Dr Margie Zakhem - Researcher Profile

Biography

Margie works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

PHD IN SCIENCE

Institution: Monash University

Year awarded: 1999

BACHELOR OF SCIENCE (HONS)

Institution: Monash University

Year awarded: 1994

Publications

Journal Articles

Ratnayake, U., Quinn, T.A., Zakhem, M.E., Dickinson, H., Walker, D.W., 2012, Behaviour and hippocampus-specific changes in spiny mouse neonates after treatment of the mother with the viral-mimetic Poly I:C at mid-pregnancy, Brain Behavior And Immunity [P], vol 26, issue 8, Academic Press, Untied States, pp. 1288-1299.

Fleiss, B., Parkington, H.C., Coleman, H.A., Dickinson, H., Yawno, T., Zakhem, M., Hirst, J.J., Walker, D.W., 2012, Effect of maternal administration of allopregnanolone before birth asphyxia on neonatal hippocampal function in the spiny mouse, Brain Research [P], vol 1433, Elsevier BV, The Netherlands, pp. 9-19.

Baburamani, A.A., Lo, C.Y., Zakhem, M.E., Walker, D.W., 2012, Morphological evaluation of the cerebral blood vessels in the late gestation fetal sheep following hypoxia in utero, Microvascular Research [P], vol 85, issue 1, Academic Press, United States, pp. 1-9.

Ireland, Z., Zakhem, M., Dickinson, H., Snow, R., Walker, D., 2011, A maternal diet supplemented with creatine from mid-pregnancy protects the newborn spiny mouse brain from birth hypoxia, Neuroscience [P], vol 194, Pergamon, United Kingdom, pp. 372-379.

Fleiss, B., Coleman, H., Zakhem, M.E., Ireland, Z., Walker, D., Parkington, H., 2011, Effects of birth asphyxia on neonatal hippocampal structure and function in the spiny mouse, International Journal of Developmental Neuroscience [P], vol 29, issue 7, Pergamon, UK, pp. 757-766.

Zarruk, J., Garcia-Yebenes, I., Romera, V., Ballesteros, I., Moraga, A., Cuartero, M., Hurtado, O., Sobrado, M., Pradillo, J., Fernandez-Lopez, D., Serena, J., Zakhem, M., Moro, M., Lizasoain, I., 2011, Neurological tests for functional outcome assessment in rodent models of ischaemic stroke, Revista de Neurologia [P], vol 53, issue 10, Viguera Editores, Spain, pp. 607-618.

Rodricks, C.L., Gibbs, M.E., Castillo-Melendez, M., Miller, S.L., 2010, The effect of hypoxia on the functional and structural development of the chick brain, International Journal of Developmental Neuroscienc..., vol 28, issue 4, Pergamon, UK, Canada, pp. 343-350.

Yawno, T., Hirst, J.J., Zakhem, M.E., Walker, D.W., 2009, Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain, Neuroscience [P], vol 163, issue 3, Pergamon, UK, pp. 838-847.

Hutton, L.C., Castillo-Melendez, M., Smythe, G.A., Walker, D.W., 2008, Microglial activation, macrophage infiltration, and evidence of cell death in the fetal brain after uteroplacental administration of lipopolysaccharide in sheep in late gestation, American Journal of Obstetrics and Gynecologyy, vol 198, issue 1, Mosby, Inc., United States, pp. 117.e1-117.e11.

Dickinson, H., Walker, D.W., Zakhem, M.E., 2008, Onset of feeding at birth-Perinatal development of the hypothalamic mechanisms that induce appetite and feeding in the newborn, Neuroscience Letters, vol 436, issue 1, Elsevier Ireland Ltd, Ireland, pp. 1-6.

Hutton, L.C., Yan, E.B., Yawno, T., Castillo-Melendez, M., Hirst, J.J., Walker, D.W., 2007, Injury of the developing cerebellum: A brief review of the effects of endotoxin and asphyxial challenges in the late gestation sheep fetus, Cerebellum, vol E-Pub, Taylor & Francis Ltd, Abingdon, England, UK, pp. 1-10.

Miller, S.L., Chai, M., Loose, J.M., Castillo-Melendez, M., Walker, D.W., Jenkin, G., Wallace, E.M., 2007, The effects of maternal betamethasone administration on the intrauterine growth-restricted fetus, Endocrinology, vol 148, issue 3, The Endocrine Society, Chevy Chase USA, pp. 1288-1295.

Hutton, L.C., Castillo-Melendez, M., Walker, D.W., 2007, Uteroplacental inflammation results in blood brain barrier breakdown, increased activated caspase 3 and lipid peroxidation in the late gestation ovine fetal cerebellum, Developmental Neuroscience, vol 29, issue 4-5, Karger, Basel, Switzerland, pp. 341-354.

