Prof David Jans - Researcher Profile

Biography

David works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Professor.

Qualifications

DIPLOMA IN RADIATION SAFETY

Institution: University of Tuebingen

Year awarded: 1991

DOCTOR OF PHILOSOPHY

Institution: Australian National University

Year awarded: 1985

Publications

Book Chapters

Wagstaff, K., Jans, D., 2010, Protein Transduction: Cell Penetrating Peptides and their Therapeutic Applications, in Frontiers in Medicinal Chemistry (5), eds Atta-ur-Rahman, AB Reitz, MI Choudhary, Bentham Science Publishers Ltd, The Netherlands, pp. 98-126.

Davies, R., Jans, D.A., Wagstaff, K.M., 2010, Use of fluorescence photobleaching techniques to measure the kinetics of intracellular transport, in Microscopy: Science, Technology, Applications and Education, eds A Mendez-Vilas and J Diaz, Formatex, Spain, pp. 756-763.

Forwood, J., Kaur, G., Jans, D.A., 2007, Nuclear import properties of the sex-determining factor SRY, in Protein Targeting Protocols (Methods in Molecular Biology), eds Mark van der Giezen, Humana Press, Totowa NJ USA, pp. 83-97.

Pryor, M.J., Rawlinson, S.M., Wright, P.J., Jans, D.A., 2006, CRM1-dependent nuclear export of dengue virus type 2 NS5, in New Treatment Strategies for Dengue and Other Flaviviral Diseases, eds G Bock (organizer) and J Goode, John Wiley & Sons, Chichester UK, pp. 149-163.

Jans, D.A., Thomas, R.J., Gillespie, M.T., 2003, Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles, in Vitamins and Hormones, eds Gerald Litwack, Academic Press Inc., San Diego USA, pp. 345-384.

Journal Articles

Kaur, G., Lieu, K.G., Jans, D.A., 2013, 70kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex determining factor SRY, Journal Of Biological Chemistry [P], vol 288, issue 6, American Society for Biochemistry and Molecular Biology Inc, USA, pp. 4148-4157.

Miyamoto, Y., Baker, M., Whiley, P.A.F., Arjomand, A., Ludeman, J.P., Wong, C.L., Jans, D.A., Loveland, K.A.L., 2013, Towards delineation of a developmental {alpha}-importome in the mammalian male germline, Biochimica et Biophysica Acta - Molecular Cell Research [P], vol 1833, issue 3, Elsevier BV, The Netherlands, pp. 731-742.

Oksayan, S., Wiltzer, L., Rowe, C.L., Blondel, D., Jans, D.A., Moseley, G.W., 2012, A novel nuclear trafficking module regulates the nucleocytoplasmic localization of the rabies virus interferon antagonist, P protein, Journal Of Biological Chemistry [P], vol 287, issue 33, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 28112-28121.

Whiley, P., Miyamoto, Y., McLachlan, R., Jans, D., Loveland, K., 2012, Changing subcellular localization of nuclear transport factors during human spermatogenesis, International Journal Of Andrology [P], vol 35, issue 2, Wiley-Blackwell, USA, pp. 158-169.

Wiltzer, L., Larrous, F., Oksayan, S., Ito, N., Marsh, G.A., Blondel, D., Bourhy, H., Jans, D.A., Moseley, G.W., 2012, Conservation of a unique mechanism of immune evasion across the Lyssavirus genus, Journal Of Virology [P], vol 86, issue 18, American Society for Microbiology, USA, pp. 10194-10199.

Kuusisto, H.V., Wagstaff, K.M., Alvisi, G., Martino Roth, D., Jans, D.A., 2012, Global enhancement of nuclear localization-dependent nuclear transport in transformed cells, Faseb Journal [P], vol 26, issue 3, Federation of American Societies for Experimental Biology, USA, pp. 1181-1193.

Wagstaff, K.M., Sivakumaran, H., Heaton, S.M., Harrich, D., Jans, D.A., 2012, Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus, Biochemical Journal [E], vol 443, issue 3, Portland Press Ltd, UK, pp. 851-856.

Younessi, P., Jans, D.A., Ghildyal, R., 2012, Modulation of host cell nucleocytoplasmic trafficking during picornavirus infection, Infectious Disorders - Drug Targets [P], vol 12, issue 1, Bentham Science Publishers Ltd, The Netherlands, pp. 59-67.

Caly, L., Wagstaff, K.M., Jans, D.A., 2012, Nuclear trafficking of proteins from RNA viruses: potential target for antivirals?, Antiviral Research [P], vol 95, issue 3, Elsevier BV, The Netherlands, pp. 202-206.

Lin, M., Sivakumaran, H., Apolloni, A., Wei, T., Jans, D.A., Harrich, D., 2012, Nullbasic, a potent anti-HIV Tat mutant, induces CRM1-dependent disruption of HIV Rev trafficking, PLoS ONE [P], vol 7, issue 12 (Art. No.: e51466), Public Library of Science, USA, pp. 1-12.

Ghildyal, R., Jans, D.A., Bardin, P.G., Mills, J., 2012, Protein-protein interactions in RSV assembly: potential targets for attenuating RSV strains, Infectious Disorders - Drug Targets [P], vol 12, issue 2, Bentham Science Publishers Ltd, The Netherlands, pp. 103-109.

Ng, I.E., Ng, D.C., Jans, D.A., Bogoyevitch, M.A., 2012, Selective STAT3-{alpha} or -{beta} expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes, Biochemical Journal [P], vol 447, issue Part 1, Portland Press Ltd, UK, pp. 125-136.

Moseley, G., Jans, D., 2012, Subcellular trafficking of pathogens: targeting for therapeuticsUntitled Publication, Infectious Disorders - Drug Targets [P], vol 12, issue 1, Bentham Science Publishers Ltd, The Netherlands, pp. 2-3.

Miyamoto, Y., Baker, M.A., Whiley, P.A., Arjomand, A., Ludeman, J.P., Wong, C.L., Jans, D.A., Loveland, K.A., 2012, Towards delineation of a developmental alpha-importome in the mammalian male germline, Biochimica et Biophysica Acta - Molecular Cell Research [P], vol 1833, issue 3, Elsevier BV, Netherlands, pp. 731-742.

Wagstaff, K.M., Rawlinson, S.M., Hearps, A., Jans, D.A., 2011, An AlphaScreen®-based assay for high-throughput screening for specific inhibitors of nuclear import, Journal of Biomolecular Screening [P], vol 16, issue 2, Sage Publications, Inc., USA, pp. 192-200.

