Prof Peter Scammells - Researcher Profile

Biography

Position

Head of Medicinal Chemistry
Faculty of Pharmacy and Pharmaceutical Sciences

Co-theme Leader - Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Research & Supervision Interests

• The development of adenosine agonists as antiarrhythmic agents
• The design and synthesis of allosteric enhancers of adenosine as cardioprotective agents
• The synthesis and study of bivalent and polyvalent ligands
• New syntheses of pharmaceutical opiates
• Novel p38 MAPK inhibitors as anti-inflammatory agents
• Applications of ionic liquids in pharmaceutical synthesis

Keywords

Novel p38 MAPK inhibitors as anti-inflammatory age, adenosine agonists as antiarrhythmic agents, allosteric enhancers of adenosine as cardioprotect, bivalent and polyvalent ligands, plications of ionic liquids in pharmaceutical synt, syntheses of pharmaceutical opiates

Qualifications

PHILOSOPHY

Institution: Griffith University

Year awarded: 1991

SCIENCE (HONS)

Institution: Griffith University

Year awarded: 1987

Publications

Book Chapters

Hutchinson, S.A., Scammells, P.J., 2006, A1 Adenosine Receptor Agonists: Medicinal Chemistry and Therapeutic Potential, in Frontiers in Medicinal Chemistry. Volume 3, eds Atta-ur-Rahman, Allen B Reitz, M. Iqbal Choudhary and Cheryl P Kordik, Bentham Science Publishers, The Netherlands, pp. 125-151.

Journal Articles

Macdougall, P.E., Aitken, H.M., Scammells, P.J., Kavanagh, Y., Kyne, S.H., Schiesser, C.H., 2012, 7-Selenabicyclo[2.2.1]heptane, Chemical Communications [P], vol 48, issue 73, The Royal Society of Chemistry, England, pp. 9126-9128.

Orbell, G.B., Scammells, P.J., 2012, Improved synthesis of 14-hydroxy opioid pharmaceuticals and intermediates, RSC Advances: An International Journal to Further the Chemical Sciences [E], vol 2, issue 30, R S C Publications, UK, pp. 11318-11325.

Orbell, G.B., Scammells, P.J., 2012, Polonovski-type N-demethylation of N-methyl alkaloids using substituted ferrocene redox catalysts, Synthesis-Stuttgart [P], vol 44, issue 16, Georg Thieme Verlag, Germany, pp. 2587-2594.

Debono, A.J., Xie, J.H., Ventura, S., Pouton, C.W., Capuano, B., Scammells, P.J., 2012, Synthesis and biological evaluation of N-substituted noscapine analogues, Chemmedchem [P], vol 7, issue 12, Wiley - V C H Verlag GmbH & Co. KGaA, Germany, pp. 2122-2133.

Gosling, J.I., Baker, S.P., Haynes, J.M., Kassiou, M., Pouton, C.W., Warfe, L., White, P.J., Scammells, P.J., 2012, Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N6-substituents as adenosine A1 receptor agonists, Chemmedchem [P], vol 7, issue 7, Wiley-V C H Verlag GMBH, Germany, pp. 1191-1201.

Valant, C., Aurelio, L., Devine, S.M., Ashton, T.D., White, J.M., Sexton, P.M., Christopoulos, A., Scammells, P.J., 2012, Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A1 receptor, Journal of Medicinal Chemistry [P], vol 55, issue 5, American Chemical Society, USA, pp. 2367-2375.

Hausler, N., Devine, S., McRobb, F.M., Warfe, L., Pouton, C.W., Haynes, J.M., Bottle S.E., White, P.J., Scammells, P.J., 2012, Synthesis and pharmacological evaluation of dual acting antioxidant A2A adenosine receptor agonists, Journal of Medicinal Chemistry [P], vol 55, issue 7, American Chemical Society, USA, pp. 3521-3534.

Vinh, N., Simpson, J.S., Scammells, P.J., Chalmers, D.K., 2012, Virtual screening using a conformationally flexible target protein: models for ligand binding to p38 alpha MAPK, Journal Of Computer-Aided Molecular Design [P], vol 26, issue 4, Springer, Netherlands, pp. 409-423.

Canals, M., Lane, J., Wen, A., Scammells, P., Sexton, P., Christopoulos, A., 2011, A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation, Journal Of Biological Chemistry [P], vol 287, issue 1, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 650-659.

Shonberg, J., Scammells, P., Capuano, B., 2011, Design strategies for bivalent ligands targeting GPCRs, Chemmedchem [P], vol 6, issue 6, WILEY-BLACKWELL, USA, pp. 963-974.

Walker, J., Fairfull-Smith, K., Anzai, K., Lau, S., White, P., Scammells, P., Bottle, 2011, Edaravone containing isoindoline nitroxides for the potential treatment of cardiovascular ischaemia, MedChemComm [P], vol 2, issue 5, ROYAL SOC CHEMISTRY, England, pp. 436-441.

Orbell, G., Scammells, P., 2011, Efficient iron-catalyzed n-demethylation of tertiary mmine-n-oxides under oxidative conditions, Australian Journal of Chemistry [E], vol 64, issue 11, CSIRO PUBLISHING, AUSTRALIA, pp. 1515-1521.

Orbell, G., Scammells, P., 2011, Further investigations into the N-demethylation of oripavine using iron and stainless steel, Organic & Biomolecular Chemistry [P], vol 9, issue 4, ROYAL SOC CHEMISTRY, England, pp. 1008-1011.

