Dr Elizabeth Yuriev - Researcher Profile

Biography

Elizabeth works in the Faculty of Pharmacy & Pharm Science at Monash University as a Senior Lecturer.

Research & Supervision Interests

Carbohydrate antigens in cancer, infection, and organ transplantation

Protein recognition of carbohydrate and peptide ligands

G protein-coupled receptor drug discovery

GPCR modelling

Molecular docking

Keywords

GPCR, molecular dynamics, homology modelling; docking, antibody; carbohydrate; drug design; peptide; transplantation; structural biology;, cancer, infection, molecular modelling, crystallography, xenotransplantation, antibody, therapeutics

Qualifications

PHD

Institution: Victoria University

Year awarded: 1997

Publications

Book Chapters

Agostino, M.J., Ramsland, P.A., Yuriev, E., 2012, Docking of carbohydrates into protein binding sites, in Structural glycobiology, eds Elizabeth Yuriev and Paul Ramsland, CRC Press, Boca Raton USA, pp. 1-347.

Christiansen, D., Agostino, M.J., Yuriev, E., Ramsland, P.A., Sandrin, M.S., 2012, Structural glycobiology - applications in organ transplantation, in Structural glycobiology, eds Elizabeth Yuriev and Paul Ramsland, CRC Press, Boca Raton USA, pp. 1-347.

Agostino, M.J., Farrugia, W., Sandrin, M.S., Scott, A.M., Yuriev, E., Ramsland, P.A., 2012, Structural glycobiology of antibody recognition in xenotransplantation and cancer immunotherapy, in Anticarbohydrate antibodies, eds Paul Kosma and Sven Muller-Loennies, Springer, New York USA, pp. 203-228.

Journal Articles

Agostino, M.J., Yuriev, E., Ramsland, P.A., 2012, Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping, PLoS ONE [P], vol 7, issue 4, Public Library of Science, USA, pp. 1-12.

McRobb, F.M., Crosby, I.T., Yuriev, E., Lane, J.R.D., Capuano, B., 2012, Homobivalent ligands of the atypical antipsychotic clozapine: Design, synthesis, and pharmacological evaluation, Journal of Medicinal Chemistry [P], vol 55, issue 4, American Chemical Society, USA, pp. 1622-1634.

Huang, J.X., Azad, M.A.K., Yuriev, E., Baker, M.A., Nation, R.L., Li, J., Cooper, M.A., Velkov, T., 2012, Molecular characterization of lipopolysaccharide binding to human alpha-1-acid glycoprotein, Journal of Lipids [E], vol 2012, Hindawi Publishing Corporation, USA, pp. 1-15.

Agostino, M., Sandrin, M., Thompson, P., Farrugia, W., Ramsland, P., Yuriev, E., 2011, Carbohydrate-mimetic peptides: structural aspects of mimicry and therapeutic implications, Expert Opinion on Biological Therapy [P], vol 11, issue 2, Informa UK Ltd, UK, pp. 211-224.

Agostino, M.J., Sandrin, M.S., Thompson, P.E., Farrugia, W., Ramsland, P.A., Yuriev, E., 2011, Carbohydrate-mimetic peptides: structural aspects of mimicry and therapeutic implications, Expert Opinion on Biological Therapy [P], vol 11, issue 2, Informa Healthcare, UK, pp. 211-224.

Yuriev, E., Agostino, M., Ramsland, P., 2011, Challenges and advances in computational docking: 2009 in review, Journal Of Molecular Recognition [P], vol 24, issue 2, John Wiley & Sons Ltd., United Kingdom, pp. 149-164.

Velkov, T., Horne, J., Scanlon, M., Capuano, B., Yuriev, E., Lawen, A., 2011, Characterization of the N-methyltransferase activities of the multifunctional polypeptide cyclosporin synthetase, Chemistry and Biology [P], vol 18, issue 4, Cell Press, USA, pp. 464-475.

Feketeova, L., Yuriev, E., Orbell, J., Khairallah, G., O'Hair, R., 2011, Gas-phase formation and reactions of radical cations of guanosine, deoxyguanosine and their homodimers and heterodimers, International Journal of Mass Spectrometry [P], vol 304, issue 2-3, Elsevier BV, Netherlands, pp. 74-82.

Agostino, M., Sandrin, M., Thompson, P., Ramsland, P., Yuriev, E., 2011, Peptide inhibitors of xenoreactive antibodies mimic the interaction profile of the native carbohydrate antigens, Biopolymers [P], vol 96, issue 2, John Wiley & Sons, Inc., United States, pp. 193-206.

