Prof Robert Widdop - Researcher Profile

Biography

Robert works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Professor.

Qualifications

PHD

Institution: Monash University

Year awarded: 1986

Publications

Books

Loiacono, R.E., Widdop, R.E. (eds), 1997, Proceedings of ASCEPT, ASCEPT, Sydney NSW Australia.

Journal Articles

McCarthy, C.A., Widdop, R.E., Denton, K.M., Jones, E.S., 2013, Update on the Angiotensin AT(2) Receptor, Current Hypertension Reports [P], vol 15, issue 1, Springer Healthcare, USA, pp. 25-30.

McCarthy, C.A., Vinh, A., Broughton, B.R., Sobey, C.G., Callaway, J.K., Widdop, R.E., 2012, Angiotensin II Type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats, Hypertension [P], vol 60, issue 6, Lippincott Williams & Wilkins, USA, pp. 1531-1537.

Bosnyak, S., Widdop, R.E., Denton, K.M., Jones, E.S., 2012, Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats, International Journal of Hypertension [E], vol 2012, issue 192567, Hindawi Publishing Corporation, USA, pp. 1-9.

Gaspari, T.A., Vinh, A., Jones, E.S., Widdop, R.E., 2012, Ganging up on Angiotensin II Type 1 Receptors in Vascular Remodeling, Hypertension [P], vol 60, issue 1, Lippincott Williams & Wilkins, USA, pp. 17-19.

Jones, E.S., Black, M.J., Widdop, R.E., 2012, Influence of Angiotensin II Subtype 2 Receptor (AT(2)R) Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II Subtype 1 Receptor (AT(1)R) Blockade, International Journal of Hypertension [E], vol 2012, issue 543062, Hindawi Publishing Corporation, USA, pp. 1-11.

Lee, S., Brait, V.H., Arumugam, T., Evans, M., Kim, H.H.A., Widdop, R.E., Drummond, G.R., Sobey, C.G., Jones, E.S., 2012, Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo, Experimental & Translational Stroke Medicine [E], vol 4, issue 1 (Art. No.: 16), BioMed Central Ltd, UK, pp. 1-9.

Chan, C., Moore, J., Budzyn, K., Guida, E., Diep, H., Vinh, A., Jones, E.S., Widdop, R.E., Armitage, J.A., Sakkal, S., Ricardo, S.D., Sobey, C.G., Drummond, G.R., 2012, Reversal of vascular macrophage accumulation and hypertension by a CCR2 antagonist in deoxycorticosterone/salt-treated mice, Hypertension [P], vol 60, issue 5, Lippincott Williams & Wilkins, USA, pp. 1207-1212.

Hilliard, L.M., Jones, E.S., Steckelings, U.M., Unger, T., Widdop, R.E., Denton, K.M., 2012, Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension, Hypertension [P], vol 59, issue 2, Lippincott Williams & Wilkins, USA, pp. 409-414.

Sampson, A.K., Hilliard, L.M., Moritz, K.M., Thomas, M.C., Tikellis, C., Widdop, R.E., Denton, K.M., 2012, The arterial depressor response to chronic low-dose angiotensin II infusion in female rats is estrogen dependent, American Journal of Physiology - Regulatory Integrative and Comparative Physiology [E], vol 302, issue 1, American Physiological Society, USA, pp. R159-R165.

Gaspari, T., Liu, H., Welungoda, I., Hu, Y., Widdop, R., Knudsen, L., Simpson, R., Dear, A., 2011, A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model, Diabetes and Vascular Disease Research [P], vol 8, issue 2, Sage Publications Ltd, UK, pp. 117-124.

Jones, E.S., Del Borgo, M.P., Kirsch, J., Clayton, D.J., Bosnyak, S., Welungoda, I.K., Hausler, N., Unabia, S., Perlmutter, P., Thomas, W.G., Aguilar, M.I., Widdop, R.E., 2011, A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function, Hypertension [P], vol 57, issue 3, Lippincott Williams & Wilkins, USA, pp. 570-576.

