Dr Paul Crellin - Researcher Profile

Biography

Paul works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 1998

SCIENCE (HONS)

Institution: Monash University

Year awarded: 1993

Publications

Journal Articles

Pelosi, A., Smith, D.J., Brammananth, R., Topolska, A.E., Billman-Jacobe, H., Nagley, P., Crellin, P.K., Coppel, R.L., 2012, Identification of a novel gene product that promotes survival of mycobacterium smegmatis in macrophages, PLoS ONE [P], vol 7, issue 2 (e31788), Public Library of Science, USA, pp. 1-11.

Rainczuk, A.K., Yamaryo-Botte, Y., Brammananth, R., Stinear, T.P., Seemann, T., Coppel, R.L., McConville, M.J., Crellin, P.K., 2012, The lipoprotein LpqW is essential for the mannosylation of periplasmic glycolipids in Corynebacteria, Journal Of Biological Chemistry [P], vol 287, issue 51, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 42726-42738.

Crellin, P.K., Brammananth, R., Coppel, R.L., 2011, Decaprenylphosphoryl-beta-D-ribose 2'-epimerase, the target of benzothiazinones and dinitrobenzamides, is an essential enzyme in Mycobacterium smegmatis, PLoS ONE [P], vol 6, issue 2 (Art. No: e16869), Public Library of Science, USA, pp. 1-8.

Botte, C., Yamaryo-Botte, Y., Janouskovec, J., Rupasinghe, T., Keeling, P., Crellin, P., Coppel, R., Marechal, E., McConville, M., McFadden, G., 2011, Identification of plant-like galactolipids in Chromera velia, a photosynthetic relative of malaria parasites, Journal Of Biological Chemistry [P], vol 286, issue 34, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 29893-29903.

Scoble, J.A., McAlister, A.D., Fulton, Z.J., Troy, S.T., Byres, E., Vivian, J., Brammananth, R., Wilce, M.C.J., Le Nours, J., Zaker-Tabrizi, L., Coppel, R.L., Crellin, P., Rossjohn, J., Beddoe, T.C., 2010, Crystal structure and comparative functional analyses of a Mycobacterium aldo-keto reductase, Journal of Molecular Biology [P], vol 398, issue 1, Academic Press, UK, pp. 26-39.

Morita, Y.S., Yamaryo, Y., Miyanagi, K., Callaghan, J.M., Patterson, J.H., Crellin, P., Coppel, R.L., Billman-Jacobe, H., Kinoshita, T., McConville, M.J., 2010, Stress-induced synthesis of phosphatidylinositol 3-phosphate in mycobacteria, Journal Of Biological Chemistry [P], vol 285, issue 22, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 16643-16650.

Crellin, P., Vivian, J., Scoble, J.A., Chow, F.M., West, N.P., Brammananth, R., Proellocks, N.I., Shahine, A.E., Le Nours, J., Wilce, M.C., Britton, W.J., Coppel, R.L., Rossjohn, J., Beddoe, T.C., 2010, Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability, Journal Of Biological Chemistry [P], vol 285, issue 39, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 30050-30060.

Lyras, D., Adams, V.M., Ballard, S.A., Teng, W.L., Howarth, P., Crellin, P., Bannam, T.L., Songer, J., Rood, J.I., 2009, tISCpe8, an IS1595-family lincomycin resistance element located on a conjugative plasmid in Clostridium perfringens, Journal Of Bacteriology [P], vol 191, issue 20, American Society for Microbiology, USA, pp. 6345-6351.

Lea-Smith, D.J., Martin, K., Pyke, J.S., Tull, D., McConville, M.J., Coppel, R.L., Crellin, P., 2008, Analysis of a new mannosyltransferase required for the synthesis of phosphatidylinositol mannosides and lipoarbinomannan reveals two lipomannan pools in corynebacterineae, Journal of Biological Chemistry, vol 283, issue 11, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 6773-6782.

Fulton, Z.J., McAlister, A.D., Wilce, M.C., Brammananth, R., Zaker-Tabrizi, L., Perugini, M.A., Bottomley, S.P., Coppel, R.L., Crellin, P., Rossjohn, J., Beddoe, T.C., 2008, Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species, Journal of Biological Chemistry, vol 283, issue 41, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 27881-27890.

Fulton, Z.J., Crellin, P., Brammananth, R., Zaker-Tabrizi, L., Coppel, R.L., Rossjohn, J., Beddoe, T.C., 2008, Expression, purification, crystallization and preliminary X-ray characterization of a putative glycosyltransferase of the GT-A fold found in mycobacteria, Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, vol 64, issue Pt 5, Wiley-Blackwell Munksgaard, Denmark, pp. 428-431.

Crellin, P., Kovacevic, S., Martin, K.L., Brammananth, R., Morita, Y.S., Billman-Jacobe, H., McConville, M.J., Coppel, R.L., 2008, Mutations in pimE restore lipoarabinomannan synthesis and growth in a Mycobacterium smegmatis lpqW mutant, Journal of Bacteriology, vol 190, issue 10, American Society for Microbiology, USA, pp. 3690-3699.

Lea-Smith, D.J., Pyke, J.S., Tull, D., McConville, M.J., Coppel, R.L., Crellin, P., 2007, The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan, Journal of Biological Chemistry, vol 282, issue 15, American Society of Biochemistry & Molecular Biology Inc, Bethesda MD USA, pp. 11000-11008.

