Dr Galina Polekhina - Researcher Profile

Biography

Galina works in the Centre for Cancer Research at Monash Institute of Medical Research as a Senior Research Fellow.

Qualifications

GRADUATE DIPLOMA IN SOFTWARE DEVELOPMENT

Institution: Royal Melbourne Institute of Technology / Melbourne

Year awarded: 2005

PH.D. DEGREE IN SCIENCE

Institution: University of Aarhus / Denmark

Year awarded: 1996

APPLIED MATHEMATICS

Institution: Moscow State University / Russia

Year awarded: 1989

Publications

Book Chapters

Feil, S., Polekhina, G., Gorman, M., Parker, M., 2010, Introduction, in Proteins: Membrane Binding and Pore Formation, eds Gregor Anderluh & Jeremy Lakey, Springer Science+Business Media, New York, United States, pp. 1-13.

Polekhina, G., Feil, S., Tang, J., Rossjohn, J., Giddings, K., Tweten, R., Parker, M., 2006, Comparative three-dimensional structure of cholesterol-dependent cytolysins, in The comprehensive sourcebook of Bacterial Protein Toxins, eds Joseph E. Alouf & Michel R. Popoff, Academic Press, United States, pp. 659-670.

Feil, S., Polekhina, G., Tang, J., Parker, M., 2006, Membrane insertion of pore-forming protein toxins, in Recent Research developments in toxins from bacteria and other organisms, eds Daniel Gillet & Ludger Johannes, Research Signpost, India, pp. 149-181.

Journal Articles

Ascher, D.B., Polekhina, G., Parker, M.W., 2012, Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 68, issue 4, Wiley-Blackwell Publishing, Inc., United States, pp. 468-471.

Polekhina, G., Ascher, D., Kok, S., Waltham, M., 2011, Crystallization and preliminary X-ray analysis of the N-terminal domain of human thioredoxin-interacting protein, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 67, issue Pt 5, Wiley-Blackwell Publishing, Inc., United States, pp. 613-617.

Wickham, S., Hotze, E., Farrand, A., Polekhina, G., Nero, T., Tomlinson, S., Parker, M., Tweten, R., 2011, Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9, Journal Of Biological Chemistry [P], vol 286, issue 23, American Society for biochemistry and Molecular Biology Inc., United States, pp. 20952-20962.

McKinstry, W.J., Polekhina, G., Diefenbach-Jagger, H., Sato, K., Onuma, E., Gillespie, M.T., Martin, T.J., Parker, M.W., 2009, Crystallization of the receptor-binding domain of parathyroid hormone-related protein in complex with a neutralizing monoclonal antibody Fab fragment, Acta Crystallographica Section F: Structural Biology..., vol 65, issue Pt 4, Wiley-Blackwell Publishing, Inc., USA, UK, pp. 336-338.

McKinstry, W.J., Polekhina, G., Diefenbach-Jagger, H., Ho, P.W., Sato, K., Onuma, E., Gillespie, M.T., Martin, T.J., Parker, M.W., 2009, Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor, Journal Of Biological Chemistry [P], vol 284, issue 23, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 15557-15563.

Rossjohn, J., Polekhina, G., Feil, S.C., Morton, C.J., Tweten, R.K., Parker, M.W., 2007, Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins, Journal of Molecular Biology, vol 367, issue 5, Academic Press Ltd Elsevier Science Ltd, London England UK, pp. 1227-1236.

House, C.M., Hancock, N.C., Moller, A., Cromer, B.A., Fedorov, V., Bowtell, D.D., Parker, M.W., Polekhina, G., 2006, Elucidation of the substrate binding site of Siah ubiquitin ligase, Structure [P], vol 14, issue 4, Cell Press, United States, pp. 695-701.

Kong, G.K., Galatis, D., Barnham, K.J., Polekhina, G., Adams, J.J., Masters, C.L., Cappai, R., Parker, M.W., McKinstry, W.J., 2005, Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 61, issue 1, Wiley-Blackwell Publishing Inc, United States, pp. 93-95.