Ford, L., Atefi, F., Singer, R., Scammells, P., 2011, Grignard reactions in pyridinium and phosphonium ionic liquids, European Journal of Organic Chemistry [P], vol 2011, issue 5, WILEY-BLACKWELL, USA, pp. 942-950.

Scammells, P., Flynn, B., Aurelio, L., 2011, New methodology for the N-alkylation of 2-amino-3-acylthiophenes, Organic & Biomolecular Chemistry [P], vol 9, issue 13, ROYAL SOC CHEMISTRY, England, pp. 4886-4902.

Devine, S., Scammells, P., 2011, Synthesis and utility of 2-halo-O(6)-(benzotriazol-1-yl)-functionalized purine nucleosides, European Journal of Organic Chemistry [P], vol 2011, issue 6, WILEY-V C H VERLAG GMBH, GERMANY, pp. 1092-1098.

Aurelio, L., Christopoulos, A., Flynn, B., Scammells, P., Sexton, P., Valant, C., 2011, The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A(1) adenosine receptor, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 12, Pergamon-Elsevier Science Ltd, UK, pp. 3704-3707.

Urmaliya, V., Pouton, C., Devine, S., Haynes, J., Warfe, L., Scammells, P., White, P., 2010, A novel highly selective adenosine A1 receptor agonist VCP28 reduces ischemia injury in a cardiac cell line and ischemia-reperfusion injury in isolated rat hearts at concentrations that do not affect heart rate, Journal Of Cardiovascular Pharmacology [P], vol 56, issue 3, Lippincott Williams & Wilkins, United States, pp. 282-292.

Valant, C., Aurelio, L., Urmaliya, V., White, P., Scammells, P., Sexton, P., Christopoulos, A., 2010, Delineating the mode of action of adenosine A1 receptor allosteric modulators, Molecular Pharmacology [P], vol 78, issue 3, American Society for Pharmacology and Experimental Therapeutics, United States, pp. 444-455.

Aurelio, L., Valant, C., Flynn, B., Sexton, P., White, J., Christopoulos, A., Scammells, P., 2010, Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A1 adenosine receptor modulation, Journal of Medicinal Chemistry [P], vol 53, American Chemical Society, United States, pp. 6550-6559.

Ford, L., Harjani, J., Atefi, F., Garcia, M., Singer, R., Scammells, P., 2010, Further studies on the biodegradation of ionic liquids, Green Chemistry [P], vol 12, issue 10, Royal Society of Chemistry, United Kingdom, pp. 1783-1789.

Kok, G., Scammells, P., 2010, N-demethylation of N-methyl alkaloids with ferrocene, Bioorganic & Medicinal Chemistry Letters [P], vol 20, Pergamon, United Kingdom, pp. 4499-4502.

Goeminne, A., Scammells, P., Devine, S., Flynn, B., 2010, Richter cyclization and co-cyclization reactions of triazene-masked diazonium ions, Tetrahedron Letters [P], vol 51, issue 52, Pergamon, United Kingdom, pp. 6882-6885.

Harjani, J., Abraham, T., Gomez, A., Garcia, M., Singer, R., Scammells, P., 2010, Sonogashira coupling reactions in biodegradable ionic liquids derived from nicotinic acid, Green Chemistry [P], vol 12, issue 4, Royal Society of Chemistry, United Kingdom, pp. 650-655.

El-Kabbani, O., Scammells, P.J., Day, T., Dhagat, U., Endo, S., Matsunaga, T., Soda, M., Hara, A., 2010, Structure-based optimization and biological evaluation of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors, European Journal of Medicinal Chemistry [P], vol 45, issue 11, Elsevier Masson, France, pp. 5309-5317.

Devine, S.M., Gregg, A., Figler, H., McIntosh, K., Urmaliya, V., Linden, J., Pouton, C.W., White, P.J., Bottle, S.E., Scammells, P.J., 2010, Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists, Bioorganic & Medicinal Chemistry Letters [P], vol 18, issue 9, Pergamon, United Kingdom, pp. 3078-3087.

Kok, G.B., Pye, C.C., Singer, R.D., Scammells, P.J., 2010, Two-step iron(0)-mediated N-demethylation of N -methyl alkaloids, Journal Of Organic Chemistry [P], vol 75, issue 14, American Chemical Society, United States, pp. 4806-4811.

Aurelio, L., Valant, C., Figler, H., Flynn, B.L., Linden, J., Sexton, P., Christopoulos, A., Scammells, P.J., 2009, 3- and 6-substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists, Bioorganic & Medicinal Chemistry [P], vol 17, issue 20, Pergamon, UK, pp. 7353-7361.

Aurelio, L., Valant, C., Flynn, B.L., Sexton, P.M., Christopoulos, A., Scammells, P.J., 2009, Allosteric modulators of the adenosine A1 receptor: Synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes, Journal of Medicinal Chemistry [P], vol 52, issue 14, American Chemical Society, USA, pp. 4543-4547.

Orbell, G.B., Ashton, T.D., Scammells, P.J., 2009, An Improved Process for the N-Demethylation of Opiate Alkaloids using an Iron(II) Catalyst in Acetate Buffer, Advanced Synthesis and Catalysis [P], vol 351, issue 1-2, Wiley - V C H Verlag GmbH & Co. KGaA, Germany, pp. 283-286.

