell, M., Ooms, L., Davies, E.M., Hilton, A., Collinge, J., Hilton, D., Kile, B., Mitchell, C., Hibbs, M., Jane, S., Curtis, D., 2011, An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation, Blood [P], vol 117, issue 20, American Society of Hematology, United States, pp. 5362-5371.

Cowling, B., Cottle, D.L., Wilding, B., D'Arcy, C.E., Mitchell, C.A., Mcgrath, M.J., 2011, Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: A comprehensive review of the clinical, histological and pathological features, Neuromuscular Disorders [P], vol 21, issue 4, Elsevier Ltd, UK, pp. 237-251.

Nguyen, M.T., Joya, J., Kee, A.J., Domazetovska, A., Yang, N., Hook, J.W., Lemckert, F., Kettle, E., Valova, V.A., Robinson, P.J., North, K., Gunning, P.W., Mitchell, C.A., Hardeman, E.C., 2011, Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy, Brain [P], vol 134, issue 12, Oxford University Press, UK, pp. 3516-3529.

Balamatsias, D., Kong, A., Waters, J.E., Sriratana, A., Gurung, R., Bailey, C.G., Rasko, J.E. ., Tiganis, T., Macaulay, S.L., Mitchell, C.A., 2011, Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes, Journal Of Biological Chemistry [P], vol 286, issue 50, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 43229-43240.

Astle, M., Ooms, L., Cole, A., Binge, L., Dyson, J., Layton, M., Petratos, S., Sutherland, C., Mitchell, C., 2011, Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP) collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation, Journal Of Biological Chemistry [P], vol 286, issue 26, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 23407-23418.

Rahman, P., Huysmans, R., Wiradjaja, F., Gurung, R., Ooms, L., Sheffield, D., Dyson, J., Layton, M., Sriratana, A., Takada, H., Tiganis, T., Mitchell, C., 2011, Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton, Journal Of Biological Chemistry [P], vol 286, issue 34, American Society of Biochemistry and Molecular Biology Inc., USA, pp. 29758-29770.

Fedele, C.G., Ooms, L.M., Ho, M., Vieusseux, J.L., O'Toole, S.A., Millar, E.K., Lopez-Knowles, E., Sriratana, A., Gurung, R., Baglietto, L., Giles, G., Bailey, C.G., Rasko, J.E., Shields, B.J., Price, J.T., Majerus, P.W., Sutherland, R.L., Tiganis, T., McLean, C., Mitchell, C.A., 2010, Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers, Proceedings Of The National Academy Of Sciences O..., vol 107, issue 51, National Academy of Sciences, USA, pp. 22231-22236.

Sasaki, J., Kofuji, S., Itoh, R., Momiyama, T., Takayama, K., Murakami, H., Chida, S., Tsuya, Y., Takasuga, S., Eguchi, S., Asanuma, K., Horie, Y., Miura, K., Davies, E.M., Mitchell, C., Yamazaki, M., Hirai, H., Takenawa, T., Suzuki, A., Sasaki, T., 2010, The PtdIns(3,4)P 2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death, Nature [P], vol 465, issue 7297, Nature Publishing Group, UK, pp. 497-501.

Naughtin, M.J., Sheffield, D.A., Rahman, P., Hughes, W.E., Gurung, R., Stow, J., Nandurkar, H., Dyson, J.M., Mitchell, C.A., 2010, The myotubularin phosphatase MTMR4 regulates sorting from early endosomes, Journal Of Cell Science [P], vol 123, issue Pt 18, The Company of Biologists Ltd, UK, pp. 3071-3083.

Schessl, J., Taratuto, A.L., Sewry, C., Battini, R., Chin, S.S., Maiti, B., Dubrovsky, A.L., Erro, M.G., Espada, G., Robertella, M., Saccoliti, M., Olmos, P., Bridges, L.R., Standring, P., Hu, Y., Zou, Y., Swoboda, K.J., Scavina, M., Goebel, H., Mitchell, C.A., Flanigan, K.M., Muntoni, F., Bonnemann, C.G., 2009, Clinical, histological and genetic characterization of reducing body myopathy caused by mutations in FHL1, Brain, vol 132, issue 2, Oxford University Press, UK, pp. 452-464.

