Dr Amanada Zatta - Researcher Profile

Biography

Amanda is a NHMRC Peter Doherty Research Fellow in the Transfusion Research Unit, operating within the Critical Care Division at the Department of Epidemiology and Preventive Medicine, Monash University. Amanda has a PhD in Cardiovascular physiology & pathophysiology and trained both in Australia and overseas. In February 2009, Amanda transitioned from laboratory based research into clinical research. She was appointed Project Manager of the Australian and New Zealand Haemostasis Registry which collected data on the administration of activated recombinant factor VII for treatment against critical bleeding in patients. More recently, Amanda is establishing a Massive Transfusion Registry (MTR) in Australia and New Zealand with the support of Transfusion Outcomes Research Collaborative, which is a partnership between the Blood Service and Monash University and with an educational grant from CSL Biotherapies. The aim of the registry is to collect data on the incidence, clinical contexts and outcomes of critical bleeding events that require a massive transfusion.

Research Projects:

Massive Transfusion Regisrty

Massive Transfusion-Validation Study

Qualifications

PHD

Institution: Griffith University Gold Goast

Year awarded: 2004

BACHELOR OF HEALTH SCIENCE WITH HONOURS

Institution: Griffith University

Year awarded: 2000

BACHELOR OF SCIENCE

Institution: Griffith University Gold Coast

Year awarded: 1999

Publications

Journal Articles

Chu, P., Zatta, A.J., Kiriazis, H., Chin-Dusting, J., Du, X., Marshall, T., Kaye, D., 2011, CXCR4 antagonism attenuates the cardiorenal consequences of mineralocorticoid excess, Circulation: Heart Failure [P], vol 4, issue 5, Lippincott Williams & Wilkins, United States, pp. 651-658.

Leighton, B., Wall, M., Lockhart, E., Phillips, L., Zatta, A., 2011, Use of recombinant factor VIIa in patients with amniotic fluid embolism: A systematic review of case reports, Anesthesiology [P], vol 115, issue 6, Lippincott Williams & Wilkins, United States, pp. 1201-1208.

Byrne, M., Zatta, A., Galli, C., Power, J., Kaye, D., 2010, Recirculating delivery improves myocardial cell engraftment, Journal of Interventional Cardiology: An international forum for global cardiovascular therapies [P], vol 23, issue 1, Wiley-Blackwell Publishing, Inc., United States, pp. 14-17.

Venardos, K., Zatta, A., Marshall, T., Ritchie, R., Kaye, D., 2009, Reduced L-arginine transport contributes to the pathogenesis of myocardial ischemia-reperfusion injury, Journal Of Cellular Biochemistry [P], vol 108, issue 1, Wiley-Blackwell, United States, pp. 156-168.

Phillips, L.E., Zatta, A.J., Schembri, N.L., Noone, A., Isbister, J., 2009, Uncontrolled bleeding in surgical patients: The role of recombinant activated factor VIIa, Current Drug Targets [P], vol 10, issue 8, Bentham Science Publishers Ltd, Netherlands, pp. 744-770.

Zatta, A., Kin, H., Yoshishige, D., Jiang, R., Wang, N., Reeves, J., Mykytenko, J., Guyton, R., Zhao, Z., Caffrey, J., Vinten-Johansen, J., 2008, Evidence that cardioprotection by postconditioning involves preservation of myocardial opioid content and selective opioid receptor activation, American Journal of Physiology - Heart and Circulatory Physiology [E], vol 294, issue 3, American Psychological Association, United States, pp. 1444-1451.

Kin, H., Wang, N., Mykytenko, J., Reeves, J., Deneve, J., Jiang, R., Zatta, A., Guyton, R., Vinten-Johansen, J., Zhao, Z., 2008, Inhibition of myocardial apoptosis by postconditioning is associated with attenuation of oxidative stress-mediated nuclear factor-kappaB translocation and TNFalpha release, Shock [P], vol 29, issue 6, American Psychological Association, United States, pp. 761-768.