Irvine, J.C., Kemp-Harper, B.K., Widdop, R.E., 2011, Chronic administration of the HNO donor Angeli's salt does not lead to tolerance, cross-tolerance, or endothelial dysfunction: Comparison with GTN and DEA/NO, Antioxidants and Redox Signaling [P], vol 14, issue 9, Mary Ann Liebert, Inc. Publishers, USA, pp. 1615-1624.

Hilliard, L.M., Nematbakhsh, M., Kett, M.M., Teichman, E., Sampson, A.K., Widdop, R.E., Evans, R.G., Denton, K.M., 2011, Gender differences in pressure-natriuresis and renal autoregulation: Role of the Angiotensin type 2 receptor, Hypertension [P], vol 57, issue 2, Lippincott Williams & Wilkins, USA, pp. 275-282.

Steckelings, U., Larhed, M., Hallberg, A., Widdop, R., Jones, E., Wallinder, C., Namsolleck, P., Dahlof, B., Unger, T., 2011, Non-peptide AT2-receptor agonists, Current Opinion in Pharmacology [P], vol 11, issue 2, Elsevier Ltd. * Current Opinion Journals, UK, pp. 187-192.

Bosnyak, S., Jones, E., Christopoulos, A., Aguilar, M., Thomas, W., Widdop, R., 2011, Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors, Clinical Science [P], vol 121, issue 7, Portland Press Ltd, UK, pp. 297-303.

Brown, R.D., Hilliard, L.M., Head, G.A., Jones, E.S., Widdop, R.E., Denton, K.M., 2011, Sex differences in the pressor and tubuloglomerular feedback response to angiotensin II, Hypertension [P], vol E, Lippincott Williams & Wilkins, USA, pp. 1-7.

Clayton, D., Hanchapola, I., Hausler, N., Unabia, S., Lew, R.A., Widdop, R.E., Smith, A.I., Perlmutter, P., Aguilar, M.-., 2010, Beta-amino acid substitution to investigate the recognition of angiotensin II (AngII) by angiotensin converting enzyme 2 (ACE2), Journal Of Molecular Recognition [P], vol 24, issue 2, John Wiley & Sons Ltd, UK & USA, pp. 235-244.

Libinaki, R., Tesanovic, S., Heal, A., Nikolovski, B., Vinh, A., Widdop, R.E., Gaspari, T.A., Devaraj, S., Ogru, E., 2010, Effect of tocopheryl phosphate on key biomarkers of inflammation: Implication in the reduction of atherosclerosis progression in a hypercholesterolaemic rabbit model, Clinical And Experimental Pharmacology And Physio..., vol 37, issue 5-6, Wiley-Blackwell Publishing Asia, Australia, pp. 587-592.

Porrello, E.R., Meeker, W.F., Thomas, W.G., Widdop, R.E., Delbridge, L.M., 2010, Glucocorticoids suppress growth in neonatal cardiomyocytes co-expressing AT2 and AT1 angiotensin receptors, Neonatology [P], vol 97, issue 3, S Karger AG, Switzerland, pp. 257-265.

Bosnyak, S., Welungoda, I.K., Hallberg, A., Alterman, M., Widdop, R.E., Jones, E.S., 2010, Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats, British Journal of Pharmacology [P], vol 159, issue 3, John Wiley & Sons Ltd, UK, pp. 709-716.

Steckelings, U.M., Widdop, R.E., Paulis, L., Unger, T., 2010, The angiotensin AT2 receptor in left ventricular hypertrophy, Journal of Hypertension [P], vol 28, issue Suppl 1, Lippincott Williams & Wilkins, Ltd, UK, pp. S50-S55.

