Dr Sue Xiang - Researcher Profile

Biography

Sue works in the Department of Immunology, Central Clinical School, Faculty of Medicine, Nursing & Health Sciences at Monash University as a Senior Research Manager/Senior Research Fellow. The broad goal of her work is to develop nanovaccines for infectious diseases and cancer. More specifically, 1) study nanoparticles (such as  polymeric particles, solid core nanoparticles, magnetic nanoparticles etc.) and their functions in immunomodulations and vaccine delivery; 2) progress the nanovaccine formulations to human clinical trials.

Keywords

n,n'-carbonyldiimidazole; superparamagnetic nanoparticles; magnetite; particulate vaccine carrier, nanovaccine, nanoparticles, immunology, dendritic cells, vaccine, immunotherapy, immunity, type 1 and 2 immunity; nanobead size; ovalbumin; rsv vaccine; mice

Qualifications

GRAD. DIPLOMA IN COPORATE GOVERNANCE

Institution: Australian Institute of Company Directors

Year awarded: 2006

DOCTOR OF PHILOSOPHY

Institution: University of Sydney

Year awarded: 2000

MASTER OF SCIENCE

Institution: La Trobe University, Melbourne

Year awarded: 1992

BIOLOGICAL ENGINEERING

Institution: Jinan University, China

Year awarded: 1988

Publications

Book Chapters

Xiang, S.D., Fuchsberger, M., Karlson, T., Hardy, C.L., Selomulya, C., Plebanski, M., 2013, Nanoparticles, Immunomodulation and Vaccine Delivery, in Frontiers in Nanobiomedical Research: Volume 1 Handbook of Immunological Properties of Engineered Nanomaterials, eds Marina A Dobrovolskaia and Scott E McNeil, World Scientific, USA, pp. 449-476.

Journal Articles

Al-deen, F.M.N., Ma, C.W.C., Xiang, S.D., Selomulya, C., Plebanski, M., Coppel, R.L., 2013, On the efficacy of malaria DNA vaccination with magnetic gene vectors, Journal of Controlled Release [P], vol 168, issue 1, Elsevier Science BV, Netherlands, pp. 10-17.

Hardy, C., LeMasurier, J., Belz, G., Scalzo-Inguanti, K., Yao, J., Xiang, S., Kanellakis, P., Bobik, A., Strickland, D.H., Rolland, J., O'Hehir, R., Plebanski, M., 2012, Inert 50-nm polystyrene nanoparticles that modify pulmonary dendritic cell function and inhibit allergic airway inflammation, Journal of Immunology [E], vol 188, issue 3, American Association of Immunologists, USA, pp. 1431-1441.

Park, A., Govindaraj, C., Xiang, S.D., Halo, J., Quinn, M., Scalzo-Inguanti, K., Plebanski, M., 2012, Substantially modified ratios of effector to regulatory T cells during chemotherapy in ovarian cancer patient return to pre-treatment levels at completion: implications for immunology, Cancers [E], vol 4, M D P I AG, Switzerland, pp. 581-600.

Xiang, S.D., Selomulya, C., Ho, J., Apostolopoulos, V., Plebanski, M., 2010, Delivery of DNA vaccines: an overview on the use of biodegradable polymeric and magnetic nanoparticles, Wiley Interdisciplinary Reviews:Nanomedicine and Nanobiotechnology [P], vol 2, issue 3, John Wiley & Sons, United States, pp. 205-218.

Plebanski, M., Katsara, M., Sheng, K., Xiang, S., Apostolopoulos, V., 2010, Methods to measure T-cell responses, Expert Review of Vaccines [P], vol 9, issue 6, Expert Review Ltd, UK, pp. 595-600.

Ho, J., Al-deen, F., Al-Abboodi, A., Selomulya, C., Xiang, S., Plebanski, M., Forde, G., 2010, N,N'-Carbonyldiimidazole-mediated functionalization of superparamagnetic nanoparticles as vaccine carrier, Colloids and Surfaces B: Biointerfaces [P], vol 83, issue 1, Elsevier Science BV, Netherlands, pp. 83-90.

Proudfoot, O., Drew, N., Scholzen, A., Xiang, S.D., Plebanski, M., 2008, Investigation of a novel approach to scoring Giemsa-stained malaria-infected thin blood films, Malaria Journal, vol 7, issue 62, BioMed Central Ltd, United Kingdom, pp. 1-6.

Xiang, S.D., Scalzo-Inguanti, K., Minigo, G., Park, A., Hardy, C.L., Plebanski, M., 2008, Promising particle-based vaccines in cancer therapy, Expert Review of Vaccines, vol 7, issue 7, Expert Reviews Ltd., United Kingdom, pp. 1103-1119.

Greenwood, D.L., Dynon, K., Kalkanidis, M., Xiang, S.D., Plebanski, M., Scheerlinck, J., 2008, Vaccination against foot-and-mouth disease virus using peptides conjugated to nano-beads, Vaccine, vol 26, issue 22, Elsevier Ltd, United Kingdom, pp. 2706-2713.

Mottram, P.L., Leong, D., Crimeen-Irwin, B., Gloster, S., Xiang, S.D., Meanger, J., Ghildyal, R., Vardaxis, N.J., Plebanski, M., 2007, Type 1 and 2 immunity following vaccination is influenced by nanoparticle size: formulation of a model vaccine for respiratory syncytial virus, Molecular Pharmaceutics, vol 4, issue 1, American Chemical Society, USA, pp. 73-84.

Kalkanidis, M., Pietersz, G.A., Xiang, S.D., Mottram, P.L., Crimeen-Irwin, B., Ardipradja, K., Plebanski, M., 2006, Methods for nano-particle based vaccine formulation and evaluation of their immunogenicity, Methods [P], vol 40, issue 1, Academic Press, United States, pp. 20-29.

Xiang, S.D., Scholzen, A., Minigo, G., David-Shields, C., Apostolopoulos, V., Mottram, P.L., Plebanski, M., 2006, Pathogen recognition and development of particulate vaccines: Does size matter?, Methods [P], vol 40, issue 1, Academic Press, United States, pp. 1-9.

Gamvrellis, A., Leong, D., Hanley, J.C., Xiang, S.D., Mottram, P.L., Plebanski, M., 2004, Vaccines that facilitate antigen entry into dendritic cells, Immunology And Cell Biology [P], vol 82, issue 5, Nature Publishing Group, United Kingdom, pp. 506-516.

Xiang, S., Denver, R.A., Bailey, M.J., Krum, H., 2003, Physiologic determinants of endothelin concentrations in human saliva, Clinical Chemistry, vol 49, issue 12, American Association for Clinical Chemistry, Washington USA, pp. 2012-2019.

Xiang, S., Allman, B., Porter, C., 2003, Quantitative phase imaging: Extending imaging capability, American Laboratory [P], vol 35, issue 3, International Scientific Communications, Inc., United States, pp. 58-67.

Xiang, S., Benson, E., Dunn, I., 2001, Tracking membrane and secretory immunoglobulin alpha heavy chain mRNA variation during B-cell differentiation by real-time quantitative polymerase chain reaction, Immunology And Cell Biology [P], vol 79, issue 5, BLACKWELL SCIENCE ASIA, 54 UNIVERSITY ST, P O BOX 378, CARLTON, VICTORIA 3053, AUSTRALIA, pp. 472-481.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Developing a therapeutic nano-vaccine against ovarian cancer.

Supervisors:

Plebanski, M (Joint-co), Xiang, S (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of TNFR2 T cells in human disease.

Supervisors:

Plebanski, M (Main), Xiang, S (Associate).