Harjani, J.R., Singer, R.D., Garcia, M.T., Scammells, P.J., 2009, Biodegradable pyridinium ionic liquids: design, synthesis and evaluation, Green Chemistry [P], vol 11, issue 1, Royal Society of Chemistry, UK, pp. 83-90.

Stewart, G.D., Valant, C., Dowell, S.J., Mijaljica, D., Devenish, R.J., Scammells, P.J., Sexton, P., Christopoulos, A., 2009, Determination of adenosine A1 receptor agonist and antagonist pharmacology using Saccharomyces cerevisiae: Implications for ligand screening and functional selectivity, Journal Of Pharmacology And Experimental Therapeu..., vol 331, issue 1, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 277-286.

Harjani, J.R., Farrell, J., Garcia, M.T., Singer, R.D., Scammells, P.J., 2009, Further investigation of the biodegradability of imidazolium ionic liquids, Green Chemistry [P], vol 11, issue 6, Royal Society of Chemistry, UK, pp. 821-829.

Foitzik, R., Devine, S., Hausler, N.E., Scammells, P.J., 2009, Linear and convergent approaches to 2-substituted adenosine-5 '-N-alkylcarboxamides, Tetrahedron [P], vol 65, issue 43, Pergamon, UK, pp. 8851-8857.

Atefi, F., Garcia, M.T., Singer, R.D., Scammells, P.J., 2009, Phosphonium ionic liquids: design, synthesis and evaluation of biodegradability, Green Chemistry [P], vol 11, issue 10, Royal Society of Chemistry, UK, pp. 1595-1604.

Johnston-Hall, G., Harjani, J.R., Scammells, P.J., Monteiro, M.J., 2009, RAFT-mediated polymerization of styrene in readily biodegradable ionic liquids, Macromolecules [P], vol 42, issue 5, American Chemical Society, USA, pp. 1604-1609.

Aurelio, L., Flynn, B.L., Scammells, P.J., 2009, Reaction pathways to 2-aminothiophenes and thiophene-3-carbonitriles, Australian Journal of Chemistry [E], vol 62, issue 5, C S I R O Publishing, Australia, pp. 402-406.

El-Kabbani, O., Scammells, P.J., Gosling, J.I., Dhagat, U., Endo, S., Matsunaga, T., Soda, M., Hara, A., 2009, Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1), Journal of Medicinal Chemistry [P], vol 52, issue 10, American Chemical Society, USA, pp. 3259-3264.

Adams, T.E., El Sous, M., Hawkins, B.C., Hirner, S., Holloway, G.A., Khoo, M., Owen, D.J., Savage, G.P., Scammells, P.J., Rizzacasa, M.A., 2009, Total Synthesis of the Potent Anticancer Aglaia Metabolites (-)-Silvestrol and (-)-Episilvestrol and the Active Analogue (-)-4-Desmethoxyepisilvestrol, Journal Of The American Chemical Society [P], vol 131, issue 4, American Chemical Society, USA, pp. 1607-1616.

Ferguson, G.N., Valant, C., Horne, H.J., Figler, H., Flynn, B.L., Linden, J., Chalmers, D.K., Sexton, P., Christopoulos, A., Scammells, P.J., 2008, 2-Aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists, Journal of Medicinal Chemistry, vol 51, issue 19, American Chemical Society, USA, pp. 6165-6172.

Aurelio, L., Figler, H., Flynn, B.L., Linden, J., Scammells, P.J., 2008, 5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers, Bioorganic and Medicinal Chemistry, vol 16, issue 3, Pergamon, UK, pp. 1319-1327.

Valant, C., Gregory, K.J., Hall, N.E., Scammells, P.J., Lew, M., Sexton, P., Christopoulos, A., 2008, A novel mechanism of G protein-coupled receptor functional selectivity: Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand, Journal of Biological Chemistry, vol 283, issue 43, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 29312-29321.

Halim, R., Scammells, P.J., Flynn, B.L., 2008, Alternating lodonium-mediated reaction cascades giving indole- And quinoline-containing polycycles, Organic Letters, vol 10, issue 10, American Chemical Society, Web, pp. 1967-1970.

Devine, S., Scammells, P.J., 2008, An efficient convergent synthesis of adenosine-5'-N-alkyluronamides, Tetrahedron, vol 64, issue 8, Pergamon, UK, pp. 1772-1777.

Ashton, T.D., Scammells, P.J., 2008, Microwave-assisted direct amination: Rapid access to multi-functionalized N6-substituted adenosines, Australian Journal of Chemistry, vol 61, issue 1, CSIRO Publishing, Australia, pp. 49-58.

Ashton, T.D., Baker, S.P., Hutchinson, S.A., Scammells, P.J., 2008, N6-substituted C5'-modified adenosines as A1 adenosine receptor agonists, Biorganic and Medicinal Chemistry, vol 16, issue 4, Pergamon, UK, pp. 1861-1873.

Foitzik, R., Bottle S.E., White, J.M., Scammells, P.J., 2008, Synthesis of 1,1,3,3-tetraalkylisoindolines using a microwave-assisted Grignard reaction, Australian Journal of Chemistry, vol 61, issue 3, CSIRO Publishing, Australia, pp. 168-171.

Karellas, P., McNaughton, M., Baker, S.P., Scammells, P.J., 2008, Synthesis of bivalent beta2-adrenergic and adenosine A 1 receptor ligands, Journal of Medicinal Chemistry, vol 51, issue 19, American Chemical Society, USA, pp. 6128-6137.