Szabo, M., Agostino, M., Malone, D., Yuriev, E., Capuano, B., 2011, The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 22, PERGAMON-ELSEVIER SCIENCE LTD, ENGLAND, pp. 6782-6787.

Neale, D., Thompson, P., White, P., Chalmers, D., Yuriev, E., Manallack, D., 2010, Binding mode prediction of PDE4 inhibitors: a comparison of modelling methods, Australian Journal of Chemistry [E], vol 63, issue 3, C S I R O Publishing, Australia, pp. 396-404.

Hutchinson, A., Ramsland, P., Jones, D., Agostino, M., Lund, M., Jennings, C., Bockhorni, V., Yuriev, E., Edmundson, A., Raison, R., 2010, Free ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form, Journal of Immunology [E], vol 185, The American Association of Immunologists, Bethesda MD USA, pp. 4179-4188.

McRobb, F., Capuano, B., Crosby, I., Chalmers, D., Yuriev, E., 2010, Homology modeling and docking evaluation of aminergic G protein-coupled receptors, Journal Of Chemical Information And Modeling [P], vol 50, issue 4, American Chemical Society, United States, pp. 626-637.

Agostino, M., Sandrin, M., Thompson, P., Yuriev, E., Ramsland, P., 2010, Identification of preferred carbohydrate binding modes in xenoreactive antibodies by combining conformational filters and binding site maps, Glycobiology [P], vol 20, issue 6, Oxford University Press, United States, pp. 724-735.

Capuano, B., Crosby, I., Forsyth, C.M., McRobb, F.M., Moudretski, V.V., Taylor, D.A., Vom, A., Yuriev, E., 2010, New hybrids of clozapine and haloperidol and their isosteric analogues: Synthesis, X-ray crystallography, conformational analysis and preliminary pharmacological evaluation, Structural Chemistry [P], vol 21, issue 3, Springer New York LLC, United States, pp. 613-628.

Capuano, B., Crosby, I.T., McRobb, F.M., Podloucka, A., Taylor, D.A., Vom, A., Yuriev, E., 2010, The synthesis and preliminary pharmacological evaluation of a series of substituted 4-phenoxypropyl analogues of the atypical antipsychotic clozapine, Australian Journal of Chemistry [E], vol 63, issue 1, C S I R O Publishing, Australia, pp. 116-124.

Manallack, D.T., Chalmers, D.K., Yuriev, E., 2010, Using the beta2-adrenoceptor for structure-based drug design, Journal of Chemical Education [P], vol 87, issue 6, American Chemical Society, United States, pp. 625-627.

Katsara, M., Yuriev, E., Ramsland, P.A., Tselios, T., Deraos, G., Lourbopoulos, A., Grigoriadis, N., Matsoukas, J., Apostolopoulos, V., 2009, Altered peptide ligands of myelin basic protein (MBP87-99) conjugated to reduced mannan modulate immune responses in mice, Immunology [P], vol 128, issue 4, Wiley-Blackwell Publishing Ltd., USA, pp. 521-533.

Yuriev, E., Chalmers, D.K., Capuano, B., 2009, Conformational Analysis of Drug Molecules: A Practical Exercise in the Medicinal Chemistry Course, Journal of Chemical Education [P], vol 86, issue 4, American Chemical Society, Division of Chemical Education, USA, pp. 477-478.

Khairallah, G.N., Stewart, M.B., Yuriev, E., Xu, Y., Orbell, J.D., O'Hair, R.A.J., 2009, Gas phase supramolecular cluster ions of deoxyguanosine induced by binding to (2,2':6'2''-terpyridine)-platinum(II) and (diethylenetriamine)-platinum(II), Dalton Transactions [P], vol 3.580, issue 9, Royal Society of Chemistry, UK, pp. 1542-1548.

Agostino, M.J., Sandrin, M.S., Thompson, P., Yuriev, E., Ramsland, P.A., 2009, In silico analysis of antibody-carbohydrate interactions and its application to xenoreactive antibodies, Molecular Immunology [P], vol 47, issue 2-3, Pergamon, UK, pp. 233-246.

Agostino, M.J., Jene, C., Boyle, T.P., Ramsland, P.A., Yuriev, E., 2009, Molecular docking of carbohydrate ligands to antibodies: Structural validation against crystal structures, Journal Of Chemical Information And Modeling [P], vol 49, issue 12, American Chemical Society, USA, pp. 2749-2760.

Yuriev, E., Agostino, M.J., Farrugia, W., Christiansen, D., Sandrin, M.S., Ramsland, P.A., 2009, Structural biology of carbohydrate xenoantigens, Expert Opinion on Biological Therapy [P], vol 9, issue 8, Informa Healthcare, UK, pp. 1017-1029.

