Prof Colin Pouton - Researcher Profile

Biography

Position

Head of Pharmaceutical Biology
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology - Executive
Monash Institute of Pharmaceutical Sciences

 

Research & Supervision Interests

• Use of stem cells, and cells derived by differentiation of stem cells, in drug discovery
• Molecular pharmacology of G protein-coupled receptors (eg adenosine, serotonin and melanocortin receptors)
• Design and performance of delivery systems for nucleic acid therapeutics (DNA and RNA).
• Lipid-based delivery systems for oral delivery of poorly water-soluble drugs

Qualifications

DOCTOR OF PHILOSOPHY

Institution: University of London

Year awarded: 1982

PHARMACY

Institution: University of Bath

Year awarded: 1976

Publications

Journal Articles

White, P.J., Hickey, P.L., Tu, L.S., Headey, S.J., Scanlon, M., Boyd, B.J., Pouton, C.W., 2012, Colloidal characteristics and formulation of pure protein particulate vaccines, Journal of Pharmacy and Pharmacology [P], vol 64, issue 10, John Wiley & Sons Ltd, United Kingdom, pp. 1386-1393.

Lau, S., Graham, B., Cao, N., Boyd, B.J., Pouton, C.W., White, P.J., 2012, Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation, Molecular Pharmaceutics [P], vol 9, issue 1, American Chemical Society, USA, pp. 71-80.

Watmuff, B., Pouton, C.W., Haynes, J.M., 2012, In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: Implications for transplantation, PLoS ONE [P], vol 7, issue 2, Public Library of Science, USA, pp. 1-11.

Anby, M.U., Williams, H.D., McIntosh, M.P., Benameur, H., Edwards, G.A., Pouton, C.W., Porter, C.J., 2012, Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems, Molecular Pharmaceutics [P], vol 9, issue 9, American Chemical Society, USA, pp. 2063-2079.

Nefzger, C., Su, C.T.E., Fabb, S.A., Hartley, B.J., Zeng, W., Haynes, J.M., Pouton, C.W., 2012, Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells, Stem Cells [P], vol 30, issue 7, Wiley-Blackwell, USA, pp. 1349-1361.

Debono, A.J., Xie, J.H., Ventura, S., Pouton, C.W., Capuano, B., Scammells, P.J., 2012, Synthesis and biological evaluation of N-substituted noscapine analogues, Chemmedchem [P], vol 7, issue 12, Wiley - V C H Verlag GmbH & Co. KGaA, Germany, pp. 2122-2133.

Gosling, J.I., Baker, S.P., Haynes, J.M., Kassiou, M., Pouton, C.W., Warfe, L., White, P.J., Scammells, P.J., 2012, Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N6-substituents as adenosine A1 receptor agonists, Chemmedchem [P], vol 7, issue 7, Wiley-V C H Verlag GMBH, Germany, pp. 1191-1201.

Hausler, N., Devine, S., McRobb, F.M., Warfe, L., Pouton, C.W., Haynes, J.M., Bottle S.E., White, P.J., Scammells, P.J., 2012, Synthesis and pharmacological evaluation of dual acting antioxidant A2A adenosine receptor agonists, Journal of Medicinal Chemistry [P], vol 55, issue 7, American Chemical Society, USA, pp. 3521-3534.

Mohsin, K., Pouton, C.W., 2012, The influence of the ratio of lipid to surfactant and the presence of cosolvent on phase behaviour during aqueous dilution of lipid-based drug delivery systems, Journal of Drug Delivery Science and Technology [P], vol 22, issue 6, Editions de Sante, France, pp. 531-540.

Williams, H.D., Sassene, P.J., Kleberg, K., Bakala-N'Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carriere, F., Mullertz, A., Porter, C.J., Pouton, C.W., 2012, Toward the establishment of standardized in vitro tests for lipid-based formulations, Part 1: Method parameterization and comparison of in vitro digestion profiles across a range of representative formulations, Journal of Pharmaceutical Sciences [P], vol 101, issue 9, Wiley-Blackwell, Malden, Massachusetts USA, pp. 3360-3380.