Loh, K.Y., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B.J., Skiba, B., Ooms, L.M., Stepto, N.K., Wu, B.J., Mitchell, C.A., Tonks, N., Watt, M.J., Febbraio, M.A., Crack, P.J., Andrikopoulos, S., Tiganis, T., 2009, Reactive oxygen species enhance insulin sensitivity, Cell Metabolism [P], vol 10, issue 4, Cell Press, USA, pp. 260-272.

Ivetac, I., Gurung, R., Hakim, S., Horan, K.A., Sheffield, D.A., Binge, L.C., Majerus, P.W., Tiganis, T., Mitchell, C.A., 2009, Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1, EMBO Reports, vol 10, issue 5, Nature Publishing Group, United Kingdom, Germany, pp. 487-493.

Denley, A., Gymnopoulos, M., Kang, S., Mitchell, C.A., Vogt, P.K., 2009, Requirement of phosphatidylinositol(3,4,5)trisphosphate in phosphatidylinositol 3-kinase-induced oncogenic transformation, Molecular Cancer Research [P], vol 7, issue 7, American Association for Cancer Research, USA, pp. 1132-1138.

Cottle, D.L., McGrath, M.J., Wilding, B.R., Cowling, B.S., Kane, J.m., D'Arcy, C.E., Holdsworth, M., Hatzinisiriou, I., Prescott, M., Brown, S., Mitchell, C.A., 2009, SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis, Journal Of Biological Chemistry [P], vol 284, issue 39, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 26964-26977.

Ooms, L.M., Horan, K.A., Rahman, P., Seaton, G., Gurung, R., Kethesparan, D.S., Mitchell, C.A., 2009, The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease, Biochemical Journal, vol 419, issue 1, Portland Press Ltd, UK, pp. 29-49.

Buzza, M.S., Dyson, J.M., Choi, H., Gardiner, E.E., Andrews, R.K., Kaiserman, D., Mitchell, C.A., Berndt, M.C., Dong, J., Bird, P.I., 2008, Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor, Journal of Biological Chemsitry, vol 283, issue 33, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 22498-22504.

Yang, Z., Browning, C.F., Hallaq, H., Yermalitskaya, L., Esker, J., Hall, M.R., Link, A.J., Ham, A.L., Mcgrath, M.J., Mitchell, C.A., Murray, K.T., 2008, Four and a half LIM protein 1: A partner for KCNA5 in human atrium, Cardiovascular Research, vol 78, issue 3, Oxford University Press, United Kingdom, pp. 449-457.

Cowling, B.S., Mcgrath, M.J., Nguyen, M., Cottle, D., Kee, A.J., Brown, S., Schessl, J., Zou, Y., Joya, J., Bonnemann, C.G., Hardeman, E.C., Mitchell, C.A., 2008, Identifi cation of FHL1 as a regulator of skeletal muscle mass: Implications for human myopathy, The Journal of Cell Biology, vol 183, issue 6, Rockefeller University Press, USA, pp. 1033-1048.

Waters, J.E., Astle, M.V., Ooms, L.M., Balamatsias, D., Gurung, R., Mitchell, C.A., 2008, P-Rex1 - a multidomain protein that regulates neurite differentiation, Journal of Cell Science, vol 121, issue 17, The Company of Biologists Ltd., United Kingdom, pp. 2892-2903.

Schessl, J., Zou, Y., Mcgrath, M.J., Cowling, B.S., Maiti, B., Chin, S.S., Sewry, C., Battini, R., Hu, Y., Cottle, D., Rosenblatt, M., Spruce, L., Ganguly, A., Kirschner, J., Judkins, A.R., Golden, J.A., Goebel, H., Muntoni, F., Flanigan, K.M., Mitchell, C.A., Bonnemann, C.G., 2008, Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy, Journal of Clinical Investigation, vol 118, issue 3, American Society for Clinical Investigation, United States, pp. 904-912.