Tesanovic Kljajic, S., Vinh, A., Gaspari, T.A., Casley, D., Widdop, R.E., 2010, Vasoprotective and atheroprotective effects of angiotensin (1-7) in apolipoprotein E-deficient mice, Arteriosclerosis Thrombosis And Vascular Biology [P], vol 30, issue 8, Lippincott Williams & Wilkins, USA, pp. 1606-1613.

McCarthy, C.A., Vinh, A., Callaway, J.K., Widdop, R.E., 2009, Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke, Stroke, vol 40, issue 4, Lippincott Williams & Wilkins, USA, pp. 1482-1489.

Vinh, A., Gaspari, T.A., Jones, E.S., Widdop, R.E., 2009, Functional Cardiovascular Effects of Angiotensin Peptides: Focus on Atherosclerosis and Hypertension, Current Hypertension Reviews [P], vol 5, issue 3, Bentham Science Publishers Ltd, The Netherlands, pp. 227-236.

Vinh, A., Gaspari, T.A., Liu, H., Dousha, L., Widdop, R.E., Dear, A.E., 2008, A novel histone deacetylase inhibitor reduces abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice, Journal of Vascular Research, vol 45, Karger, Switzerland, pp. 143-152.

Jones, E.S., Vinh, A., McCarthy, C.A., Gaspari, T.A., Widdop, R.E., 2008, AT2 receptors: Functional relevance in cardiovascular disease, Pharmacology & Therapeutics, vol 120, issue 3, Elsevier Inc., United States, pp. 292-316.

Vinh, A., Widdop, R.E., Chai, S.Y., Gaspari, T.A., 2008, Angiotensin IV-evoked vasoprotection is conserved in advanced atheroma, Atherosclerosis, vol 200, issue 1, Elsevier Ireland Ltd, Ireland, pp. 37-44.

Vinh, A., Widdop, R.E., Drummond, G.R., Gaspari, T.A., 2008, Chronic angiotensin IV treatment reverses endothelial dysfunction in ApoE-deficient mice, Cardiovascular Research, vol 77, Elsevier Science BV, Amsterdam, The Netherlands, pp. 178-187.

Porrello, E.R., Widdop, R.E., Delbridge, L.M.D., 2008, Early origins of cardiac hypertrophy: Does cardiomyocyte attrition programme for pathological 'catch-up' growth of the heart?, Clinical and Experimental Pharmacology & Physiology, vol 35, issue 11, Wiley-Blackwell Publishing Asia, Australia, pp. 1358-1364.

Sampson, A.K., Moritz, K.M., Jones, E.S., Flower, R.L., Widdop, R.E., Denton, K.M., 2008, Enhanced angiotensin II type 2 receptor mechanisms mediate decreases in arterial pressure attributable to chronic low-dose angiotensin II in female rats, Hypertension, vol 52, issue 4, Lippincott Williams & Wilkins, United States, pp. 666-671.

Irvine, J.C., Ritchie, R.H., Favaloro, J.L., Andrews, K.L., Widdop, R.E., Kemp-Harper, B.K., 2008, Nitroxyl (HNO): the Cinderella of the nitric oxide story, Trends in Pharmacological Sciences, vol 29, issue 12, Elsevier Ltd, UK, pp. 601-608.

Sampson, A.K., Widdop, R.E., Denton, K.M., 2008, Sex-differences in circadian blood pressure variations in response to chronic angiotensin II infusion in rats, Clinical and Experimental Pharmacology & Physiology, vol 35, issue 4, Wiley-Blackwell Publishing Asia, Australia, pp. 391-395.

Widdop, R.E., Vinh, A., Henrion, D., Jones, E.S., 2008, Vascular angiotensin AT2 receptors in hypertension and ageing, Clinical and Experimental Pharmacology & Physiology, vol 35, issue 4, Wiley-Blackwell Publishing Asia, Australia, pp. 386-390.

Irvine, J.C., Favaloro, J.L., Widdop, R.E., Kemp, B.K., 2007, Nitroxyl anion donor, Angeli's salt, does not develop tolerance in rat isolated aortae, Hypertension, vol 49, issue 4, Lipponcott Williams & Wilkins, Philadelphia PA USA, pp. 885-892.