Capuano, B., Crosby, I.T., Forsyth, C.M., Lloyd, E.J., Vom, A., Yuriev, E., 2008, 8-Chloro-5-(4-phenethylpiperazin-1 - Yl)pyrido[2,3-b][1,5]benzoxazepine, Acta Crystallographica. Section E: Structure Reports Online, vol 64, issue Part 10, Wiley-Blackwell, Denmark, pp. O1865-O1866.

Katsara, M., Yuriev, E., Ramsland, P.A., Deraos, G., Tselios, T., Matsoukas, J., Apostolopoulos, V., 2008, A double mutation of MBP83-99 peptide induces IL-4 responses and antagonizes IFN-gamma responses, Journal of Neuroimmunology, vol 200, issue 1-2, Elsevier Science BV, Netherlands, pp. 77-89.

Yuriev, E., Sandrin, M.S., Ramsland, P.A., 2008, Antibody-ligand docking: insights into peptide-carbohydrate mimicry, Molecular Simulation, vol 34, issue 4, Taylor and Francis Limited, UK, pp. 461-468.

Apostolopoulos, V., Yuriev, E., Lazoura, E., Yu, M., Ramsland, P.A., 2008, MHC and MHC-like molecules: Structural perspectives on the design of molecular vaccines, Human Vaccines, vol 640, issue 6, Landes Bioscience, USA, pp. 252-267.

Katsara, M., Yuriev, E., Ramsland, P.A., Deraos, G., Tselios, T., Matsoukas, J., Apostolopoulos, V., 2008, Mannosylation of mutated MBP83-99 peptides diverts immune responses from Th1 to Th2, Molecular Immunology, vol 45, issue 13, Pergamon, UK, pp. 3661-3670.

Milland, J., Yuriev, E., Xing, P., McKenzie, I., Ramsland, P.A., Christiansen, D., Sandrin, M.S., 2008, Reply to 'Response to Milland et al.: Carbohydrate residues downstream of the terminal gal alpha(1,3)gal epitope modulate the specificity of xenoreactive antibodies', Immunology and Cell Biology, vol 86, issue 8, Nature Publishing Group, USA, pp. 633-634.

Milland, J., Yuriev, E., Xing, P., McKenzie, I., Ramsland, P.A., Sandrin, M.S., 2007, Carbohydrate residues downstream of the terminal Galalpha(1,3)Gal epitope modulate the specificity of xenoreactive antibodies, Immunology and Cell Biology, vol 85, issue 8, Nature Publishing Group, New York, USA, pp. 623-632.

Capuano, B., Crosby, I.T., Fallon, G.D., Forsyth, C.M., Lloyd, E.J., Podloucka, A., Yuriev, E., 2007, Geometric forms of 8-chloro-11-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin- 11-yl)piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine-acetone-pentane (2/1/1), Acta Crystallographica. Section E: Structure Reports Online, vol 63, issue 10, Blackwell Publishing, England, pp. O4034-U2899.

Capuano, B., Crosby, I.T., Forsyth, C.M., Lloyd, E.J., Vom, A., Yuriev, E., 2006, 5,5'-(Piperazine-1,4-diyl)bis(8-chloropyrido-[2,3-b][1,5]benzoxazepine), Acta Crystallographica. Section E: Structure Reports Online, vol 62, issue 12, Blackwell Munksgaard, Denmark, pp. O5434-O5436.

Capuano, B., Crosby, I.T., Lim, S.E.K., Lloyd, E.J., Yuriev, E., 2005, Synthesis of 8-chloro-11-(4-(3-(p-tolyloxy)propyl)piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, Molbank, vol 12, issue December, MDPI, Switzerland, pp. M454/1-M454/2.

Yuriev, E., Farrugia, W., Scott, A.M., Ramsland, P.A., 2005, Three-dimensional structures of carbohydrate determinants of Lewis system antigens: Implications for effective antibody targeting of cancer, Immunology and Cell Biology, vol 83, issue 6, Blackwell Publishing Asia, Australia, pp. 709-717.

Yuriev, E., Kong, D.C.M., Iskander, M.N., 2004, Investigation of structure-activity relationships in a series of glibenclamide analogues, European Journal of Medicinal Chemistry, vol 39, issue 10, Editions Scientifiques Medicales Elsevier, Paris France, pp. 835-847.

