Dr Natalie Trevaskis - Researcher Profile

Biography

Position

Lecturer
Research Fellow
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

Qualifications

PHD

Institution: Monash University

Year awarded: 2006

PHARMACY (WITH HONOURS)

Institution: Monash University

Year awarded: 2002

Publications

Journal Articles

Caliph, S.M., Trevaskis, N., Charman, W.N., Porter, C.J., 2012, Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies, Journal of Pharmaceutical Sciences [P], vol 101, issue 9, Wiley-Blackwell, Malden, Massachusetts USA, pp. 3540-3546.

Trevaskis, N., Charman, W., Porter, C., 2011, Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption, Molecular Pharmaceutics [P], vol 8, American Chemical Society, USA, pp. 1132-1139.

Trevaskis, N., Nguyen, G., Scanlon, M., Porter, C., 2011, Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte?, Pharmaceutical Research [P], vol 28, issue 9, Kluwer Academic/Plenum Publishers, USA, pp. 2176-2190.

Trevaskis, N., Charman, W., Porter, C., 2010, Targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?, Molecular Pharmaceutics [P], vol 7, issue 6, American Chemical Society, United States, pp. 2297-2309.

Trevaskis, N., Shanker, R., Charman, W.N., Porter, C.J., 2010, The mechanism of lymphatic access of two cholesteryl ester transfer protein inhibitors (CP524,515 and CP532,623) and evaluation of their impact on lymph lipoprotein profiles, Pharmaceutical Research [P], vol 27, issue 9, Springer, USA, pp. 1949-1964.

Trevaskis, N., McEvoy, C.L., McIntosh, M.P., Edwards, G.A., Shanker, R., Charman, W.N., Porter, C.J., 2010, The role of the intestinal lymphatics in the absorption of two highly lipophilic cholesterol ester transfer protein inhibitors (CP524,515 and CP532,623), Pharmaceutical Research [E], vol 27, Springer Science, USA, pp. 878-893.

Trevaskis, N., Shackleford, D., Charman, W.N., Edwards, G.A., Gardin, A., Appel-Dingemanse, S., Kretz, O., Galli, B., Porter, C.J., 2009, Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism, Pharmaceutical Research [P], vol 26, issue 6, Springer New York LLC, USA, pp. 1486-1495.

Trevaskis, N., Charman, W.N., Porter, C.J., 2008, Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update, Advanced Drug Delivery Reviews, vol 60, issue 6, Elsevier BV, Netherlands, pp. 702-716.

Porter, C.J., Trevaskis, N., Charman, W.N., 2007, Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs, Nature Reviews - Drug Discovery, vol 6, issue 14, Nature Publishing Group, UK, pp. 231-248.

Trevaskis, N.L., Lo, C., Ma, L., Tso, P., Irving, H.R., Porter, C.J.H., Charman, W.N., 2006, An acute and coincident increase in FABP expression and lymphatic lipid and drug transport occurs during intestinal infusion of lipid-based drug formulations to rats, Pharmaceutical Research, vol 23, issue 8, Springer New York LLC, USA, pp. 1786-1796.

Trevaskis, N., Porter, C.J.H., Charman, W.N., 2006, An examination of the interplay between enterocyte-based metabolism and lymphatic drug transport in the rat, Drug Metabolism and Disposition, vol 34, issue 5, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 729-733.

Trevaskis, N., Porter, C.J.H., Charman, W.N., 2006, The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport, The Journal of Pharmacology and Experimental Therapeutics, vol 316, issue 2, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 881-891.

Trevaskis, N.L., Tso, P., Rider, T., Charman, W.N., Porter, C.J.H., Jandacek, R., 2006, Tissue uptake of DDT is independent of chylomicron metabolism, Archives of Toxicology, vol 80, issue 4, Springer, Germany, pp. 196-200.

Trevaskis, N., Porter, C.J.H., Charman, W.N., 2005, Bile increases intestinal lymphatic drug transport in the fasted rat, Pharmaceutical Research, vol 22, issue 11, Springer, USA, pp. 1863-1870.

Teaching Commitment

• Lecturer in non-linear pharmacokinetics
• Pharmaceutics tutorials (pharmacokinetics, drug delivery, biopharmaceutics and drug formulations)

Activities

Affiliations with institutes

Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Drug delirem/drug targeting to lumocytes via the intestional lymph.

Supervisors:

Porter, C (Main), Trevaskis, N (Associate).