Marland, Z., Beddoe, T.C., Zaker-Tabrizi, L., Lucet, I., Brammananth, R., Whisstock, J.C., Wilce, M.C.J., Coppel, R.L., Crellin, P.K., Rossjohn, J., 2006, Hijacking of a substrate-binding protein scaffold for use in mycobacterial cell wall biosynthesis, Journal of Molecular Biology, vol 359, issue 4, Academic Press Ltd Elsevier Science Ltd, London UK, pp. 983-997.

Liu, D., Crellin, P., Chalmers, R., 2005, Cyclic changes in the affinity of protein-DNA interactions drive the progression and regulate the outcome of the Tn 10 transposition reaction, Nucleic Acids Research, vol 33, issue 6, Oxford University Press, Oxford UK, pp. 1982-1992.

Marland, Z., Beddoe, T.C., Zaker-Tabrizi, L., Coppel, R.L., Crellin, P., Rossjohn, J., 2005, Expression, purification, crystallization and preliminary X-ray diffraction analysis of an essential lipoprotein implicated in cell-wall biosynthesis in Mycobacteria, Acta Crystallographica, vol 61, issue 12, Blackwell Publishing, Oxford England, pp. 1081-1083.

Matsoso, L., Kana, B.D., Crellin, P., Lea-Smith, D.J., Pelosi, A., Powell, D.R., Dawes, S.S., Rubin, H., Coppel, R.L., Mizrahi, V., 2005, Function of the cytochrome bc1-aa3 branch of the respiratory network in mycobacteria and network adaptation occurring in response to its disruption, Journal of Bacteriology, vol 187, issue 18, American Society for Microbiology, USA, pp. 6300-6308.

Crellin, P., Sewitz, S., Chalmers, R., 2004, DNA looping and catalysis: the IHF-folded arm of Tn10 promotes conformational changes and hairpin resolution, Molecular Cell, vol 13, Cell Press, Massachusetts USA, pp. 537-547.

Sewitz, S., Crellin, P., Chalmers, R., 2003, The positive and negative regulation of Tn10 transposition by IHF is mediated by structurally asymmetric transposon arms, Nucleic Acids Research, vol 31, issue 20, Oxford University Press, Oxford UK, pp. 5868-5876.

Crellin, P., Chalmers, R., 2001, Protein-DNA contacts and conformational changes in the Tn10 transpososome during assembly and activation for cleavage, The EMBO Journal, vol 20, issue 14, Nature Publishing Group, New York USA, pp. 3882-3891.

Chalmers, R., Sewitz, s., Lipkow, K., Crellin, P., 2000, Complete nucleotide sequence of Tn10, Journal of Bacteriology, vol 182, issue 10, American Society for Microbiology, Washington DC USA, pp. 2970-2972.

Billington, S.J., Huggins, A.S., Johanesen, P.A., Crellin, P.K., Cheung, J., Katz, M.E., Wright, C.L., Haring, V., Rood, J.I., 1999, Complete nucleotide sequence of the 27-kilobase virulence related locus ("vrl") of "Dichelobacter nodosus": evidence for extrachromosomal origin, Infection and Immunity, vol 67 issue 3, American Society for Microbiology, Washington USA, pp. 1277-1286.

Lyras, D., Storie, C., Huggins, A.S., Crellin, P.K., Bannam, T.L., Rood, J.I., 1998, Chloramphenicol resistance in Clostridium difficile is encoded on Tn4453 transposons that are closely related to Tn4451 from Clostridium perfringens, Antimicrobial Agents and Chemotherapy, vol 42 no 7, American Society for Microbiology, Washington USA, pp. 1563-1567.

Crellin, P.K., Rood, J.I., 1998, Tn4451 from Clostridium perfringens is a mobilizable transposon that encodes the functional Mob protein, TnpZ, Molecular Microbiology, vol 27 no 3, Blackwell Science Ltd, Oxford UK, pp. 631-642.

Crellin, P.K., Rood, J.I., 1997, The resolvase / invertase domain of the site - specific recombinase TnpX is functional and recognizes a target sequence that resembles the junction of the circular form of the Clostridium perfringens transposon Tn4451, Journal of Bacteriology, vol 179, American Society for Microbiology, Washington DC, pp. 5148-5156.

Conference Proceedings

Rood, J.I., Lyras, D., Crellin, P.K., 1998, Mobilisable transposons from the clostridia, Microbiology Australia, Hobart 27 September - 2 October 1998, Ink Press International, Subiaco WA Australia, p. S50.3.

Crellin, P.K., Rood, J.I., 1997, Evidence that Tn4451 from Clostridium perfringens is a mobilizable transposon, Clostridia 97 - Pathogenesis, Onzain, France, 22-25/06/97, Societe Francaise de Microbiologie, Paris France, p. 28.

Lyras, D., Crellin, P.K., Rood, J.I., 1997, Functional analysis of chloramphenicol resistance transposons from Clostridium perfringens and Clostridium difficile, Clostridia 97 - Pathogenesis, 41150 Onzain, France, 22-25/06/97, Societe Francaise de Microbiologie, Paris, p. 27.

Rood, J.I., Crellin, P.K., Lyras, D., 1997, Site-specific excision and mobilisation of clostridial chloramphenicol resistance transposons, Transposition and site-specific recombination, Santa Fe, New Mexico, 01-07/03/97, Keystone Symposia, Silverthorne CO, p. 36.

Other

Crellin, P.K., 1998, Functional analysis of the clostridial transposon Tn4451.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigation processes of Mycobacterial cell wall Biosynthesis.

Supervisors:

Coppel, R (Joint-co), Crellin, P (Joint).

Completed Supervision

Student:

Lea-Smith, D.

Program of Study:

The identification and characterisation of novel cell wall genes in Corynebacterineae. (PHD) 2006.

Supervisors:

Coppel, R (Main), Crellin, P (Associate).