Ms Denise Wootten - Researcher Profile

Biography

Position

Research Fellow
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Qualifications

BIOCHEMISTRY ( DOCTOR OF PHILOSOPHY)

Institution: University of Birmingham

Year awarded: 2008

BACHELOR OF SCIENCE (HON)

Institution: University of Birmingham

Year awarded: 2003

Publications

Book Chapters

Wootten, D., Simms, J.W., Hay, D.L., Christopoulos, A., Sexton, P., 2010, Receptor activity modifying proteins and their potential as drug targets, in Progress in Molecular Biology and Translational Science, eds CA Lunn, Academic Press, UK, pp. 53-79.

Journal Articles

Wootten, D.L., Savage, E.E., Valant, C., May, L.T., Sloop, K.W., Ficorilli, J., Showalter, A.D., Willard, F.S., Christopoulos, A., Sexton, P.M., 2012, Allosteric modulation of endogenous metabolites as an avenue for drug discovery, Molecular Pharmacology [P], vol 82, issue 2, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 281-290.

Furness, S.G.B., Wootten, D.L., Christopoulos, A., Sexton, P.M., 2012, Consequences of splice variation on secretin family G protein-coupled receptor function, British Journal of Pharmacology [P], vol 166, issue 1, Wiley-Blackwell, Malden USA, pp. 98-109.

Harikumar, K.G., Wootten, D.L., Pinon, D.I., Koole, C.R., Ball, A.M., Furness, S.G., Graham, B., Dong, M., Christopoulos, A., Miller, L.J., Sexton, P.M., 2012, Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 109, issue 45, National Academy of Sciences, USA, pp. 18607-18612.

Koole, C.R., Wootten, D.L., Simms, J., Savage, E.E., Miller, L.J., Christopoulos, A., Sexton, P.M., 2012, Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function, Journal Of Biological Chemistry [P], vol 287, issue 6, American Society for Biochemistry and Molecular Biology Inc, Bethesda USA, pp. 3659-3673.

Koole, C.R., Wootten, D.L., Simms, J.W., Miller, L.J., Christopoulos, A., Sexton, P., 2012, Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation, Journal Of Biological Chemistry [P], vol 287, issue 6, The American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 3642-3658.

Willard, F.S., Wootten, D.L., Showalter, A.D., Savage, E.E., Ficorilli, J., Farb, T.B., Bokvist, K., Alsina-Fernandez, J., Furness, S.G., Christopoulos, A., Sexton, P.M., Sloop, K.W., 2012, Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin, Molecular Pharmacology [P], vol 82, issue 6, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 1066-1073.

Wootten, D., Simms, J., Koole, C., Woodman, O., Summers, R., Christopoulos, A., Sexton, P., 2011, Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids, Journal Of Pharmacology And Experimental Therapeutics [P], vol 336, issue 2, Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic fl, AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, pp. 540-550.

Koole, C., Wootten, D., Simms, J., Valant, C., Miller, L., Christopoulos, A., Sexton, P., 2011, Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation, Molecular Pharmacology [P], vol 80, issue 3, American Society of Pharmacology & Experimental Therapeutics, USA, pp. 486-497.

Koole, C., Wootten, D., Simms, J., Valant, C., Sridhar, R., Woodman, O., Miller, L., Summers, R., Christopoulos, A., Sexton, P.M., 2010, Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: Implications for drug screening, Molecular Pharmacology [P], vol 78, issue 3, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 456-465.

Wheatley, M., Simms, J.W., Hawtin, S.R., Wesley, V.J., Wootten, D.L., Conner, M., Lawson, Z., Conner, A.C., Baker, A., Cashmore, Y., Kendrick, R., Parslow, R.A., 2007, Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors, Biochemical Society Transactions, vol 35, issue Pt 4, Portland Press Ltd, London England, pp. 717-720.

Conner, M., Hawtin, S.R., Simms, J.W., Wootten, D.L., Lawson, Z., Conner, A.C., Parslow, R.A., Wheatley, M., 2007, Systematic analysis of the entire second extracellular loop of the V 1a vasopressin receptor: Key residues, conserved throughout a G-protein-coupled receptor family, identified, The Journal of Biological Chemistry, vol 282, issue 24, American Society for Biochemistry & Molecular Biology, Inc., Bethesda USA, pp. 17405-17412.

Conner, A.C., Simms, J.W., Conner, M.T., Wootten, D.L., Wheatley, M., Poyner, D.D., 2006, Diverse functional motifs within the three intracellular loops of the CGRP1 receptor, Biochemistry, vol 45, issue 43, American Chemical Society, Washington USA, pp. 12976-12985.

Activities

Affiliations with institutes

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Proteomic approaches to characterize novel aspects of ligand-directed trafficking of receptor signal.

Supervisors:

Sexton, P (Main), Furness, S (Associate), Wootten, D (Associate).