Cottle, D., Mcgrath, M.J., Cowling, B.S., Coghill, I.D., Brown, S., Mitchell, C.A., 2007, FHL3 binds MyoD and negatively regulates myotube formation, Journal of Cell Science, vol 120, issue Pt 8, Company of Biologists Ltd, Cambridge England UK, pp. 1423-1435.

Wiradjaja, F., Ooms, L.M., Tahirovic, S., Kuhne, E.S., Devenish, R.J., Munn, A.L., Piper, R.C., Mayinger, P., Mitchell, C.A., 2007, Inactivation of the phosphoinositide phosphatases Sac1p and Inp54p leads to accumulation of phosphatidylinositol 4,5-Bisphosphate on vacuole membranes and vacuolar fusion defects, Journal of Biological Chemistry, vol 282, issue 22, American Society of Biochemistry & Molecular Biology Inc, Bethesda MD USA, pp. 16295-16307.

Horan, K.A., Watanabe, K., Kong, A.M., Bailey, C.G., Rasko, J.E., Sasaki, T., Mitchell, C.A., 2007, Regulation of FcgammaR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3-mediated phagocytosis by differential recruitment of these 5-phosphatases..., Blood, vol 110, issue 13, American Society of Hematology, USA, pp. 4480-4491.

Ramshaw, H.S., Guthridge, M.A., Stomski, F.C., Barry, E.F., Ooms, L.M., Mitchell, C.A., Begley, C.G., Lopez, A.F., 2007, The Shc-binding site of the ?c subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis, Blood, vol 110, issue 10, American Society of Hematology, Washington DC USA, pp. 3582-3590.

Astle, M.V., Horan, K.A., Ooms, L.M., Mitchell, C.A., 2007, The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?, Biochemical Society Symposium, vol 3.324, Portland Press Ltd, London England UK, pp. 161-181.

Mcgrath, M.J., Cottle, D.L., Nguyen, M., Dyson, J.M., Coghill, I.D., Robinson, P.A., Holdsworth, M., Hardeman, E.C., Mitchell, C.A., Brown, S., Cowling, B.S., 2006, Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly, The Journal of Biological Chemistry, vol 281, issue 11, The American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 7666-7683.

Kong, A.M., Horan, K.A., Sriratana, A., Bailey, C.G., Collyer, L.J., Nandurkar, H.H., Shisheva, A., Layton, M.J., Rasko, J.E., Rowe, T., Mitchell, C.A., 2006, Phosphatidylinositol 3-phosphate [PtdIns(3)P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: Endogenous PtdIns(3)P can promote GLUT4 translocation to the plasma membrane, Molecular and Cellular Biology, vol 26, issue 16, American Society for Microbiology, Washington DC USA, pp. 6065-6081.

Astle, M.V., Seaton, G., Davies, E.M., Fedele, C.G., Rahman, P., Arsala, L., Mitchell, C.A., 2006, Regulation of phosphoinositide signaling by the inositol polyphosphate 5-phosphatases, IUBMB Life, vol 58, issue 8, Taylor & Francis Inc., Philadelphia USA, pp. 451-456.

Ooms, L.M., Fedele, C.G., Astle, M.V., Ivetac, I., Cheung, V., Pearson, R.B., Layton, M.J., Forrai, A., Nandurkar, H., Mitchell, C.A., 2006, The inositol polyphosphate 5-phosphatase, PIPP, is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation, Molecular Biology of the Cell, vol 17, issue 2, American Society for Cell Biology, Bethesda USA, pp. 607-622.