Harjani, J.R., Singer, R.D., Garcia, M.T., Scammells, P.J., 2008, The design and synthesis of biodegradable pyridinium ionic liquids, Green Chemistry, vol 10, issue 4, Royal Society Chemistry, UK, pp. 436-438.

Bouquillon, S., Courant, T., Dean, D., Gathergood, N., Morrissey, S., Pegot, B., Scammells, P.J., Singer, R.D., 2007, Biodegradable ionic liquids: Selected synthetic applications, Australian Journal of Chemistry, vol 60, issue 11, CSIRO Publishing, Australia, pp. 843-847.

Gregg, A.D., Bottle S.E., Devine, S., Figler, H., Linden, J., White, P.J., Pouton, C.W., Urmaliya, V., Scammells, P.J., 2007, Dual acting antioxidant A1 adenosine receptor agonists, Bioorganic & Medicinal Chemistry Letters, vol 17, issue 19, Pergamon, England, pp. 5437-5441.

Butcher, A., Gregg, A.D., Scammells, P.J., Rose' Meyer, R.B., 2007, Effect of a novel partial adenosine A1 receptor agonist VCP102 in reducing ischemic damage in the mouse heart, Drug Development Research, vol 68, issue 8, John Wiley & Sons, USA, pp. 529-537.

Dong, Z., Scammells, P.J., 2007, New methodology for the N-demethylation of opiate alkaloids, Journal of Organic Chemistry, vol 72, issue 26, American Chemical Society, USA, pp. 9881-9885.

Aumann, K.M., Scammells, P.J., Whitehead, J.M., Schiesser, C.H., 2007, On the stability of 2-aminoselenophene-3-carboxylates: potential dual-acting selenium-containing allosteric enhancers of A1 adenosine receptor binding, Organic & Biomolecular Chemistry, vol 5, issue 8, Royal Society of Chemistry, UK, pp. 1276-1281.

Ashton, T.D., Aumann, K.M., Baker, S.P., Schiesser, C.H., Scammells, P.J., 2007, Structure-activity relationships of adenosines with heterocyclic N6-substituents, Bioorganic & Medicinal Chemistry Letters, vol 17, issue 24, Pergamon-Elsevier Science, England, pp. 6779-6784.

El Sous, M., Khoo, M., Holloway, G.A., Owen, D., Scammells, P.J., Rizzacasa, M.A., 2007, Total synthesis of (-)-episilvestrol and (-)-silvestrol, Angewandte Chemie (International Edition), vol 46, issue 41, Wiley - VCH Verlag & Co., Germany, pp. 7835-7838.

Nikolakopoulos, G., Figler, H., Linden, J., Scammells, P.J., 2006, 2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers, Bioorganic & Medicinal Chemistry, vol 14, issue 7, Pergamon, UK, pp. 2358-2365.

Ashton, T.D., Scammells, P.J., 2006, An expedient synthesis of N6-substituted-5'-modified adenosines, Bioorganic & Medicinal Chemistry Letters, vol 16, issue 17, Pergamom, UK, pp. 4564-4566.

Gathergood, N., Scammells, P.J., Garcia, M.T., 2006, Biodegradable ionic liquids: Part III. The first readily biodegradable ionic liquids, Green Chemistry, vol 8, issue 2, Royal Society of Chemistry, UK, pp. 156-160.

Thavaneswaran, S., Scammells, P.J., 2006, Further investigation of the N-demethylation of tertiary amine alkaloids using the non-classical Polonovski reaction, Bioorganic & Medicinal Chemistry Letters, vol 16, issue 11, Pergamon, UK, pp. 2868-2871.

Thavaneswaran, S., McCamley, K., Scammells, P.J., 2006, N-demethylation of Alkaloids, Natural Product Communication, vol 1, issue 10, Natural Product, Inc., USA, pp. 885-897.

Scammells, P.J., Ashton, T.D., 2005, An improved synthesis of 5'-fluoro-5'-deoxyadenosines, Bioorganic and Medicinal Chemistry Letters, vol 15, Elsevier Pergamon, UK, pp. 3361-3363.

Garcia, M.T., Gathergood, N., Scammells, P.J., 2005, Biodegradable ionic liquids Part II. Effect of the anion and toxicology, Green Chemistry, vol 7, The Royal Society of Chemistry, UK, pp. 9-14.

Anastos, N., Barnett, N.W., Lewis, S.W., Gathergood, N., Scammells, P.J., Sims, D.N., 2005, Determination of psilocin and psilocybin using flow injection analysis with acidic potassium permanganate and tris(2,2'-bipyridyl)ruthenium(II) chemiluminescence detection respectively, Talanta, vol 67, Elsevier, Netherlands, pp. 354-359.

Scammells, P.J., Scott, J.L., Singer, R.D., 2005, Ionic liquids: the neglected issues, Australian Journal of Chemistry, vol 58, issue 3, CSIRO, Publishing, Melbourne Vic Australia, pp. 155-169.

Hutchinson, S.A., Scammells, P.J., 2004, A(1) adenosine receptor agonists: medicinal chemistry and therapeutic potential, Current Pharmaceutical Design [P], vol 10, issue 17, Bentham Science Publishers Ltd., Netherlands, pp. 2021-2039.

