Assoc Prof Michelle Leech - Researcher Profile

Biography

Michelle works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as an Associate Professor.

Qualifications

ARTHRITIS RESEARCH DEPT MEDICINE

Institution: Monash University

Year awarded: 2000

FELLOW OF RACP - PHYSICIAN TRAINING

Institution: Royal Australian College of Physicians

Year awarded: 2000

MBBS

Institution: Monash University

Year awarded: 1987

Publications

Journal Articles

Gregory, J.L., Hall, P.H., Leech, M.T., Morand, E.F., Hickey, M.J., 2009, Independent roles of macrophage migration inhibitory factor and endogenous, but not exogenous glucocorticoids in regulating leukocyte trafficking, Microcirculation [P], vol 16, issue 8, John Wiley & Sons Ltd, United Kingdom, pp. 735-748.

Taranto, E., Xue, J.R., Morand, E.F., Leech, M.T., 2009, Modulation of expression and cellular distribution of p21 by macrophage migration inhibitory factor, Journal of Inflammation [P], vol 6, issue 24, BioMed Central Ltd, United Kingdom, pp. 1-10.

Odobasic, D., Leech, M.T., Xue, J.R., Holdsworth, S.R., 2008, Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis, Immunology, vol 124, issue 4, Wiley-Blackwell Publishing Ltd, United Kingdom, pp. 503-513.

Leech, M.T., Xue, J.R., Dacumos, A., Hall, P.H., Santos, L.L., Yang, Y.H., Li, M., Kitching, A.R., Morand, E.F., 2008, The tumour suppressor gene p53 modulates the severity of antigen-induced arthritis and the systemic immune response, Clinical and Experimental Immunology, vol 152, issue 2, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 345-353.

Yang, Y.H., Toh, M., Clyne, C., Leech, M.T., Aeberli, D., Xue, J.R., Dacumos, A., Sharma, L., Morand, E.F., 2006, Annexin 1 negatively regulates IL-6 expression via effects on p38 MAPK and MAPK phosphatase-1, The Journal of Immunology, vol 177, issue 11, American Association of Immunologists, USA, pp. 8148-8153.

Aeberli, D., Yang, Y.H., Mansell, A.S., Santos, L.L., Leech, M.T., Morand, E.F., 2006, Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase-1 and p38 MAP kinase, FEBS Letters, vol 580, issue 3, Elsevier, Amsterdam The Netherlands, pp. 974-981.

Taranto, E., Leech, M.T., 2006, Expression and function of cell cylce proteins in rheumatoid arhritis synovial tissue, Histology and Histopathology, vol 21, issue 2, Histology and Histopathology, Spain, pp. 205-211.

Santos, L.L., Milenkovski, G., Hall, P.H., Leech, M.T., Sharma, L., Takeda, K., Akira, S., Kitching, A.R., Morand, E.F., 2006, IL-18 is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis, Immunology and Cell Biology, vol 84, issue 2, Blackwell Publishing, Oxford England, pp. 166-173.

Morand, E.F., Leech, M.T., Bernhagen, J., 2006, MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis, Nature Reviews Drug Discovery, vol 5, issue 5, Nature Publishing Group, London England, pp. 399-411.

Aeberli, D., Leech, M.T., Morand, E.F., 2006, Macrophage migration inhibitory factor and glucocorticoid sensitivity, Rheumatology, vol 45, issue 8, Oxford Univerisity Press, UK, pp. 937-943.

Taranto, E., Xue, J.R., Lacey, D., Hutchinson, P.E., Smith, M., Morand, E.F., Leech, M.T., 2005, Detection of the p53 regulator murine double-minute protein 2 in rheumatoid arthritis, Journal of Rheumatology, vol 32, issue 3, Journal of Rheumatology Publishing Co. Ltd., Canada, pp. 424-429.

Santos, L.L., Lacey, D., Yang, Y.H., Leech, M.T., Morand, E.F., 2004, Activation of Synovial Cell p38 MAP Kinase by Macrophage Migration Inhibitory Factor, The Journal of Rheumatology, vol 31, issue 6, Journal of Rheumatology Publishing Co, Canada, pp. 1038-1043.

