Dr Simone Beckham - Researcher Profile

Biography

Simone works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Keywords

Innate immunity, viral surveillance, Nucleic acid sensors , scabies; protease; inactivated catalytic triad, scabies; serine protease; skin; filaggrin; substrate specificity

Qualifications

PHD IN BIOCHEMISTRY

Institution: Monash University

Year awarded: 2000

BSC (HONORS)

Institution: La Trobe

Year awarded: 1996

Publications

Journal Articles

Beckham, S.A., Brouwer, J.M., Roth, A., Wang, D., Sadler, A.J., John, M., Jahn-Hofmann, K., Williams, B.R.G., Wilce, J.A., Wilce, M.C.J., 2013, Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly, Nucleic Acids Research [P], vol 41, issue 5, Oxford University Press, UK, pp. 3436-3445.

Norbury, L.J., Hung, A., Beckham, S.A., Pike, R.N., Spithill, T.W., Craik, C.S., Choe, Y., Fecondo, J.V., Smooker, P.M., 2012, Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference, Biochimie [P], vol 94, issue 5, Elsevier Masson, France, pp. 1119-1127.

Sashindranath, M., Sales, E., Daglas, M., Freeman, R., Samson, A.L., Cops, E., Beckham, S.A., Galle, A.A., McLean, C., Morganti-Kossmann, M.C., Rosenfeld, J.V., Madani, R., Vassalli, J., Su, E.J., Lawrence, D.A., Medcalf, R.L., 2012, The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans, Brain [P], vol 135, issue Part 11, Oxford University Press, United Kingdom, pp. 3251-3264.

Norbury, L.J., Beckham, S.A., Pike, R.N., Grams, R., Spithill, T.W., Fecondo, J.V., Smooker, P.M., 2011, Adult and juvenile Fasciola cathepsin L proteases: Different enzymes for different roles, Biochimie [P], vol 93, issue 3, Elsevier Masson, France, pp. 604-611.

Reinstein, O., Neves, M., Saad, M., Boodram, S., Lombardo, S., Beckham, S., Brouwer, J., Audette, G., Groves, P., Wilce, M., Johnson, P., 2011, Engineering a structure switching mechanism into a steroid-binding aptamer and hydrodynamic analysis of the ligand binding mechanism, Biochemistry [P], vol 50, issue 43, American Chemical Society, USA, pp. 9368-9376.

Beckham, S.A., Piedrafita, D.M., Phillips, C.I., Samarawickrema, N., Law, R.H.P., Smooker, P.M., Quinsey, N.S., Irving, J.A., Greenwood, D.L., Verhelst, S.H.L., Bogyo, M., Turk, B., Coetzer, T.H., Wijeyewickrema, L.C., Spithill, T.W., Pike, R.N., 2009, A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites, International Journal of Biochemistry and Cell Biolog..., vol 41, issue 7, Pergamon, UK, pp. 1601-1612.

Beckham, S.A., Boyd, S.E., Reynolds, S., Willis, C., Johnstone, M., Mika, A., Simerska, P., Wijeyewickrema, L.C., Smith, A.I., Kemp, D.J., Pike, R.N., Fischer, K., 2009, Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite sarcoptes scabiei, Journal Of Biological Chemistry [P], vol 284, issue 49, American Society for Biochemistry & Molecular Biology Inc, USA, pp. 34413-34422.

Fischer, K., Langendorf, C., Irving, J.A., Reynolds, S., Willis, C., Beckham, S.A., Law, R.H.P., Yang, S., Bashtannyk-Puhalovich, T.A., McGowan, S., Whisstock, J., Pike, R.N., Kemp, D.J., Buckle, A.M., 2009, Structural mechanisms of inactivation in scabies mite serine protease paralogues, Journal of Molecular Biology [P], vol 390, issue 4, Academic Press, UK, pp. 635-645.

Pasay, C., Arlian, L., Morgan, M., Gunning, R., Rossiter, L., Holt, D., Walton, S., Beckham, S.A., McCarthy, J., 2009, The effect of insecticide synergists on the response of scabies mites to pyrethroid acaricides, Public Library of science: Neglected Tropical Diseases [P], vol 3, issue 1 (e354), Public Library of Science, USA, pp. 1-8.

Beckham, S.A., Law, R.H., Smooker, P.M., Quinsey, N.S., Caffrey, C.R., McKerrow, J.H., Pike, R.N., Spithill, T.W., 2006, Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite, Biological Chemistry, vol 387, issue 8, Walter de Gruyter & Co., Berlin Germany, pp. 1053-1061.