Prof Tony Tiganis - Researcher Profile

Biography

Tony works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Professor.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: University of Melbourne

Year awarded: 2005

Publications

Journal Articles

Tiganis, T., 2013, PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis, Febs Journal [P], vol 280, issue 2, Wiley-Blackwell Publishing Ltd, UK, pp. 445-458.

Shields, B.J., Wiede, F., Gurzov, E., Wee, K.T.B., Hauser, C., Zhu, H., Molloy, T.J., O'Toole, S.A., Daly, R.J., Sutherland, R.L., Mitchell, C.A., McLean, C.A., Tiganis, T., 2013, TCPTP regulates SFK and STAT3 signalling and is lost in triple negative breast cancers, Molecular and Cellular Biology [P], vol 33, issue 3, American Society for Microbiology, USA, pp. 557-570.

Pagnon, J., Matzaris, M., Stark, R., Meex, R.C., Macaulay, S.L., O'Brien, P.E., Tiganis, T., Watt, M.J., Brown, W.A., 2012, Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase, Endocrinology [P], vol 153, issue 9, The Endocrine Society, USA, pp. 4278-4289.

Wiede, F., Chew, S., Van Vliet, C.J., Poulton, I.J., Kyparissoudis, K., Sasmono, T., Loh, K.Y., Tremblay, M.L., Godfrey, D.I., Sims, N.A., Tiganis, T., 2012, Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice, PLoS ONE [P], vol 7, issue 5 (Art. ID: e36703), Public Library of Science, USA, pp. 1-15.

Loh, K., Merry, T., Galic, S., Wu, B., Watt, M.J., Zhang, S., Zhang, Z., Neel, B., Tiganis, T., 2012, T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice, Diabetologia [P], vol 55, issue 2, Springer, Germany, pp. 468-478.

Visinoni, S., Khalid, N.F.I., Joannides, C.N., Shulkes, A., Yim, M., Whitehead, J., Tiganis, T., Lamont, B., Favaloro, J.M., Proietto, J., Andrikopoulos, S., Fam, B.C., 2012, The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity, Diabetes [P], vol 61, issue 5, American Diabetes Association, USA, pp. 1122-1132.

Bettaieb, A., Liu, S., Xi, Y., Nagata, N., Matsuo, K., Matsuo, I., Chahed, S., Bakke, J., Keilhack, H., Tiganis, T., Haj, F.G., 2011, Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase, Journal Of Biological Chemistry [P], vol 286, issue 11, American Society for Biochemistry & Molecular Biology Inc, USA, pp. 9225-9235.

Wu, C., Buszard, B., Teng, C., Warr, C., Tiganis, T., Meng, T., 2011, Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signaling, Biochemical Journal [P], vol 439, issue 1, Portland Press Ltd, UK, pp. 151-159.

Loh, K., Fukushima, A., Zhang, X.M., Galic, S., Briggs, D.I., Enriori, P., Simonds, S., Wiede, F., Reichenbach, A., Hauser, C., Sims, N.A., Bence, K.K., Zhang, S., Zhang, Z., Kahn, B., Neel, B., Andrews, Z.B., Cowley, M.A., Tiganis, T., 2011, Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance, Cell Metabolism [P], vol 14, issue 5, Cell Press, USA, pp. 684-699.

Balamatsias, D., Kong, A., Waters, J.E., Sriratana, A., Gurung, R., Bailey, C.G., Rasko, J.E. ., Tiganis, T., Macaulay, S.L., Mitchell, C.A., 2011, Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes, Journal Of Biological Chemistry [P], vol 286, issue 50, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 43229-43240.

Tiganis, T., 2011, Reactive oxygen species and insulin resistance: The good, the bad and the ugly, Trends in Pharmacological Sciences [P], vol 32, issue 2, Elsevier Ltd, UK, pp. 82-89.

Rahman, P., Huysmans, R., Wiradjaja, F., Gurung, R., Ooms, L., Sheffield, D., Dyson, J., Layton, M., Sriratana, A., Takada, H., Tiganis, T., Mitchell, C., 2011, Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton, Journal Of Biological Chemistry [P], vol 286, issue 34, American Society of Biochemistry and Molecular Biology Inc., USA, pp. 29758-29770.

Wiede, F., Shields, B.J., Chew, K.[.H., Kyparissoudis, K., van Vliet, C.J., Galic, S., Tremblay, M.L., Russell, S.M., Godfrey, D.I., Tiganis, T., 2011, T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice, Journal of Clinical Investigation [P], vol 121, issue 12, American Society for Clinical Investigation, USA, pp. 4758-4774.

Wong, S., Tan, W., Carey, K.T., Fukushima, A., Tiganis, T., Cole, T.J., 2010, Glucocorticoids stimulate hepatic and renal catecholamine inactivation by direct rapid induction of the dopamine sulfotransferase Sult1d1, Endocrinology [P], vol 151, The Endocrine Society, USA, pp. 185-194.