Young, J., Major, A., Miyamoto, Y., Loveland, K., Jans, D., 2011, Distinct effects of importin alpha2 and alpha4 on Oct3/4 localization and expression in mouse embryonic stem cells, Faseb Journal [P], vol 25, issue 11, Federation of American Societies for Experimental Biology, USA, pp. 3958-3965.

Kaur, G., Jans, D.A., 2011, Dual nuclear import mechanisms of sex determining factor SRY: Intracellular Ca2{+} as a switch, Faseb Journal [P], vol 25, issue 2, Federation of American Societies for Experimental Biology, USA, pp. 665-675.

Ly Huynh, J., Lieu, K., Major, A., Whiley, P., Holt, J., Loveland, K., Jans, D., 2011, Importin alpha2-interacting proteins with nuclear roles during mammalian spermatogenesis, Biology Of Reproduction [P], vol 85, issue 6, Society for the Study of Reproduction, USA, pp. 1191-1202.

Martino Roth, D., Moseley, G., Pouton, C., Jans, D., 2011, Mechanism of microtubule-facilitated "fast track" nuclear import, Journal Of Biological Chemistry [P], vol 286, issue 16, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 14335-14351.

Alvisi, G., Marin, O., Pari, G., Mancini, M., Avanzi, S., Loregian, A., Jans, D., Ripalti, A., 2011, Multiple phosphorylation sites at the C-terminus regulate nuclear import of HCMV DNA polymerase processivity factor ppUL44, Virology [P], vol 417, issue 2, Academic Press, USA, pp. 259-267.

Jans, D., 2011, Preface: Central role of nuclear transport in signalling, viral infection and development, Biochimica et Biophysica Acta - Molecular Cell Research [P], vol 1813, issue 9, Elsevier Science BV, The Netherlands, p. 1561.

Fulcher, A., Jans, D., 2011, Regulation of nucleocytoplasmic trafficking of viral proteins: An integral role in pathogenesis?, Biochimica et Biophysica Acta [P], vol 1813, issue 12, Elsevier BV, The Netherlands, pp. 2176-2190.

Itman, C.M., Wong, C., Hunyadi, B.L., Ernst, M.R., Jans, D.A., Loveland, K.A., 2011, Smad3 dosage determines androgen responsiveness and sets the pace of postnatal testis development, Endocrinology [P], vol 152, issue 5, The Endocrine Society, USA, pp. 2076-2089.

Wati, S., Rawlinson, S.M., Ivanov, R., Dorstyn, L., Beard, M.R., Jans, D.A., Pitson, S.M., Burrell, C.J., Li, P., Carr, J.M., 2011, Tumour necrosis factor alpha (TNF-alpha) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-alpha to activate nuclear factor kappaB and reduced sphingosine kinase-1 a, Journal Of General Virology [P], vol 92, issue Pt. 4, Society for General Microbiology, UK, pp. 807-818.

Perdomo, J., Fock, E., Kaur, G., Yan, F., Khachigian, L.M., Jans, D.A., Chong, B.H., 2010, A monopartite sequence is essential for P45 NF-E2 nuclear translocation, transcriptional activity and platelet production, Journal Of Thrombosis And Haemostasis [P], vol 8, issue 11, Wiley-Blackwell Publishing Ltd, UK & USA, pp. 2542-2553.

Fulcher, A.J., Dias, M.M., Jans, D.A., 2010, Binding of p110 retinoblastoma protein inhibits nuclear import of simian virus SV40 large tumor antigen, Journal Of Biological Chemistry [P], vol 285, issue 23, American Society for Biochemistry & Molecular Biology Inc, USA, pp. 17744-17753.

Kaur, G., Delluc-Clavieres, A., Poon, I.K., Forwood, J., Glover, D., Jans, D.A., 2010, Calmodulin-dependent nuclear import of HMG-box family nuclear factors: Importance of the role of SRY in sex reversal, Biochemical Journal [P], vol 430, issue 1, Portland Press Ltd, UK, pp. 39-48.

Lara-Chacon, B., Bermudez de Leon, M., Leocadio, D., Gomez, P., Fuentes-Mera, L., Martinez-Vieyra, I., Ortega, A., Jans, D.A., Cisneros, B., 2010, Characterization of an Importin in alpha/beta-recognized nuclear localization signal in beta-dystroglycan, Journal Of Cellular Biochemistry [P], vol 110, issue 3, John Wiley & Sons Inc, USA, pp. 706-717.

Moseley, G.W., Leyton, D.L., Glover, D.J., Filmer, R.P., Jans, D.A., 2010, Enhancement of protein transduction-mediated nuclear delivery by interaction with dynein/microtubules, Journal of Biotechnology [P], vol 145, Elsevier BV, The Netherlands, pp. 222-225.

Heffernan, C., Whiley, P., Milionis, A., Verma, P., Holland, M., Jans, D., D'Cruz, N., 2010, Lineage-specific expression of heterochromatin protein 1gamma in post-compaction, in vitro-produced bovine embryos, Reproduction, Fertility and Development [P], vol 22, issue 6, CSIRO Publishing, Australia, pp. 1022-1031.

Yang, S.N.Y., Takeda, A.A.S., Fontes, M.R.M., Harris, J.M., Jans, D.A., Kobe, B., 2010, Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening, Journal Of Biological Chemistry [P], vol 285, issue 26, American Society for Biochemistry & Molecular Biology Inc, USA, pp. 19935-19946.

Ito, N., Moseley, G.W., Blondel, D., Shimizu, K., Rowe, C.L., Ito, Y., Masatani, T., Nakagawa, K., Jans, D.A., Sugiyama, M., 2010, Role of interferon antagonist activity of rabies virus phosphoprotein in viral pathogenicity, Journal Of Virology [P], vol 84, issue 13, American Society for Microbiology, USA, pp. 6699-6710.

Fulcher, A.J., Roth, D.M., Fatima, S., Alvisi, G., Jans, D.A., 2010, The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal, Faseb Journal [P], vol 24, Federation of American Societies for Experimental Biology, USA, pp. 1454-1466.

Glover, D., Leyton, D.L., Moseley, G.W., Jans, D.A., 2010, The efficiency of nuclear plasmid DNA delivery is a critical determinant of transgene expression at the single cell level, Journal Of Gene Medicine [P], vol 12, John Wiley & Sons, Inc., USA, pp. 77-85.