Capuano, B., Crosby, I.T., Fallon, G.D., Lloyd, E.J., Yuriev, E., Egan, S., 2003, 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine methanol solvate monohydrate, Acta Crystallographica Section E: Structure Reports Online [P], vol E59, issue 9, Wiley-Blackwell Munksgaard, Denmark, pp. 1367-1369.

Apostolopoulos, V., Yuriev, E., Ramsland, P.A., Halton, J., Osinski, C., Li, W., Plebanski, M., Paulsen, H., McKenzie, I.F., 2003, A glycopeptide in complex with MHC class 1 uses the GaINAc residue as an anchor, Proceedings of the National Academy of Sciences of the United States of America, vol 100, issue 25, National Academy of Sciences, USA, pp. 15029-15034.

Ramsland, P.A., Farrugia, W., Yuriev, E., Edmundson, A.B., Sandrin, M.S., 2003, Evidence for structurally conserved recognition of the major carbohydrate xenoantigen by natural antibodies, Cellular and Molecular Biology, vol 49, issue 2, C M B Association, France, pp. 307-317.

Yuriev, E., Ramsland, P.A., 2002, Mcg light chain dimer as a model system for ligand design: a docking study, Journal of Molecular Recognition, vol 15, issue 5, John Wiley & Sons Ltd., UK, pp. 331-340.

Yuriev, E., Ramsland, P.A., Edmundson, A.B., 2002, Recognition of IgG-derived Peptides by a Human IgM with an Unusual Combining Site, Scandinavian Journal Of Immunology [P], vol 55, issue 3, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 242-253.

Edmundson, A.B., Tribbick, G., Plompen, S., Geysen, H.M., Yuriev, E., Ramsland, P.A., 2001, Binding of Synthetic Peptides by a Human Monoclonal IgM with an Unusual Combining Site Structure, Journal of Molecular Recognition, vol 14, issue 4, John Wiley and Sons, UK, pp. 229-238.

Yuriev, E., Ramsland, P.A., Edmundson, A.B., 2001, Docking of Combinatorial Peptide Libraries into a Broadly Cross-reactive Human IgM, Journal of Molecular Recognition, vol 14, issue 3, John Wiley and Sons, UK, pp. 172-184.

Ramsland, P.A., Yuriev, E., Edmundson, A.B., 2001, Immunoglobulin Cross-Reactivity Examined by Library Screening, Crystallography and Docking Studies, Combinatorial Chemistry and High Throughput Screening, vol 4, issue 5, Bentham Science, Netherlands, pp. 397-408.

Costas, C., Yuriev, E., Meyer, K.L., Guion, S., Hanna, M.M., 2000, RNA-Protein Crosslinking to AMP Residues at Internal Positions in RNA with a New Photocrosslinking ATP Analog, Nucleic Acids Research, vol 28, issue 9, Oxford University Press, UK, pp. 1849-1858.

Yuriev, E., Orbell, J.D., 1998, Steric aspects of the binding of monofunctional platinum (II) complexes to sites of nucleobases: Metal complex "Flatness" as a structural element of speciation, Inorganic Chemistry, vol 37 issue 24, American Chemical Society, USA, pp. 6269-6275.

Teaching Commitment

Bachelor of Pharmaceutical Science:

Foundation coordinator (Year 1 [Semesters 1 and 2]; Year 2 [Semester 1])

PSC1031 Physical Chemistry I (Unit Coordinator)

PSC1022 Bioorganic and medicinal chemistry II

PSC3122 Chemical technologies for the pharmaceutical sciences

Bachelor of Pharmacy:

PAC1211 Physicochemical basis of pharmacy (Unit Coordinator)

PAC1142 Bioorganic and medicinal chemistry II

 

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

GPCR Modelling and Application for Structure-based Drug Design.

Supervisors:

Chalmers, D (Joint), Yuriev, E (Joint-co).

Completed Supervision

Student:

Agostino, M.

Program of Study:

The development and application of in silico mapping techniques for the study of carbohydrate-protein interactions. (PHD) 2011.

Supervisors:

Yuriev, E (Main), Ramsland, P (Associate), Thompson, P (Associate).

Student:

Mcrobb, F.

Program of Study:

Studies of G protein-coupled receptor structure and function: receptor modeling and synthesis of bivalent ligands. (PHD) 2011.

Supervisors:

Capuano, B (Main), Crosby, I (Associate), Yuriev, E (Associate).

Student:

Vom, A.

Program of Study:

A fragment-based approach to the identification of novel ketopantoate reductase inhibitors. (PHD) 2012.

Supervisors:

Simpson, J (Main), Capuano, B (Associate), Yuriev, E (Associate).