Toh, M., Yang, Y.H., Leech, M.T., Santos, L.L., Morand, E.F., 2004, Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of mitogen-activated protein kinases, in rheumatoid arthritis: up-regulation by interleukin-1beta and glucocorticoids, Arthritis & Rheumatism, vol 50, issue 10, Wiley-Liss, United States, pp. 3118-3128.

Foote, A.M., Briganti, E.M., Kipen, Y., Santos, L.L., Leech, M.T., Morand, E.F., 2004, Macrophage migration inhibitory factor in systemic lupus erythematosus, Journal of Rheumatology, vol 23, issue 2, Journal of Rheumatology Publishing Co., Canada, pp. 268-273.

Gregory, J., Leech, M.T., David, J.R., Yang, Y.H., Dacumos, A., Hickey, M.J., 2004, Reduced Leukocyte-Endothelial Cell Interactions in the Inflamed Microcirculation of Macrophage Migration Inhibitory Factor-Deficient Mice, Arthritis & Rheumatism, vol 50, issue 9, Wiley-Liss, USA, pp. 3023-3034.

Lacey, D., Sampey, A.V., Mitchell, R.A., Bucala, R., Santos, L.L., Leech, M.T., Morand, E.F., 2003, Control of fibroblast-like synoviocyte proliferation by macrophage migration inhibitory factor, Arthritis & Rheumatism, vol 48, issue 1, John Wile & Sons, Inc., New York USA, pp. 103-109.

Hoi, A.Y., Morand, E.F., Leech, M.T., 2003, Is macrophage migration inhibitory factor a therapeutic target in systemic lupus erythematosus?, Immunology and Cell Biology, vol 81, issue 5, Blackwell Publishing Asia, Carlton Vic Australia, pp. 367-373.

Morand, E.F., Bucala, R., Leech, M.T., 2003, Macrophage migration inhibitory factor. An emerging therapeutic target in rheumatoid arthritis, Arthritis & Rheumatism, vol 48, issue 2, John Wiley & Sons, Inc., New York USA, pp. 291-299.

Leech, M.T., Lacey, D., Xue, J.R., Santos, L.L., Hutchinson, P., Wolvetang, E.J., David, J.R., Bucala, R.M., Morand, E.F., 2003, Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis, Arthritis & Rheumatism, vol 48, issue 7, John Wiley & Sons, Inc., New York USA, pp. 1881-1889.

Morand, E.F., Leech, M.T., Iskander, M.N., 2003, Therapeutic opportunities for antagonism of macrophage migration inhibitory factor, Expert Opinion on Therapeutic Patients, vol 13, issue 8, Ashley Publications Ltd, UK, pp. 1189-1212.

Morand, E.F., Leech, M., Weedon, H., Metz, C.N., Bucala, R., Smith, M.D., 2002, Macrophage migration inhibitory factor in rheymatoid arthritis: clinical correlations, Rheumatology, vol 41, issue 5, Oxford University Press, Oxford UK, pp. 558-562.

Morand, E., Leech, M., 2001, Hypothalamic-pituitary-adrenal axis regulation of inflammation in rheumatoid arthritis, Immunology and Cell Biology, vol 79, Blackwell Science Asia, Carlton Vic Australia, pp. 395-399.

Leech, M., Huang, X.R., Morand, E.F., Holdsworth, S.R., 2000, Endogenous glucocorticoids modulate experimental anti-glomerular basement membrane glomerulonephritis, Clinical and Experimental Immunology, vol 119, Blackwell Science Ltd, Oxford England, pp. 161-168.

Leech, M., Littlejohn, G.O., 2000, Inflammatory arthritis and fibromyalgia rationate for early intervention, Current Therapeutics, vol 41 issue 2, Adis Press Australasia, Balgewlah Australia, pp. 16-21.

Leech, M., Metz, C.N., Bucala, R., Morand, E.F., 2000, Regulation of Macrophage Migration Inhibitory Factor by Endogenous Glucocorticoids in Rat Adjuvant-Induced Arthritis, Arthritis and Rheumatism, vol 43 issue 4, Lippincott Williams & Wilkins, Philadelphia PA USA, pp. 827-833.