Williams, H.D., Anby, M.U., Sassene, P.J., Kleberg, K., Bakala-N'Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carriere, F., Mullertz, A., Pouton, C.W., Porter, C.J., 2012, Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion, Molecular Pharmaceutics [P], vol 9, issue 11, American Chemical Society, Washington DC, USA, pp. 3286-3300.

Goulburn, A., Alden, D., Davis, R.P., Micallef, S.J., Ng, E.S., Yu, Q.C., Lim, S.M., Soh, C., Elliott, D., Hatzistavrou, T., Bourke, J., Watmuff, B., Lang, R.J., Haynes, J.M., Pouton, C.W., Giudice, A., Trounson, A.O., Anderson, S.A., Stanley, E., Elefanty, A., 2011, A targeted NKX2.1 hesc reporter line enables identification of human basal forebrain derivatives, Stem Cells [P], vol 29, issue 3, AlphaMed Press, Inc., USA, pp. 462-473.

Lau, S., Graham, B., Boyd, B., Pouton, C., White, P., 2011, Commercially supplied amine-modified siRNAs may require ultrafiltration prior to conjugation with amine-reactive compounds, Journal of Nucleic Acids [E], vol 2011, issue 154609, SAGE-Hindawi Access to Research, England, pp. 1-5.

Nefzger, C., Haynes, J., Pouton, C., 2011, Directed expression of gata2, mash1, and foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells, Stem Cells [P], vol 29, issue 6, WILEY-BLACKWELL, USA, pp. 928-939.

Zeng, W., Fabb, S., Haynes, J., Pouton, C., 2011, Extended periods of neural induction and propagation of embryonic stem cell-derived neural progenitors with EGF and FGF2 enhances Lmx1 a expression and neurogenic potential, Neurochemistry International [P], vol 59, issue 3, PERGAMON-ELSEVIER SCIENCE LTD, ENGLAND, pp. 394-403.

Martino Roth, D., Moseley, G., Pouton, C., Jans, D., 2011, Mechanism of microtubule-facilitated "fast track" nuclear import, Journal Of Biological Chemistry [P], vol 286, issue 16, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 14335-14351.

Khaira, S., Nefzger, C., Beh, S., Pouton, C., Haynes, J., 2011, Midbrain and forebrain patterning delivers immunocytochemically and functionally similar populations of neuropeptide Y containing GABAergic neurons, Neurochemistry International [P], vol 59, issue 3, PERGAMON-ELSEVIER SCIENCE LTD, ENGLAND, pp. 413-420.

Elliott, D.A., Braam, S.R., Koutsis, K., S Ng, E., Jenny, R., Lagerqvist, E.L., Biben, C., Hatzistavrou, T., Hirst, C.E., Yu, Q.C., Skelton, R.J., Ward-van Oostwaard, D., Lim, S.M., Khammy, O., Li, X., Hawes, S.M., Davis, R.P., Goulburn, A.L., Passier, R., Prall, O.W., Haynes, J.M., Pouton, C.W., Kaye, D.M., Mummery, C.L., Elefanty, A.G., Stanley, E., 2011, NKX2-5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes, Nature Methods [P], vol 8, issue 12, Nature Publishing Group, UK, pp. 1037-1040.

King, D., Warren, D., Pouton, C., Chalmers, D., 2011, Using molecular dynamics to study liquid phase behavior: Simulations of the ternary sodium laurate/sodium oleate/water system, Langmuir [P], vol 27, issue 18, AMERICAN CHEMICAL SOCIETY, USA, pp. 11381-11393.

Lau, S., Graham, B., Boyd, B., Pouton, C., White, P., 2011, Utilisation of albumin to enhance in vivo delivery of SiRNA across the vascular endothelium, Journal Of Gene Medicine [P], vol 13, issue 7-8, WILEY-BLACKWELL, USA, p. 438.

Urmaliya, V., Pouton, C., Devine, S., Haynes, J., Warfe, L., Scammells, P., White, P., 2010, A novel highly selective adenosine A1 receptor agonist VCP28 reduces ischemia injury in a cardiac cell line and ischemia-reperfusion injury in isolated rat hearts at concentrations that do not affect heart rate, Journal Of Cardiovascular Pharmacology [P], vol 56, issue 3, Lippincott Williams & Wilkins, United States, pp. 282-292.