Rajapakse, N.W., Eppel, G.A., Widdop, R.E., Evans, R.G., 2006, ANG II type 2 receptors and neural control of intrarenal blood flow, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol 291, issue 6, The American Physiological Society, Bethesda USA, pp. R1669-R1676.

Zulli, A., Burrell, L.M., Widdop, R.E., Black, M.J., Buxton, B.F., Hare, D.L., 2006, Immunolocalization of ACE2 and AT2 Receptors in Rabbit Atherosclerotic Plaques, Journal of Histochemistry & Cytochemistry, vol 54, issue 2, Histochemical SOC Inc., Seattle USA, pp. 147-150.

Duke, L.M., Evans, R.G., Widdop, R.E., 2005, AT2 receptors contribute to acute blood pressure-lowering and vasodilator effects of AT1 receptor antagonism in conscious normotensive but not hypertensive rats, American Journal of Physiology - Heart and Circulatory Physiology, vol 288, issue 5, American Physiological Society, Bethesda USA, pp. H2289-H2297.

Duke, L.M., Widdop, R.E., Kett, M.M., Evans, R.G., 2005, AT2 receptors mediate tonic renal medullary vasoconstriction in renovascular hypertension, British Journal of Pharmacology, vol 144, issue 4, Nature Publishing Group, London England, pp. 486-492.

Walters, P.E., Gaspari, T.A., Widdop, R.E., 2005, Angiotensin-(1-7) Acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats, Hypertension, vol 45, issue 5, Lippincott Williams & Wilkins, Philadelphia USA, pp. 960-966.

McDougall, S.J., Widdop, R.E., Lawrence, A.J., 2005, Central autonomic integration of psychological stressors: focus on cardiovascular modulation, Autonomic Neuroscience: Basic and Clinical, vol 123, issue 1-2, Elsevier, Amsterdam The Netherlands, pp. 1-11.

McDougall, S.J., Lawrence, A.J., Widdop, R.E., 2005, Differential cardiovascular responses to stressors in hypertensive and normotensive rats, Experimental Physiology, vol 90, issue 1, Blackwell Publishing Ltd, Oxford England, pp. 141-150.

McDougall, S.J., Widdop, R.E., Lawrence, A.J., 2005, Differential gene expression in WKY and SHR brain following acute and chronic air-puff stress, Molecular Brain Research, vol 133, issue 2, Elsevier, Amsterdam The Netherlands, pp. 329-336.

You, D., Loufrani, L., Baron, C., Levy, B.I., Widdop, R.E., Henrion, D., 2005, High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive rats, Circulation, vol 111, issue 8, Lippincott Williams & Wilkins, USA, pp. 1006-1011.

Roulston, C.L., Lawrence, A.J., Widdop, R.E., Jarrott, B., 2005, Minocycline Treatment Attenuates Microglia Activation and Non-Angiotensin II [125I] CGP42112 Binding in Brainstem Following Nodose Ganglionectomy, Neuroscience, vol 135, issue 4, Pergamon-Elsevier Science Ltd, Oxford UK, pp. 1241-1253.

Li, X.C., Widdop, R.E., 2004, AT2 receptor-mediated vasodilatation is unmasked by AT1 receptor blockade in conscious SHR, British Journal of Pharmacology, vol 142, issue 5, Nature Publishing Group, London UK, pp. 821-830.

Jones, E.S., Black, M.J., Widdop, R.E., 2004, Angiotensin AT2 receptor contributes to cardiovascular remodelling of aged rats during chronic AT1 receptor blockade, Journal of Molecular and Cellular Cardiology, vol 37, issue 5, Academic Press, UK, pp. 1023-1030.