Fodero-Tavoletti, M.T., Hardy, M.P., Cornell, B.H., Katsis, F., Sadek, C.M., Mitchell, C.A., Kemp, B.E., Tiganis, T., 2005, Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization, Biochemical Journal, vol 389, issue Pt2, Portland Press Ltd, London England, pp. 343-354.

Zhang, X., Walsh, B., Mitchell, C.A., Rowe, T., 2005, TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7, Biochemical and Biophysical Research Communications, vol 335, issue 1, Elsevier, San Diego USA, pp. 154-161.

Dyson, J.M., Kong, A.M., Wiradjaja, F., Astle, M.V., Gurung, R., Mitchell, C.A., 2005, The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2, International Journal of Biochemistry & Cell Biology, vol 37, issue 11, Pergamon-Elsevier Science Ltd, Oxford UK, pp. 2260-2265.

Ivetac, I., Munday, A.D., Kisseleva, M.V., Zhang, X., Luff, S.E., Tiganis, T., Whisstock, J.C., Rowe, T., Majerus, P., Mitchell, C.A., 2005, The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane, Molecular Biology of the Cell, vol 16, issue 5, American Society for Cell Biology, Bethesda USA, pp. 2218-2233.

Wang, Y., Keogh, R.J., Keogh, M.J., Mitchell, C.A., Frey, R.S., Javaid, K., Malik, A.B., Schurmans, S., Tridandapani, S., Marsh, C.B., 2004, SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling, The Journal of Immunology, vol 173, issue 11, The American Association of Immunologists, Bethesda USA, pp. 6820-6830.

Zhang, X., Ellis, S., Sriratana, A., Mitchell, C.A., Rowe, T., 2004, Sec15 is an effector for the Rab11 GTPase in mammalian cells, The Journal of Biological Chemistry, vol 279, issue 41, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 43027-43034.

Schmid, A.C., Wise, H.M., Mitchell, C.A., Nussbaum, R., Woscholski, R., 2004, Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation, FEBS Letters, vol 576, issue 1-2, Elsevier Science BV, Amsterdam The Netherlands, pp. 9-13.

Coghill, I.D., Brown, S., Cottle, D.L., Mcgrath, M.J., Robinson, P.A., Nandurkar, H.H., Dyson, J.M., Mitchell, C.A., 2003, FHL3 is an actin-binding protein that regulates -actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly, Journal of Biological Chemistry, vol 278, issue 26, American Society for Biochemistry and Molecular BIology Inc., Bethesda USA, pp. 24139-24152.

Gurung, R., Tan, A., Ooms, L.M., Mcgrath, M.J., Huysmans, R.D., Munday, A.D., Prescott, M., Whisstock, J.C., Mitchell, C.A., 2003, Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization: the inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following, Journal of Biological Chemistry, vol 278, issue 13, American Society for Biochemistry and Molecular Biology Inc., Bethesda USA, pp. 11376-11385.

Nandurkar, H.H., Layton, M.J., Laporte, J., Selan, C., Corcoran, L., Caldwell, K., Mochizuki, Y., Majerus, P., Mitchell, C.A., 2003, Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP, Proceedings of the National Academy of Sciences of the United States of America, vol 100, issue 15, National Academy of Science, Washington USA, pp. 8660-8665.

Dyson, J.M., Munday, A.D., Kong, A.M., Huysmans, R.D., Matzaris, M., Layton, M.J., Nandurkar, H.H., Berndt, M.C., Mitchell, C.A., 2003, SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeleton, Blood, vol 102, issue 3, American Society of Hematology, Washington USA, pp. 940-948.

Mcgrath, M.J., Mitchell, C.A., Coghill, I.D., Robinson, P.A., Brown, S., 2003, Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces 51 integrin-dependent myocyte elongation, American Journal of Physiology-Cell Physiology, vol 285, issue 6, American Physiological Society, Bethesda USA, pp. 1513-1526.

Mitchell, C.A., Gurung, R., Kong, A.M., Dyson, J.M., Tan, A., Ooms, L.M., 2002, Inositol polyphosphate 5-phospatases: Lipid phosphatases with flair, IUBMB Life, vol 25, issue 1, Taylor & Francis, Philadelphia PA USA, pp. 25-36.