Gathergood, N., Garcia, M.T., Scammells, P.J., 2004, Biodegradable ionic liquids: Part I. Concept, preliminary targets and evaluation, Green Chemistry, vol 6, Royal Society of Chemistry, UK, pp. 166-175.

Hemeon, I., Barnett, N.W., Gathergood, N., Scammells, P.J., Singer, R.D., 2004, Manganese Dioxide Allylic and Benzylic Oxidation Reactions in Ionic Liquids, Australian Journal of Chemistry, vol 57, CSIRO publishing, Australia, pp. 125-128.

Hutchinson, S.A., Baker, S.P., Linden, J., Scammells, P.J., 2004, New potent and selective A1 adenosine receptor agonists, Bioorganic & Medicinal Chemistry, vol 12, Pergamon, UK, pp. 4877-4884.

McCamley, K., Warner, N.A., Lamoureux, M.M., Scammells, P.J., Singer, R.D., 2004, Quantification of chloride ion impurities in ionic liquids using ICP-MS analysis, Green Chemistry, vol 6, issue 7, Royal Society of Chemistry, UK, pp. 341-344.

Lutjens, H., Zickgraf, A., Figler, H., Linden, J., Olsson, R.A., Scammells, P.J., 2003, 2-Amino-3-benzoylthiophene Allosteric Enhancers of A1 Adenosine Agonist Binding: New 3, 4- and 5-Modifications, Journal of Medicinal Chemistry, vol 46, American Chemical Society, USA, pp. 1870-1877.

Gathergood, N., Scammells, P.J., Fallon, G.D., 2003, 7,8-Didehydro-4,5-epoxy-17-methyl-morphinan-6-yl naphthalene-1-carboxylate, Acta Crystallographica Section E: Structure Reports Online, vol E59, Blackwell Munksgaard, Denmark, pp. 1918-1919.

McCamley, K., Ripper, J.A., Singer, R.D., Scammells, P.J., 2003, Efficient N-Demethylation of opiate alkaloids using a modified nonclassical Polonovski reaction, Journal of Organic Chemistry, vol 68, issue 25, American Chemical Society, USA, pp. 9847-9850.

Gathergood, N., Scammells, P.J., Fallon, G.D., 2003, Inter- and intramolecular C-H...interactions in morphine bis(1-naph-thoate), Acta Crystallographica Section C: Crystal Structure Communications, vol C59, Blackwell Munksgaard, Denmark, pp. 485-487.

Gathergood, N., Scammells, P.J., 2003, Preparation of the 4-hydroxytryptamine scaffold via palladium-catalyzed cyclization: a practical and versatile synthesis of psilocin, Organic Letters, vol 5, issue 6, American Chemical Society, USA, pp. 921-923.

Trandberg, C.E., Zickgraf, A., Giunta, B.N., Luetjens, H., Figler, H., Murphree, L.J., Falke, R., Fleischer, H., Linden, J., Scammells, P.J., Olsson, R.A., 2002, 2-Amino-3-aroyl-4,5-alkylthiophenes: Agonist Allosteric Enhancers at Human A1 Adenosine Receptors, Journal of Medicinal Chemistry, vol 45, American Chemical Society, USA, pp. 382-389.

Gathergood, N., Scammells, P., 2002, Design and preparation of room-temperature ionic liquids containing biodegradable side chains, Australian Journal of Chemistry, vol 55, issue 9, C S I R O Publishing, Australia, pp. 557-560.

Hemeon, I., De Amicis, C., Jenkins, H., Scammells, P., Singer, R.D., 2002, Endo selective Diels-Alder reactions of furan in ionic liquids, Synlett: Accounts and Rapid Communications in Synthetic Chemistry, vol 11, issue November, Georg Thieme Verlag, Germany, pp. 1815-1818.

Hutchinson, S.A., Scammells, P.J., 2002, New 2, N6-Distributed Adenosines: Potent and Selective A1 Adenosine Receptor Agonists, Bioorganic and Medicinal Chemistry, vol 10, Pergamon, pp. 1115-1122.

Beauglehole, A.R., Baker, S.P., Scammells, P.J., 2002, New irreversible adenosine A1 antagonists based on FSCPX, Bioorganic & Medicinal Chemistry Letters, vol 12, issue 21, Pergamon, UK, pp. 3179-3182.

Duthie, A., Scammells, P.J., Katsifis, A., Tiekink, E.R.T., 2001, (1,3-Benzo[d]dioxol-5-yl) (2-pyridyl) methyl cyanide, Acta Crystallographica Section E Structure Reports Online, vol E 57, Blackwell Munksgaard, Denmark, pp. 104-105.

Scammells, P.J., Tranberg, C., Tiekink, E.R.T., 2001, 6,7 Dimethyl-5-phenyl-1H-thieno [2,3-e]-[1,4]diazepin-2(3H)-one, Acta Crystallographica Section E: Structure Reports online, vol E 57, Blackwell Munksgaard, Denmark, pp. 344-345.

Singer, R.D., Scammells, P.J., 2001, Alternative Methods for the MnO2 oxidation of codeine methyl ether to thebaine utilizing ionic liquids, Tetrahedron letters, vol 42, Pergamon, pp. 6831-6833.

Duthie, A., Scammells, P.J., Katsifis, A., Tiekink, E.R.T., 2001, Crystal Structure of (4-Bromonaphthalen-2-yl) acetonitrile, Z. Krist., vol 216, issue 4, R Oldenbourg Verlag, Germany, pp. 531-532.