Chailertvanitkul, V.A., Pouton, C.W., 2010, Adenovirus: a blueprint for non-viral gene delivery, Current Opinion in Biotechnology [P], vol 21, issue 5, Elsevier Ltd, United Kingdom, pp. 627-632.

Urmaliya, V., Pouton, C., Ledent, C., Short, J., White, P., 2010, Cooperative cardioprotection through adenosine A1 and A 2A receptor agonism in ischemia-reperfused isolated mouse heart, Journal Of Cardiovascular Pharmacology [P], vol 56, issue 4, Lippincott Williams & Wilkins, Inc., USA, pp. 379-388.

Chen, Q., Jin, L., Cook, W., Mohn, D., Lagerqvist, E., Elliott, D., Haynes, J., Boyd, N., Stark, W., Pouton, C., Stanley, E., Elefanty, A., 2010, Elastomeric nanocomposites as cell delivery vehicles and cardiac support devices, Soft Matter [P], vol 6, issue 19, Royal Society of Chemistry, UK, pp. 4715-4726.

Lagerqvist, E.L., Finnin, B.A.L., Pouton, C.W., Haynes, J.M., 2010, Endothelin-1 and angiotensin II modulate rate and contraction amplitude in a subpopulation of mouse embryonic stem cell-derived cardiomyocyte-containing bodies, Stem Cell Research [P], vol 6, issue 1, Elsevier BV, Netherlands, pp. 23-33.

Hsieh, M.J., White, P.J., Pouton, C.W., 2010, Interaction of viruses with host cell molecular motors, Current Opinion in Biotechnology [P], vol 21, Elsevier Ltd, United Kingdom, pp. 633-639.

Irving, H.R., Tochon-Danguy, N., Chinkwo, K.A., Li, J.G., Grabbe, C., Shapiro, M., Pouton, C.W., Coupar, I.M., 2010, Investigations into the binding affinities of different human 5-HT 4 receptor splice variants, Pharmacology [P], vol 85, issue 4, S. Karger AG, Switzerland, pp. 224-233.

Devine, S.M., Gregg, A., Figler, H., McIntosh, K., Urmaliya, V., Linden, J., Pouton, C.W., White, P.J., Bottle, S.E., Scammells, P.J., 2010, Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists, Bioorganic & Medicinal Chemistry Letters [P], vol 18, issue 9, Pergamon, United Kingdom, pp. 3078-3087.

Xie, J.H., Hollande, F., Haynes, J.M., Pouton, C.W., Ventura, S., 2010, Troubleshooting immunohistochemical labelling of proliferating cell nuclear antigen (PCNA) in cryocut tissue sections of mouse prostate, Journal of Pharmacological and Toxicological Methods [P], vol 61, Elsevier Inc, United States, pp. 98-101.

Warren, D., Benameur, H., Porter, C.J., Pouton, C.W., 2010, Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility, Journal Of Drug Targeting [P], vol 18, issue 10, Informa Healthcare, United Kingdom, pp. 704-731.

Kuo, C.(., Sinha, S., Jazayeri, J., Pouton, C.W., 2009, A stably engineered, suicidal strain of Listeria monocytogenes delivers protein and/or DNA to fully differentiated intestinal epithelial monolayers, Molecular Pharmaceutics [P], vol 6, issue 4, American Chemical Society, United States, pp. 1052-1061.

Urmaliya, V., Church, J.E., Coupar, I.M., Rose'Meyer, R., Pouton, C.W., White, P.J., 2009, Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine, Journal Of Cardiovascular Pharmacology [P], vol 53, issue 5, Lippincott Williams & Wilkins, United States, pp. 424-433.

Mohsin, K., Long, M.A., Pouton, C.W., 2009, Design of lipid-based formulations for oral administration of poorly water-soluble drugs: Precipitation of drug after dispersion of formulations in aqueous solution, Journal of Pharmaceutical Sciences [P], vol 98, issue 10, John Wiley & Sons, Inc., United States, pp. 3582-3595.

Martino Roth, D., Harper, I.S., Pouton, C.W., Jans, D.A., 2009, Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus, Journal Of Cellular Biochemistry [P], vol 107, issue 6, John Wiley & Sons, Inc., USA, pp. 1160-1167.

