Assoc Prof Bernard Flynn - Researcher Profile

Biography

Position

Associate Professor
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Qualifications

DOCTOR OF PHILOSOPHY (ORGANIC CHEMISTRY)

Institution: University of Adelaide

Year awarded: 1993

BACHELOR OF SCIENCE (HONS)

Institution: University of Melbourne

Year awarded: 1988

Publications

Journal Articles

Kerr, D.J., Flynn, B.L., 2012, A new approach to highly substituted cyclopentanoids from a concise formal synthesis of (+)-roseophilin, Organic Letters [P], vol 14, issue 7, American Chemical Society, USA, pp. 1740-1743.

Flynn, B.L., Banwell, M., 2012, Convergent total syntheses of the pentacyclic lamellarins K, T, U and W via the addition of azomethine ylides to tethered tolans, Heterocycles [P], vol 84, issue 2, Japan Institute of Heterocyclic Chemistry, Japan, pp. 1141-1170.

Kerr, D.J., Miletic, M., Chaplin, J.H., White, J.M., Flynn, B.L., 2012, Oxazolidinone-promoted, torquoselective Nazarov cyclizations, Organic Letters [P], vol 14, issue 7, American Chemical Society, USA, pp. 1732-1735.

Lobachevsky, P.N., Smith, J., Denoyer, D., Skene, C.E., White, J.M., Flynn, B.L., Kerr, D.J., Hicks, R., Martin, R.F., 2012, Tumour targeting of Auger emitters using DNA ligands conjugated to octreotate, International Journal of Radiation Biology [P], vol 88, issue 12, Informa Healthcare, UK, pp. 1009-1018.

Flynn, B., Gurmit, G., Grobelny, D., Chaplin, J., Paul, D., Leske, A., Lavranos, T., Chalmers, D., Charman, S., Kostewicz, E., Shackleford, D., Morizzi, J., Hamel, E., Jung, K., Kremmidiotis, G., 2011, Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties, Journal of Medicinal Chemistry [P], vol 54, issue 17, AMER CHEMICAL SOC, USA, pp. 6014-6027.

Scammells, P., Flynn, B., Aurelio, L., 2011, New methodology for the N-alkylation of 2-amino-3-acylthiophenes, Organic & Biomolecular Chemistry [P], vol 9, issue 13, ROYAL SOC CHEMISTRY, England, pp. 4886-4902.

Bui, C., Flynn, B., 2011, The evaluation of solution-and solid-phase approaches to the divergent synthesis cinnoline and phenanthrene ring systems, Molecular Diversity [P], vol 15, Springer Netherlands, Netherlands, pp. 83-89.

Aurelio, L., Christopoulos, A., Flynn, B., Scammells, P., Sexton, P., Valant, C., 2011, The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A(1) adenosine receptor, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 12, Pergamon-Elsevier Science Ltd, UK, pp. 3704-3707.

Kerr, D., White, J., Flynn, B., 2010, A reductive-coupling plus Nazarov cyclization sequence in the asymmetric synthesis of five-membered carbocycles, Journal Of Organic Chemistry [P], vol 75, issue 21, American Chemical Society, United States, pp. 7073-7084.

Masters, K.S., Flynn, B.L., 2010, An efficient synthesis of (+-)-frondosin B using a Stille-Heck reaction sequence, Organic & Biomolecular Chemistry [P], vol 8, issue 6, Royal Society of Chemistry, United Kingdom, pp. 1290-1292.

Kremmidiotis, G., Leske, A., Lavranos, T., Beaumont, D., Gasic, J., Hall, A., O'Callaghan, M., Matthews, C., Flynn, B., 2010, BNC105: A novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy, Molecular Cancer Therapeutics [P], vol 9, issue 6, American Association for Cancer Research, United States, pp. 1562-1573.