Castillo-Melendez, M.E., Yan, E.B., Walker, D.W., 2005, Expression of erythropoietin and its receptor in the brain of late-gestation fetal sheep, and responses to asphyxia caused by umbilical cord occlusion, Developmental Neuroscience, vol 27, issue 2-4, S Karger AG, Switzerland, pp. 220-227.

Miller, S.L., Yan, E.B., Castillo-Melendez, M.E., Jenkin, G., Walker, D.W., 2005, Melatonin provides neuroprotection in the late-gestation fetal sheep brain in response to umbilical cord occlusion, Developmental Neuroscience, vol 27, issue 2-4, S Karger AG, Switzerland, pp. 200-210.

Yan, E.B., Unthank, J.K., Castillo-Melendez, M.E., Miller, S.L., Langford, S.J., Walker, D.W., 2005, Novel method for in vivo hydroxyl radical measurement by microdialysis in fetal sheep brain in utero, Journal of Applied Physiology, vol 98, issue 6, American Physiological Society, USA, pp. 2304-2310.

Yan, E., Zakhem, M., Smythe, G., Walker, D., 2005, Quinolinic acid promotes albumin deposition in Purkinje cell, astrocytic activation and lipid peroxidation in fetal brain, Neuroscience [P], vol 134, issue 3, Pergamon, United Kingdom, pp. 867-875.

Yan, E.B., Castillo-Melendez, M.E., Nicholls, T.A., Hirst, J.J., Walker, D.W., 2004, Cerebrovascular responses in the fetal sheep brain to low-dose endotoxin, Pediatric Research, vol 55, issue 5, International Pediatric Research Foundation, Inc., Baltimore USA, pp. 855-863.

Nguyen, P., Yan, E.B., Castillo-Melendez, M.E., Walker, D.W., Hirst, J.J., 2004, Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion, Journal of Physiology, vol 560, issue 2, Blackwell Publishing Ltd, Oxford UK, pp. 593-602.

Castillo-Melendez, M.E., Chow, J.M., Walker, D.W., 2004, Lipid peroxidation, caspase-3 immunoreactivity, and pyknosis in late-gestation fetal sheep brain after umbilical cord occlusion, Pediatric Research, vol 55, issue 5, International Pediatric Research Foundation, Inc., USA, pp. 864-871.

Calloway, J.K., Castillo-Melendez, M.E., Giardina, S.F., Krstew, E.V., Beart, P.M., Jarrott, B., 2004, Sodium channel blocking activity of AM-36 and sipatrigine (BW619C89): in vitro and in vivo evidence, Neuropharmacology, vol 47, issue 1, Permagon-Elsevier Science Ltd, Oxford UK, pp. 146-155.

Castillo-Melendez, M.E., McKinley, M.J., Summers, R.J., 2000, Intracerebroventicular administration of the beta3-adrenoceptor agonist CL 316243 causes Fos immunoreactivity in discrete regions of rat hypothalamusi, Neuroscience Letters, vol 290, Elsevier, Shannon Ireland, pp. 161-164.

Lawrence, A.J., Castillo-Melendez, M.E., McLean, K.J., Jarrott, B., 1998, The distribution of nitric oxide synthase- adenosine deaminase- and neuropeptide Y-immunoreactivity through the entire rat nucleus tractus solitarius. Effect of unilateral nodose ganglionectomy, Journal of Chemical Neuroanatomy, vol 15, Elsevier, Amsterdam Netherlands, pp. 27-40.

Conference Proceedings

Castillo-Melendez, M.E., Summers, R.J., 1999, Regulation of immediate early gene expression by the beta3-adrenoceptor agonist CL316243 in rat brain, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Sydney, NSW, Dec 1999, ASCEPT, Sydney NSW Australia, pp. 118-Post 1-92.

Callaway, J.K., Knight, M., Castillo-Melendez, M.E., Watkins, D., Beart, P.M., Jarrott, B., 1998, Am36, a novel neuroprotective agent, reduces neuronal damage in a middle cerebral artery occlusion model of stroke in conscious rats, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart, TAS, December 1998, ASCEPT, Sydney NSW Australia, p. 43.

Castillo-Melendez, M.E., Jarrott, B., Lawrence, A.J., 1997, Autoradiographic visualisation of adenosine A1 receptors in the brain stem of normotensive and hypertensive rats, Society for Neuroscience Abstracts, October 25-30, 1997, Society for Neuroscience, Washington, p. 1783.

Other

Castillo-Melendez, M.E., 1999, Biochemical characterisation of purinergic systems in the brain stem and nodose ganglia in relation to hypertension.

Postgraduate Research Supervisions

Completed Supervision

Student:

Baburamani, A.

Program of Study:

An investigation into the effect of in utero hypoxia on cerebral blood vessels and brain activity in late gestation fetal sheep. (PHD) 2011.

Supervisors:

Walker, D (Main), Zakhem, M (Associate).