Dr Claire Hirst - Researcher Profile

Biography

Claire works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

SCIENCE

Institution: Monash University

Year awarded: 2005

Publications

Journal Articles

Costa, M., Sourris, K., Lim, S.M., Yu, Q.C., Hirst, C.E., Parkington, H.C., Jameson, V.J., Dear, A.E., Liu, H.B., Micallef, S.J., Koutsis, K., Elefanty, A.G., Stanley, E., 2013, Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization, Stem Cell Research [P], vol 10, issue 1, Elsevier BV, The Netherlands, pp. 103-117.

Yu, Q.C., Hirst, C.E., Costa, M., Ng, E.S.S., Schiesser, J.V., Gertow, K.A., Stanley, E.G., Elefanty, A.G., 2012, APELIN promotes hematopoiesis from human embryonic stem cells, Blood [P], vol 119, issue 26, American Society of Hematology, USA, pp. 6243-6254.

Micallef, S.J., Li, X., Schiesser, J.V., Hirst, C.E., Yu, Q.C., Lim, S.M., Nostro, M.C., Elliott, D.A., Sarangi, F., Harrison, L.C., Keller, G., Elefanty, A.G., Stanley, E.G., 2012, INS GFP/w human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells, Diabetologia [P], vol 55, issue 3, Springer, Germany, pp. 694-706.

Song, B., Sun, G., Herszfeld, D., Sylvain, A., Campanale, N.V., Hirst, C.E., Caine, S., Parkington, H.C., Tonta, M.A., Coleman, H.A., Short, M.A., Ricardo, S.D., Reubinoff, B., Bernard, C.C.A., 2012, Neural differentiation of patient specific iPS cells as a novel approach to study the pathophysiology of multiple sclerosis, Stem Cell Research [P], vol 8, issue 2, Elsevier BV, The Netherlands, pp. 259-273.

Pereira, L.A., Wong, M., Mossman, A.K., Sourris, K., Janes, M.E., Knezevic, K., Hirst, C.E., Lim, S.M., Pimanda, J.E., Stanley, E.G., Elefanty, A.G., 2012, Pdgfr{alpha} and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells, Stem Cell Research [P], vol 8, issue 2, Elsevier BV, Netherlands, pp. 165-179.

Elliott, D.A., Braam, S.R., Koutsis, K., S Ng, E., Jenny, R., Lagerqvist, E.L., Biben, C., Hatzistavrou, T., Hirst, C.E., Yu, Q.C., Skelton, R.J., Ward-van Oostwaard, D., Lim, S.M., Khammy, O., Li, X., Hawes, S.M., Davis, R.P., Goulburn, A.L., Passier, R., Prall, O.W., Haynes, J.M., Pouton, C.W., Kaye, D.M., Mummery, C.L., Elefanty, A.G., Stanley, E., 2011, NKX2-5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes, Nature Methods [P], vol 8, issue 12, Nature Publishing Group, UK, pp. 1037-1040.

Hirst, C.E., Lim, S.-., Pereira, L.A., Mayberry, R.A., Stanley, E.G., Elefanty, A.G., 2010, Expression from a betageo gene trap in the Slain1 gene locus is predominantly associated with the developing nervous system, International Journal of Developmental Biology [P], vol 54, issue 8-9, Universidad del Pais Vasco, Spain, pp. 1383-1388.

Heraud, P.R., Ng, E.S.S., Caine, S., Yu, Q.C., Hirst, C.E., Mayberry, R.A., Bruce, A.J., Wood, B.R., McNaughton, D., Stanley, E., Elefanty, A.G., 2010, Fourier transform infrared microspectroscopy identifies early lineage commitment in differentiating human embryonic stem cells, Stem Cell Research [P], vol 4, issue 2, Elsevier BV, The Netherlands, pp. 140-147.

Lim, S.M., Pereira, L.A., Wong, M.S., Hirst, C.E., Van Vranken, B.E., Pick, M., Trounson, A.O., Elefanty, A.G., Stanley, E., 2009, Enforced expression of mixll during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation, Stem Cells, vol 27, AlphaMed Press, Inc., United States, pp. 363-374.

Stanley, E., Micallef, S.J., Janes, M.E., Li, X., Davis, R., Davis, R.W., Davis, R.P.F., Hirst, C.E., Jackson, S.A., Jackson, S.E., Ng, E.S.M., Ng, E., Elefanty, A.G., 2006, Directed differentiation of embryonic stem cells toward pancreatic endoderm. 2.115, Cytometry Part A, vol 69A, issue 5, Wiley Liss, USA, p. 399.

Hirst, C.E., Ng, E.S., Azzola, L.S., Voss, A.K., Thomas, T., Stanley, E.G., Elefanty, A.G., 2006, Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene, Developmental Biology, vol 293, issue 1, Academic Press Inc. Elsevier Science, San Diego USA, pp. 90-103.

Hirst, C.E., Buzza, M.S., Bird, C.H., Warren, H.S., Cameron, P.U., Zhang, M., Ashton-Rickardt, P.G., Bird, P.I., 2003, The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency, The Journal of Immunology, vol 170, issue 2, American Association of Immunologists, Bethesda USA, pp. 805-815.

Bird, C., Blink, E., Hirst, C.E., Buzza, M.S., Steele, P.M., Sun, J., Jans, D.A., Bird, P.I., 2001, Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1, Molecular and Cellular Biology, vol 21, issue 16, American Society of Microbiology, Washington DC USA, pp. 5396-5407.

Hirst, C.E., Buzza, M.S., Sutton, V.R., Trapani, J.A., Loveland, K.L., Bird, P.I., 2001, Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction, Molecular Human Reproduction, vol 7, issue 12, Oxford University Press, Oxford England, pp. 1133-1142.

Buzza, M.S., Hirst, C.E., Bird, C., Hosking, P., McKendrick, J., Bird, P.I., 2001, The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses, Cellular Immunology, vol 210, issue 1, Academic Press Inc, San Diego California USA, pp. 21-29.

Scott, F.L., Hirst, C., Sun, J., Bird, C., Bottomley, S.P., Bird, P.I., 1999, The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, Cathepsin G, Blood, vol 93 issue 6, American Society of Haematology, Washington DC USA, pp. 2089-2097.

Scott, F.L., Hirst, C., Sun, J., Bird, C., Bottomley, S.P., Bird, P.I., 1999, The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule proterase, Cathepsin G, Blood, vol 93, no 6, The American Society of Hematology, USA, pp. 2089-2097.

Bird, P.I., Sun, J., Bird, C., Sutton, V.R., Hirst, C., Novak, A., Kumar, S., Trapani, J.A., 1998, Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzzyme B-mediated apoptosis without perturbing the fast cell death pathway, Mol and Cell Biology, vol 18,11, American Soc for Microbiology, USA, pp. 6387-6398.

Postgraduate Research Supervisions

Completed Supervision

Student:

Yu, Q.

Program of Study:

Expression profiling in the characterization of differentiating human embryonic stem cells. (PHD) 2012.

Supervisors:

Elefanty, A (Main), Stanley, E (Associate), Hirst, C (Associate).