Fedele, C.G., Ooms, L.M., Ho, M., Vieusseux, J.L., O'Toole, S.A., Millar, E.K., Lopez-Knowles, E., Sriratana, A., Gurung, R., Baglietto, L., Giles, G., Bailey, C.G., Rasko, J.E., Shields, B.J., Price, J.T., Majerus, P.W., Sutherland, R.L., Tiganis, T., McLean, C., Mitchell, C.A., 2010, Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers, Proceedings Of The National Academy Of Sciences O..., vol 107, issue 51, National Academy of Sciences, USA, pp. 22231-22236.

Fukushima, A., Loh, K., Galic, S., Fam, B., Shields, B., Wiede, F., Tremblay, M.L., Watt, M.J., Andrikopoulos, S., Tiganis, T., 2010, T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis, Diabetes [P], vol 59, issue 8, American Diabetes Association, USA, pp. 1906-1914.

Pang, S.S., Berry, R., Chen, Z., Kjer-Nielsen, L., Perugini, M.A., King, G.F., Wang, C., Chew, S.H., La Gruta, N.L., Williams, N.K., Beddoe, T.C., Tiganis, T., Cowieson, N.P., Godfrey, D.I., Purcell, A.W., Wilce, M.C., McCluskey, J., Rossjohn, J., 2010, The structural basis for autonomous dimerization of the pre-T-cell antigen receptor, Nature [P], vol 467, issue 7317, Nature Publishing Group, UK, pp. 844-848.

Beddoe, T.C., Chen, Z., Clements, C.S., Ely, L.K., Bushell, S.R., Vivian, J.P., Kjer-Nielsen, L., Pang, S.S., Dunstone, M.A., Liu, Y.C., Macdonald, W.A., Perugini, M.A., Wilce, M.C.J., Burrows, S.R., Purcell, A.W., Tiganis, T., Bottomley, S.P., McCluskey, J., Rossjohn, J., 2009, Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor, Immunity [P], vol 30, issue 6, Cell Press, USA, pp. 777-788.

Loh, K.Y., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B.J., Skiba, B., Ooms, L.M., Stepto, N.K., Wu, B.J., Mitchell, C.A., Tonks, N., Watt, M.J., Febbraio, M.A., Crack, P.J., Andrikopoulos, S., Tiganis, T., 2009, Reactive oxygen species enhance insulin sensitivity, Cell Metabolism [P], vol 10, issue 4, Cell Press, USA, pp. 260-272.

Ivetac, I., Gurung, R., Hakim, S., Horan, K.A., Sheffield, D.A., Binge, L.C., Majerus, P.W., Tiganis, T., Mitchell, C.A., 2009, Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1, EMBO Reports, vol 10, issue 5, Nature Publishing Group, United Kingdom, Germany, pp. 487-493.

Shields, B.J., Tiganis, T., 2009, Replication checkpoint control by a PTK/STAT3/cyclin D1 axis, Cell Cycle, vol 8, issue 2, Landes Bioscience, USA, pp. 223-230.

Shields, B.J., Court, N.W., Hauser, C., Bukczynska, P.E., Tiganis, T., 2008, Cell cycle-dependent regulation of SFK, JAK1 and STAT3 signalling by the protein tyrosine phosphatase TCPTP, Cell Cycle, vol 7, issue 21, Landes Bioscience, USA, pp. 3405-3416.

Shields, B.J., Hauser, C., Bukczynska, E.P., Court, N.W., Tiganis, T., 2008, DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression, Cancer Cell, vol 14, issue 2, Cell Press, United States, pp. 166-179.

Lu, X., Malumbres, R., Shields, B.J., Jiang, X., Sarosiek, K.A., Natkunam, Y., Tiganis, T., Lossos, I.S., 2008, PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling, Blood, vol 112, issue 10, American Society of Hematology, United States, pp. 4098-4108.

Tiganis, T., Bennett, A.M., 2007, Protein tyrosine phosphatase function: The substrate perspective, Biochemical Journal, vol 402, issue 1, Portland Press Ltd, London England UK, pp. 1-15.

Lu, X., Chen, J., Sasmono, T., Hsi, E.D., Sarosiek, K.A., Tiganis, T., Lossos, I.S., 2007, T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6, Molecular and Cellular Biology, vol 27, issue 6, American Society of Microbiologists, Washington DC USA, pp. 2166-2179.

Galic, S., Hauser, C., Kahn, B.B., Haj, F.G., Neel, B.G., Tonks, N., Tiganis, T., 2005, Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP, Molecular and Cellular Biology, vol 25, issue 2, American Society for Microbiology, Washington USA, pp. 819-829.

Fodero-Tavoletti, M.T., Hardy, M.P., Cornell, B.H., Katsis, F., Sadek, C.M., Mitchell, C.A., Kemp, B.E., Tiganis, T., 2005, Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization, Biochemical Journal, vol 389, issue Pt2, Portland Press Ltd, London England, pp. 343-354.

Van Vliet, C.J., Bukczynska, P.E., Puryer, M.A., Sadek, C.M., Shields, B.J., Tremblay, M.L., Tiganis, T., 2005, Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase, Nature Immunology, vol 6, issue 3, Nature Publishing Group, New York USA, pp. 253-260.