Robinson, P.A., Brown, S., Mcgrath, M.J., Coghill, I.D., Gurung, R., Mitchell, C.A., 2002, Skeletal muscle LIM protein 1 regulates intergrin-mediated myoblast adhesion, spreading and migration, American Journal of Physiology - Cell Physiology, vol 284, issue 3, American Physiological Society, Bethesda MD USA, pp. C681-C695.

Nandurkar, H., Caldwell, K., Whisstock, J.C., Layton, M., Gaudet, E., Norris, F., Majerus, P., Mitchell, C.A., 2001, Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: Identification of a myotubularin-related protein lacking catalytic activity, Proceedings of the National Academy of Sciences of the United States of America, vol 98, issue 17, National Academy of Sciences, Washington DC USA, pp. 9499-9504.

Andrews, R.K., Munday, A.D., Mitchell, C.A., Berndt, M.C., 2001, Interaction of calmodulin with the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex, Blood, vol 98, issue 3, American Society of Hematology, Washington DC USA, pp. 681-687.

O'Malley, C.J., Mccoll, B.K., Kong, A.M., Ellis, S., Wijayaratnam, P.P., Sambrook, J., Mitchell, C.A., 2001, Mammalian inositol polyphosphate 5-phosphatase II can compensate for the absence of all three yeast Sac1-like-domain-containing 5-phosphatases, Biochemical Journal, vol 355, issue 3, Portland Press, England UK, pp. 805-817.

Dyson, J.M., O'Malley, C.J., Becanovic, J., Munday, A.D., Berndt, M.C., Coghill, I.D., Nandurkar, H., Ooms, L.M., Mitchell, C.A., 2001, The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin, Journal of Cell Biology, vol 155, issue 6, Rockefeller University Press, New York NY USA, pp. 1065-1079.

Wiradjaja, F., Ooms, L.M., Whisstock, J.C., Mccoll, B.K., Helfenbaum, L., Sambrook, J., Gething, M., Mitchell, C.A., 2001, The yeast inositol polyphosphate 5-phosphatase Inp54p localizes to the endoplasmic reticulum via a C-terminal hydrophobic anchoring tail, Journal of Biological Chemistry, vol 276, issue 10, American Society for Biochemsitry and Molecular Biology Inc, Bethesda MD USA, pp. 7643-7653.

Smith, A., Surviladze, Z., Gaudet, E., Backer, J., Mitchell, C.A., Wilson, B., 2001, p110b and p110d phosphatidylinositol 3-kinases up-regulate Fce RI-activated Ca2+ influx by enhancing inositol 1,4-5-trisphosphate production, Journal of Biological Chemistry, vol 276, issue 20, American Society for Biochemistry and Molecular Biology Inc, Bethesda MD USA, pp. 17213-17220.

Kong, A.M., Speed, C.J., O'Malley, C., Layton, M.J., Meehan, T., Loveland, K.L., Cheema, S.S., Ooms, L.M., Mitchell, C.A., 2000, Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network, Journal of Biological Chemistry, vol 275, American Soc for Biochem & Molecular Biology, Inc, Bethesda USA, pp. 24052-24064.

Yang, J., Moravec, C., Sussman, M.A., Dipaola, N.R., Fu, D., Hawthorn, L., Mitchell, C.A., Young, J.B., Francis, G.S., McCarthy, P.M., Bond, M., 2000, Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays, Circulation, vol 102 (25), Lippincott Williams & Wilkins, Philadelphia USA, pp. 3046-3052.

Tao, F.C., Tolloczko, B., Mitchell, C.A., Powell, W.S., Martin, J.G., 2000, Inositol (1,4,5) trisphosphate metabolism and enhanced calcium mobilization in airway smooth muscle of hyperresponsive rats, American Journal of Respiratory Cell and Molecular Biology, vol 23, issue 4, American Lung Association, USA, pp. 514-520.

