Dr Isabelle Lucet - Researcher Profile

Biography

Isabelle works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Senior Research Fellow.

Qualifications

PHD (DEPARTMENT OF MEDICINE)

Institution: University of Angers, France

Year awarded: 1994

BACHELOR OF SCIENCE (HONS)

Institution: University of Nantes, France

Year awarded: 1990

MASTER OF SCIENCES IN BIOCHEMISTRY AND BIOLOGY

Institution: University of Bordeauxx, France

Year awarded: 1989

Publications

Book Chapters

Lucet, I.S., Bamert, R.S., 2013, Production and crystallization of recombinant JAK proteins, in JAK-STAT Signalling [Methods in Molecular Biology V967], eds S.E. Nicholson and N.A. Nicola, Humana Press, USA, pp. 275-300.

Wilks, A.F., Lucet, I.S., 2012, Drug discovery and non-human kinomes, in Kinase Drug Discovery, eds R.A. Ward & F. Goldberg, Royal Society of Chemistry, UK, pp. 262-285.

Journal Articles

Kershaw, N.J., Murphy, J.M., Liau, N.P.D., Varghese, L.N., Laktyushin, A., Whitlock, E.L., Lucet, I., Nicola, N.A., Babon, J., 2013, SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition, Nature Structural and Molecular Biology [E], vol E-pub, Nature Publishing Group, USA, pp. 1-10.

Lucet, I.S., Tobin, A., Drewry, D., Wilks, A.F., Doerig, C.D., 2012, Plasmodium kinases as targets for new-generation antimalarials, Future Medicinal Chemistry [P], vol 4, issue 18, Future Science Ltd, UK, pp. 2295-2310.

Babon, J.J., Kershaw, N.J., Murphy, J.M., Varghese, L.N., Laktyushin, A., Young, S.N., Lucet, I.S., Norton, R.S., Nicola, N.A., 2012, Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity, Immunity [P], vol 36, issue 2, Cell Press, USA, pp. 239-250.

Williams, N.K., Lucet, I., Klinken, S.P., Ingley, E., Rossjohn, J., 2009, Crystal structures of the Lyn protein tyrosine kinase domain in Its apo- and inhibitor-bound state, Journal of Biological Chemistry, vol 284, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 284-291.

Pellicci, D.G., Patel, O., Kjer-Nielsen, L., Pang, S.S., Sullivan, L.C., Kyparissoudis, K., Brooks, A.G., Reid, H.H., Gras, S., Lucet, I.S., Koh, R., Smyth, M.J., Mallevaey, T., Matsuda, J.L., Gapin, L., McCluskey, J., Godfrey, D.I., Rossjohn, J., 2009, Differential Recognition of CD1d-alpha-Galactosyl Ceramide by the Vbeta8.2 and Vbeta7 Semi-invariant NKT T Cell Receptors, Immunity [P], vol 31, issue 1, Cell Press, USA, pp. 47-59.

Williams, N.K., Bamert, R.S., Patel, O., Wang, C., Walden, P.M., Wilks, A.F., Fantino, E., Rossjohn, J., Lucet, I.S., 2009, Dissecting Specificity in the Janus Kinases: The Structures of JAK-Specific Inhibitors Complexed to the JAK1 and JAK2 Protein Tyrosine Kinase Domains, Journal of Molecular Biology, vol 387, issue 1, Academic Press, USA, pp. 219-232.

Walter, M., Lucet, I., Patel, O., Broughton, S.E., Bamert, R.S., Williams, N.K., Fantino, E., Wilks, A.F., Rossjohn, J., 2007, The 2.7 Angstrom crystal structure of the autoinhibited human c-Fms kinase domain, Journal of Molecular Biology, vol 367, issue 3, Academic Press Ltd Elsevier Science Ltd, London England UK, pp. 839-847.

Marland, Z., Beddoe, T.C., Zaker-Tabrizi, L., Lucet, I., Brammananth, R., Whisstock, J.C., Wilce, M.C.J., Coppel, R.L., Crellin, P.K., Rossjohn, J., 2006, Hijacking of a substrate-binding protein scaffold for use in mycobacterial cell wall biosynthesis, Journal of Molecular Biology, vol 359, issue 4, Academic Press Ltd Elsevier Science Ltd, London UK, pp. 983-997.

Lucet, I.S., Fantino, E., Styles, M., Bamert, R.S., Patel, O.G., Broughton, S.E., Walter, M., Burns, C.J., Treutlein, H., Wilks, A.F., Rossjohn, J., 2006, The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor, Blood, vol 107, issue 20 September 2005, American Society of Hematology, Washington DC USA, pp. 176-183.

Adams, V.M., Lucet, I., Tynan, F.E., Chiarezza, M., Howarth, P., Kim, J., Rossjohn, J., Lyras, D., Rood, J.I., 2006, Two distinct regions of the large serine recombinase TnpX are required for DNA binding and biological function, Molecular Microbiology, vol 60, issue 3, Blackwell Publishing, UK, pp. 591-601.

Lucet, I.S., Tynan, F.E., Adams, V.M., Rossjohn, J., Lyras, D., Rood, J.I., 2005, Identification of the structural and functional domains of the large serine recombinase TnpX from Clostridium perfringens, The Journal of Biological Chemistry, vol 280, issue 4, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 2503-2511.

Adams, V.M., Lucet, I.S., Lyras, D., Rood, J.I., 2004, DNA binding properties of TnpX indicate that different synapses are formed in the excision and integration of the Tn4451 family, Molecular Microbiology, vol 53, issue 4, Blackwell Publishing Ltd, Oxford UK, pp. 1195-1207.

Lyras, D., Adams, V.M., Lucet, I., Rood, J.I., 2004, The large resolvase TnpX is the only transposon-encoded protein required for transposition of the Tn4451/3 family of integrative mobilizable elements, Molecular Microbiology, vol 51, issue 6, Blackwell Publishing Ltd, Oxford UK, pp. 1787-1800.

McGowan, S., Lucet, I.S., Cheung, J.K., Awad, M.M., Whisstock, J.C., Rood, J.I., 2002, The FxRxHrS motif: a conserved region essential for DNA binding of the VirR response regulator from Clostridium perfringens, Journal of Molecular Biology, vol 322, issue 5, Academic Press Ltd Elsevier Science Ltd, London England, pp. 997-1011.

Feucht, A., Lucet, I.S., Yudkin, M.D., Errington, J., 2001, Cytological and biochemical characterization of the FtsA cell division protein of Bacillus subtilis, Molecular Microbiology, vol 40, issue 1, Blackwell Publishing, Oxford England, pp. 115-125.

Lucet, I.S., Feucht, A., Yudkin, M.D., Errington, J., 2000, Direct interaction between the cell division protein FtsZ and the cell differentiation protein SpollE, The EMBO Journal, vol 19, issue 7, Nature Publishing Group, New York USA, pp. 1467-1475.