White, P.J., Anastasopoulos, F., Pouton, C.W., Boyd, B.J., 2009, Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides., Expert Reviews in Molecular Medicine [P], vol 11, issue e10, Cambridge University Press, UK, pp. 1-19.

Khaira, S.K., Pouton, C.W., Haynes, J.M., 2009, P2X2, P2X4 and P2Y1 receptors elevate intracellular Ca2+ in mouse embryonic stem cell-derived GABAergic neurons, British Journal of Pharmacology [P], vol 158, issue 8, John Wiley and Sons Ltd, UK, pp. 1922-1931.

Warren, D., Chalmers, D.K., Pouton, C.W., 2009, Structure and dynamics of glyceride lipid formulations, with propylene glycol and water, Molecular Pharmaceutics [E], vol 6, issue 2, American Chemical Society, United States, pp. 604-614.

Porter, C.J., Pouton, C.W., Cuine, J., Charman, W.N., 2008, Enhancing intestinal drug solubilisation using lipid-based delivery systems, Advanced Drug Delivery Reviews, vol 60, issue 6, Elsevier BV, Netherlands, pp. 673-691.

Cuine, J., mcevoy, c., Charman, W.N., Pouton, C.W., Edwards, G.A., Benameur, H., Porter, C.J., 2008, Evaluation of the impact of surfactant digestion on the bioavailability of Danazol after oral administration of lipidic self-emulsifying formulations to dogs, Journal of Pharmaceutical Sciences, vol 97, issue 2, John-Wiley & Sons, USA, pp. 995-1012.

Pouton, C.W., Porter, C.J., 2008, Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies, Advanced Drug Delivery Reviews, vol 60, issue 6, Elsevier B.V., Netherlands, pp. 625-637.

White, P.J., Anastasopoulos, F., Church, J.E., Kuo, C.(., Boyd, B.J., Hickey, P.L., Sze Tu, L., Burns, P., Lew, A.M., Heath, W.R., Davey, G.M., Pouton, C.W., 2008, Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants, Vaccine, vol 26, issue 52, Elsevier Ltd, Netherlands, pp. 6824-6831.

Tarwadi, T., Jazayeri, J., Prankerd, R., Pouton, C.W., 2008, Preparation and in vitro evaluation of novel lipopeptide transfection agents for efficient gene delivery, Bioconjugate Chemistry, vol 19, issue 4, American Chemical Society, USA, pp. 940-950.

Roth, D., Moseley, G.W., Glover, D., Pouton, C.W., Jans, D.A., 2007, A microtubule-facilitated nuclear import pathway for cancer regulatory proteins, Traffic, vol 8, issue 6, Blackwell Publishing, Oxford England UK, pp. 673-686.

Irving, H.R., Tan, Y.Y., Tochon-Danguy, N., Liu, H., Chetty, N., Desmond, P.V., Pouton, C.W., Coupar, I.M., 2007, Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon, Life Sciences, vol 80, issue 13, Elsevier Inc, USA, pp. 1198-1205.

Gregg, A.D., Bottle S.E., Devine, S., Figler, H., Linden, J., White, P.J., Pouton, C.W., Urmaliya, V., Scammells, P.J., 2007, Dual acting antioxidant A1 adenosine receptor agonists, Bioorganic & Medicinal Chemistry Letters, vol 17, issue 19, Pergamon, England, pp. 5437-5441.

Moseley, G.W., Roth, D., De Jesus, M., Leyton, D.L., Filmer, R., Pouton, C.W., Jans, D.A., 2007, Dynein light chain association sequences can facilitate nuclear protein import, Molecular Biology of the Cell, vol 18, issue 8, The American Society for Cell Biology, Bethesda MD USA, pp. 3204-3213.

Pouton, C.W., Haynes, J.M., 2007, Embryonic stem cells as a source of models for drug discovery, Nature Reviews Drug Discovery, vol 6, issue 8, Nature Publishing Group, London, England, pp. 605-616.

Raye, W.S., Tochon-Danguy, N., Pouton, C.W., Haynes, J.M., 2007, Heterogeneous population of dopaminergic neurons derived from mouse embryonic stem cells: preliminary phenotyping based on receptor expression and function, European Journal of Neuroscience, vol 25, issue 7, Blackwell Publishing Ltd, UK, pp. 1961-1970.