Newton, H.J., Pearson, J.S., Badea, L., Kelly, M., Lucas, M., Holloway, G., Wagstaff, K.M., Dunstone, M.A., Sloan, J., Whisstock, J.C., Kaper, J.B., Robins-Browne, R.M., Jans, D.A., Frankel, G., Phillips, A.D., Coulson, B.S., Hartland, E.L., 2010, The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65, Plos Pathogens [P], vol 6, issue 5 (e1000898), Public Library of Science, USA, pp. 1-16.

Sivakumaran, H., van der Horst, A., Fulcher, A.J., Apolloni, A., Lin, M., Jans, D.A., Harrich, D., 2009, Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat, Journal Of Virology [P], vol 83, issue 22, American Society for Microbiology, USA, pp. 11694-11703.

Rawlinson, S.M., Pryor, M.J., Wright, P.J., Jans, D.A., 2009, CRM1-mediated nuclear export of dengue virus RNA polymerase NS5 modulates interleukin-8 induction and virus production, Journal of Biological Chemistry, vol 284, issue 23, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 15589-15597.

Itman, C.M., Small, C., Griswold, M., Nagaraja, A.K., Matzuk, M.M., Brown, C.W., Jans, D.A., Loveland, K.A.L., 2009, Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes, Developmental Dynamics [P], vol 238, issue 7, John Wiley & Sons, Inc., USA, pp. 1688-1700.

Moseley, G.W., Lahaye, X., Roth, D.M., Oksayan, S., Filmer, R.P., Rowe, C.L., Blondel, D., Jans, D.A., 2009, Dual modes of rabies P-protein association with microtubules: a novel strategy to suppress the antiviral response, Journal Of Cell Science [P], vol 122, issue 20, The Company of Biologists Ltd, UK, pp. 3652-3662.

Tannukit, S., Crabb, T.L., Hertel, K.J., Wen, X., Jans, D.A., Paine, M.L., 2009, Identification of a novel nuclear localization signal and speckle-targeting sequence of tuftelin-interacting protein 11, a splicing factor involved in spliceosome disassembly, Biochemical And Biophysical Research Communicat..., vol 390, issue 3, Academic Press, USA, pp. 1044-1050.

Wagstaff, K.M., Jans, D.A., 2009, Importins and beyond: Non-conventional nuclear transport mechanisms, Traffic [P], vol 10, issue 9, Wiley-Blackwell Munksgaard, Denmark, pp. 1188-1198.

Foong, Y.Y., Jans, D.A., Rolph, M.S., Gahan, M.E., Mahalingam, S., 2009, Interleukin-15 mediates potent antiviral responses via an interferon-dependent mechanism, Virology [P], vol 393, issue 2, Academic Press, USA, pp. 228-237.

Martino Roth, D., Harper, I.S., Pouton, C.W., Jans, D.A., 2009, Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus, Journal Of Cellular Biochemistry [P], vol 107, issue 6, John Wiley & Sons, Inc., USA, pp. 1160-1167.

Glover, D., Ng, S.M., Mechler, A.I., Martin, L.L., Jans, D.A., 2009, Multifunctional protein nanocarriers for targeted nuclear gene delivery in nondividing cells, Faseb Journal [P], vol 23, issue 9, Federation of American Societies for Experimental Biology, USA, pp. 2996-3006.

Wagstaff, K.M., Jans, D.A., 2009, Nuclear drug delivery to target tumour cells, European Journal of Pharmacology [P], vol 625, issue 1-3, Elsevier BV, The Netherlands, pp. 174-180.

Jans, D.A., 2009, Nuclear transport in development and disease - The importance of importins, Seminars In Cell & Developmental Biology [P], vol 20, issue 5, Academic Press, UK, p. 575.

Itman, C.M., Miyamoto, Y., Young, J.C., Jans, D.A., Loveland, K.A.L., 2009, Nucleocytoplasmic transport as a driver of mammalian gametogenesis, Seminars In Cell & Developmental Biology [P], vol 20, issue 5, Academic Press, United Kingdom, pp. 607-619.

Caly, L., Jans, D.A., Piller, S.C., 2009, Proteolytic cleavage of HIV-1 GFP-Vpr fusions at vovel sites within virions and living cells: Concerns for intracellular trafficking studies, Journal of Fluorescence, vol 19, Springer New York LLC, USA, pp. 567-573.

Ghildyal, R., Jordan, B., Li, D., Dagher, H., Bardin, P.G., Gern, J.E., Jans, D.A., 2009, Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport, Journal Of Virology [P], vol 83, issue 14, American Society for Microbiology, USA, pp. 7349-7352.

Alvisi, G., Roth, D.M., Camozzi, D., Pari, G.S., Loregian, A., Ripalti, A., Jans, D.A., 2009, The flexible loop of the human cytomegalovirus DNA polymerase processivity factor ppUL44 is required for efficient DNA binding and replication in cells, Journal Of Virology [P], vol 83, issue 18, American Society for Microbiology, USA, pp. 9567-9576.

Ghildyal, R., Ho, A., Dias, M., Soegiyono, L., Bardin, P.G., Tran, K.C., Teng, M.N., Jans, D.A., 2009, The respiratory syncytial virus matrix protein possesses a Crm1-mediated nuclear export mechanism, Journal of Virology, vol 83, issue 11, American Society for Microbiology, USA, pp. 5353-5362.

Kim, W.S., Elliott, D.A., Kockx, M., Kritharides, L., Rye, K., Jans, D.A., Garner, B., 2008, Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches, Biochemical Journal, vol 409, Portland Press Ltd, London England UK, pp. 701-709.

Li, D., Jans, D.A., Bardin, P.G., Meanger, J., Mills, J., Ghildyal, R., 2008, Association of respiratory syncytial virus M protein with viral nucleocapsids is mediated by the M2-1 protein, Journal Of Virology [P], vol 82, issue 17, American Society for Microbiology, USA, pp. 8863-8870.

D'Cruz, N.T., Prashadkumar, S., Wilson, K.J., Heffernan, C., Cooney, M.A., French, A.J., Jans, D.A., Verma, P.J., Holland, M.K., 2008, Dynamic changes in localization of chromobox (CBX) family members during the maternal to embryonic transition, Molecular Reproduction & Development, vol 75, issue 3, Wiley-Liss, United States, pp. 477-488.

