Prof Andis Graudins - Researcher Profile

Biography

Professor of Emergency Medicine and Clincial Toxicology reseach at Monash University and Southern Health.

Toxicology interests include treatment of severe cardiovascular drug poisoning, and investigation of novel antidotes for treatment of drug poisoning as well as management of paracetamol poisoning. Involved in both clinical and basic science toxicology research including pharamcokinetics and animal models of severe CVS poisoning.

Emergency Medicine interests include analgesia research in the ED and care of patients with frequent emergency department representation.

Research & Supervision Interests

Clinical Toxicology: Paracetamol Poisoning, Cardiovascular Drug Poisoning and antidote development, Serotoning Syndrome, Antidepressant poisoning, Natural Toxins- snake and spider envenomation

Acute analgesia research - intranasal drug delivery

Frequent Emergency Department Reattenders

Keywords

Acetaminophen/Paracetamol Poisoning, Analgesia research, Antidotes, Cardiovascular Toxicology, Clinical Toxicology, Poisoning, Overdose, , Emergency Medicine, absorption acetaminophen/administration & dosage acetaminophen/pharmacokinetics a, antidote; cardiac arrest; poisoning; resuscitation, antidote; emulsion; intravenous; lipid; overdose; poisoning

Qualifications

DOCTOR OF PHILOSOPHY

Institution: University of Technology, Sydney

Year awarded: 2003

BACHELOR OF MEDICINE, BACHELOR OF SURGERY

Institution: University of New South Wales

Year awarded: 1984

Publications

Journal Articles

James, L.P., Chiew, A., Abdel-Rahman, S.M., Letzig, L., Graudins, A., Day, P., Roberts, D., 2012, Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations, European Journal Of Clinical Pharmacology [P], vol tba, Springer, Germany, pp. 1-7.

Graudins, A., Little, M., Pineda, S.S., Hains, P.G., King, G.F., Broady, K., Nicholson, G.M., 2012, Cloning and activity of a novel alpha-latrotoxin from red-back spider venom, Biochemical Pharmacology [P], vol 83, issue 1, Elsevier Inc., United States, pp. 170-183.

Kalam, Y., Graudins, A., 2012, Levosimendan does not improve cardiac output or blood pressure in a rodent model of propranolol toxicity when administered using various dosing regimens, International Journal Of Toxicology [P], vol 31, issue 2, Sage Publications Ltd, United States, pp. 166-174.

Kalam, Y., Graudins, A., 2012, Levosimendan infusion improves cardiac output but not blood pressure in a rodent model of severe metoprolol toxicity, Human and Experimental Toxicology [P], vol 31, issue 9, Sage Publications Ltd, United Kingdom, pp. 955-963.

Kalam, Y., Graudins, A., 2012, The effects of fructose-1,6-diphosphate on haemodynamic parameters and survival in a rodent model of propranolol and verapamil poisoning, Clinical Toxicology [P], vol 50, issue 7, Informa Healthcare, United States, pp. 546-554.

Cave, G., Harvey, M., Graudins, A., 2011, Intravenous lipid emulsion as antidote: A summary of published human experience, EMA - Emergency Medicine Australasia [E], vol 23, issue 2, Wiley-Blackwell Publishing Asia, Australia, pp. 123-141.

Gunja, N., Graudins, A., 2011, Management of cardiac arrest following poisoning, EMA - Emergency Medicine Australasia [E], vol 23, issue 1, Wiley-Blackwell Publishing Asia, Australia, pp. 16-22.

Graudins, A., Wong, K., 2010, Comparative hemodynamic effects of levosimendan alone and in conjunction with 4-aminopyridine or calcium chloride in a rodent model of severe verapamil poisoning, Journal of medical toxicology : official journal of the American College of Medical Toxicology [P], vol 6, issue 2, Springer New York LLC, United States, pp. 85-93.

Graham, G., Day, R., Graudins, A., Mohamudally, A., 2010, FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): Are they reasonable?, Inflammopharmacology [P], vol 18, issue 57, Birkhaeuser Verlag AG, Switzerland, pp. 47-55.

Graudins, A., Chiew, A., Chan, B., 2010, Overdose with modified-release paracetamol results in delayed and prolonged absorption of paracetamol, Internal Medicine Journal [P], vol 40, issue 1, Wiley-Blackwell Publishing Asia, Australia, pp. 72-76.