Cuine, J., Charman, W.N., Pouton, C.W., Edwards, G.A., Porter, C.J., 2007, Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs, Pharmaceutical Research, vol 24, issue 4, Springer Science & Business Media, New York, pp. 748-757.

Pouton, C.W., Wagstaff, K.M., Roth, D., Moseley, G.W., Jans, D.A., 2007, Targeted delivery to the nucleus, Advanced Drug Delivery Reviews, vol 59, issue 8, Elsevier Science BV, Amsterdam, pp. 698-717.

Pouton, C.W., 2006, Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system, European Journal of Pharmaceutical Sciences, vol 29, Elsevier BV, Netherlands, pp. 278-287.

Warren, D.B., Chalmers, D.K., Hutchison, K., Dang, W., Pouton, C.W., 2006, Molecular dynamics simulations of spontaneous bile salt aggregation, Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol 280, issue 1-3, Elsevier Science BV, Amsterdam Netherlands, pp. 182-193.

Pouton, C.W., Allsopp, T., 2005, Embryonic stem cell science and the therapeutic interface, Advanced Drug Delivery Reviews, vol 57, Elsevier BV, Netherlands, pp. 1891-1893.

Pouton, C.W., Haynes, J.M., 2005, Pharmaceutical applications of embryonic stem cells, Advanced Drug Delivery Reviews, vol 57, issue 13, Elsevier BV, Netherlands, pp. 1918-1934.

Martin, F., Roth, D.M., Jans, D.A., Pouton, C.W., Partridge, L.J., Monk, P.N., Moseley, G.W., 2005, Tetraspanins in viral infections: a fundamental role in viral biology?, Journal of Virology, vol 79, issue 17, American Society for Microbiology, USA, pp. 10839-10851.

Lang, R.J., Haynes, J.M., Kelly, J., Johnson, J., Geenhalgh, J., O'Brien, C., Mulholland, E.L., Baker, L., Munsie, M., Pouton, C.W., 2004, Electrical and neurotransmitter activity of mature neurons derived from mouse embryonic stem cells by Sox-1 lineage selection and directed differentiation, European Journal of Neuroscience, vol 20, issue 12, Blackwell Publishing Ltd, UK, pp. 3209-3221.

Matthews, S.E., Pouton, C.W., Threadgill, M.D., 2001, Formation of hybrid polymethylene-poly(oxyethylene) macrocycles, Tetrahedron Letters, vol 42, pp. 1355-1357.

Bremner, K.H., Seymour, L.W., Pouton, C.W., 2001, Harnessing nuclear localization pathways for transgene delivery, Current Opinion in Molecular Therapeutics, vol 3, pp. 170-177.

Pouton, C.W., Seymour, L.W., 2001, Key issues in non-viral gene delivery, Advanced Drug Delivery Reviews, vol 46, pp. 187-203.

Pouton, C.W., 2000, Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems, European Journal of Pharmaceutical Sciences, vol 11, pp. S93-S98.

Pouton, C.W., Charman, W.N., 1997, The potential of oily formulations for drug delivery to the gastro-intestinal tract, Advanced Drug Delivery Reviews, vol 25, Elsevier Science, UK, pp. 1-2.

Conference Proceedings

Lau, S., Graham, B., Boyd, B., Pouton, C., White, P., 2011, Utilisation of albumin to enhance in vivo delivery of sirna across the vascular endothelium, The Journal of Gene Medicine, 04-06 Mat 2011, John Wiley & Sons, England, p. e1.

Khaira, S.K., Pouton, C.W., Haynes, J.M., 2006, Basic pharmacological investigation of embryonic mouse stem cell derived GABAergic neurons, Proceedings of the 3rd Australian Health and Medical Research Congress, 26 Nov - 1 Dec 2006, Australian Health and Medical Research Congress, Melbourne Vic Australia, p. 427.

Khaira, S.K., Tochon-Danguy, N., Pouton, C.W., Haynes, J.M., 2006, Characterisation of GABAergic neurons derived from mouse embryonic stem cells, Cytometry Part A, John Wiley & Sons, Inc, USA, p. 419.