Hannan, R.E., Gaspari, T.A., Davis, E.A., Widdop, R.E., 2004, Differential regulation by AT1 and AT2 receptors of angiotensin II-stimulated cyclic GMP production in rat uterine artery and aorta, British Journal of Pharmacology, vol 141, issue 6, Nature Publishing Group, UK, pp. 1024-1031.

McDougall, S.J., Widdop, R.E., Lawrence, A.J., 2004, Medial prefrontal cortical integration of psychological stress in rats, European Journal of Neuroscience, vol 20, issue 9, Blackwell Publishing, Oxford UK, pp. 2430-2440.

Roulston, C.L., Lawrence, A.J., Jarrott, B., Widdop, R.E., 2004, Non-angiotensin II [125I] CGP42112 binding is a sensitive marker of neuronal injury in brainstem following unilateral nodose ganglionectomy: comparison with markers for activated microglia, Neuroscience, vol 127, issue 3, Pergamon-Elsevier Science Ltd, Oxford UK, pp. 753-767.

Hannan, R.E., Widdop, R.E., 2004, Vascular angiotensin II actions mediated by angiotensin II type 2 receptors, Current Hypertension Reports, vol 6, issue 2, Current Science Inc., Philadelphia USA, pp. 117-123.

Widdop, R.E., Jones, E.S., Hannan, R.E., Gaspari, T.A., 2003, Angiotensin AT2 receptors: cardiovascular hope or hype?, British Journal of Pharmacology, vol 140, issue 5, Nature Publishing Group, London England, pp. 809-824.

Duke, L.M., Paull, J.R.A., Widdop, R.E., 2003, Cardiovascular status following combined angiotensin-converting enzyme and AT1 receptor inhibition in conscious spontaneously hypertensive rats, Clinical and Experimental Pharmacology and Physiology, vol 30, issue 5/6, Blackwell Publishing Asia, Carlton Vic Australia, pp. 317-323.

Duke, L.M., Eppel, G.A., Widdop, R.E., Evans, R.G., 2003, Disparate roles of AT2 receptors in the renal cortical and medullary circulations of anesthetized rabbits, Hypertension, vol 42, issue 2, Lippincott Williams & Wilkins, Philadelphia USA, pp. 200-205.

Hannan, R.E., Davis, E.A., Widdop, R.E., 2003, Fuctional role of angiotensin II AT2 receptor in modulation of AT1 receptor-mediated contraction in rat uterine artery: involvement of bradykinin and nitric oxide, British Journal of Pharmacology, vol 140, issue 5, Nature Publishing Group, London England, pp. 987-995.

Zulli, A., Widdop, R.E., Hare, D.L., Buxton, B.F., Black, M.J., 2003, High methionine and cholesterol diet abolishes endothelial relaxation, Arteriosclerosis Thrombosis and Vascular Biology, vol 23, issue 8, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1358-1363.

Roulston, C.L., Lawrence, A.J., Jarrott, B., Widdop, R.E., 2003, L ocalization of AT2 receptors in the nucleus of the solitary tract of spontaneously hypertensive and Wistar Kyoto rats using [125I] CGP42112: upregulation of a non-angiotensin II binding site following unilateral nodose ganglionectomy., Brain Research, vol 968, issue 1, Elsevier, Amsterdam The Netherlands, pp. 139-155.

Widdop, R.E., Matrougui, K., Levy, B.I., Henrion, D., 2002, AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade, Hypertension, vol 40, Lippincott Williams & Wilkins, Philadelphia USA, pp. 516-520.

Paull, J.R., Widdop, R., 2001, Persistent cardiovascular effects of chronic renin-angiotensin system inhibition following withdrawal in adult spontaneoulsy hypertensive rats, Journal of Hypertension, vol 19, issue 8, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1393-1402.

Paull, J.R., Li, X.C., Sampey, D.B., Widdop, R., 2001, Pharmacodynamic contribution to the vasodilator effect of chronic AT1 receptor blockade in SHR, Hypertension, vol 37, issue 1, Lippincott Williams & Wilkins, Philadelphia USA, pp. 91-98.

