Dr Francis Chiu - Researcher Profile

Biography

Position

Bioanalysis team leader
Centre for Drug Candidate Optimisation
Monash Institute of Pharmaceutical Sciences

Qualifications

PHARMACEUTICAL CHEMISTRY

Institution: University of Sydney, Sydney, NSW

Year awarded: 1986

B PHARMACY (HON 1)

Institution: University of Sydney, Sydney, NSW

Year awarded: 1981

Publications

Journal Articles

Hung, L., Villemagne, V., Cheng, L., Sherratt, N., Ayton, S., White, A., Crouch, P., Lim, S., Leong, S., Wilkins, S., George, J., Roberts, B., Pham, C., Liu, X., Chiu, F., Shackleford, D., Powell, A., Masters, C., Bush, A., O'Keefe, G., Culvenor, J., Cappai, R., Cherny, R., Donnelly, P., Hill, A., Finkelstein, D., Barnham, K., 2012, The hypoxia imaging agent CU(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease, Journal of Experimental Medicine [P], vol 209, issue 4, Rockefeller University Press, New York, pp. 837-854.

Soon, R., Velkov, T., Chiu, F., Thompson, P., Kancharla, R., Roberts, K., Larson, I., Nation, R., Li, J., 2011, Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions, Analytical Biochemistry [P], vol 409, issue 2, Academic Press, United States, pp. 273-283.

Charman, S., Arbe-Barnes, S., Bathurst, I., Brun, R., Campbell, M., Charman, W., Chiu, F., Chollet, J., Craft, C., Creek, D., Dong, Y., Matile, H., Maurer, M., Morizzi, J., Nguyen, T., Papastogiannidis, P., Scheurer, C., Shackleford, D., Sriraghavan, K., Stingelin, L., Tang, Y., Urwyler, H., Wang, X., White, K., Wittlin, S., Zhou, L., Vennerstrom, J., 2011, Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 108, issue 11, National Academy of Sciences, Washington D.C., USA, pp. 4400-4405.

Johnstone, K.D., Karoli, T., Liu, L., Dredge, K., Copeman, E., Li, C.P., Davis, K., Hammond, E., Bytheway, I., Kostewicz, E.S., Chiu, F.C.K., Shackleford, D., Charman, S.A., Charman, W.N., Harenberg, J., Gonda, T., Ferro, V., 2010, Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth, Journal of Medicinal Chemistry [P], vol 53, issue 4, American Chemical Society, USA, pp. 1686-1699.

Tang, Y., wittlin, s., Charman, S.A., Chollet, J., Chiu, F.C.K., Morizzi, J., Johnson, L., Santo Tomas, J., Scheurer, C., Christopher Snyder, Zhou, L., Dong, Y., Charman, W.N., Matile, H., Urwyler, H., Dorn, A., Vennerstrom, J., 2010, The comparative antimalarial properties of weak base and neutral synthetic ozonides, Bioorganic & Medicinal Chemistry Letters [P], vol 20, issue 2, Pergamon, UK, pp. 563-566.

Evison, B.J., Bilardi, R.A., Chiu, F.C.K., Pezzoni, G., Phillips, D.R., Cutts, S.M., 2009, CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity, Nucleic Acids Research [E], vol 37, issue 19, Oxford University Press, UK, pp. 6355-6370.

Li, J., Nation, R.L., Cao, G., Ali, F., Chiu, F.C.K., Zavascki, A.P., 2009, Development and validation of a reversed-phase high-performance liquid chromatography assay for polymyxin B in human plasma - authors' response, Journal Of Antimicrobial Chemotherapy [P], vol 63, issue 3, Oxford University Press, United Kingdom, pp. 628-629.

Bhamidipati, R.K., Morizzi, J., Chiu, F.C.K., Shackleford, D., Charman, S.A., 2009, Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography, Journal of Chromatography B: Analytical Technologie..., vol 877, issue 27, Elsevier BV, The Netherlands, pp. 2989-2995.

Creek, D.J., Ryan, E., Charman, W.N., Chiu, F.C.K., Prankerd, R., Vennerstrom, J., Charman, S.A., 2009, Stability of peroxide antimalarials in the presence of human hemoglobin, Antimicrobial Agents And Chemotherapy [P], vol 53, issue 8, American Society for Microbiology, USA, pp. 3496-3500.

Zhou, L., Alker, A., Ruf, A., Wang, X., Chiu, F.C.K., Morizzi, J., Charman, S.A., Charman, W.N., Scheurer, C., Wittlin, S., Dong, Y., Hunziker, D., Vennerstrom, J., 2008, Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277, Bioorganic and Medicinal Chemistry Letters, vol 18, issue 5, Pergamon, UK, pp. 1555-1558.

Cao, G., Ali, F.E.A., Chiu, F.C.K., Zavascki, A.P., Nation, R.L., Li, J., 2008, Development and validation of a reversed-phase high-performance liquid chromatography assay for polymyxin B in human plasma, Journal of Antimicrobial Chemotherapy, vol 62, issue 5, Oxford University Press, United Kingdom, pp. 1009-1014.