Wagstaff, K.M., Fan, J.Y., De Jesus, M., Tremethick, D.J., Jans, D.A., 2008, Efficient gene delivery using reconstituted chromatin enhanced for nuclear targeting, The FASEB Journal, vol 22, issue 7, Federation of American Societies for Experimental Biology, United States, pp. 2232-2242.

Dowling, D., Nasr-Esfahani, S., Tan, C.H., O'Brien, K., Howard, J.L., Jans, D.A., Purcell, D.F., Stoltzfus, C.M., Sonza, S., 2008, HIV-1 infection induces changes in expression of cellular splicing factors that regulate alternative viral splicing and virus production in macrophages, Retrovirology, vol 5, issue 18, BioMed Central Ltd., United Kingdom, pp. 1-12.

Caly, L., Saksena, N.K., Piller, S., Jans, D.A., 2008, Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor, Retrovirology, vol 5, issue 1, BioMed Central Ltd., United Kingdom, United States, Netherlands, pp. 67-73.

Maddika, S., Wiechec, E., Ande, S.R., Poon, I.K., Fischer, U., Wesselborg, S., Jans, D.A., Schulze-Osthoff, K., Los, M., 2008, Interaction with PI3-kinase contributes to the cytotoxic activity of Apoptin, Oncogene, vol 27, Nature Publishing Group, UK, pp. 3060-3065.

Fulcher, A., Ahmed, C.M.I., Noon-Song, E.N., Kwan, R.Y.Q., Subramaniam, P.S., Johnson, H.M., Jans, D.A., 2008, Interferon gamma is recognised by importin alpha/beta: Enhanced nuclear localising and transactivation activities of an interferon gamma mimetic, FEBS Letters, vol 582, issue 11, Elsevier BV, Netherlands, pp. 1569-1574.

Elliott, D., Kim, W.S., Jans, D.A., Garner, B., 2008, Macrophage apolipoprotein-E knockdown modulates caspase-3 activation without altering sensitivity to apoptosis, Biochimica et Biophysica ACTA-General Subjects, vol 1780, Elsevier Science BV, Amsterdam The Netherlands, pp. 145-153.

Alvisi, G., Rawlinson, S.M., Ghildyal, R., Ripalti, A., Jans, D.A., 2008, Regulated nucleocytoplasmic trafficking of viral gene products: A therapeutic target?, Biochimica et Biophysica ACTA-Proteins and Proteomics, vol 1784, Elsevier Science BV, Amsterdam The Netherlands, pp. 213-227.

Sinigalia, E., Alvisi, G., Mercorelli, B., Coen, D.M., Pari, G.S., Jans, D.A., Ripalti, A., Palu, G., Loregian, A., 2008, Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells, Journal of Virology, vol 82, issue 24, American Society for Microbiology, United States, pp. 12574-12579.

Kuusisto, H.V., Wagstaff, K.M., Alvisi, G., Jans, D.A., 2008, The C-terminus of apoptin represents a unique tumor cell-enhanced nuclear targeting module, International Journal of Cancer, vol 123, issue 12, John Wiley & Sons, Inc., United States, Switzerland, Germany, pp. 2965-2969.

Hearps, A.C., Wagstaff, K.M., Piller, S., Jans, D.A., 2008, The N-terminal basic domain of the HIV-1 matrix protein does not contain a conventional nuclear localization sequence but is required for DNA binding and protein self-association, Biochemistry, vol 47, issue 7, Americal Chemical Society, United States, pp. 2199-2210.

Roth, D., Moseley, G.W., Glover, D., Pouton, C.W., Jans, D.A., 2007, A microtubule-facilitated nuclear import pathway for cancer regulatory proteins, Traffic, vol 8, issue 6, Blackwell Publishing, Oxford England UK, pp. 673-686.

Alvisi, G., Musiani, D., Jans, D.A., Ripalti, A., 2007, An importin alpha/beta-recognized bipartite nuclear localization signal mediates targeting of the human herpes simplex virus type 1 DNA polymerase catalytic subunit pUL30 to the nucleus, Biochemistry, vol 46, issue 32, American Chemical Society, Washington DC USA, pp. 9155-9163.

Janssen, K., Hofmann, T.G., Jans, D.A., Hay, R.T., Schulze-Osthoff, K., Fischer, U., 2007, Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies, Oncogene, vol 26, Nature Publishing Group, London UK, pp. 1557-1566.

Elliott, D., Kim, W.S., Jans, D.A., Garner, B., 2007, Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies, Neuroscience Letters, vol 416, issue 2, Elsevier Ireland Ltd, Shannon Ireland, pp. 206-210.

Moseley, G.W., Roth, D., De Jesus, M., Leyton, D.L., Filmer, R., Pouton, C.W., Jans, D.A., 2007, Dynein light chain association sequences can facilitate nuclear protein import, Molecular Biology of the Cell, vol 18, issue 8, The American Society for Cell Biology, Bethesda MD USA, pp. 3204-3213.

Jans, D.A., Wagstaff, K.M., 2007, Getting to the heart of a tumour cell, Pharma Focus Asia, vol 0, issue 5, Ochre Media, Hyderabad, India, pp. 21-24.

Wagstaff, K.M., Glover, D., Tremethick, D.J., Jans, D.A., 2007, Histone-mediated transduction as an efficient means for gene delivery, Molecular Therapy, vol 15, issue 4, Nature Publishing Group, New York NY USA, pp. 721-731.

Pryor, M.J., Rawlinson, S.M., Butcher, R.E., Barton, C., Waterhouse, T.A., Vasudevan, S.G., Bardin, P.G., Wright, P.J., Jans, D.A., Davidson, A.D., 2007, Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection, Traffic, vol 8, issue 7, Blackwell Publishing, Oxford England UK, pp. 795-807.

Conway-Campbell, B.L., Wooh, J.W., Brooks, A.J., Gordon, D., Brown, R.J., Lichanska, A.M., Chin, H.S., Barton, C., Boyle, G.M., Parsons, P.G., Jans, D.A., Waters, M.J., 2007, Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis, Proceedings of the National Academy of Sciences of the United States of America (PNAS), vol 104, issue 33, National Academy of Sciences, Washington DC USA, pp. 13331-13336.

Moseley, G.W., Filmer, R., De Jesus, M., Jans, D.A., 2007, Nucleocytoplasmic distribution of rabies virus P-protein is regulated by phosphorylation adjacent to C-terminal nuclear import and export signals, Biochemistry, vol 46, issue 43, American Chemical Society, Washington DC USA, pp. 12053-12061.

