Miss Meagan Mcgrath - Researcher Profile

Biography

Meagan works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 2005

Publications

Journal Articles

Friedrich, F.W., Wilding, B.R., Reischmann, S., Crocini, C., Lang, P., Charron, P., Muller, O.J., McGrath, M.J., Vollert, I., Hansen, A., Linke, W.A., Hengstenberg, C., Bonne, G., Morner, S., Wichter, T., Madeira, H., Arbustini, E., Eschenhagen, T., Mitchell, C.A., Isnard, R., Carrier, L., 2012, Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy, Human Molecular Genetics [P], vol 21, issue 14, Oxford University Press, UK, pp. 3237-3254.

Cowling, B., Cottle, D.L., Wilding, B., D'Arcy, C.E., Mitchell, C.A., Mcgrath, M.J., 2011, Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: A comprehensive review of the clinical, histological and pathological features, Neuromuscular Disorders [P], vol 21, issue 4, Elsevier Ltd, UK, pp. 237-251.

Cottle, D.L., McGrath, M.J., Wilding, B.R., Cowling, B.S., Kane, J.m., D'Arcy, C.E., Holdsworth, M., Hatzinisiriou, I., Prescott, M., Brown, S., Mitchell, C.A., 2009, SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis, Journal Of Biological Chemistry [P], vol 284, issue 39, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 26964-26977.

Yang, Z., Browning, C.F., Hallaq, H., Yermalitskaya, L., Esker, J., Hall, M.R., Link, A.J., Ham, A.L., Mcgrath, M.J., Mitchell, C.A., Murray, K.T., 2008, Four and a half LIM protein 1: A partner for KCNA5 in human atrium, Cardiovascular Research, vol 78, issue 3, Oxford University Press, United Kingdom, pp. 449-457.

Cowling, B.S., Mcgrath, M.J., Nguyen, M., Cottle, D., Kee, A.J., Brown, S., Schessl, J., Zou, Y., Joya, J., Bonnemann, C.G., Hardeman, E.C., Mitchell, C.A., 2008, Identifi cation of FHL1 as a regulator of skeletal muscle mass: Implications for human myopathy, The Journal of Cell Biology, vol 183, issue 6, Rockefeller University Press, USA, pp. 1033-1048.

Schessl, J., Zou, Y., Mcgrath, M.J., Cowling, B.S., Maiti, B., Chin, S.S., Sewry, C., Battini, R., Hu, Y., Cottle, D., Rosenblatt, M., Spruce, L., Ganguly, A., Kirschner, J., Judkins, A.R., Golden, J.A., Goebel, H., Muntoni, F., Flanigan, K.M., Mitchell, C.A., Bonnemann, C.G., 2008, Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy, Journal of Clinical Investigation, vol 118, issue 3, American Society for Clinical Investigation, United States, pp. 904-912.

Cottle, D., Mcgrath, M.J., Cowling, B.S., Coghill, I.D., Brown, S., Mitchell, C.A., 2007, FHL3 binds MyoD and negatively regulates myotube formation, Journal of Cell Science, vol 120, issue Pt 8, Company of Biologists Ltd, Cambridge England UK, pp. 1423-1435.

Mcgrath, M.J., Cottle, D.L., Nguyen, M., Dyson, J.M., Coghill, I.D., Robinson, P.A., Holdsworth, M., Hardeman, E.C., Mitchell, C.A., Brown, S., Cowling, B.S., 2006, Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly, The Journal of Biological Chemistry, vol 281, issue 11, The American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 7666-7683.

Coghill, I.D., Brown, S., Cottle, D.L., Mcgrath, M.J., Robinson, P.A., Nandurkar, H.H., Dyson, J.M., Mitchell, C.A., 2003, FHL3 is an actin-binding protein that regulates -actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly, Journal of Biological Chemistry, vol 278, issue 26, American Society for Biochemistry and Molecular BIology Inc., Bethesda USA, pp. 24139-24152.

Gurung, R., Tan, A., Ooms, L.M., Mcgrath, M.J., Huysmans, R.D., Munday, A.D., Prescott, M., Whisstock, J.C., Mitchell, C.A., 2003, Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization: the inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following, Journal of Biological Chemistry, vol 278, issue 13, American Society for Biochemistry and Molecular Biology Inc., Bethesda USA, pp. 11376-11385.

Mcgrath, M.J., Mitchell, C.A., Coghill, I.D., Robinson, P.A., Brown, S., 2003, Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces 51 integrin-dependent myocyte elongation, American Journal of Physiology-Cell Physiology, vol 285, issue 6, American Physiological Society, Bethesda USA, pp. 1513-1526.

Robinson, P.A., Brown, S., Mcgrath, M.J., Coghill, I.D., Gurung, R., Mitchell, C.A., 2002, Skeletal muscle LIM protein 1 regulates intergrin-mediated myoblast adhesion, spreading and migration, American Journal of Physiology - Cell Physiology, vol 284, issue 3, American Physiological Society, Bethesda MD USA, pp. C681-C695.

Brown, S., Coghill, I.D., Mcgrath, M.J., Robinson, P.A., 2001, Role of LIM domains in mediating signaling protein interactions, IUBMB Life, vol 51, Taylor and Francis Group, Philadelphia USA, pp. 359-364.

Brown, S., Mcgrath, M.J., Ooms, L.M., Gurung, R., Maimone, M.M., Mitchell, C.A., 1999, Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1, Journal of Biological Chemistry, vol 274, no 38, American Soc. for Biochem. and Mol. Biol. Inc., www.jbc.org, pp. 27083-27091.

Brown, S., Biben, C., Ooms, L.M., Maimone, M.M., Mcgrath, M.J., Gurung, R., Harvey, R.P., Mitchell, C.A., 1999, The cardiac expression of striated muscle LIM protein 1 (SLIM1) is restricted to the outflow tract of the developing heart, Journal of molecular and cellular cardiology, vol 31, Academic Press Ltd., London England, pp. 837-843.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Molecular mechanisms in the pathogenesis of fhl1 myopathies.

Supervisors:

Mitchell, C (Main), Mcgrath, M (Associate).