McDougall, S.J., Roulston, C.L., Widdop, R.E., Lawrence, A.J., 2000, Characterisation of vasopressin V1A, angiotensin AT1 and AT2 receptor distribution and density in normotensive and hypertensive rat brain stem and kidney: effects of restraint stress, Brain Research, vol 883, Elsevier, Amsterdam Netherlands, pp. 148-156.

McDougall, S.J., Paull, J.R.A., Widdop, R.E., Lawrence, A.J., 2000, Differential cardiovascular responses in wistar-Kyoto and spontaneously hypertensive rats, Hypertension, vol 35, Lippincott Williams and Wilkins, East Washington PA USA, pp. 126-129.

Barber, M.N., Sampey, D.B., Widdop, R.E., 1999, AT2 receptor stimulation enhances antihypertensive effect of AT1 receptor antagonist in hypertensive rats, Hypertension, vol 34, Lippincott, Philadelphia, pp. 1112-1116.

Widdop, R.E., Sampey, D.B., Jarrott, B., 1999, Cardiovascular effects of angiotensin (1-7) in conscious spontaneously hypertensive rats, Hypertension, vol 34 part 2, Lippincott Williams and Wilkins, Washington Philadelphia USA, pp. 964-968.

Bunting, M.W., Widdop, R.E., 1999, Differential haemodynamic effects of endothelin receptor antagonist, SB209670, in conscious hypertensive and normotensive rats, European Journal of Pharmacology, vol 381, Elsevier, Amsterdam Netherlands, pp. 13-21.

Li, X.C., Beart, P.M., Monn, J.A., Jones, N.M., Widdop, R.E., 1999, Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats, British Journal of Pharmacology, vol 128, Stockton Press, Basingstoke England, pp. 823-829.

Jones, N.M., Beart, P.M., Monn, J.A., Widdop, R.E., 1999, Type I and II metabotropic glutamate receptors mediate depressor and bradycardiac actions in the nucleus of the solitary tract of anaesthetised rats, European Journal of Pharmacology, vol 380, Elsevier Science, Amsterdam Netherlands, pp. 129-135.

Sampey, D.B., Burrell, L.M., Widdop, R.E., 1999, Vasopressin V2 receptor enhances gain of baroreflex in conscious spontaneously hypertensive rats, American Journal of Physiology, vol 276, American Physiological Society, Bethesda Maryland USA, pp. R872-R879.

Okuniewski, R., Davis, E.A., Jarrott, B., Widdop, R.E., 1998, A comparison of the development of renal hypertension in male and female rats, Clinical Science, vol 95, The Biochemical Society and the Medical Research s, UK, pp. 445-451.

Zwart, A.S., Davis, E.A., Widdop, R.E., 1998, Modulation of AT1 receptor - mediated contraction of rat uterine artery by AT2 receptors, British Journal of Pharmacology, vol 125, Stockton Press, Basingstoke Hampshire UK, pp. 1429-1436.

Widdop, R.E., Li, X.C., 1997, A simple versatile method for measuring tail cuff systolic blood pressure in conscious rats, Clinical Science, vol 93, Portland Press Ltd, UK, pp. 191-194.

Beart, P.M., Krstew, E., Widdop, R.E., 1997, Analyses of FR 127519 and KSG - 504 as CholecystokininA Receptor Antagonists in the Rat Isolated Nodose Ganglion, Pharmacology Reviews and Communications, vol 9, Harwood Academic, Netherland, pp. 27-35.

Bunting, M.W., Beart, P.M., Widdop, R.E., 1997, Effects of the CCKA receptor antagonists SR 27897B and PD140548 on baroreflex function in conscious rats, European Journal of Pharmacology, vol 337, Elsevier Science, Netherland, pp. 35-39.