Khaira, S.K., Tochon-Danguy, N., Pouton, C.W., Haynes, J.M., 2006, Characterisation of GABAergic neurons drived from mouse embryonic stem cells, Proceedings of the 4th ISSCR Meeting, 29 June - 1 July 2006, p. 129.

Irving, H.R., Tan, Y.Y., Tochon-Danguy, N., Liu, H., Chetty, N., Desmond, P.V., Pouton, C.W., Coupar, I.M., 2006, Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon, Proceedings of the Australian Society for Biochemistry and Molecular Biology, 25-28 September 06, p. 109.

Irving, H.R., Chetty, N., Desmond, P.V., Tan, Y.Y., Tochon-Danguy, N., Liu, H., Pouton, C.W., Coupar, I.M., 2006, Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon, Proceedings of the Australian Health & Medical Research Congress, 26 Nov - 1 Dec 2006, pp. 404-405.

Nefzger, C., Haynes, J.M., Pouton, C.W., 2006, GABA and dopamine release from differentiated neurons derived from mouse ES cells in adherent monoculture or obtained via the formation of embryoid bodies, Proceedings of the 4th ISSCR meeting, 29 June - 1 July 2006, p. 211.

Haynes, J.M., Khaira, S.K., Tochon-Danguy, N., Pouton, C.W., 2006, GABAergic neurons derived from mouse embryonic stem cells: a brief characterization, Acta Pharmacologica Sinica, 2-7 July 2006, Blackwell Publishing, Beijing China, p. 238.

Warren, D., Chalmers, D.K., Pouton, C.W., 2006, Molecular dynamics simulations of mono-, di- and tri-glyceride formulations, Molecular Modelling 2006.

Pouton, C.W., 2006, Pharmaceutical applications of embryonic stem cells, 3-7 Sept 2006.

Mohsin, K., Long, M., Pouton, C.W., 2006, Relationship between type of lipid formulation and precipitation of drug on dispersion, Final Program - 2006 AAPS Annual Meeting and Exposition, 29 Oct - 2 Nov 2006, American Association of Pharmaceutical Scientists.

Warren, D., Chalmers, D.K., Pouton, C.W., 2005, Spontaneous aggregation and dynamics of mixed bile salt / phospholipid micelles and lipid formulations using molecular dynamics simulations, Australian Colloid and Interface Symposium, Royal Australian Chemical Institute - Colloid and Surface Science, Sydney NSW Australia, p. 156.

Warren, D., Prankerd, R.J., Pouton, C.W., 2003, Phase behaviour determination of aqueous bile salt / phospholipid systems using isothermal titration micro-calorimetry, Proceedings of the APSA: Integrating Research into Practice, Australasian Pharmaceutical Science Association, Sydney NSW Australia.

Other

Binks, P., Critchley, M., Irving, R.A., Pouton, C.W., White, P.J., 2007, Microarray Device, Australia.

Charman, W.N., Porter, C.J.H., Pouton, C.W., Dias, M., Georgiou, M., Guffogg, P., Steele, D.F., Wheeler, D., 2005, Oral delivery system comprising a biliquid foam, USA.

Teaching Commitment

• Responsible for teaching programs in biochemistry, cell biology, biotechnology, physiology, and pharmacology

Activities

Affiliations with research centres

Executive
Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Other committees

Member
Scientific Advisory Council
Bio21

Grants

Title:

A novel nanoparticle-based approach to gene silencing in vivo: extravasation of siRNA via albumin.

Investigators:

White, P, Boyd, B, Pouton, C, Graham, B, Judkins, C

Funding:

(2010 - 2013). Heart Foundation. $119,625.00

Title:

Colon cancer stem cells: an exciting model for the discovery of anti-cancer drugs and the identification of new tumour markers.

Investigators:

Hollande, F, Mantamadiotis, T, Pouton, C

Funding:

(2007 - 2011). Helen Macpherson Smith Trust. $25,000.00

Title:

Determination of the most promising strategy for cell therapy of Alzheimer's disease following transplantation of embryonic stem cell derived neural stem cells or neural proginitors into the hippo..