Chiew, A., Day, P., Salonikas, C., Naidoo, D., Graudins, A., Thomas, R., 2010, The comparative pharmacokinetics of modified-release and immediate-release paracetamol in a simulated overdose model, EMA - Emergency Medicine Australasia [E], vol 22, issue 6, Wiley-Blackwell Publishing Asia, Australia, pp. 548-555.

Blacklow, B., Kornhauser, R.S., Hains, P.G., Loiacono, R., Escoubas, P., Graudins, A., Nicholson, G.M., 2010, alpha-Elapitoxin-Aa2a, a long-chain snake alpha-neurotoxin with potent actions on muscle (alpha1)2betagammadelta nicotinic receptors, lacks the classical high affinity for neuronal alpha7 nicotinic receptors, Biochemical Pharmacology [P], vol 81, issue 2, Elsevier Inc., USA, pp. 314-325.

Graudins, A., 2009, Letter regarding Levosimendan in a rat model of severe verapamil poisoning, Journal of medical toxicology : official journal of the American College of Medical Toxicology [P], vol 5, issue 3, Springer New York LLC, USA, p. 1.

Dowling, J., Isbister, G., Kirkpatrick, C., Naidoo, D., Graudins, A., 2008, Population pharmacokinetics of intravenous, intramuscular, and intranasal naloxone in human volunteers, Therapeutic Drug Monitoring [P], vol 30, issue 4, Lippincott Williams & Wilkins, United States, pp. 490-496.

Graudins, A., Najafi, J., Rur-Sc, M., 2008, Treatment of experimental verapamil poisoning with levosimendan utilizing a rodent model of drug toxicity, Clinical Toxicology [P], vol 46, issue 1, Informa Healthcare, United States, pp. 50-56.

Isbister, G., Friberg, L., Stokes, B., Buckley, N., Lee, C., Gunja, N., Brown, S., MacDonald, E., Graudins, A., Holdgate, A., Duffull, S., 2007, Activated charcoal decreases the risk of QT prolongation after citalopram overdose, Annals Of Emergency Medicine [P], vol 50, issue 5, Mosby, Inc., United States, pp. 593-600.e46.

Nicholson, G., Graudins, A., Wilson, H., Little, M., Broady, K., 2006, Arachnid toxinology in Australia: from clinical toxicology to potential applications, Toxicon : official journal of the International Society on Toxinology [P], vol 48, issue 7, Pergamon, United Kingdom, pp. 872-898.

Tan, C., Graudins, A., 2006, Comparative pharmacokinetics of Panadol Extend and immediate-release paracetamol in a simulated overdose model, Emergency Medicine Australasia (Print) [P], vol 18, issue 4, Wiley-Blackwell Publishing Asia, Australia, pp. 398-403.

Kaye, K., Welch, S., Graudins, L., Graudins, A., Rotem, T., Davis, S., Day, R., 2005, Pethidine in emergency departments: Promoting evidence-based prescribing, Medical Journal Of Australia [P], vol 183, issue 3, Australasian Medical Publishing Company Pty. Ltd., Australia, pp. 129-133.

Mallows, J., Chan, B., Graudins, A., 2005, Quality of poisoning management advice in the Monthly Index of Medical Specialties Annual, Emergency Medicine Australasia (Print) [P], vol 17, issue 5-6, Wiley-Blackwell Publishing Asia, Australia, pp. 511-519.

Kerr, F., Dawson, A., Whyte, I., Buckley, N., Murray, L., Graudins, A., Chan, B., Trudinger, B., 2005, The Australasian clinical toxicology investigators collaboration randomized trial of different loading infusion rates of N-acetylcysteine, Annals Of Emergency Medicine [P], vol 45, issue 4, Mosby, Inc., United States, pp. 402-408.

Teaching Commitment

Southern Clinical School
Departmetn of Pharmacology 

Clinical Activity

Consultant Emergency Physcian, Southern Health

Consultatn Clinical Toxciologist, Southern Health

Consulting

Clinical Toxicologist: NSW Poisons Information Centre, Childrens Hospital at Westmead, NSW

Clinical Toxicologist: Victorian Poisons Information Centre, The Austin Hospital, Heidelberg, Victoria.

Emergency Physician and Clinical Toxicologist Southern Health, Melbourne, Victoria