Mykytenko, J., Reeves, J., Kin, H., Wang, N., Zatta, A., Jiang, R., Guyton, R., Vinten-Johansen, J., Zhao, Z., 2008, Persistent beneficial effect of postconditioning against infarct size: Role of mitochondrial KATP channels during reperfusion, Basic Research In Cardiology [P], vol 103, issue 5, Springer Heidelberg, Germany, pp. 472-484.

Mykytenko, J., Kerendi, F., Reeves, J., Kin, H., Zatta, A., Jiang, R., Guyton, R., Vinten-Johansen, J., Zhao, Z., 2007, Long-term inhibition of myocardialinfarction by postconditioning during reperfusion, Basic Research In Cardiology [P], vol 102, issue 1, Springer Heidelberg, Germany, pp. 90-100.

Jiang, R., Zatta, A., Kin, H., Wang, N., Reeves, J., Mykytenko, J., Deneve, J., Zhao, Z., Guyton, R., Vinten-Johansen, J., 2007, PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1/2 pathway in in vivo rat hearts, American Journal Of Physiology-Heart And Circulatory Physiology [P], vol 293, issue 5, American Psychological Association, United States, pp. 2845-2852.

Vinten-Johansen, J., Zhao, Z., Jiang, R., Zatta, A., Dobson, G., 2007, Preconditioning and postconditioning: Innate cardioprotection from ischemia-reperfusion injury, Journal Of Applied Physiology [P], vol 103, issue 4, American Psychological Association, United States, pp. 1441-1448.

Zatta, A., Matheme, G., Headrick, J., 2006, Adenosine receptor-mediated coronary vascular protection in post-ischemic mouse heart, Life Sciences [P], vol 78, issue 21, Pergamon-Elsevier Science Ltd, England, pp. 2426-2437.

Zatta, A., Kin, H., Lee, G., Wang, N., Jiang, R., Lust, R., Reeves, J., Mykytenko, J., Guyton, R., Zhao, Z., Vinten-Johansen, J., 2006, Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling, Cardiovascular Research [P], vol 70, issue 2, Oxford University Press, Oxford, pp. 315-324.

Willems, L., Zatta, A., Holmgren, K., Ashton, K., Headrick, J., 2005, Age-related changes in ischemic tolerance in male and female mouse hearts, Journal Of Molecular And Cellular Cardiology [P], vol 38, issue 2, Academic Press Ltd, Elsevier Science Lltd, England, pp. 245-256.

Zatta, A., Headrick, J., 2005, Mediators of coronary reactive hyperaemia in isolated mouse heart, British Journal of Pharmacology [P], vol 144, issue 4, Wiley-Blackwell, England, pp. 576-587.

Vinten-Johansen, J., Zhao, Z., Jiang, R., Zatta, A., 2005, Myocardial protection in reperfusion with postconditioning, Expert Review of Cardiovascular Therapy [P], vol 3, issue 6, Expert Reviews, London, pp. 1035-1045.

Kin, H., Zatta, A., Loyfe, M., Amerson, B., Halkos, M., Kerendi, F., Zhao, Z., Guyton, R., Headrick, J., Vinten-Johansen, J., 2005, Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine, Cardiovascular Research [P], vol 67, issue 1, Oxford University Press, England, pp. 124-133.

Vinten-Johansen, J., Zhao, Z., Zatta, A., Kin, H., Halkos, M., Kerendi, F., 2005, Postconditioning: A new link in nature's armor against myocardial ischemia-reperfusion injury, Basic Research In Cardiology [P], vol 100, issue 4, Springer Heidelberg, Germany, pp. 295-310.

Kerendi, F., Kin, H., Halkos, M., Jiang, R., Zatta, A., Zhao, Z., Guyton, R., Vinten-Johansen, J., 2005, Remote postconditioning: Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors, Basic Research In Cardiology [P], vol 100, issue 5, Springer Heidelberg, Germany, pp. 404-412.