Investigators:

Pouton, C, Haynes, J, Short, J, Nicolazzo, J

Funding:

(2010 - 2014). Australian Stem Cell Centre. $145,286.00

Title:

Developmental Candidates for Cell based therapies for Parkinson's Disease.

Investigators:

Pouton, C, Snyder, E, Parish, C

Funding:

(2010 - 2015). Department of Innovation, Industry and Regional Development (DIIRD) via Florey Neurosciences Institutes. $668,961.00

Title:

Evaluation of the role of cartillage degrading enzymes in the pathogenesis of rheumatoid and osteoarthritis.

Investigators:

Jazayeri, J, Pouton, C, Carroll, G

Funding:

(2008 - 2011). L E W Carty Charitable Fund. $9,881.00

Title:

Focal Adhesion Kinase (FAK).

Investigators:

Scammells, P, Pouton, C

Funding:

(2009 - 2014). Cancer Therapeutics CRC Pty Ltd. $1,212,627.96

Title:

Functional characterisation of neurons derived from embryonic stem cells and NS cells.

Investigators:

Pouton, C, Haynes, J, Bello, P, Arico, M

Funding:

(2007 - 2011). Australian Research Council (ARC). $18,000.00

(2007 - 2011). Australian Research Council (ARC). $75,354.00

(2007 - 2011). Stem Cell Sciences. $26,000.00

(2008 - 2012). Australian Research Council (ARC). $0.00

Title:

InjectMan/FemtoJet Microinjector.

Investigators:

Haynes, J, Pouton, C, Jazayeri, J, Waldhuber, M

Funding:

(2003 - 2007). National Health & Medical Research Council (NHMRC). $41,729.00

Title:

Kopf Sterotaxic equipment.

Investigators:

Short, J, Haynes, J, Pouton, C

Funding:

(2009 - 2013). Collier Charitable Fund. $3,000.00

Title:

Mechanisms of enhancement of absorption of poorly water-soluble drugs from the gastrointestinal tract mediated by lipids, surfactants and polymers.

Investigators:

Pouton, C, Porter, C, Benameur, H, Hutchison, K

Funding:

(2008 - 2012). Australian Research Council (ARC). $273,120.00

(2008 - 2012). Australian Research Council (ARC). $76,880.00

(2008 - 2012). Capsugel Division of Pfizer. $240,000.00

(2008 - 2012). Monash University. $20,000.00

Title:

Neurons isolated from embryonic stem cells as functional models for drug discovery.

Investigators:

Haynes, J, Pouton, C, Lang, R, Munsie, M

Funding:

(2004 - 2008). Australian Research Council (ARC). $400,295.00

(2004 - 2008). Stem Cell Sciences. $109,598.00

(2005 - 2010). Australian Research Council (ARC). $51,319.00

Title:

Novel Approaches towards targeting normoxic and hypoxi cancer tissue.

Investigators:

Flynn, B, Pouton, C, Sloan, E, Kerr, D

Funding:

(2011 - 2014). National Breast Cancer Foundation. $185,200.00

Title:

Phenom Benchtop SEM from FEI.

Investigators:

Boyd, B, Nation, R, Pouton, C, Porter, C, Scanlon, M

Funding:

(2009 - 2013). National Health & Medical Research Council (NHMRC). $70,000.00

Title:

Protein Gel Electrophoresis equipment package.

Investigators:

Jazayeri, J, Raye, W, Pouton, C, White, P, Kerr, K, Irving, H, Mantamadiotis, T, Haynes, J, Malone, D

Funding:

(2007 - 2011). Collier Charitable Fund. $2,500.00

Title:

Sympathetic nervous system regulation of the tumour microenvironment.

Investigators:

Sloan, E, Moeller, A, Mileshkin, L, Pouton, C

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC). $382,524.00

Title:

The purchase of a FACSInventors Share of Relenza Royalty.

Investigators:

Pouton, C

Funding:

(2006 - 2010). Tattersalls. $50,000.00

Title:

Tissue electrophysiology Rig I.D. 264650.

Investigators:

Exintaris, B, Ventura, S, Haynes, J, Pouton, C, Coupar, I, Short, J

Funding:

(2005 - 2009). National Health & Medical Research Council (NHMRC). $60,000.00

Title:

Z-drive for TE2000U microscope.