Munday, A.D., Berndt, M.C., Mitchell, C.A., 2000, Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3xi, Blood, vol 96 issue 2, American Society for Hematology, Washington USA, pp. 577-584.

Speed, C.J., Mitchell, C.A., 2000, Sustained elevation in inositol 1,4,5-trisphosphate results in inhibition of phosphatidylinositol transfer protein activity and chronic depletion of the agonist-sensitive phosphoinositide pool, Journal of Cell Biology, vol 113, Company of Biologists Ltd, Cambridge UK, pp. 2631-2638.

Whisstock, J.C., Romero, S., Gurung, R., Nandurkar, H., Ooms, L.M., Bottomley, S.P., Mitchell, C.A., 2000, The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis, Journal of Biological Chemistry, vol 275 issue 47, Amer Soc for Biochem & Molecular Biology, Bethesda USA, pp. 37055-37061.

Ooms, L.M., McColl, B.K., Wiradjaja, F., Wijayaratnam, A.P.W., Gleeson, P.A., Gething, M., Sambrook, J., Mitchell, C.A., 2000, The yeast inositol polyphosphate 5-phosphatases Inp52p and Inp53p translocate to actin patches following hyperosmotic stress: Mechanism for regulating phosphatidylinositol 4,5-bisphosphate at plasma membrane invaginations, Molecular and Cellular Biology, vol 20 issue 24, American Society for Microbiology, Washington USA, pp. 9376-9390.

Brown, S., Mcgrath, M.J., Ooms, L.M., Gurung, R., Maimone, M.M., Mitchell, C.A., 1999, Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1, Journal of Biological Chemistry, vol 274, no 38, American Soc. for Biochem. and Mol. Biol. Inc., www.jbc.org, pp. 27083-27091.

Brown, S., Biben, C., Ooms, L.M., Maimone, M.M., Mcgrath, M.J., Gurung, R., Harvey, R.P., Mitchell, C.A., 1999, The cardiac expression of striated muscle LIM protein 1 (SLIM1) is restricted to the outflow tract of the developing heart, Journal of molecular and cellular cardiology, vol 31, Academic Press Ltd., London England, pp. 837-843.

Speed, C.J., Neylon, C.B., Little, P.J., Mitchell, C.A., 1999, Underexpression of the 43 kDa inositol polyphosphate 5-phosphatase is associated with spontaneous calcium oscillations and enhanced calcium responses followig endothelin-1 stimulation, Journal of Cell Science, vol 112, The Company of Biologists Ltd, Cambridge UK, pp. 669-679.

Mitchell, C.A., Speed, C.J., Bird, P.I., O'Malley, C., Matzaris, M., Badger, A., 1998, Distinct membrane and cystosolic forms of inositol polyphosphate 5-phosphatase II. Efficient localization requires two discrete domains, Journal of Biological Chemistry, vol 273, American Soc. for Biiochem. and Mol. Biol., USA, pp. 8256-8267.

Mitchell, C.A., Munday, A.D., St Clair, F., Phillips, W., Thomas, R.J.S., 1998, Increased levels of phosphatidylinositol 3-Kinase activity in human colorectal tumours cancer, Cancer, vol 83, 1, American Cancer Society, USA, pp. 41-47.

Other

Mitchell, C., Fedele, C., 2010, Breast Cancer breakthrough, Monash Memo, Monash University, Australia.

Awards

Academic awards (national, international)

Sir John Monash Distinguished Professor
Only 5 appointees in the last 20 years and only woman
Monash University

Honours

Dean's Prize for Excellence in Research in the Medical Faculty
Monash University

Monash University 50th Anniversary Research Award
Monash University

Prizes for research supervision

Vice-Chancellor's Award for Distinguished Post-graduate Supervision
Monash University

Supervised prize-winning project

Top-ranked Project Grant in Australia
National Heart Foundation