Morand, E.F., Leech, M., 1999, Glucocorticoid regulation of inflammation: The plot thickens, Inflammation Research, vol 48, Birkhauser Verlag AG, Basel Switzerland, pp. 557-560.

Leech, M., Metz, C.N., Hall, P., Hutchinson, P., Gianis, K., Smith, M., Weedon, H., Holdsworth, S.R., Bucala, R., Morand, E.F., 1999, Macrophage Migration Inhibitory Factor In Rheumatoid Arthritis - Evidence of Proinflammatory Function and Regulation by Glucocorticoids, Arthritis and Rheumatism, vol 42(8), Lippincott Williams & Wilkins, Philadelphia PA USA, pp. 1601-1608.

Leech, M., Hutchinson, P., Holdsworth, S.R., Morand, E.F., 1998, Endogenous glucocorticoids modulate neutrophil migration and synovial P-selectin but not neutrophil phagocytic or oxidative function in experimental arthritis, Clinical and Experimental Immunology, vol 112 no 3, Blackwell Science Ltd, PO Box 88 Oxford OX2 ONE UK, pp. 383-388.

Leech, M., Metz, C.N., Santos, L., Peng, T., Holdsworth, S.R., Bucala, R., Morand, E.F., 1998, Involvement of Macrophage Migration Inhibitory Factor In The Evolution of Rat Adjuvant Arthritis, Arthritis and Rheumatism, vol 41 no 5, American College of Rheumatology, Philadelphia USA, pp. 910-917.

Yang, Y., Leech, M., Hutchinson, P., Holdsworth, S.R., Morand, E.F., 1997, Antiinflammatory effect of lipocortin 1 in experimental arthritis, Inflammation, vol 21, Plenum Publishing Corporation, 232 Spring St New York NY USA, pp. 583-596.

Yang, Y., Hutchinson, P., Leech, M., Morand, E.F., 1997, Exacerbation of Adjuvant Arthritis by Adrenalectomy Is Associated with Reduced Leukocyte Lipcortin 1, The Journal of Rheumatology, vol 24, The Journal of Rheumatology Publishing Co Ltd, Toronto Canada, pp. 1758-1764.

Conference Proceedings

Yang, Y.H., Aeberli, D., Leech, M.T., Dacumos - Hill, A., Xue, J.R., Morand, E.F., 2009, Annexin-1 regulates inflammatory response via glucocorticoid-induced genes, Symposium 7: Cancer: From genes to therapy, April 24-27, The Australia Chinese Association for Biomedical Sciences Inc., Australia, p. 200.

Leech, M., Metz, C.N., Smith, M., Bucala, R., Morand, E.F., 1998, First Description of Macrophage Migration Inhibitory Factor in RA, American College of Rheumatology/Association of Rheumatology Health Professionals, San Diego USA Nov 8-12, American College of Rheumatology, Atlanta USA, p. s97.

Other

Morand, E.F., Leech, M.T., 2005, Macrophage migration inhibitory factor in rheumatoid arthritis, Frontiers in Biosciences, vol 10, Frontiers in Biosciences Inc, United States, pp. 12-22.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Citrullination in rheumatic diseases.

Supervisors:

Leech, M (Main), Morand, E (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

GILZ as an Immunomodulator in a mouse model of Rheumatoid Arthritis.

Supervisors:

Morand, E (Main), Leech, M (Associate).

Completed Supervision

Student:

Taranto, E.

Program of Study:

Macrophage migration inhibitory factor effects on cell cycle proteins in rheumatoid arthritis. (PHD) 2010.

Supervisors:

Morand, E (Main), Leech, M (Associate).

Student:

Toh, M.

Program of Study:

Regulation of signal transduction factors by the glucocorticoid-induced molecules MIF and MKP-1 in rheumatoid arthritis. (PHD) 2006.

Supervisors:

Morand, E (Main), Leech, M (Associate).