Polekhina, G., Feil, S.C., Gupta, A., O'Donnell, P., Stapleton, D., Parker, M.W., 2005, Crystallization of the glycogen-binding domain of the AMP-activated protein kinase beta subunit and preliminary X-ray analysis, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 61, issue 1, Wiley-Blackwell Publishing Inc, United States, pp. 39-42.

Polekhina, G., Giddings, K.S., Tweten, R.K., Parker, M.W., 2005, Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 102, issue 3, Natl Acad Sciences, United States, pp. 600-605.

Polekhina, G., Gupta, A., van Denderen, B.J., Feil, S.C., Kemp, B.E., Stapleton, D., Parker, M.W., 2005, Structural basis for glycogen recognition by AMP-activated protein kinase, Structure [P], vol 13, issue 10, Cell Press, United States, pp. 1453-1462.

Polekhina, G., Giddings, K.S., Tweten, R.K., Parker, M.W., 2004, Crystallization and preliminary X-ray analysis of the human-specific toxin intermedilysin, Acta Crystallographica Section D-Biological Crystallography [P], vol 60, issue Pt 2, Wiley-Blackwell Pblishing Inc., United States, pp. 347-349.

Austin, C.J., Mizdrak, J., Matin, A., Sirijovski, N., Kosim-Satyaputra, P., Willows, R.D., Roberts, T.H., Truscott, R.J., Polekhina, G., Parker, M.W., Jamie, J.F., 2004, Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase, Protein Expression And Purification [P], vol 37, issue 2, Academic Press Inc Elsevier Science, United States, pp. 392-398.

Polekhina, G., Gupta, A., Michell, B., van Denderen, B.J., Murthy, S., Feil, S.C., Jennings, I.G., Campbell, D.J., Witters, L.A., Parker, M.W., Kemp, B.E., Stapleton, D.I., 2003, AMPK beta subunit targets metabolic stress sensing to glycogen, Current Biology [P], vol 13, issue 10, Cell Press, United States, pp. 867-871.

Kong, G.K., Polekhina, G., McKinstry, W.J., Parker, M.W., Dragani, B., Aceto, A., Paludi, D., Principe, D.R., Mannervik, B., Stenberg, G., 2003, Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase p1-1, Journal Of Biological Chemistry [P], vol 278, issue 2, American Society of Biochemistry & Molecular Biology Inc, United States, pp. 1291-1302.

Micaloni, C., Kong, G.K., Mazzetti, A.P., Nuccetelli, M., Antonini, G., Stella, L., McKinstry, W.J., Polekhina, G., Rossjohn, J., Federici, G., Ricci, G., Parker, M.W., Lo Bello, M., 2003, Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences, Journal of Molecular Biology [P], vol 325, issue 1, Academic Press Ltd Elsevier Science Ltd, London, England, pp. 111-122.

Farrow, K.A., Lyras, D., Polekhina, G., Koutsis, K., Parker, M.W., Rood, J.I., 2002, Identification of Essential Residues in the Erm(B) rRNA Methyltransferase of Clostridium perfringens, Antimicrobial Agents and Chemotherapy, vol 46, issue 5, American Society for Microbiology, Washington DC USA, pp. 1253-1261.

Conference Proceedings

Parker, M.W., Rossjohn, J., Oakley, A.J., Polekhina, G., McKinstry, W.J., Feil, S.C., Lo Bello, M., Di Ilio, C., Spithill, T.W., Board, P.G., 1998, Evolution of functional diversity - structural studies of an enzyme superfamily, Proceedings of the Australian Society for Biochemistry and Molecular Biology, Adelaide 28 September - 1 October 1998, Aust Soc for Biochemistry & Molecular Biology, Kent Town SA, pp. S-22-03-s-22-03.