Investigators:

Haynes, J, Pouton, C, Raye, W

Funding:

(2007 - 2011). Collier Charitable Fund. $2,500.00

Title:

Advanced Fluorescence Imaging Facility: From Super High Resolution to Whole Animal Imaging.

Investigators:

Porter, C, Caruso, F, Heath, W, Nation, R, Prawer, S, Wijburg, O, Pouton, C, Johnston, A, Sloan, E, Kaminskas, L, Shepherd, R

Funding:

(2011 - 2015). Australian Research Council (ARC). $0.00

(2011 - 2015). Monash University. -$100,000.00

(2011 - 2015). Monash University. -$205,000.00

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

A study of Adenovirus proteins as a DNA delivery vehicle to the nucleus.

Supervisors:

Pouton, C (Joint-co), White, P (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Biological Evaluation of Smo antagonists using SANT1 as a lead compound in hedgehog signalling.

Supervisors:

Pouton, C (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Identification and isolation of prostate cancer stem cells from prostate cancer cell lines..

Supervisors:

Ventura, S (Main), Haynes, J (Associate), Hollande, F (Associate), Pouton, C (Associate), Sloan, E (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Molecular dynamics simulations of lipid drug delivery systems.

Supervisors:

Chalmers, D (Joint), Pouton, C (Joint-co), Porter, C (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Using lipid based formulations to enhance drug exposure.

Supervisors:

Porter, C (Joint-co), Pouton, C (Associate), Williams, H (Associate).

Completed Supervision

Student:

Cook, A.

Program of Study:

PROSTATIC STROMAL CELL FUNCTION: MODULATION OF CONTRACTILITY AND VIABILITY BY CGMP-DEPENDENT PROTEIN KINASE.. (PHD) 2004.

Supervisors:

Haynes, J (Main), Pouton, C (Associate).

Student:

Khaira, S.

Program of Study:

Characterisation of GABAergic neurons derived from mouse embryonic stem cells. (PHD) 2009.

Supervisors:

Haynes, J (Main), Hollande, F (Associate), Pouton, C (Associate).

Student:

Kuo, C.

Program of Study:

Listeria-based protein and gene delivery system. (PHD) 2007.

Supervisors:

Pouton, C (Main), Jazayeri, J (Associate).

Student:

Lagerqvist, E.

Program of Study:

Functional characterisation of cardiomyocytes derived from mouse and human embryonic stem cells. (PHD) 2011.

Supervisors:

Haynes, J (Joint-Co), Pouton, C (Joint).

Student:

Martino Roth, D.

Program of Study:

The role of microtubules in nuclear protein transport. (PHD) 2008.

Supervisors:

Jans, D (Joint), Pouton, C (Joint-Co).

Student:

Mohsin, K.

Program of Study:

Design of lipid-based formulations for oral administration of poorly water-soluble drugs. (PHD) 2009.

Supervisors:

Pouton, C (Main).

Student:

Murphy, N.

Program of Study:

Haplotyping with peptide nucleic acids: a novel method for tissue typing. (PHD) 2011.

Supervisors:

Irving, H (Joint), Pouton, C (Joint-Co).

Student:

Nefzger, C.

Program of Study:

Neural differentiation of murine embryonic stem cells with a focus on serotonergic neuron differentiation. (PHD) 2009.

Supervisors:

Haynes, J (Joint), Pouton, C (Joint-Co).

Student:

Roberts, B.

Program of Study:

A physicochemical investigation of novel lipopeptide-based non-viral transfection agents. (Masters) 2009.

Supervisors:

Prankerd, R (Main), Pouton, C (Associate).

Student:

Upadhyay, A.

Program of Study:

Evaluation of the role of Leukaemia inhibitory factor receptor antagonist in inflammatory arthritis. (PHD) 2011.

Supervisors:

Pouton, C (Main).

Student:

Urmaliya, V.

Program of Study:

Adenosine receptor-mediated cardioprotection. (PHD) 2010.

Supervisors:

White, P (Main), Coupar, I (Associate), Pouton, C (Associate).

Student:

Xie, J.

Program of Study:

A Biological study of growth and development in the mouse prostate. (Masters) 2009.

Supervisors:

Pouton, C (Main).