Assoc Prof Frank Alderuccio - Researcher Profile

Biography

Frank works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as an Associate Professor.

Qualifications

GRADUATE CERTIFICATE IN HIGHER EDUCATION

Institution: Monash University

Year awarded: 2005

PHD: IMMUNOLOGY

Institution: Monash University

Year awarded: 1988

Publications

Book Chapters

Toh, B., Whittingham, S.F., Alderuccio, F.P., 2006, Gastritis and pernicious anemia, in The Autoimmune Diseases, eds Noel R Rose and Ian R Mackay, Elsevier, United States of America, pp. 527-546.

Toh, B.H., Sentry, J.W., Alderuccio, F.P., 2002, Autoimmune gastritis and Perniciious anemia, in The Molecular Pathology of Autoimmune Diseases, eds Theofilopoulos and Bona, Taylor and Francis, Ann Arbor MI USA, pp. 841-853.

Toh, B.H., Biondo, M., Marshall, A.J., Greenwood, D., Sentry, J.W., Alderuccio, F.P., 2002, The Gastric H/K ATPase in the pathogenesis of autoimmune gastritis, in Mechanisms and consequences of proton transport, eds Urushidani, Forte and Sachs, Kluwer Academic Publishers, Boston, pp. 107-114.

Journal Articles

Toh, B., Chan, C., Alderuccio, F., 2012, Cutting edge issues in autoimmune gastritis, Clinical Reviews in Allergy and Immunology [P], vol 42, Humana Press, USA, pp. 269-278.

Nasa, Z., Chung, J., Chan, J., Toh, B., Alderuccio, F.P., 2012, Nonmyeloablative conditioning generates autoantigen-encoding bone marrow that prevents and cures an experimental autoimmune disease, American Journal Of Transplantation [P], vol 12, issue 8, Wiley-Blackwell Publishing, Inc., United States, pp. 2062-2071.

Siatskas, C., Seach, N.L., Sun, G., Emerson-Webber, A.C., Silvain, A., Toh, B., Alderuccio, F.P., Backstrom, B.T., Boyd, R.L., Bernard, C.C., 2012, Thymic gene transfer of myelin oligodendrocyte glycoprotein ameliorates the onset but not the progression of autoimmune demyelination, Molecular Therapy [P], vol 20, issue 7, Nature Publishing Group, UK, pp. 1349-1359.

Alderuccio, F., Nasa, Z., Chung, J., Ko, H., Chan, M., Toh, B., 2011, Hematopoietic stem cell gene therapy as a treatment for autoimmune diseases, Molecular Pharmaceutics [P], vol 8, issue 5, American Chemical Society, USA, pp. 1488-1494.

Chan, J., Hosseini, H., Oh, D., Chen, X., Chan, S., Yagita, H., Alderuccio, F., Toh, B., 2011, NON-MYELOABLATIVE TRANSPLANTATION OF SELF-ANTIGEN EXPRESSING BONE MARROW PREVENTS AUTOIMMUNE DISEASE BY PERIPHERAL TOLERANCE MECHANISM, Journal Of Gene Medicine [P], vol 13, issue 7-8, JOHN WILEY & SONS LTD, USA, pp. 423-424.

Hosseini, H., Oh, D., Chan, S.T., Chen, X., Nasa, Z., Yagita, H., Alderuccio, F., Toh, B., Chan, J.M., 2011, Non-myeloablative transplantation of bone marrow expressing self-antigen establishes peripheral tolerance and completely prevents autoimmunity in mice, Gene Therapy [P], vol E, issue 0, Nature Publishing Group, USA, pp. 1-10.

Chan, J.M., Alderuccio, F., Toh, B., 2011, Transplantation of genetically modified haematopoietic stem cells to induce antigen-specific tolerance as a cure for autoimmune diseases, Current Stem Cell Research and Therapy [P], vol 6, issue 1, Bentham Science Publishers Ltd, Netherlands, pp. 44-49.

Chen, X., Chan, S.T., Hosseini, H., Layton, D.S., Boyd, R.L., Alderuccio, F.P., Toh, B., Chan, M.K.J., 2011, Transplantation of retrovirally transduced bone marrow prevents autoimmune disease in aged mice by peripheral tolerance mechanisms, Autoimmunity [P], vol 44, issue 5, Informa Healthcare, UK, pp. 384-393.

Alderuccio, F., Chan, M., Ko, H., Chung, J., Nasa, Z., Toh, B., 2010, A molecular Trojan horse: Hijacking the bone marrow to treat autoimmune diseases, Discovery medicine [P], vol 9, issue 49, Solariz, Inc, United States, pp. 512-518.