Ripper, J.A., Tiekink, E.R.T., Scammells, P.J., 2001, Photochemical N-Demethylation of alkaloids, Bioorganic and Medicinal Chemistry Letters 11, vol 11, Pergamon, pp. 443-445.

Baker, S.P., Scammells, P.J., Belardinelli, L., 2000, British Journal of Pharmacology, Differential A1-adenosine receptor reserve for inhibition of cyclic AMP accumulation and G-protein activation in DDT 1 MF-2 cells, vol 130, issue 5, Nature Publishing Group, UK, pp. 1156-1164.

Beauglehole, A., Baker, S.P., Scammells, P.J., 2000, Fluorosulfonyl Substituted Xanthines as Selective Irreversible Antagonists for the A1 Adenosine Receptor, Journal of Medicinal Chemistry, vol 43, American Chemical Society, USA, pp. 4973-4980.

Beauglehole, A., Baker, S.P., Scammells, P.J., 2000, Fluorosulfonyl-substituted Xanthines as Selective Irreversible Antagonists for the A1-Adenosine Receptor, Journal of Medicinal Chemistry, vol 43, American Chemical Society, USA, pp. 4973-4980.

Other

Scammells, P., Kok, G., 2011, A method for the N-demethylation of N-methyl heterocycles, AU.

Scammells, P.J., Aurelio, L., Christopoulos, A., Sexton, P., Valant, C., Flynn, B.L., Linden, J., 2009, A1 adenosine receptor allosteric enhancers, USA, AU.

Scammells, P.J., Gathergood, N., Ripper, J.A., 2008, Chemical Methods (USA), USA.

Scammells, P.J., Gathergood, N., Ripper, J.A., 2007, Chemical Methods (Australia), Australia.

Linden, J.M., Olsson, R.A., Scammells, P.J., 2006, 2-Amino-3-Aroyl-4,5 Alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors.

Owen, D.J., Rizzacasa, M.A., El Sous, M., Spinello, M., Scammells, P.J., Holloway, G.A., 2006, Processes and intermediates, Europe, Asia, USA, Australia.

Linden, J., Olsson, R.A., Scammells, P.J., 2004, 2-amino-3-Aroyl-4,5 Alkylthiophenes:Agonist Allosteric Enhancers at Human A1 Adenosine Receptors, USA.

Scammells, P.J., Gathergood, N., Ripper, J.A., 2002, Chemical methods, Australia Europe USA.

Teaching Commitment

Bachelor of Pharmaceutical Science:

• PSC2121 Synthetic Chemistry I (unit coordinator)
• PSC3121 Synthetic Medicinal Chemistry

Activities

Affiliations with research centres

Co-theme leader
Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Grants

Title:

ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology.

Investigators:

Scammells, P, Schiesser, C, Easton, C, Hearn, M, Radom, L, Angus, J, Davies, M, O'Hair, R, Coote, M, Bottle, , Wille, U, Jackson, W, Sherburn, M, Barker, P, Rizzardo, E, Jarrott, B, Such, C, Rogers, P

Funding:

(2005 - 2009). Australian Research Council (ARC). $421,016.00

(2005 - 2009). Australian Research Council (ARC). $842,035.00

(2005 - 2009). Monash University. $225,000.00

(2005 - 2010). Monash University. $112,500.00

(2010 - 2011). Australian Research Council (ARC). $46,780.00

(2010 - 2011). Australian Research Council (ARC). $93,559.00

(2010 - 2011). Monash University. $12,500.00

(2010 - 2011). Monash University. $25,000.00

Title:

Allosteric Enhancers of Adenosine Agonist Binding.

Investigators:

Scammells, P

Funding:

( - ). Australian Institute of Nuclear Science & Engineering. $0.00

Title:

Allosteric Enhancers: Leads for the Therapy of Cardiovascular Disease.

Investigators:

Scammells, P, Flynn, B

Funding:

(2005 - 2009). Australian Research Council (ARC). $270,000.00

Title:

Allosteric Modulators as Novel Probes of G-Protein Coupled Receptor Function.

Investigators:

Scammells, P, Christopoulos, A, Flynn, B

Funding:

(2008 - 2011). Australian Research Council (ARC). $300,000.00

(2008 - 2011). Australian Research Council (ARC). $75,354.00

(2008 - 2012). Australian Research Council (ARC). $0.00

Title:

Applications of the Polonovski Reaction in the Synthesis of Bioactive Opiates.

Investigators:

Scammells, P, Capuano, B

Funding:

(2009 - 2013). Australian Research Council (ARC). $78,420.00

(2009 - 2013). GlaxoSmithKline, Australia. $39,000.00

Title:

CRC Cancer Therapeutics - Equipment.

Investigators:

Scammells, P

Funding:

(2009 - 2014). Cancer Therapeutics CRC Pty Ltd. $291,823.19

Title:

Development of Novel Anti-Inflammatory Agents.

Investigators:

Krum, H, Scammells, P, Wang, B

Funding:

(2009 - 2012). National Health & Medical Research Council (NHMRC). $110,330.00

(2009 - 2013). National Health & Medical Research Council (NHMRC). $90,270.00

(2009 - 2015). National Health & Medical Research Council (NHMRC). $0.00

(2010 - 2015). National Health & Medical Research Council (NHMRC). $0.00

Title:

Development of a diversity-oriented synthesis platform.

