Dr Yuan Yang - Researcher Profile

Biography

Yuan works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Keywords

Animal Model, Annexin, Arthritis, Immunology, Molecular Biology

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 1999

MEDICINE

Institution: Harbin Medical University, Harbin, China

Year awarded: 1988

MEDICINE

Institution: Harbin Medical University, Harbin, China

Year awarded: 1982

Publications

Journal Articles

Yang, Y.H., Song, W., Deane, J.A., Kao, W., Ooi, J., Ngo, D., Kitching, A.R., Morand, E.F., Hickey, M.J., 2013, Deficiency of annexin A1 in CD4+ T cells exacerbates T cell-dependent inflammation, Journal Of Immunology [P], vol 90, issue 3, American Association of Immunologists, United States, pp. 997-1007.

Yuan, J., Morand, E.F., Song, W., Cheng, Q., Stewart, A., Yang, Y.H., 2013, Regulation of lung fibroblast activation by annexin A1, Journal Of Cellular Physiology [P], vol 228, issue 2, John Wiley & Sons, Inc., United States, pp. 476-484.

Gantier, M.P.M., Stunden, H.J., McCoy, C., Behlke, M.A., Wang, D., Liaskos, M., Sarvestani, S., Yang, Y.H., Xu, D., Corr, S.C., Morand, E.F., Williams, B.R.G., 2012, A miR-19 regulon that controls NF-{kappa}B signaling, Nucleic Acids Research [P], vol 40, issue 16, Oxford University Press, United Kingdom, pp. 8048-8058.

Qin, C., Buxton, K.D., Pepe, S., Cao, A., Venardos, K.M., Love, J.E., Kaye, D.M., Yang, Y.H., Morand, E.F., Ritchie, R.H., 2012, Reperfusion-induced myocardial dysfunction is prevented by endogenous annexin-A1 and its N-terminal derived peptide Ac-ANX-A1 (2-26), British Journal of Pharmacology [P], vol 168, issue 1, John Wiley & Sons Ltd., United Kingdom, pp. 238-252.

Yang, Y.H., Ngo, D., Jones, M.E., Simpson, E., Fritzemeier, K.H., Morand, E.F., 2010, Endogenous estrogen regulation of inflammatory arthritis and cytokine expression in male mice, predominantly via estrogen receptor alpha, Arthritis & Rheumatism-Arthritis Care & Research [P], vol 62, issue 4, John Wiley & Sons, Inc., United States, pp. 1017-1025.

Beaulieu, E.V., Ngo, D., Santos, L.L., Yang, Y.H., Smith, M.D., Jorgensen, C., Escriou, V., Scherman, D., Courties, G., Apparailly, F., Morand, E., 2010, Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis, Arthritis and Rheumatism [E], vol 62, issue 9, John Wiley & Sons, Inc, United States, pp. 2651-2661.

Yang, Y.H., Aeberli, D., Dacumos - Hill, A., Xue, J.R., Morand, E.F., 2009, Annexin-1 regulates macrophage IL-6 and TNF via glucocorticoid-induced leucine zipper, Journal of Immunology [E], vol 183, issue 2, American Association of Immunologists, United States, pp. 1435-1445.

Wang, I.D., Yang, Y.H., Liu, Y., Song, H.T., Zhang, L.Y., Li, P.I., 2008, Decreased expression of annexin A1 during the progression of cervical neoplasia, Journal of International Medical Research [P], vol 36, issue 4, Field House Publishing, UK, pp. 665-672.

Leech, M.T., Xue, J.R., Dacumos, A., Hall, P.H., Santos, L.L., Yang, Y.H., Li, M., Kitching, A.R., Morand, E.F., 2008, The tumour suppressor gene p53 modulates the severity of antigen-induced arthritis and the systemic immune response, Clinical and Experimental Immunology, vol 152, issue 2, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 345-353.