Aurelio, L., Valant, C., Flynn, B., Sexton, P., White, J., Christopoulos, A., Scammells, P., 2010, Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A1 adenosine receptor modulation, Journal of Medicinal Chemistry [P], vol 53, American Chemical Society, United States, pp. 6550-6559.

Goeminne, A., Scammells, P., Devine, S., Flynn, B., 2010, Richter cyclization and co-cyclization reactions of triazene-masked diazonium ions, Tetrahedron Letters [P], vol 51, issue 52, Pergamon, United Kingdom, pp. 6882-6885.

Aurelio, L., Valant, C., Figler, H., Flynn, B.L., Linden, J., Sexton, P., Christopoulos, A., Scammells, P.J., 2009, 3- and 6-substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists, Bioorganic & Medicinal Chemistry [P], vol 17, issue 20, Pergamon, UK, pp. 7353-7361.

Aurelio, L., Valant, C., Flynn, B.L., Sexton, P.M., Christopoulos, A., Scammells, P.J., 2009, Allosteric modulators of the adenosine A1 receptor: Synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes, Journal of Medicinal Chemistry [P], vol 52, issue 14, American Chemical Society, USA, pp. 4543-4547.

Masters, K.J., Flynn, B.L., 2009, Alternation of Chemoselective Control in Stille-Heck and Heck-Stille Reaction Sequences, Advanced Synthesis and Catalysis [P], vol 351, issue 4, WILEY-V C H VERLAG GMBH, Germany, pp. 530-536.

Aurelio, L., Flynn, B.L., Scammells, P.J., 2009, Reaction pathways to 2-aminothiophenes and thiophene-3-carbonitriles, Australian Journal of Chemistry [E], vol 62, issue 5, C S I R O Publishing, Australia, pp. 402-406.

Ferguson, G.N., Valant, C., Horne, H.J., Figler, H., Flynn, B.L., Linden, J., Chalmers, D.K., Sexton, P., Christopoulos, A., Scammells, P.J., 2008, 2-Aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists, Journal of Medicinal Chemistry, vol 51, issue 19, American Chemical Society, USA, pp. 6165-6172.

Aurelio, L., Figler, H., Flynn, B.L., Linden, J., Scammells, P.J., 2008, 5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers, Bioorganic and Medicinal Chemistry, vol 16, issue 3, Pergamon, UK, pp. 1319-1327.

Masters, K.S., Flynn, B.L., 2008, A concise approach to the polycyclic scaffold of frondosin D, Journal Of Organic Chemistry [P], vol 73, issue 20, American Chemical Society, USA, pp. 8081-8084.

Halim, R., Scammells, P.J., Flynn, B.L., 2008, Alternating lodonium-mediated reaction cascades giving indole- And quinoline-containing polycycles, Organic Letters, vol 10, issue 10, American Chemical Society, Web, pp. 1967-1970.

Gurmit, G.S., Grobelny, D., Chaplin, J.H., Flynn, B.L., 2008, An Efficient Synthesis and Substitution of 3-Aroyl-2-bromobenzo[b]furans, Journal Of Organic Chemistry [P], vol 73, issue 3, American Chemical Society, USA, pp. 1131-1134.

Cianci, J., Baell, J.B., Flynn, B.L., Gable, R.W., Mould, J., Paul, D., Harvey, A.J., 2008, Synthesis and Biological Evaluation of Chalcones as Inhibitors of the Voltage-Gated Potassium Channel Kv1.3, Bioorganic & Medicinal Chemistry Letters [P], vol 18, issue 6, Pergamon, UK, pp. 2055-2061.

Kerr, D.J., Hamel, E., Jung, K., Flynn, B.L., 2007, The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4, Bioorganic & Medicinal Chemistry [P], vol 15, issue 9, Pergamon, United Kingdom, pp. 3290-3298.

Gurmit, G.S., Grobelny, D., Flynn, B.L., 2006, A practical method for phosphorylation of combretastatin A-4 with phosphorus oxychloride, Organic Preparations and Procedures International [P], vol 38, issue 6, Taylor & Francis Inc., USA, pp. 604-608.

