Dr Andre Samson - Researcher Profile

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Address

Australian Centre for Blood Diseases
6th Floor, Burnet Tower, The Alfred Hospital

Biography

Dr Samson was awarded his PhD in 2007. Dr Andre Samson is currently a Research Fellow employed by the Australian Centre for Blood Diseases (ACBD) at the Monash University's Alfred Hospital (AMREP) Campus. Dr Samson's main research interests are in studying the mechanisms and consequences of tissue injury and cell death.

 

 

 

Of particular note, Dr Samson discovered that end-stage cell death triggers rapid "en masse" aggregation of numerous intracellular proteins. This novel form of protein aggregation occurs irrespective of cell type or mechanism of cell death and, importantly, occurs in vivo in both human and mouse tissues following acute injury. The importance of this protein aggregation event to host responses to tissue injury is a continuing theme of Dr Samson's research.

Beyond this main research activity, Dr Samson is also interested in how blood-derived factors influence neuronal cell viability.

Dr Samson's particular areas of technical expertise include advanced microscopy, primary neuronal cell culturing, cellular toxicity assays and various protein-based biochemical assays.

Keywords

DAMPs, NMDA receptor, primary neuronal cultures, neurotoxicity, apoptosis, necrosis, proteolysis, dead cell removal, plasminogen activation, fibrinolysis, confocal microscopy, tissue injury, cell death, protein misfolding, protein misfolding, neurotrauma, stroke

Qualifications

DOCTOR OF PHILOSOPHY
Institution: Monash University
Year awarded: 2007
BACHELOR OF SCIENCE (HONOURS)
Institution: Monash University
Year awarded: 2002

Publications

Journal Articles

Deliyanti, D., Miller, A.G., Tan, G., Binger, K., Samson, A.L., Wilkinson-Berka, J.L., 2012, Neovascularization is attenuated with aldosterone synthase inhibition in rats with retinopathy, Hypertension [P], vol 59, issue 3, Lippincott Williams & Wilkins, USA, pp. 607-613.

Samson, A.L., Knaupp, A.S., Sashindranath, M., Borg, R.J., Au, A.E., Cops, E.J., Saunders, H.M., Cody, S.H., McLean, C., Nowell, C.J., Hughes, V.A., Bottomley, S.P., Medcalf, R.L., 2012, Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin, Cell Reports [E], vol 2, issue 4, Cell Press, USA, pp. 889-901.

Sashindranath, M., Sales, E., Daglas, M., Freeman, R., Samson, A.L., Cops, E., Beckham, S.A., Galle, A.A., McLean, C., Morganti-Kossmann, M.C., Rosenfeld, J.V., Madani, R., Vassalli, J., Su, E.J., Lawrence, D.A., Medcalf, R.L., 2012, The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans, Brain [P], vol 135, issue Part 11, Oxford University Press, United Kingdom, pp. 3251-3264.

Sashindranath, M., Samson, A., Downes, C.E., Crack, P., Lawrence, A.J., Li, Q., Ng, A.Q.P., Jones, N.C., Farrugia, J., Abdella, E., Vassalli, J., Madani, R., Medcalf, R., 2011, Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation, Laboratory Investigation [P], vol 91, issue 7, Nature Publishing Group, United Kingdom, pp. 1079-1091.

Liu, Y., Gao, X., Fang, L., Jennings, N., Su, Y., Xu, Q., Samson, A., Kiriazis, H., Wang, X., Shan, L., Sturgeon, S., Medcalf, R., Jackson, S., Dart, A., Du, X., 2011, Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction, Arteriosclerosis, Thrombosis, and Vascular Biology [E], vol 31, issue 4, Lippincott Williams & Wilkins, United States, pp. 834-841.

Niego, B., Samson, A., Petersen, K., Medcalf, R., 2011, Thrombin-induced activation of astrocytes in mixed rat hippocampal cultures is inhibited by soluble thrombomodulin, Brain Research [P], vol 1381, Elsevier BV, Netherlands, pp. 38-51.

Samson, A.L., Borg, R.J., Niego, B., Wong, C.H., Crack, P.J., Yongqing, T., Medcalf, R.L., 2009, A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury, Blood [P], vol 114, issue 9, American Society of Hematology, USA, pp. 1937-1946.

Samson, A.L., Nevin, S.T., Medcalf, R.L., 2008, Low molecular weight contaminants in commercial preparations of plasmin and t-PA activate neurons, Journal of Thrombosis and Haemostasis, vol 6, issue 12, Wiley-Blackwell Publishing Ltd., United Kingdom, United States, pp. 2218-2220.

Samson, A.L., Nevin, S.T., Croucher, D., Niego, B., Daniel, P.B., Weiss, T.W., Moreno, E., Monard, D., Lawrence, D.A., Medcalf, R.L., 2008, Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function, Journal of Neurochemistry, vol 107, issue 4, Wiley-Blackwell Publishing Ltd., UK, USA, pp. 1091-1101.

Daniel, P.B., Lux, W., Samson, A.L., Schleuning, W., Niego, B., Weiss, T.W., Tjarnlung-Wolf, A., Medcalf, R.L., 2007, Two conserved regions within the tissue-type plasminogen activator gene promoter mediate regulation by brain-derived neurotrophic factor, FEBS Journal, vol 274, issue 9, Blackwell Publishing, UK, pp. 2411-2423.

Weiss, T.W., Samson, A.L., Niego, B., Daniel, P.B., Medcalf, R.L., 2006, Oncostatin M is a neuroprotective cytokine that inhibits excitotoxic injury in vitro and in vivo, The FASEB Journal, vol 20, issue 13, Federation of American Societies for Experimental Biology, USA, pp. 2369-2371.

Samson, A.L., Medcalf, R.L., 2006, Tissue-type plasminogen activator: a multifaceted modulator of neurotransmission and synaptic plasticity, Neuron, vol 50, issue 5, Cell Press, Cambridge USA, pp. 673-678.

Liberatore, G.T., Samson, A.L., Bladin, C., Schleuning, W., Medcalf, R.L., 2003, Vampire bat salivary plasminogen activator (desmoteplase) - a unique fibrinolytic enzyme that does not promote neurodegeneration, Stroke, vol 34, issue 2, Lippincott Williams & Wilkins, Philadelphia USA, pp. 537-543.

Teaching Commitment

Since 2010 Dr. Samson has contributed to the 3rd year Human Pathology course offered through the Faculty of Science. Each year, Dr. Samson gives a lecture, designs and delivers a practical examination class, sets an essay topic and marks written examination answers.

Activities

Organised major conferences outside the Faculty

From: 10/02/2014 To: 15/02/2014
Gordon Research Conference, Plasminogen Activation and Extra...
appointed vice-chair for the Gordon Research Seminar on Plasminogen Activation

Awards

Academic prizes (national, international)

From: 10/02/0008 To: 15/02/0008
Gordon Research Conference, Plasminogen Activation and Extra...
Top Poster Prize at international GRC on plasminogen activation and extracellular proteolysis

Postgraduate Research Supervisions

Current Supervision

Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Investigating the effects of platelet-released factors (PRFs) on the brain.
Supervisors:
Medcalf, R (Main), Samson, A (Associate).

Completed Supervision

Student:
Borg, R.
Program of Study:
The role of the plasminogen activating system in the proteolytic and phagocytic clearance of non-viable cells. (PHD) 2012.
Supervisors:
Medcalf, R (Main), Samson, A (Associate).