Dr Sophocles Chrissobolis - Researcher Profile

Biography

Dr Sophocles Chrissobolis completed his PhD at the University of Melbourne in the Department of Pharmacology where he investigated how potassium channels and rho-kinase are involved in cerebral vascular function under normal conditions and during chronic hypertension. In 2004, he was awarded an NHMRC CJ Martin Overseas Training Fellowship to work at the University of Iowa in the United States under the mentorship of Professor Frank Faraci. In 2005 he was awarded the Chancellor's prize at the University of Melbourne for excellence in his PhD thesis. While in Iowa, Dr Chrissobolis studied the involvement of antioxidant defence mechanisms in protecting against vascular dysfunction caused by angiotensin II. The American Heart Association awarded Dr Chrissobolis a Postdoctoral Fellowship in 2007 to continue his work at Iowa. Currently under the mentorship of A/Prof Chris Sobey, Dr Chrissobolis joined the Vascular Biology and Immunopharmacology group in 2009. Of Dr Chrissobolis' 17 publications to date, 9 are in journals of the American Heart Association. His current research is focused on mechanisms by which aldosterone and angiotensin II are involved in cerebrovascular disease.

Qualifications

PHD

Institution: The University of Melbourne

Year awarded: 2004

BACHELOR OF SCIENCE (HONOURS)

Institution: The University of Melbourne

Year awarded: 2000

Publications

Journal Articles

Dinh, Q.N., Arumugam, T.V., Young, M.J., Drummond, G.R., Sobey, C.G., Chrissobolis, S., 2012, Aldosterone and the mineralocorticoid receptor in the cerebral circulation and stroke, Experimental & Translational Stroke Medicine [E], vol 4, issue 1 (Art. No.: 21), BioMed Central Ltd, UK, pp. 1-21.

Chrissobolis, S., Banfi, B., Sobey, C.G., Faraci, F.M., 2012, Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain, Journal Of Applied Physiology [P], vol 113, issue 2, American Physiological Society, USA, pp. 184-191.

Chrissobolis, S., Miller, A.A., Drummond, G.R., Kemp-Harper, B.K., Sobey, C.G., 2011, Oxidative stress and endothelial dysfunction in cerebrovascular disease, Frontiers in Bioscience [P], vol 16, Frontiers in Bioscience, USA, pp. 1733-1745.

Jackman, K.A., Woodman, O.L., Chrissobolis, S., Sobey, C.G., 2007, Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries, Brain Research [P], vol 1141, Elsevier BV, The Netherlands, pp. 99-107.

Chrissobolis, S., Sobey, C.G., 2006, Recent evidence for an involvement of rho-kinase in cerebral vascular disease, Stroke, vol 37, issue 8, Lippincott Williams & Wilkins, Philadelphia Pennsylvania USA, pp. 2174-2180.

Chrissobolis, s., Budzyn, K., Marley, P.D., Sobey, C.G., 2004, Evidence that estrogen suppresses Rho-kinase function in the cerebral circulation in vivo, Stroke, vol 35, Lippincott Williams & Wilkins, Philadelphia USA, pp. 2200-2205.

Paravicini, T.M., Chrissobolis, S., Drummond, G.R., Sobey, C.G., 2004, Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo, Stroke, vol 35, Lippincott Williams & Wilkins, Philadelphia USA, pp. 584-589.

Paravicini, T.M., Chrissobolis, S., Drummond, G.R., Sobey, C.G., 2004, Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo, Stroke, vol 35, issue 2, Lippincott Williams & Wilkins, Philadelpha PA USA, pp. 584-589.

Chrissobolis, s., Sobey, C.G., 2004, Influence of gender on K+-induced cerebral vasodilatation, Stroke, vol 35, Lippincott Williams & Wilkins, Philadelphia USA, pp. 747-752.

Chrissobolis, S., Sobey, C.G., 2003, Inwardly rectifying potassium channels in the regulation of vascular tone, Current Drug Targets, vol 4, issue 4, Bentham Science Publishers Ltd, Sharjah UAE, pp. 281-289.

Chrissobolis, s., Sobey, C.G., 2002, Inhibitory effects of protein kinase C on inwardly rectifying K+- and ATP-sensitive K+ channel-mediated responses of the basilar artery, Stroke, vol 33, Lippincott Williams & Wilkins, Philadephia USA, pp. 1692-1697.

Chrissobolis, S., Ziogas, J., Anderson, C.R., Chu, Y., Faraci, F.M., Sobey, C.G., 2002, Neuronal NO mediates cerebral vasodilator responses to K+ in hypertensive rats, Hypertension, vol 39, issue 4, Lippincott Williams & Wilkins, Philadelphia, PA, USA, pp. 880-885.

Faraci, F.M., Sobey, C.G., Chrissobolis, S., Lund, D.D., Heistad, D.D., Weintraub, N.L., 2001, Arachidonate dilates basilar artery by lipoxygenase-dependent mechanism and activation of K+ channels, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol 281, issue 1, American Physiological Society, Bethesda MD USA, pp. R246-R253.

Chrissobolis, s., Sobey, C.G., 2001, Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C, Circulation Research, vol 88, Lippincott Williams & Wilkins, USA, pp. 774-779.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Mechanisms contributing to cerebrovascular disease and stroke.

Supervisors:

Sobey, C (Main), Chrissobolis, S (Associate).