Evison, B.J., Chiu, F.C.K., Pezzoni, G., Phillips, D.R., Cutts, S.M., 2008, Formaldehyde-activated pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets, Molecular Pharmacology, vol 74, issue 1, The American Society for Pharmacology and Experimental Therapeutics, USA, pp. 184-194.

Kgomotso, T., Chiu, F.C.K., Ng, K., 2008, Genistein- and daidzein 7-O-beta-D-glucuronic acid retain the ability to inhibit copper-mediated lipid oxidation of low density lipoprotein, Molecular Nutrition and Food Research, vol 52, issue 12, Wiley - V C H Verlag GmbH & Co. KGaA, Germany, pp. 1457-1466.

Creek, D.J., Charman, W.N., Chiu, F.C.K., Prankerd, R.J., Dong, Y., Vennerstrom, J., Charman, S.A., 2008, Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials, Antimicrobial Agents and Chemotherapy, vol 52, issue 4, The American Society for Microbiology, USA, pp. 1291-1296.

Le, K., Chiu, F.C.K., Ng, K.F., 2007, Identification and quantification of antioxidants in Fructus Lycii, Food Chemistry, vol 105, issue 1, Elsevier BV, Netherlands, pp. 353-363.

Creek, D.J., Charman, W.N., Chiu, F.C.K., Prankerd, R.J., McCullough, K.J., Dong, Y., Vennerstrom, J., Charman, S.A., 2007, Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials, Journal of Pharmaceutical Sciences, vol 96, issue 11, Wiley-Liss Inc, New Jersey, United States, pp. 2945-2956.

Tang, Y., Dong, Y., Wittlin, S., Charman, S.A., Chollet, J., Chiu, F.C.K., Charman, W.N., Matile, H., Urwyler, H., Dorn, A., Bajpai, S., Wang, X., Padmanilayam, M., Karle, J.M., Brun, R., Vennerstrom, J., 2007, Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides, Bioorganic & Medicinal Chemistry Letters, vol 17, issue 5, Elsevier, UK, pp. 1260-1265.

Charman, S.A., Perry, C.S., Chiu, F.C.K., McIntosh, K.A., Prankerd, R.J., Charman, W.N., 2006, Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin, Journal of Pharmaceutical Sciences, vol 95, issue 2, John Wiley & Sons Inc., USA, pp. 256-267.

Perry, C.S., Charman, S.A., Prankerd, R.J., Chiu, F.C.K., Dong, Y., Vennerstrom, J.L., Charman, W.N., 2006, Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials, Journal of Pharmaceutical Sciences, vol 95, issue 4, John Wiley & Sons, Inc., USA, pp. 737-747.

Leveque, N.L., Charman, W.N., Chiu, F.C.K., 2006, Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography-mass spectrometry, Journal of Chromatography B, vol 830, issue 2, Elsevier, The Netherlands, pp. 314-321.

Perry, C.S., Charman, S.A., Prankerd, R.J., Chiu, F.C.K., Scanlon, M.J., Chalmers, D.K., Charman, W.N., 2006, The binding interaction of synthetic ozonide antimalarials with natural and modified beta-cyclodextrins, Journal of Pharmaceutical Sciences, vol 95, issue 1, John Wiley & Sons, Inc., USA, pp. 146-158.

Creek, D.J., Chiu, F.C.K., Prankerd, R.J., Charman, S.A., Charman, W.N., 2005, Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt, Journal of Pharmaceutical Sciences, vol 94, issue 8, John Wiley & Sons, Inc., USA, pp. 1820-1829.

Dong, Y., Chollet, J., Matile, H., Charman, S.A., Chiu, F.C.K., Charman, W.N., Scorneaux, B., Urwyler, H., Santo Tomas, J., Scheurer, C., Snyder, C., Dorn, A., Wang, X., Karle, J.M., Tang, Y., Wittlin, S., Brun, R., Vennerstrom, J.L., 2005, Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes, Journal of Medicinal Chemistry, vol 48, issue 15, American Chemical Society, USA, pp. 4953-4961.

Vennerstrom, J.L., Arbe-Barnes, S., Brun, R., Charman, S.A., Chiu, F.C.K., Chollet, J., Dong, Y., Dorn, A., Hunziker, D., Matile, H., McIntosh, K.A., Padmanilayam, M., Santo Tomas, J., Scheurer, C., Scorneaux, B., Tang, Y., Urwyler, H., Wittlin, S., Charman, W.N., 2004, Identification of an antimalarial synthetic trioxolane drug development candidate, Nature, vol 430, issue 7002, Nature Publishing group, UK, pp. 900-904.

Activities

Affiliations with institutes

Centre for Drug Candidate Optimisation
Monash Institute of Pharmaceutical Sciences