Investigators:

Scammells, P, Bui, C

Funding:

(2005 - 2009). Australian Research Council (ARC). $225,000.00

(2006 - 2009). Iliad Chemicals Pty Ltd. $105,000.00

Title:

Discovery and development of dihydropteroate synthase (DHPS) inhibitors.

Investigators:

Swarbrick, J, Scammells, P, Macreadie, I

Funding:

(2005 - 2010). Monash University - CSIRO Collaborative Research Scheme. $50,000.00

Title:

Enhanced drug delivery using nanoparticulate dendrimer vectors.

Investigators:

Porter, C, Scammells, P, Krippner, G

Funding:

(2003 - 2007). Australian Research Council (ARC). $135,884.00

(2003 - 2007). Australian Research Council (ARC). $69,098.00

(2003 - 2007). Starpharma Pty Ltd. $186,000.00

Title:

Finnigan LCQ Deca XP Max Ultra-Sensitive 3D Ion Tap L/MS(n) System.

Investigators:

Scammells, P

Funding:

(2007 - 2011). National Health & Medical Research Council (NHMRC). $85,000.00

Title:

Focal Adhesion Kinase (FAK).

Investigators:

Scammells, P, Pouton, C

Funding:

(2009 - 2014). Cancer Therapeutics CRC Pty Ltd. $1,212,627.96

Title:

High throughput analysis and screening facility.

Investigators:

Sexton, P, Christopoulos, A, Whisstock, J, Rossjohn, J, Scammells, P, Drummond, G, Beddoe, T, Mackay, C, Charman, W, Hertzog, P

Funding:

(2009 - 2014). National Health & Medical Research Council (NHMRC). $325,000.00

Title:

Melbourne Biomolecular NMR Network.

Investigators:

Stone, M, Gooley, P, Scanlon, M, Langford, S, Wilce, J, Separovic, F, Tuck, K, Bottomley, S, Whisstock, J, Reynolds, E, Scammells, P

Funding:

(2009 - 2013). Australian Research Council (ARC). $1,400,000.00

(2009 - 2013). Monash University. $0.00

(2009 - 2013). The University of Melbourne. -$372,500.00

Title:

New Methodology for the Manufacture of Opioid Pharmaceuticals and the Discovery of Novel Opiate Receptor Ligands.

Investigators:

Scammells, P, Graham, B, Scott, C

Funding:

(2011 - 2015). Australian Research Council (ARC). $210,000.00

(2011 - 2015). Australian Research Council (ARC). $81,666.00

(2011 - 2015). GlaxoSmithKline, Australia. $120,000.00

(2011 - 2015). Monash University. $17,500.00

Title:

Norbornyl Substituted Adenosine Receptor Ligands: Potential Cardiovascular Pharmaceuticals.

Investigators:

Scammells, P

Funding:

(2002 - 2003). Australian Research Council (ARC). $86,472.00

Title:

Refrigerated Incubator.

Investigators:

El-Kabbani, O, Scammells, P, Prankerd, R

Funding:

(2007 - 2011). Collier Charitable Fund. $2,500.00

Title:

Synthesis of Novel Selenium-Containing Antioxidants and Related Therapeutic Agents.

Investigators:

Scammells, P, Schiesser, C

Funding:

(2003 - 2007). Victorian Department of Innovation, Industry & Regional Development (DIIRD). $0.00

Title:

Synthesis of novel selenium containing antioxidants and related therapeutic agents.

Investigators:

Scammells, P

Funding:

(2004 - 2008). Victorian Department of Innovation, Industry & Regional Development (DIIRD). $25,000.00

Title:

The Synthesis and Pharmacological Evaluation of Novel Bivalent Dopamine D2 and Adenosine A2A Ligands for the Treatment of Parkinson s Disease.

Investigators:

Capuano, B, Scammells, P, Jorg, M

Funding:

(2010 - 2014). Australian Research Council (ARC). $78,420.00

(2010 - 2014). GSK Centre for Cognitive and Neurodegenerative Disorders. $18,000.00

Title:

The development of novel task specific and biodegradable ionic liquids.

Investigators:

Scammells, P, Singer, R

Funding:

(2005 - 2008). Australian Research Council (ARC). $51,100.00

Title:

Understanding Allosteric Modulation and Functional Selectivity at G Protein-Coupled Receptors.

Investigators:

Scammells, P, Christopoulos, A

Funding:

(2011 - 2014). Australian Research Council (ARC). $67,500.00

(2011 - 2014). Monash University. $27,000.00

(2011 - 2015). Australian Research Council (ARC). $420,000.00

Title:

Small Molecule NMR Facility of Accelerated Drug Discovery.

Investigators:

Separovic, F, Scanlon, M, Marriott, P, Urban, S, Scammells, P, Schiesser, C

Funding:

(2004 - 2015). Australian Research Council (ARC). $0.00

(2004 - 2015). Monash University. $0.00

(2004 - 2015). Royal Melbourne Institute of Technology (RMIT). $0.00

(2004 - 2015). The University of Melbourne. $0.00

Title:

X-ray Molecular Structure Elucidation Facillity (MSEF).