Ko, H.-., Chung, J.-., Nasa, Z., Chan, J., Siatskas, C., Toh, B.-., Alderuccio, F., 2010, Targeting MOG expression to dendritic cells delays onset of experimental autoimmune disease, Autoimmunity [P], vol 44, issue 3, Informa Healthcare, United Kingdom, pp. 177-187.

Ko, H., Kinkel, S., Hubert, F., Nasa, Z., Chan, M., Siatskas, C., Hirubalan, P., Toh, B., Scott, H., Alderuccio, F., 2010, Transplantation of autoimmune regulator-encoding bone marrow cells delays the onset of experimental autoimmune encephalomyelitis, European Journal Of Immunology [P], vol 40, issue 12, Wiley - VCH Verlag GmbH & Co. KGaA, Germany, pp. 3499-3509.

Alderuccio, F.P., Chan, M.K.J., Scott, D., Toh, B., 2009, Gene therapy and bone marrow stem-cell transfer to treat autoimmune disease, Trends in Molecular Medicine [P], vol 15, issue 8, Elsevier Ltd, United Kingdom, pp. 344-351.

Field, J., Alderuccio, F.P., Hertzog, P.J., Toh, B., 2008, GM-CSF-induced autoimmune gastritis in interferon alpha receptor deficient mice, Journal of Autoimmunity, vol 31, issue 3, Academic Press, United Kingdom, pp. 274-280.

Chan, J., Ban, E., Chun, K.H., Wang, S., McQualter, J.L., Bernard, C.C.A., Toh, B., Alderuccio, F.P., 2008, Methylprednisolone induces reversible clinical and pathological remission and loss of lymphocyte reactivity to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis, Autoimmunity, vol 41, issue 5, Informa Healthcare, United Kingdom, pp. 405-413.

Chan, J., Ban, E., Chun, K.H., Wang, S., Backstrom, B.T., Bernard, C.C.A., Toh, B., Alderuccio, F.P., 2008, Transplantation of bone marrow transduced to express self-antigen establishes deletional tolerance and permanently remits autoimmune disease., Journal of Immunology, vol 181, issue 11, American Association of Immunologists, United States, pp. 7571-7580.

Alderuccio, F.P., Chan, J., Toh, B., 2008, Tweaking the immune system: Gene therapy-assisted autologous haematopoietic stem cell transplantation as a treatment for autoimmune disease, Autoimmunity, vol 41, issue 8, Taylor & Francis Ltd, United Kingdom, pp. 679-685.

Alderuccio, F.P., Chan, J.W., Toh, B., 2007, Haematopoietic stem cell based gene therapy as a strategy to treat autoimmune disease, Advances in Gene, Molecular and Cell Therapy, vol 1, issue 2, Global Science Books, Japan, pp. 141-149.

Siatskas, C., Chan, M.K.J., Field, J., Murphy, K., Nasa, Z., Toh, B., Alderuccio, F.P., 2006, Gene therapy strategies towards immune tolerance to treat the autoimmune diseases, Current Gene Therapy, vol 6, issue 1, Bentham Science Publishers, Netherlands, pp. 45-58.

Alderuccio, F.P., Siatskas, C., Chan, M.K.J., Field, J., Murphy, K., Nasa, Z., Toh, B., 2006, Haematopoietic stem cell gene therapy to treat autoimmune disease., Current Stem Cell Research and Therapy, vol 1, Bentham Science Publishers, Netherlands, pp. 279-287.

Chan, M.K.J., Siatskas, C., Field, J., Toh, B., Alderuccio, F.P., 2006, Mechanisms and applications of stem cell gene therapy in autoimmunity, Drug Discovery Today: Disease Mechanisms, vol 3, issue 2, Elsevier Ltd, England, pp. 219-223.

Biondo, M.A., Field, J., Toh, B., Alderuccio, F.P., 2006, Prednisolone promotes remission and gastric mucosal regeneration in experimental autoimmune gastritis, Journal of Pathology, vol 209, issue 3, John Wiley & Sons Ltd, UK, pp. 384-391.

Chan, M.K.J., Clements, W., Field, J., Nasa, Z., Lock, P., Yap, F., Toh, B., Alderuccio, F.P., 2006, Transplantation of bone marrow genetically engineered to express proinsulin II protects againts autoimmune insulitis in NOD mice, The Journal of Gene Medicine, vol 8, issue 11, John Wiley & Sons, Inc., UK, pp. 1281-1290.

Field, J., Biondo, M.A., Murphy, K., Alderuccio, F.P., Toh, B., 2005, Experimental autoimmune gastritis: mouse models of human organ-specific autoimmune disease, International Reviews of Immunology, vol 24, issue 1-2, Taylor & Francis Inc., USA, pp. 93-110.