Wagstaff, K.M., Jans, D.A., 2007, Nucleocytoplasmic transport of DNA: enhancing non-viral gene transfer, Biochemical Journal, vol 406, issue 2, Portland Press Ltd, London England UK, pp. 185-202.

Glover, D., Glouchkova, L., Lipps, H.J., Jans, D.A., 2007, Overcoming Barriers to Achieve Safe, Sustained and Efficient Non-Viral Gene Therapy, Advances in Gene, Molecular and Cell Therapy [P], vol 1, issue 2, Global Science Books Ltd, UK, pp. 126-140.

Hearps, A.C., Jans, D.A., 2007, Regulating the functions of the HIV-1 matrix protein, AIDS Research and Human Retroviruses, vol 23, issue 3, Mary Ann Liebert Inc, New Rochelle NY USA, pp. 341-346.

Holt, J., Ly Huynh, J., Efthymiadis, A., Hime, G.R., Loveland, K.A.L., Jans, D.A., 2007, Regulation of nuclear import during differentiation: The IMP alpha gene family and spermatogenesis, Current Genomics [P], vol 8, issue 5, Bentham Science Publishers Ltd, The Netherlands, pp. 323-334.

Hogarth, C.A., Jans, D.A., Loveland, K.A.L., 2007, Subcellular distribution of importins correlates with germ cell maturation, Developmental Dynamics, vol 236, issue 8, Wiley-Liss, United States, pp. 2311-2320.

Pouton, C.W., Wagstaff, K.M., Roth, D., Moseley, G.W., Jans, D.A., 2007, Targeted delivery to the nucleus, Advanced Drug Delivery Reviews, vol 59, issue 8, Elsevier Science BV, Amsterdam, pp. 698-717.

Hearps, A.C., Pryor, M.J., Kuusisto, H.V., Rawlinson, S.M., Piller, S., Jans, D.A., 2007, The biarsenical dye lumiotrademark exhibits a reduced ability to specifically detect tetracysteine-containing proteins within live cells, Journal of Fluorescence, vol 17, issue 6, Springer/Plenum Publishers, New York NY USA, pp. 593-597.

Ghildyal, R., Ho, A., Jans, D.A., 2006, Central role of the respiratory syncytial virus matrix protein in infection, FEMS Microbiology Reviews, vol 30, issue 5, Blackwell Publishing, Oxford England, pp. 692-705.

Rawlinson, S.M., Pryor, M.J., Wright, P.J., Jans, D.A., 2006, Dengue virus RNA polymerase NS5: a potential therapeutic target?, Current Drug Targets, vol 7, issue 12, Bentham Science Publishers Ltd, Sharjah UAE, pp. 1623-1638.

Loveland, K.A.L., Hogarth, C., Szczepny, A., Prabhu, S.M., Jans, D.A., 2006, Expression of nuclear transport importins beta 1 and beta 3 is regulated during rodent spermatogenesis, Biology of Reproduction, vol 74, issue 28 September 2005, Society for the Study of Reproduction, Madison USA, pp. 67-74.

Hearps, A.C., Jans, D.A., 2006, HIV-1 integrase is capable of targeting DNA to the nucleus via an Importin alpha/beta-dependent mechanism, Biochemical Journal, vol 398, issue 3, Portland Press Ltd, London UK, pp. 475-484.

Alvisi, G., Jans, D.A., Ripalti, A., 2006, Human cytomegalovirus (HCMV) DNA polymerase processivity factor ppUL44 dimerizes in the cytosol before translocation to the nucleus, Biochemistry, vol 45, issue 22, American Chemical Society, Washington DC USA, pp. 6866-6872.

Alvisi, G., Ripalti, A., Ngankeu, A., Giannandrea, M., Caraffi, S.G., Dias, M., Jans, D.A., 2006, Human cytomegalovirus DNA polymerase catalytic subunit pUL54 possesses independently acting nuclear localization and ppUL44 binding motifs, Traffic, vol 7, issue 10, Blackwell Publishing, Oxford England, pp. 1322-1332.

Hogarth, C.A., Calanni, S.T., Jans, D.A., Loveland, K.A.L., 2006, Importin alpha mRNAs have distinct expression profiles during spermatogenesis, Developmental Dynamics, vol 235, issue 1, Wiley-Liss, Hoboken USA, pp. 253-262.

Wagstaff, K.M., Jans, D.A., 2006, Intramolecular masking of nuclear localization signals: analysis of importin binding using a novel AlphaScreen-based method, Analytical Biochemistry, vol 348, issue 1, Elsevier Science, San Diego USA, pp. 49-56.

Huebner, S., Eam, J.E., Huebner, A., Jans, D.A., 2006, Laminopathy-inducing lamin A mutants can induce redistribution of lamin binding proteins into nuclear aggregates, Experimental Cell Research, vol 312, issue 2, Elsevier, San Diego USA, pp. 171-183.

Wagstaff, K.M., Jans, D.A., 2006, Protein transduction: cell penetrating peptides and their therapeutic applications, Current Medicinal Chemistry, vol 13, issue 12, Bentham Science Publishers Ltd, Sharjah UAE, pp. 1371-1387.

Forwood, J., Jans, D.A., 2006, Quantitative analysis of DNA-protein interactions using double-labeled native gel electrophoresis and fluorescence-based imaging, Electrophoresis, vol 27, issue 16, Wiley-V C H Verlag GMBH, Weinheim Germany, pp. 3166-3170.

Hubner, S., Eam, J.E., Wagstaff, K.M., Jans, D.A., 2006, Quantitative analysis of localization and nuclear aggregate formation induced by GFP-lamin A mutant proteins in living HeLa cells, Journal of Cellular Biochemistry, vol 98, issue 4, Wiley-Liss, Div John Wiley & Sons Inc, Hoboken NJ USA, pp. 810-826.

Goffin, L., Vodala, S., Fraser, C., Ryan, J., Timms, M., Meusburger, S., Catimel, B., Nice, E.C., Silver, P.A., Xiao, C., Jans, D.A., Gething, M.H., 2006, The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins, Molecular Biology of the Cell, vol 17, issue 12, American Society for Cell Biology, Bethesda USA, pp. 5309-5323.