Investigators:

White, J, Abrahams, B, El-Kabbani, O, Scammells, P, Donnelly, P, Holmes, A, Kolev, S, O'Hair, R, Schiesser, C, Wedd, A, Young, C, Robson, R, Cheng, H, Boskovic, C, Dakternieks, D, Duthie, A, Hutton, C, Williams, S, Rizzacasa, M, Prankerd, R, Jazayeri, J, Thompson, P, Simpson, J, Wille, U

Funding:

(2007 - 2011). Australian Research Council (ARC). $132,600.00

(2007 - 2011). Monash University. $24,666.00

(2007 - 2011). Monash University. $49,334.00

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Design, synthesis and pharmacological evaluation of molecular probes targeting the dopamine D2 receptor.

Supervisors:

Capuano, B (Joint-co), Scammells, P (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Discovery of new treatments for Human African Trypanosomiasis (HAT).

Supervisors:

Scammells, P (Main), Orlando, L (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

High-resolution NMR studies of large proteins.

Supervisors:

Norton, R (Main), Scammells, P (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Ionic liquids as potential drug delivery vehicles.

Supervisors:

Scammells, P (Main), Porter, C (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Luminescent Bivalent GPCR-Binding Ligands.

Supervisors:

Graham, B (Joint), Scammells, P (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

New Potassium Channel Blockers for the Treatment of Multiple Sclerosis and Other Autoimmune Diseases.

Supervisors:

Norton, R (Main), Scammells, P (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Novel Approaches to sp3-Rich Chemotypes for Drug Discovery Applications.

Supervisors:

Flynn, B (Main), Scammells, P (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

SAR of Noscapine and Noscapine related analogues..

Supervisors:

Capuano, B (Joint), Scammells, P (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Structure based design, synthesis and evaluation of 20x-hydroxysteriod dehydrogenase (AKR1C1) inhibitors.

Supervisors:

Scammells, P (Main), El-Kabbani, O (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Synthesis and Pharmacological evaluation of novel bivalent Dopamine D2 and Adenosine A2a Ligands for the therapy of Parkinsons's Disease..

Supervisors:

Capuano, B (Joint-co), Scammells, P (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Synthesis and pharmacological investigation of allosteric ligands for the M1 muscarinic acetylcholine receptor.

Supervisors:

Christopoulos, A (Joint-co), Scammells, P (Joint), Capuano, B (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Synthesis of novel phosphotidylinositol-3 kinase (PI3K) inhibitors.

Supervisors:

Scammells, P (Main), Baell, J (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The malaria surface antigen AMA1: a novel drug target.

Supervisors:

Scammells, P (Main), Norton, R (Associate), Shane, D (Associate).

Completed Supervision

Student:

Ashton, T.

Program of Study:

Synthesis of A1 adenosine receptor agonists: development and application of new methodology. (PHD) 2007.

Supervisors:

Scammells, P (Main), Capuano, B (Associate).

Student:

Barlow, N.

Program of Study:

Bifunctional, bitopic and fluorescent agonists for the A1 adenosine receptor. (PHD) 2012.

Supervisors:

Scammells, P (Main).

Student:

Ciccotosto, S.

Program of Study:

THE PREPARATION AND EVALUATION OF N-ACETYLNEURAMINIC ACID DERIVATIVES AS PROBES OF SIALIC ACID-RECOGNIZING PROTEINS. (PHD) 2005.

Supervisors:

Von Itzstein, M (Main), Scammells, P (Associate).

Student:

Ferguson, G.

Program of Study:

Synthesis and pharmacological evaluation of novel heteroaromatic ligands of the A1 adenosine receptor. (PHD) 2010.

Supervisors:

Scammells, P (Main).

Student:

Jackson, K.

Program of Study:

Interrupted Nazarov cyclisations in asymmetric synthesis: towards the synthesis of the rocaglates. (PHD) 2010.

Supervisors:

Flynn, B (Main), Scammells, P (Main), Flynn, B (Associate).

Student:

Karellas, P.

Program of Study:

Synthesis of novel bivalent and multivalent ligands targeting the beta2 adrenergic and A1 adenosine receptor and the synthesis of functionalised poly-L-lysine dendrimers. (PHD) 2011.

Supervisors:

Scammells, P (Main), Porter, C (Associate).

Student:

Kerr, D.

Program of Study:

Practical Nazarov chemistry for organic synthesis: concise synthesis of roseophilin and auxiliary mediated asymmetric Nazarov reaction. (PHD) 2009.

Supervisors:

Simpson, J (Main), Scammells, P (Associate).

Student:

Mccamley, K.

Program of Study:

SYNTHETIC INVESTIGATIONS TOWARDS PHARMACEUTICAL OPIATES. (PHD) 2004.

Supervisors:

Scammells, P (Main).

Student:

Nikolakopoulos, G.

Program of Study:

Structure/activity studies of novel A1 adenosine receptor allosteric enhancers. (PHD) 2006.

Supervisors:

Scammells, P (Main).

Student:

Phan, V.

Program of Study:

SYNTHESIS OF SIALYL MIMETICS AS BIOLOGICAL PROBES. (PHD) 2004.

Supervisors:

Scammells, P (Joint-Co).

Student:

Thavaneswaran, S.

Program of Study:

The synthesis of receptor-subtype selective, peripherally-acting opiates. (PHD) 2007.

Supervisors:

Scammells, P (Main), Capuano, B (Associate).

Student:

Trower, C.

Program of Study:

A PRELIMINARY INVESTIGATION OF A SIALIDASE ACTIVITY ASSOCIATED WITH M. SMEGMATIS. (PHD) 2003.

Supervisors:

Von Itzstein, M (Main), Scammells, P (Associate).