Alderuccio, F.P., Field, J., Murphy, K., Biondo, M.A., Chan, J.W., Toh, B., 2005, Gene therapy to induce immunological tolerance for autoimmune disease, Tissue Antigens, vol 66, issue 5, Blackwell Publishing, Oxford England, pp. 344-345.

Marshall, A.J., Alderuccio, F.P., Murphy, K., Toh, B., 2005, Mechanisms of gastric mucosal cell loss in autoimmune gastritis, International Reviews of Immunology, vol 24, issue 1-2, Taylor & Francis Inc., USA, pp. 123-134.

Alderuccio, F.P., Murphy, K., Biondo, M.A., Field, J., Toh, B., 2005, Reversing the autoimmune condition: experience with experimental autoimmune gastritis, International Reviews of Immunology, vol 24, issue 1-2, Taylor & Francis Inc., USA, pp. 135-155.

Murphy, K., Chan, J.W., Toh, B., Alderuccio, F.P., 2005, The role of CD4(+)CD25(+) T regulatory cells in experimental autoimmune gastritis, Tissue Antigens, vol 66, issue 5, Blackwell Publishing, Oxford England, pp. 499-500.

Chan, J.W., Toh, B., Alderuccio, F.P., 2005, Transplantation of bone marrow engineered to express proinsulin II prevents insulitis in NOD mice, Tissue Antigens, vol 66, issue 5, Blackwell Publishing, Oxford England, p. 374.

Alderuccio, F.P., Toh, B., 2004, Induction of tolerance to self-antigens using genetically modified bone marrow cells, Expert Opinion on Biological Therapy, vol 4, issue 7, Ashley Publications Ltd, UK, pp. 1007-1014.

Toh, B., Alderuccio, F.P., 2004, Pernicious Anaemia, Autoimmunity, vol 37, issue 4, Taylor & Francis Ltd, UK, pp. 357-361.

Marshall, A.J., Toh, B., Alderuccio, F.P., 2004, Tumor necrosis factor alpha is not implicated in the genesis of experimental autoimmune gastritis, Journal of Autoimmunity, vol 22, issue 1, Academic Press, UK, pp. 1-11.

Field, J., Marshall, A.C.J., Hertzog, P.J., Wells, T.N., Alderuccio, F.P., Toh, B., 2003, Chemokine receptor CCR5 is not required for development of experimental autoimmune gastritis, Clinical Immunology, vol 109, issue 2, Academic Press Inc Elsevier Science, San Diego USA, pp. 238-247.

Alderuccio, F.P., Murphy, K., Toh, B., 2003, Stem cells engineered to express self-antigen to treat autoimmunity, Trends in Immunology, vol 24, issue 4, Elsevier Science Ltd, Oxford UK, pp. 176-180.

Murphy, K., Biondo, M.A., Toh, B., Alderuccio, F.P., 2003, Tolerance established in autoimmune disease by mating or bone marrow transplantation that target autoantigen to thymus, International Immunology, vol 15, issue 2, Oxford University Press, Oxford UK, pp. 269-277.

Alderuccio, F., Sentry, J.W., Marshall, A.J., Biondo, M., Toh, B.H., 2002, Animal models of human diseases: Experimental Autoimmune Gastritis: A model for autoimmune gastritis and pernicious anemia, Clinical Immunology, vol 102, issue 1, Academic Press Incorporating Elsevier Science, San Diego CA USA, pp. 48-52.

Greenwood, D., Gitlits, V.M., Alderuccio, F., Sentry, J.W., Toh, B.H., 2002, Autoantibodies in Neuropsychiatric Lupus, Autoimmunity, vol 35, issue 2, Taylor & Francis Ltd, Milton Park Abingdon UK, pp. 79-86.

Marshall, A.J., Alderuccio, F., Toh, B., 2002, Fas/CD95 is required for gastric mucosal damage in autoimmune gastritis, Gastroenterology, vol 123, issue 3, WB Saunders Co., Philadelphia USA, pp. 780-789.

Alderuccio, F., Biondo, M., Toh, B.H., 2002, Organ-specific autoimmunity in Granulocyte Macrophage-colony stimulating Factor (GM-CSF) deficient mice, Autoimmunity, vol 35, issue 1, Taylor and Francis Ltd, Milton Park Abingdon England, pp. 67-73.

De Silva, H., Alderuccio, F., Toh, B.H., Van Driel, I., Gleeson, P.A., 2001, Defining T Cell receptors which recognise the immunodominant epitope of the gastric autoantigen, the H/K ATPase b-subunit, Autoimmunity, vol 33, Harwood Academy Publishing GMBH, USA, pp. 1-14.