Yang, Y.H., Toh, M., Clyne, C., Leech, M.T., Aeberli, D., Xue, J.R., Dacumos, A., Sharma, L., Morand, E.F., 2006, Annexin 1 negatively regulates IL-6 expression via effects on p38 MAPK and MAPK phosphatase-1, The Journal of Immunology, vol 177, issue 11, American Association of Immunologists, USA, pp. 8148-8153.

Aeberli, D., Yang, Y.H., Mansell, A.S., Santos, L.L., Leech, M.T., Morand, E.F., 2006, Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase-1 and p38 MAP kinase, FEBS Letters, vol 580, issue 3, Elsevier, Amsterdam The Netherlands, pp. 974-981.

Gregory, J., Morand, E.F., McKeown, S.J., Ralph, J., Hall, P.H., Yang, Y.H., McColl, S.R., Hickey, M.J., 2006, Macrophage migration inhibitory factor induces macrophage recruitment via CC chemokine ligand 2, The Journal of Immunology, vol 177, issue 11, The American Association of Immunologists, Inc., USA, pp. 8072-8079.

Toh, M., Aeberli, D., Lacey, D., Yang, Y.H., Santos, L.L., Clarkson, M., Sharma, L., Clyne, C., Morand, E.F., 2006, Regulation of IL-1 and TNF receptor expression and function by endogenous macrophage migration inhibitory factor, The Journal of Immunology, vol 177, issue 7, American Association of Immunologists, USA, pp. 4818-4825.

Morand, E.F., Hall, P.H., Hutchinson, P.E., Yang, Y.H., 2006, Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1, Mediators of Inflammation, vol 2006, issue 2, Hindawi Publishing Corporation, New York USA, pp. 1-6.

Yang, Y.H., Morand, E.F., 2006, The anti-inflammatory role of annexin-1 in arthritis, Current Rheumatology Reviews [P], vol 2, issue 4, Bentham Science Publishers Ltd, Netherlands, pp. 325-331.

Yang, Y.H., Hall, P.H., Little, C.B., Fosang, A.J., Milenkovski, G., Santos, L.L., Xue, J.R., Tipping, P.G., Morand, E.F., 2005, Reduction of Arthritis severity in Protease-activated receptor-deficient mice, Arthritis & Rheumatism, vol 52, issue 4, John Wiley & Sons, Inc., USA, pp. 1325-1332.

Norman, M.U., Lister, K.J., Yang, Y.H., Issekutz, A., Hickey, M.J., 2005, TNF regulates leukocyte-endothelial cell interactions and microvascular dysfunction during immune complex-mediated inflammation, British Journal of Pharmacology, vol 144, issue 2, Nature Publishing Group, UK, pp. 265-274.

Santos, L.L., Lacey, D., Yang, Y.H., Leech, M.T., Morand, E.F., 2004, Activation of Synovial Cell p38 MAP Kinase by Macrophage Migration Inhibitory Factor, The Journal of Rheumatology, vol 31, issue 6, Journal of Rheumatology Publishing Co, Canada, pp. 1038-1043.

Toh, M., Yang, Y.H., Leech, M.T., Santos, L.L., Morand, E.F., 2004, Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of mitogen-activated protein kinases, in rheumatoid arthritis: up-regulation by interleukin-1beta and glucocorticoids, Arthritis & Rheumatism, vol 50, issue 10, Wiley-Liss, United States, pp. 3118-3128.

Yang, Y.H., Morand, E.F., Getting, S.J., Paul-Clark, M., Liu, D.L., Yona, S., Hannon, R., Buckingham, J.C., Perretti, M., Flower, R.J., 2004, Modulation of Inflammation and Response to Dexamethasone by Annexin 1 in Antigen-Induced Arthritis, Arthritis & Rheumatism, vol 50, issue 3, Wiley-Liss, USA, pp. 976-984.

Gregory, J., Leech, M.T., David, J.R., Yang, Y.H., Dacumos, A., Hickey, M.J., 2004, Reduced Leukocyte-Endothelial Cell Interactions in the Inflamed Microcirculation of Macrophage Migration Inhibitory Factor-Deficient Mice, Arthritis & Rheumatism, vol 50, issue 9, Wiley-Liss, USA, pp. 3023-3034.