Paull, J.R., Bunting, M.W., Widdop, R.E., 1997, Role of the brain renin-angiotension system in the maintenance of blood pressure in conscious spontaneously hypertensive and sinoaortic baroreceptor-denervated rats, Clinical and Experimental Pharmacology and Physiology, vol 24, Blackwell Science, Melbourne Vic Australia, pp. 667-672.

Conference Proceedings

Zulli, A., Widdop, R.E., Buxton, B.F., Burrell, L.M., Hare, D.L., 2006, Evidence for a functional role for angiotensin (1-7), angiotensin IV and the angiotensin II type 2 receptor in human blood vessels, Atherosclerosis Supplements, 12-15/11/2006, ELSEVIER IRELAND LTD, EAST PARK SHANNON CO CLARE 00000 IRELAND, p. 217.

Barber, M.N., Sampey, D.B., Widdop, R.E., 1999, AT2 receptor stimulation enhances antihypertensive effect of AT1 receptor anatagonist, candesartan, in conscious spontaneously hypertensive rats, High Blood Pressure Research Council of Australia, 21st Annual Scientific Meeting, Melbourne, Dec 1999, High Blood Pressure Council of Australia, Melbourne Vic Australia, p. 122.

Jarrott, B., Sampey, D.B., Widdop, R.E., 1999, Cardiovascular effects of angiotensin (1-7) in conscious spontaneously hypertensive rats, 8th Scientific Meeting of the Inter-American Society of Hypertension, Buenos Aires, Argentina, May 99, Inter-American Society of Hypertension, Buenos Aires, pp. A-68-Abst.276.

Widdop, R.E., Paull, J.R., 1999, Cardiovascular status during and following withdrawal from short-term antihypertensive treatment using radiotelemetry in adult hypertensive rats, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Sydney, NSW, Dec 1999, ASCEPT, Sydney NSW Australia, pp. 37-Oral 5-2.

Jones, E.S., Paull, J.R., Widdop, R.E., 1999, Does stimulation of the angiotensin AT2 receptor contribute to the antihypertensive effect of AT1 receptor antagonists in salt-restricted rats, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Sydney, NSW, Dec 1999, ASCEPT, Sydney NSW Australia, pp. 84-Post 1-23.

McDougall, S.J., Paull, J.R., Widdop, R.E., Lawrence, A.J., 1999, Effect of restraint stress on heart rate, blood pressure and vasopressin V1A receptors in WKY and SHR, Society for Neuroscience, Miami, Florida, USA, Oct 1999, Society for Neuroscience, Washington USA, pp. 1125-Abst.457.3.

Hannan, R.E., Davis, E.A., Widdop, R.E., 1999, Interactions between angiotensin II AT1 receptor-mediated contraction and bradykinin B2 receptors in rat uterine artery, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Sydney, NSW, Dec 1999, ASCEPT, Sydney NSW Australia, pp. 84-Post 1-24.

Bond, C.P., Widdop, R.E., Hodgson, W.C., 1999, Modulation of angiotensin II reactivity in the vasculature of diabetic rats, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Sydney, NSW, Dec. 1999, ASCEPT, Sydney NSW Australia, pp. 82-Post 1-19.

Zwart, A.S., Davis, E.A., Widdop, R.E., 1999, PD 123319 dose-related enhancement of Angiotensin II mediated contractile responses and role of endothelium in the rat uterine artery, Second International Symposium on Angiotensin II Antagonism, London, UK, Feb 1999, Hampton Medical Conferences Ltd, Middlesex United Kingdom, p. Poster 58.

Paull, J.R., Widdop, R.E., 1999, Persistent antohypertensive effect of long-term treatment with an ACE inhibitor and AT1 receptor antagonist in adult hypertensive rats with radiotelemetry, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Sydney, NSW, Dec 1999, ASCEPT, Sydney NSW Australia, pp. 38-Oral 5-3.