Biondo, M., Nasa, Z., Marshall, A.J., Toh, B.H., Alderuccio, F., 2001, Local transgenic expression of granulocyte macrophage-colony stimulating factor initiates autoimmunity, Journal of Immunology, vol 166, American Association of Immunologists, USA, pp. 2090-2099.

Alderuccio, F., Toh, B.H., 2000, Immunopathology of autoimmune gastritis: Lessons from mouse models, Histology & Histopathology, vol 15, Histology and Histopathology, Spain, pp. 869-879.

Toh, B.H., Sentry, J.W., Alderuccio, F., 2000, The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis, Immunology Today, vol 21, Elsevier Sci Ltd, Oxford England, pp. 352-358.

Alderuccio, F., Cataldo, V., Van Driel, I.R., Gleeson, P.A., Toh, B.H., 2000, Tolerance and autoimmunity to a gastritogenic peptide in TCR transgenic mice, International Immunology, vol 12 issue 3, Oxford University Press, UK, pp. 343-352.

Alderuccio, F., Toh, B.H., 1998, Spontaneous autoimmune gastritis in C3H/He Mice: a new mouse model for gastric immunity, American Journal of Pathology, vol 153 no 4, American Society for Investigative Pathology, Bethesda USA, pp. 1311-1318.

Alderuccio, F., Gleeson, P.A., Berzins, S.P., Martin, M., Van Driel, I.R., Toh, B.H., 1997, Expression of the Gastric H/K-ATPase alpha-subunit in the thymus may explain the dominant role of the beta-subunit in the pathogenisis of autoimmune gastritis, Autoimmunity, vol 25, OPA, Harwood Acdcdemic Publishers, Netherland, pp. 167-175.

Conference Proceedings

Nasa, Z., Chung, J., Joglekar, A., Chan, M., Toh, B., Alderuccio, F., 2011, Low toxic non-myeloablative regimen as preconditioning for induction of immune tolerance using gene therapy, 7th Biennial Meeting of the Australasian-Gene-Therapy-Society, mAY 2011, Wiley-Blackwell, USA, p. 442.

Alderuccio, F., 1997, The auto-immune response in experimental autoimmune gastritis, 25-29/3/98, p. 42.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

B cells in tolerance and autoimmunity.

Supervisors:

Alderuccio, F (Main), Mackay, F (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Induction of tolerance by gene theraphy and transfer of haematopoietic stem cells in different mouse models of autoimmunity.

Supervisors:

Alderuccio, F (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigating the long term effects of TBI on the immune and fibrinolytic system..

Supervisors:

Medcalf, R (Main), Alderuccio, F (Associate), Sashindranath, M (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Mechanisms of tolerance following genetic manipulation and transfer of bone marrow stem cells.

Supervisors:

Alderuccio, F (Main).

Completed Supervision

Student:

Biondo, M.

Program of Study:

Working with transgenic mouse models towards a cure for autoimmune disease. (PHD) 2006.

Supervisors:

Alderuccio, F (Joint), Ban-Hock, T (Joint-Co).

Student:

Crowe, N.

Program of Study:

THE ROLE FOR NKT CELLS IN TUMOR IMMUNITY. (PHD) 2003.

Supervisors:

Godfrey, D (Joint-Co), Smyth, M (Joint), Alderuccio, F (Associate).

Student:

Field, J.

Program of Study:

Experimental autoimmune gastritis: mechanisms of induction and therapeutic strategies. (PHD) 2007.

Supervisors:

Alderuccio, F (Joint), Ban-Hock, T (Joint-Co).

Student:

Ko, H.

Program of Study:

Combining gene therapy and haematopoietic stem cell transplantation to induce immune tolerance in an experimental model of multiple sclerosis. (PHD) 2010.

Supervisors:

Alderuccio, F (Main), Chan, J (Associate), Toh, B (Associate).

Student:

Marshall, A.

Program of Study:

THE ROLE OF Fas AND TNF ALPHA IN EXPERIMENTAL AUTOIMMUNE GASTRITIS. (PHD) 2003.

Supervisors:

Ban-Hock, T (Main), Alderuccio, F (Joint).

Student:

Murphy, K.

Program of Study:

Tolerance induction and autoantibody detection in autoimmune disease. (PHD) 2008.

Supervisors:

Alderuccio, F (Joint), Ban-Hock, T (Joint-Co).

Student:

Ziebell, J.

Program of Study:

. 2004.

Supervisors:

Kelly, L (Main), Morganti-Kossmann, M (Associate), Bye, N (Associate), Alderuccio, F (Associate).