Yang, Y.H., Hall, P.H., Milenkovski, G., Sharma, L., Hutchinson, P., Melis, E., Carmeliet, P., Tipping, P.G., Morand, E.F., 2004, Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant mice, American Journal of Pathology, vol 164, issue 1, American Society for Investigative Pathology, Inc, USA, pp. 109-117.

Yang, Y., Hutchinson, P., Morand, E.F., 1999, Inhibitory Effect of Annexin I on Synovial Inflammation In Rat Adjuvant Arthritis, Arthritis and Rheumatism, vol 42(7), Lippincott Williams & Wilkins, Philadelphia PA USA, pp. 1538-1544.

Yang, Y., Hutchinson, P., Santos, L., Morand, E.F., 1998, Glucocorticoid inhibition of adjuvant arthritis synovial macrophage nitric oxide production: role of lipocortin 1, Clinical and Experimental Immunology, vol 111 no 1, Blackwell Science Ltd, PO Box 88 Oxford OX2 ONE UK, pp. 117-122.

Yang, Y., Leech, M., Hutchinson, P., Holdsworth, S.R., Morand, E.F., 1997, Antiinflammatory effect of lipocortin 1 in experimental arthritis, Inflammation, vol 21, Plenum Publishing Corporation, 232 Spring St New York NY USA, pp. 583-596.

Yang, Y., Hutchinson, P., Leech, M., Morand, E.F., 1997, Exacerbation of Adjuvant Arthritis by Adrenalectomy Is Associated with Reduced Leukocyte Lipcortin 1, The Journal of Rheumatology, vol 24, The Journal of Rheumatology Publishing Co Ltd, Toronto Canada, pp. 1758-1764.

Santos, L., Morand, E.F., Yang, Y., Hutchinson, P., Holdsworth, S.R., 1997, Suppression of adjuvant arthritis and synovial macrophage inducible nitric oxide by N-iminoethyl-L ornithine, a nitric oxide synthase inhibitor, Inflammation, vol 21, Plenum Publishing Corporation, 232 Spring St New York NY USA, pp. 299-311.

Conference Proceedings

Yang, Y.H., Aeberli, D., Leech, M.T., Dacumos - Hill, A., Xue, J.R., Morand, E.F., 2009, Annexin-1 regulates inflammatory response via glucocorticoid-induced genes, Symposium 7: Cancer: From genes to therapy, April 24-27, The Australia Chinese Association for Biomedical Sciences Inc., Australia, p. 200.

Yang, Y., Hutchinson, P., Morand, E.F., 1998, Annexin I: A constructive inhibitory regulator of synovial inflammation in rat adjuvant arthritis, American College of Rheumatology/Association of Rheumatology Health Professonals, San Diego USA Nov 8-12, American College of Rheumatology, Atlanta USA, p. S97.

Grants

Title:

Annual Scientific meeting in Washington DC, USA. The CASS Foundation Limited - Postdoctoral Travel Grants.

Investigators:

Yang, Y

Funding:

(2006 - 2010). CASS Foundation Limited.

Title:

Regulation of arthritis and skin inflammation by annexin-1.

Investigators:

Yang, Y, Morand, E

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Regulation of glucocorticord sensitivity by annexin-1.

Investigators:

Yang, Y

Funding:

(2007 - 2011). National Health & Medical Research Council (NHMRC).

Title:

Regulation of leukocyte trafficking by macrophage migration inhibitory factor.

Investigators:

Leech, M, Hickey, M, Yang, Y, Tipping, P

Funding:

(2004 - 2008). National Health & Medical Research Council (NHMRC).

Postgraduate Research Supervisions

Completed Supervision

Student:

Ngo, D.

Program of Study:

The expression and function of glucocorticoid-induced leucine zipper (GILZ) in models of rheumatoid arthritis. (PHD) 2012.

Supervisors:

Morand, E (Main), Yang, Y (Associate).