Alvisi, G., Poon, I.K.H., Jans, D.A., 2006, Tumor-specific nuclear targeting: promises for anti-cancer therapy?, Drug Resistance Updates, vol 9, issue 1-2, Churchill Livingstone, Edinburgh UK, pp. 40-50.

Alvisi, G., Jans, D.A., Guo, J., Pinna, L.A., Ripalti, A., 2005, A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44, Traffic, vol 6, issue 11, Blackwell Publishing, Oxford England, pp. 1002-1013.

Poon, I.K.H., Oro, C., Dias, M.M., Zhang, J.-., Jans, D.A., 2005, A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin [2], Journal of Virology, vol 79, issue 2, American Society for Microbiology, Washington USA, pp. 1339-1341.

Poon, I.K.H., Oro, C., Dias, M.M., Zhang, J., Jans, D.A., 2005, Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells, Cancer Research, vol 65, issue 16, American Association for Cancer Research, Philadelphia USA, pp. 7059-7064.

Loveland, K.L., Hogarth, C., Mendis, S.H.S., Efthymiadis, A., Ly, J.D., Itman, C.M., Meachem, S., Brown, C.W., Jans, D.A., 2005, Drivers of germ cell maturation, Annals of the New York Academy of Sciences, vol 1061, New York Academy of Sciences, New York USA, pp. 173-182.

Caly, L., Wang, B., Mikhail, M., Gill, M.J., Beckthold, B., Salemi, M., Jans, D.A., Piller, S.C., Saksena, N.K., 2005, Evidence for host-driven selection of the HIV type 1 vpr gene in vivo during HIV disease progression in a transfusion-acquired cohort, AIDS Research Human Retroviruses, vol 21, issue 8, Mary Ann Liebert Inc, New Rochelle USA, pp. 728-733.

Sunn, K.L., Eisman, J.A., Gardiner, E.M., Jans, D.A., 2005, FRAP analysis of nucleocytoplasmic dynamics of the vitamin D receptor splice variant VDRB1: preferential targeting to nuclear speckles, Biochemical Journal, vol 388, issue 2, Portland Press, London England, pp. 509-514.

Young, D.B., Jonnalagadda, J., Gatei, M., Jans, D.A., Meyn, S., Khanna, K., 2005, Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association, Journal of Biological Chemistry, vol 280, issue 30, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 27587-27594.

Blink, E., Jiansheng, Z., Hu, W., Calanni, S.T., Trapani, J.A., Bird, P.I., Jans, D.A., 2005, Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: Modulation by the serpin inhibitor PI-9, Journal of Cellular Biochemistry, vol 95, issue 3, Wiley-Liss, Hoboken USA, pp. 598-610.

Hu, W., Kemp, B.E., Jans, D.A., 2005, Kinetic properties of nuclear transport conferred by the retinoblastoma (Rb) NLS, Journal of Cellular Biochemistry, vol 95, issue 4, Wiley-Liss, Hoboken USA, pp. 782-793.

Ghildyal, R., Ho, A., Wagstaff, K.M., Dias, M.M., Barton, C.L., Jans, P., Bardin, P., Jans, D.A., 2005, Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha, Biochemistry, vol 44, issue 38, American Chemical Society, Washington USA, pp. 12887-12895.

Soboleva, T., Jans, D.A., Johnson-Saliba, M., Baker, R.T., 2005, Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme, Journal Of Biological Chemistry [P], vol 280, issue 1, American Society for Biochemistry & Molecular Biology Inc, USA, pp. 745-752.

Wagstaff, K.M., Dias, M.M., Alvisi, G., Jans, D.A., 2005, Quantitative analysis of protein-protein interactions by native page/fluorimaging, Journal of Fluorescence, vol 15, issue 4, Springer/Plenum Publishers, New York USA, pp. 469-473.

Hogarth, C., Itman, C.M., Jans, D.A., Loveland, K.A.L., 2005, Regulated nucleocytoplasmic transport in spermatogenesis: a driver of cellular differentiation?, Bioessays, vol 27, issue 10, John Wiley & Sons Inc, Hoboken USA, pp. 1011-1025.

Poon, I.K.H., Jans, D.A., 2005, Regulation of nuclear transport: central role in development and transformation?, Traffic, vol 6, issue 3, Blackwell Munksgaard, Copenhagen Denmark, pp. 173-186.

Martin, F., Roth, D.M., Jans, D.A., Pouton, C.W., Partridge, L.J., Monk, P.N., Moseley, G.W., 2005, Tetraspanins in viral infections: a fundamental role in viral biology?, Journal of Virology, vol 79, issue 17, American Society for Microbiology, USA, pp. 10839-10851.

Glover, D.J., Lipps, H.J., Jans, D.A., 2005, Towards safe, non-viral therapeutic gene expression in humans, Nature Reviews Genetics, vol 6, issue 4, Nature Publishing Group, London England, pp. 299-310.

Catanzariti, A., Soboleva, T.A., Jans, D.A., Board, P.G., Baker, R.T., 2004, An efficient system for high-level expression and easy purification of authentic recombinant proteins, Protein Science, vol 13, issue 5, Cold Spring Harbor Labartory Press, Woodbury USA, pp. 1331-1339.

Soboleva, T.A., Jans, D.A., Johnson-Saliba, M., Baker, R.T., 2004, Nuclear-cytoplasmic shuttling of the oncogenic mouse Unp/Usp4 deubiquitylating enzyme, Journal of Biological Chemistry, vol 280, issue 1, The American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 745-752.

Oro, C., Jans, D.A., 2004, The tumour specific pro-apoptotic factor apoptin (Vp3) from chicken anaemia virus, Current Drug Targets, vol 5, issue 2, Bentham Science Publishers Ltd, Hilversum The Netherlands, pp. 179-190.

Johnson, H.M., Subramaniam, P.S., Olsnes, S., Jans, D.A., 2004, Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors, Bio Essays, vol 26, issue 9, John Wiley & Sons Ltd, Chichester England, pp. 993-1004.

Argentaro, A., Sim, H., Kelly, S., Preiss, S., Clayton, A., Jans, D.A., Harley, V.R., 2003, A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia/autosomal sex reversal, Journal of Biological Chemistry, vol 278, issue 36, American Society for Biochemistry and Molecular Biology Inc., Bethesda USA, pp. 33839-33847.

