Dr Flora Wong - Researcher Profile

Biography

Dr. Flora Wong is a Consultant Neonatologist at Monash Newborn, Monash Medical Centre, with a joint appointment as senior research fellow at the Department of Paediatrics and The Ritchie Centre, Monash University.  Her research interests are in preterm cerebral pathophysiology, cerebral blood flow and oxygenation in relation to brain injury in newborn infants undergoing intensive care. She has expertise in the application of Near Infra-red Spectroscopy to examine the cerebral pathophysiology in both animal and clinical studies, employing a translational paradigm.

 

 

 

Qualifications

DOCTOR OF PHILOSOPHY (MEDICINE)

Institution: Monash University

Year awarded: 2009

BACHELOR OF MEDICINE, BACHELOR OF SURGERY

Institution: The University of Melbourne

Year awarded: 1993

Publications

Journal Articles

Silas, R., Sehgal, A., Walker, A., Wong, F., 2012, Cerebral oxygenation during subclinical seizures in neonatal hypoxic-ischaemic encephalopathy, European Journal of Paediatric Neurology [P], vol 16, issue 3, Elsevier Ltd, United Kingdom, pp. 304-307.

Wong, F.Y., Silas, R., Hew, S., Samarasinghe, T.D., Walker, A.M., 2012, Cerebral oxygenation is highly sensitive to blood pressure variability in sick preterm infants, PLoS ONE [P], vol 7, issue 8 (Art. No: e43165), Public Library of Science, United States, pp. 1-7.

Azhan, A., Wong, F.Y., 2012, Challenges in understanding the impact of blood pressure management on cerebral oxygenation in the preterm brain, PLoS ONE [P], vol 3, PUBLIC LIBRARY SCIENCE, UNITED STATES, pp. 471-479.

Polglase, G., Miller, S.L., Barton, S., Baburamani, A.A., Wong, F.Y., Aridas, J., Gill, A.W., Moss, T.J.M., Tolcos, M., Kluckow, M., Hooper, S.B., 2012, Initiation of resuscitation with high tidal volumes causes cerebral hemodynamic disturbance, brain inflammation and injury in preterm lambs, PLoS ONE [P], vol 7, issue 6 (Art. No: e39535), Public Library of Science, United States, pp. 1-8.

Ang, H., Veldman, A., Lewis, A., Carse, E.A., Wong, F.Y., 2012, Procedural training opportunities for basic pediatric trainees during a 6-month rotation in a level III perinatal centre in Australia, Journal Of Maternal-Fetal & Neonatal Medicine [P], vol 25, issue 11, Informa Healthcare, United Kingdom, pp. 2428-2431.

Sehgal, A., Wong, F.Y., Mehta, S., 2012, Reduced cardiac output and its correlation with coronary blood flow and troponin in asphyxiated infants treated with therapeutic hypothermia, European Journal Of Pediatrics [P], vol 171, issue 10, Springer, Germany, pp. 1511-1517.

Wong, F., Smith, N., Yiallourou, S., Yorkston, S., Dymowski, A., Krishnan, L., Walker, A., Horne, R., 2011, Cerebral oxygenation is depressed during sleep in healthy term infants when they sleep pone, Pediatrics [P], vol 127, issue 3, American Academy of Pediatrics, United States, pp. e558-e565.

Veldman, A., Hennermann, J., Schwarz, G., van Spronsen, F., Wong, F., Schwahn, B., 2011, Timing of Cerebral Developmental Disruption in Molybdenum Cofactor Deficiency, Journal of Child Neurology [P], vol 26, issue 8, SAGE PUBLICATIONS INC, UNITED STATES, pp. 1059-1060.

Wong, F., Alexiou, T., Samarasinghe, T., Brodecky, V., Walker, A., 2010, Cerebral arterial and venous contributions to tissue oxygenation index measured using spatially resolved spectroscopy in newborn lambs, Anesthesiology [P], vol 113, issue 6, Lippincott Williams & Wilkins, United States, pp. 1385-1391.