Hessian, K.O., Flynn, B.L., 2006, Selective endo and exo iodocyclizations in the synthesis of Quinolines and Indoles, Organic Letters, vol 8, issue 2, American Chemical Society, USA, pp. 243-246.

Bui, C.T., Flynn, B.L., 2006, Solid-Phase Synthesis of 2,3-Disubstituted Benzo[b]thiophenes and Benzo[b]selenophenes, Journal Of Combinatorial Chemistry [P], vol 8, issue 2, American Chemical Society, USA, pp. 163-167.

Hessian, K.O., Flynn, B.L., 2003, Iodine -induced reaction cascades for the rapid construction of variously substituted benzothiophenes, Organic Letters, vol 5, issue 23, American Chemical Society, USA, pp. 4377-4380.

Other

Scammells, P.J., Aurelio, L., Christopoulos, A., Sexton, P., Valant, C., Flynn, B.L., Linden, J., 2009, A1 adenosine receptor allosteric enhancers, USA, AU.

Flynn, B.L., Baell, J.B., Chaplin, J.H., Gurmit, G.S., Grobelny, D., Harvey, A.J., Mould, J., Paul, D., 2009, Novel Aryl Potassium Channel Blockers and Uses Thereof, Worldwide.

Harvey, A.J., Flynn, B.L., Mould, J., Paul, D., Gurmit, G.S., Ripper, J.A., Cooke, R.C., Crossman, J.S., Baell, J.B., Kuchel, N.W., singh, r., 2009, Novel Potassium Channel Blockers and Uses Thereof, Worldwide.

Flynn, B.L., Chaplin, J.H., Paul, D., Grobelny, D., Kelly, B., 2008, Chemical Compounds and Processes, Worldwide.

Baell, J.B., Sleebs, B., Flynn, B.L., Street, I.P., Quazi, N., Bui, C.T., 2008, Novel Anxiolytic Compounds, Worldwide.

Flynn, B.L., Baell, J.B., Harvey, A.J., Chaplin, J.H., Paul, D., Mould, J., 2008, Novel Benzofuran Potassium Channel Blockers and Uses Thereof, Worldwide.

Flynn, B.L., Baell, J.B., Harvey, A.J., Chaplin, J.H., Paul, D., Mould, J., 2008, Novel Chromenone Potassium Channel Blockers and Uses Thereof, Worldwide.

Chaplin, J.H., Gurmit, G.S., Grobelny, D., Flynn, B.L., Kremmidiotis, G., 2007, Substituted Benzofurans, Benzothiophenes, Benzoselenophenes and Indoles and their Use as Tubulin Polymerisation Inhibitors, Worldwide.

Chaplin, J.H., Gurmit, G.S., Grobelny, D., Flynn, B.L., 2006, Novel Tubulin Polymerisation Inhibitors, Worldwide.

Teaching Commitment

Lecturing:

• Chemistry of Cardiovascular Drugs, 2nd Year Phamacy (PAC2412)
• Combinatorial Chemitsry, 3rd Year PharmSci, (VPS3022)

Higher Degree Research Projects:

• Anticancer natural product synthesis
• Chemical Biology studies of GPCRs
• Asymmetric synthetic methodology development

Activities

Affiliations with institutes

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

A synthetic medicinal chemistry study of the rocaglates: a class of potent anticancer natural produc.

Supervisors:

Flynn, B (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Novel Approaches to sp3-Rich Chemotypes for Drug Discovery Applications.

Supervisors:

Flynn, B (Main), Scammells, P (Associate).

Completed Supervision

Student:

Jackson, K.

Program of Study:

Interrupted Nazarov cyclisations in asymmetric synthesis: towards the synthesis of the rocaglates. (PHD) 2010.

Supervisors:

Flynn, B (Main), Scammells, P (Main), Flynn, B (Associate).