Trapani, J.A., Sutton, V.R., Thia, K.Y.T., Li, Y., Froelich, C.J., Jans, D.A., Sandrin, M.S., Browne, K.A., 2003, A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death, The Journal of Cell Biology, vol 106, issue 2, Rockefeller University Press, New York USA, pp. 223-233.

Harley, V.R., Layfield, S., Mitchell, C.L., Forwood, J., John, A.P., Briggs, L.J., McDowall, S.G., Jans, D.A., 2003, Defective importin recognition and nuclear import of the sex-determining factory SRY are associated with XY sex-reversing mutations, Proceedings of the National Academy of Sciences of the United States of America, vol 100, issue 12, National Academy of Sciences, Washington USA, pp. 7045-7050.

Fineberg, K.M., Fineberg, T., Graessmann, A., Luedtke, N.W., Tor, Y., Lixin, R., Jans, D.A., Loyter, A., 2003, Inhibition of nuclear import mediated by the Rev-Arginine Rich Motif by RNA molecules, Biochemistry, vol 42, issue 9, American Chemical Society, Washington USA, pp. 2625-2633.

Keough, R.A., MacMillan, E.M., Lutwyche, J.K., Gardner, J.M., Tavner, F.J., Jans, D.A., Henderson, B.R., Gonda, T.J., 2003, Myb-binding protein 1a is a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways, Experimental Cell Research, vol 289, issue 1, Academic Press Inc. Elsevier Science, San Diego USA, pp. 108-123.

Piller, S.C., Caly, L., Jans, D.A., 2003, Nuclear Import of the pre-integration complex (PIC): the Achilles heel of HIV?, Current Drug Targets, vol 4, issue 5, Bentham Science Publishers Ltd, Hilversum The Netherlands, pp. 409-429.

Schedlich, L.J., Nilsen, T., John, A.P., Jans, D.A., Baxter, R.C., 2003, Phosphorylation of insulin-like growth factor binding protein-3 by deoxyribonucleic acid-dependent protein kinase reduces ligand binding and enhances nuclear accumulation, Endocrinology, vol 144, issue 5, Endocrine Society, Bethesda USA, pp. 1984-1993.

Rosenkranz, A.A., Lunin, V.G., Gulak, P.V., Sergienko, O.V., Shumiantseva, M.A., Voronina, O.L., Gilyazova, D.G., John, A.P., Kofner, A.A., Mironov, A.F., Jans, D.A., Sobolev, A.S., 2003, Recombinant modular transporters for cell-specific nuclear delivery of locally acting drugs enhance photosensitizer activity, The FASEB Journal, vol 17, issue 9, Federation of American Societies for Experimental Biology, Bethesda USA, pp. 1121-1123.

Fontes, M.R.M., Teh, T., Toth, G., John, A.P., Pavo, I., Jans, D.A., Kobe, B., 2003, Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-, Biochemical Journal, vol 375, issue 2, Portland Press, London England, pp. 339-349.

Fontes, M.R.M., Teh, T., Jans, D.A., Brinkworth, R.I., Kobe, B., 2003, Structural basis for the specificity of bipartite nuclear localisation sequence binding by importin-, Journal of Biological Chemistry, vol 278, issue 30, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 27981-27987.

Fulcher, A.J., Jans, D.A., 2003, The HIV-1 Tat transactivator protein: a therapeutic target?, IUBMB Life, vol 55, issue 12, Taylor & Francis Inc., Philadelphia USA, pp. 669-680.

Henderson, M.J., Russell, A.J., Hird, S., Munoz, M., Clancy, J.L., Lehrbach, G.M., Calanni, S.T., Jans, D.A., Sutherland, R.L., Watts, C.K.W., 2002, EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response, Journal of Biological Chemistry, vol 277, issue 19, American Society Biochemistry Molecular Biology Inc, Bethesda MD USA, pp. 26468-26478.

Forewood, J.K., Jans, D.A., 2002, Nuclear import pathway of the telomere elongation suppressor TRFI: inhibition by importin, Biochemistry, vol 41, issue 30, American Chemical Society, Washington USA, pp. 9333-9340.

Lam, M., Thomas, R.J., Loveland, K.L., Schilders, S., Min, G., Martin, T.J., Gillespie, M.T., Jans, D.A., 2002, Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules, Molecular Endocrinology, vol 16, issue 2, Endocrine Society, Bethesda USA, pp. 390-401.

Baliga, B.C., Colussi, P.A., Read, S.H., Dias, M., Jans, D.A., 2002, Role of prodomain in importin-medicated nuclear localization and activation of Capase-2*, Journal of Biological Chemistry, vol 278, issue 7, American Society of Biochemistry and Molecular Biology Inc., Bethesda MD USA, pp. 4899-4905.

Hariton-Gazal, E., Feder, R., Mor, A., Graessmann, A., Brack-Werner, R., Jans, D.A., Gilon, C., Loyter, A., 2002, Targeting of nonkaryophilic cell-permeable peptides into the nuclei of intact cells by covalently attached nuclear localization signals, Biochemistry, vol 41, issue 29, American Chemical Society, Washington DC USA, pp. 9208-9214.

Brooks, A.J., Johansson, M., John, A.V., Xu, Y., Jans, D.A., Vasuvedan, S.B., 2002, The Interdomain Region of Dengue NS5 Protein That Binds to the Viral Helicase NS3 Contains Independently Functional Importin 1 and Improtin Recognized Nuclear Localization Signals, Journal of Biological Chemistry, vol 277, issue 39, American Society Biochemistry Molecular Biology Inc, Bethesda MD USA, pp. 36399-36407.

Chan, C., Jans, D.A., 2002, Using nuclear targeting signals to enhance non-viral gene transfer, Immunology and Cell Biology, vol 80, issue 2, Blackwell Publishing, Asia, Carlton Vic Australia, pp. 119-130.

Catimel, B., Teh, T., Fontes, M.R., Jennings, I.G., Jans, D.A., Howlett, G.J., Nice, E., Kobe, B., 2001, Biophysical characterization of interactions involving importin-alpha during nuclear import, Journal Of Biological Chemistry [P], vol 276, issue 36, American Society for Biochemistry & Molecular Biology Inc, USA, pp. 34189-34198.

Chan, C., Jans, D.A., 2001, Enhancement of MSH receptor- and GAL4-mediated gene transfer by switching the nuclear import pathway, Gene Therapy, vol 8, issue 2, Nature Publishing Group, London UK, pp. 166-171.