Veldman, A., Fischer, D., Nold, M., Wong, F., 2010, Disseminated intravascular coagulation in term and preterm neonates, Seminars In Thrombosis And Hemostasis [P], vol 36, issue 4, Thieme Medical Publishers, United States, pp. 419-428.

Veldman, A., Fischer, D., Wong, F., Kreuz, W., Sasse, M., Eberspacher, B., Mansmann, U., Schosser, R., 2010, Human protein C concentrate in the treatment of purpura fulminans: A retrospective analysis of safety and outcome in 94 pediatric patients, Critical Care [E], vol 14, issue 4 (R156), BioMed Central Ltd, United Kingdom, pp. 1-7.

Veldman, A., Santamaria-Araujo, J., Sollazzo, S., Pitt, J., Gianello, R., Yaplito-Lee, J., Wong, F., Ramsden, C., Reiss, J., Cook, I., Fairweather, D., Schwartz, G., 2010, Successful treatment of molybdenum cofactor deficiency type A with cPMP, Pediatrics [P], vol 125, issue 5, American Academy of Pediatrics, United States, pp. e1249-e1254.

Wong, F.Y., Barfield, C., Horne, R.S.C., Walker, A.M., 2009, Dopamine therapy promotes cerebral flow-metabolism coupling in preterm infants, Intensive Care Medicine [P], vol 35, issue 10, Springer, Germany, pp. 1777-1782.

Wong, F.Y., Nakamura, M., Alexiou, T., Brodecky, V., Walker, A.M., 2009, Tissue oxygenation index measured using spatially resolved spectroscopy correlates with changes in cerebral blood flow in newborn lambs, Intensive Care Medicine [P], vol 35, issue 8, Springer, Germany, pp. 1464-1470.

Wong, F.Y., Leung, T.S., Austin, T., Wilkinson, M.H., Meek, J.H., Wyatt, J.S., Walker, A.M., 2008, Impaired autoregulation in preterm infants identified by using spatially resolved spectroscopy, Pediatrics (English Edition), vol 121, issue 3, American Academy of Pediatrics, USA, pp. 604-611.

Wong, F.Y., Barfield, C., Campbell, L., Brodecky, V., Walker, A.M., 2008, Validation of cerebral venous oxygenation measured using near-infrared spectroscopy and partial jugular venous occlusion in the newborn lamb, Journal of Cerebral Blood Flow and Metabolism, vol 28, Nature Publishing Group, USA, pp. 74-80.

Wong, F.Y., Barfield, C., Walker, A.M., 2007, Power spectral analysis of two-channel EEG in hypoxic-ischaemic encephalopathy, Early Human Development, vol 83, Elsevier Ireland Ltd, Shannon Ireland, pp. 379-383.

Wong, F.Y., Mitchell, P.J., Tress, B.M., Dargaville, P.A., Loughnan, P.M., 2006, Hemodynamic disturbances associated with endovascular embolization in newborn infants with vein of Galen malformation, Journal of Perinatology, vol 26, Nature Publishing Group, UK, pp. 273-278.

Wong, F.Y., Fraser, S., Kelly, E., Acton, C., 2004, Clinical significance of isolated paraventricular cysts on cranial ultrasonography, Journal Of Paediatrics And Child Health [P], vol 40, issue 9-10, Wiley-Blackwell Publishing Ltd, UK, Australia, pp. 552-555.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Cerebral oxygenation during sleep in preterm infants..

Supervisors:

Horne, R (Main), Yiallourou, S (Associate), Wong, F (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Cranial ultrasound of the newborn: knowledge, practice and safety.

Supervisors:

Schneider-Kolsky, M (Main), Wong, F (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Therapies to reduce brain injury associated with birth asphyxia.

Supervisors:

Miller, S (Main), Jenkin, G (Associate), Wong, F (Associate).