Ivetac, I., Munday, A.D., Kisseleva, M.V., Zhang, X., Luff, S.E., Tiganis, T., Whisstock, J.C., Rowe, T., Majerus, P., Mitchell, C.A., 2005, The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane, Molecular Biology of the Cell, vol 16, issue 5, American Society for Cell Biology, Bethesda USA, pp. 2218-2233.

Shimizu, T., Miyakawa, Y., Iwata, S., Kuribara, A., Tiganis, T., Morimoto, C., Ikeda, Y., Kizaki, M., 2004, A novel mechanism for imatinib mesylate (STI571) resistance in CML cell line KT-1: Role of TC-PTP in modulating signals downstream from the BCR-ABL fusion protein, Experimental Hematology, vol 32, issue 11, Elsevier Science Inc., New York USA, pp. 1057-1063.

Meng, T., Buckley, D.A., Galic, S., Tiganis, T., Tonks, N., 2004, Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B, The Journal of Biological Chemistry, vol 279, issue 36, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 37716-37725.

Bukczynska, E.P., Klingler-Hoffmann, M., Mitchelhill, K.I., Lam, M., Ciccomancini, M., Tonks, N., Sarcevic, B., Kemp, B., Tiganis, T., 2004, The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis, Biochemical Journal, vol 380, issue 3, Portland Press, London England, pp. 939-949.

Klingler-Hoffmann, M., Bukczynska, E.P., Tiganis, T., 2003, Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells, International Journal of Cancer, vol 105, issue 3, Wiley-Liss, New York USA, pp. 331-339.

Galic, S., Klingler-Hoffmann, M., Fodero-Tavoletti, M.T., Puryer, M.A., Meng, T., Tonks, N., Tiganis, T., 2003, Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP, Molecular and Cell Biology, vol 23, issue 6, American Society for Microbiology, Washington USA, pp. 2096-2108.

Tiganis, T., 2002, Protein tyrosine phosphates: Dephosphorylating the epidermal growth factor response, IUBMB Life, vol 53, issue 1, Taylor & Francis Inc, Philadelphia PA USA, pp. 3-14.

Lam, M., Michell, B., Fodero-Tavoletti, M., Kemp, B.E., Tonks, N., Tiganis, T., 2001, Cellular stress regulates the nucleocytoplasmic distribution of the protein-tyrosine phosphatase TCPTP, Journal of Biological Chemistry, vol 276, issue 40, American Society for Biochemistry and Molecular Biology Inc, Bethesda MD USA, pp. 37700-37707.

Klingler-Hoffmann, M., Fodero-Tavoletti, M.T., Mishima, K., Narita, Y., Cavenee, W.K., Furnari, F.B., Su Huang, H., Tiganis, T., 2001, The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of Glioblastoma Cells epressing a mtant eidermal gowth factor receptor, The Journal of Bilogical Chemistry, vol 276, issue 49, The American Society for Biochemistry & Molecular Biology, Inc, Bethesda USA, pp. 46313-46318.

Other

Pang, S.S., Berry, R., Chen, Z., Kjer-Nielsen, L., Perugini, M.A., King, G.F., Wang, C., Chew, S.H., La Gruta, N.L., Williams, N.K., Beddoe, T.C., Tiganis, T., Cowieson, N.P., Godfrey, D.I., Purcell, A.W., Wilce, M.C., McCluskey, J., Rossjohn, J., 2010, Crucial link in immune development and regulation unearthed, Quality control mechanism that must take place for our immune system, Monash University, Clayton, Vic, Australia.

Postgraduate Research Supervisions

Completed Supervision

Student:

Bukczynska, P.

Program of Study:

Characterization of the Phosphatases PTEN and PP1.. (Masters) 2004.

Supervisors:

Tiganis, T (Main).

Student:

Bukczynska, P.

Program of Study:

Regulation of DEGFR signalling by the tumour supressor protein PTEN. 2001.

Supervisors:

Tiganis, T (Main).

Student:

Buszard, B.

Program of Study:

Functional characterisation of the Drosophila protein tyrosine phosphatase dPTP61F. (PHD) 2012.

Supervisors:

Tiganis, T (Joint), Warr, C (Joint-Co).

Student:

Fodero-Tavoletti, M.

Program of Study:

Cloning and characterisation of human non-transmembrane protein tyrosine phosphatase 20 (hPTPN20). (PHD) 2006.

Supervisors:

Bird, P (Joint), Tiganis, T (Joint-Co).

Student:

Galic, S.

Program of Study:

Regulation of insulin signalling by protein tyrosine phosphatases. (PHD) 2007.

Supervisors:

Tiganis, T (Main), Jans, D (Associate).

Student:

Hauser, C.

Program of Study:

Characterisation of cell cycle functions of the protein tyrosine phosphatase TCPTP. (PHD) 2010.

Supervisors:

Jans, D (Joint), Tiganis, T (Joint-Co).

Student:

Loh, K.

Program of Study:

Regulation of leptin and insulin signaling by the T cell protein tyrosine phosphatase. (PHD) 2011.

Supervisors:

Tiganis, T (Main).

Student:

Wee, K.

Program of Study:

. 2008.

Supervisors:

Tiganis, T (Main), Shields, B (Associate).