Johnson-Saliba, M., Jans, D.A., 2001, Gene therapy: optimising DNA delivery to the nucleus, Current Drug Targets, vol 2, issue 4, Bentham Science Publishing Ltd, Hilversum Netherlands, pp. 371-399.

Bird, C., Blink, E., Hirst, C.E., Buzza, M.S., Steele, P.M., Sun, J., Jans, D.A., Bird, P.I., 2001, Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1, Molecular and Cellular Biology, vol 21, issue 16, American Society of Microbiology, Washington DC USA, pp. 5396-5407.

Forwood, J., Harley, V., Jans, D.A., 2001, The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin b1, The Journal of Biological Chemistry, vol 276, issue 49, American Society for Biochemistry and Molecular Biology Inc, Bethesda USA, pp. 46575-46582.

Loveland, K.L., Herszfeld, D., Chu, B., Rames, E., Christy, E., Briggs, L.J., Shakri, R., de Kretser, D.M., Jans, D.A., 1999, Novel low molecular weight microtubule-associated protein-2 isoforms contain a functional nuclear localization sequence, Journal of Biological Chemistry, vol 274, Amer Soc Biochem Molecul Biology Inc, Bethesda USA, pp. 19261-19268.

Conference Proceedings

Loveland, K.L., Rames, E., Herszfeld, D., Chu, B., de Kretser, D.M., Briggs, L.J., Jans, D., 1998, A novel microtubule-associated protein-2 (map-2) isoform in brain and testis with nuclear localisation, Proceedings of the 29th Annual Conference of Australian Society for Reproductive Biology, PERTH, W.A. 23.8.98, Australian Society for Reproductive Biology, WA University Perth WA Australia, p. 5.

Loveland, K.L., Herszfeld, D., Chu, B., Rames, E., de Kretser, D.M., Briggs, L.J., Jans, D.A., 1998, DISTRIBUTION AND POTENTIAL FUNCTION OF A NOVEL MICROTUBULE-ASSOCIATED PROTEIN-2 (MAP-2) mRNA ISOFORM, 10th European Workshop On Molecular And Cellular Endocrinology Of The Testis, CAPRI, ITALY 28.3.98, ARES-SERONO FOUNDATION, ITALY, p. 1.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Altered Nuclear Transport in Transformed Cells.

Supervisors:

Jans, D (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Analysis of negative regulators of nuclear import (NRNIs) in spermatogenesis.

Supervisors:

Jans, D (Joint-co), Wagstaff, K (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Differential regulation of STAT3 spliceforms in response to cytokine stimulation..

Supervisors:

Jans, D (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Immune evasion strategies of Paramyxovirinae: The role of protein trafficking in host-pathogen interactions..

Supervisors:

Jans, D (Joint), Moseley, G (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigation of the Bidirectional Nuclear Transport of Importin 13 and its role in disease.

Supervisors:

Jans, D (Joint-co), Wagstaff, K (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Mechanisms of viral immune evasion: Nucleocytoplasmic trafficking of Lyssavirus phosphoproteins and their isoforms..

Supervisors:

Jans, D (Joint), Moseley, G (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Non-viral gene delivery and implications for reverse transfection cell microarray technology.

Supervisors:

Jans, D (Joint), Wagstaff, K (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Nuclear localisation mechanisms and function of the Rabies virus phosphoprotein.

Supervisors:

Jans, D (Joint), Moseley, G (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Structural resolution of the interaction between Dengue NS5 and NLS binding partners to determine a basis for chemical inhibition.

Supervisors:

Jans, D (Main), Wagstaff, K (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of microtubules in regulating nuclear trafficking: significance to viral biology.

Supervisors:

Jans, D (Joint), Moseley, G (Joint-co).

Completed Supervision

Student:

Caly, L.

Program of Study:

Investigations into the nuclear transport of Human Immunodeficiency Virus Type-1 Viral Protein R (Vpr). (PHD) 2009.

Supervisors:

Jans, D (Main).

Student:

Fulcher, A.

Program of Study:

Regulation of viral protein nuclear trafficking. (PHD) 2010.

Supervisors:

Jans, D (Main).

Student:

Galic, S.

Program of Study:

Regulation of insulin signalling by protein tyrosine phosphatases. (PHD) 2007.

Supervisors:

Tiganis, T (Main), Jans, D (Associate).

Student:

Glover, D.

Program of Study:

Engineered modular protein DNA-carriers for targeted nuclear gene delivery. (PHD) 2008.

Supervisors:

Jans, D (Main).

Student:

Hauser, C.

Program of Study:

Characterisation of cell cycle functions of the protein tyrosine phosphatase TCPTP. (PHD) 2010.

Supervisors:

Jans, D (Joint), Tiganis, T (Joint-Co).

Student:

Hearps, A.

Program of Study:

Investigating the role of matrix and integrase in the nuclear import of the HIV-1 genome. (PHD) 2007.

Supervisors:

Jans, D (Main).

Student:

Itman, C.

Program of Study:

Developmentally regulated SMAD signalling in the testis. (PHD) 2008.

Supervisors:

Jans, D (Joint), Loveland, K (Joint-Co).

Student:

Kaur, G.

Program of Study:

Dual nuclear import mechanisms of sex determining factor SRY. (PHD) 2010.

Supervisors:

Jans, D (Main).

Student:

Lieu, K.

Program of Study:

Etoposide-induced protein Ei24 is a novel negative regulator of nuclear import. (PHD) 2011.

Supervisors:

Jans, D (Main).

Student:

Lo, C.

Program of Study:

Nuclear localization of MAP2cN in the testis. (PHD) 2008.

Supervisors:

Jans, D (Joint), Loveland, K (Joint-Co).

Student:

Martino Roth, D.

Program of Study:

The role of microtubules in nuclear protein transport. (PHD) 2008.

Supervisors:

Jans, D (Joint), Pouton, C (Joint-Co).

Student:

Rawlinson, S.

Program of Study:

Subcellular trafficking of dengue virus non-structural protein 5. (PHD) 2010.

Supervisors:

Jans, D (Joint-Co), Wright, P (Joint).

Student:

Szczepny, A.

Program of Study:

Function and regulation of Hedgehog signalling in the adult mouse testis. (PHD) 2008.

Supervisors:

Loveland, K (Main), Jans, D (Associate).

Student:

Wagstaff, K.

Program of Study:

Histones optimised for nuclear targeting as novel vehicles for gene delivery. (PHD) 2007.

Supervisors:

Jans, D (Main).