Paull, J.R., Widdop, R.E., 1999, Persistent effects of short- and long- term angiotensin converting enzyme and AT1 receptor inhibition in adult SHR using radiotelemetry, High Blood Pressure Research Council of Australia, 21st Annual Scientific Meeting, Melb., Vic, Dec 1999, High Blood Pressure Council of Australia, Melbourne Vic Australia, p. 121.

Widdop, R.E., McDougall, S.J., Paull, J.R., Lawrence, A.J., 1999, Restraint stress: differential cardiovascular responses in SHR and WKY rats measured using radiotelemetry, Australian Telemetry User Group, Sydney, December 1999, Australian Telemetry User Group, Sydney NSW Australia.

Zwart, A.S., Davis, E.A., Widdop, R.E., 1999, The effect of AT2 ligands (PD 123319 and CGP 42112) on Ang II mediated contractile responses in the rat uterine artery, Second International Symposium on Angiotensin II Antagonism, London, UK, Feb 1999, Hampton Med. Conferences Ltd, Middlesex United Kingdom, p. Poster 59.

Roulston, C.L., Lawrence, A.J., Jarrott, B., Widdop, R.E., 1999, Upregulation of [125I]CGP421112 binding in the rat brainstem following nodose ganlionectomy, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Sydney, NSW, Dec 1999, ASCEPT, Sydney NSW Australia, pp. 65-Oral 12-2.

Sampey, D.B., Widdop, R.E., 1998, Antihypertensive effects of chronic angiotensin-(1-7) in spontaneously hypertensive rats (SHR), Journal of Vascular Research, Mol, Belgium, June 1998, Karger, Denmark, p. 26 p43.

Widdop, R.E., Paull, J.R., 1998, Cardiovascular effects of AT1 antagonist TCV -116, in adult spontaneously hypertensive rats using radio telemetry, Xth International Vascular Biology Meeting, Cairns, QLD, August 1998, Vascular Biology Meeting, Cairns Qld Australia, p. 60 P101.

Sampey, D.B., Widdop, R.E., 1998, Cardiovascular effects of angiotensin (1-7) in conscious spontaneously hypertensive rats, Journal of Hypertension, Amsterdam, Netherlands,June 98, Lippincott-Raven Publishers, London UK, p. S115.

Paull, J.R., Widdop, R.E., 1998, Cardiovascular effects of chronic treatment with the AT1 receptor antagonist, TCV-116, in adult spontaneously hypertensive rats, Journal of Hypertension, Amsterdam, Netherlands, June 98, Lippincott-Raven, London UK, p. S123.

Paull, J.R., Widdop, R.E., 1998, Chronic cardiovascular effects of AT1 antagonist TCV-116, in adult spontaneously hypertensive rats (SHR) using radio telemetry, Journal of Vascular Research, Mol, Belgium, June 1998, Karger, Denmark, p. 24 p38.

Zwart, A.S., Davis, E.A., Widdop, R.E., 1998, Dose-related enhancement of angiotensin II-mediated contractile responses by PD 123319 in the rat uterine artery and the role of endothelium, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart, TAS, December 1998, ASCEPT, Sydney NSW Australia, p. 183.

Bunting, M.W., Widdop, R.E., 1998, Effect of co-administratoin of angiotensin AT1 receptor antangonist, CV11974, on haemodynamics following acute myocardial infarction in conscious rats, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart, TAS, December 1998, ASCEPT, Sydney NSW Australia, p. 184.

McDougall, S.J., Paull, J.R., Widdop, R.E., Lawrence, A.J., 1998, Effect of restraint stress on heart rate, blood pressure and vasopressin V1a receptors in normotensive and hypertensive rats, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart, TAS, December 1998, ASCEPT, Sydney NSW Australia, p. 124.

Bunting, M.W., Burrell, L.M., Widdop, R.E., 1998, Effect of the AT1 receptor antagonist CV -11974, on haemodynamics following acute myocardial infarction in conscious rats, Journal of Hypertension, Amsterdam, Netherlands,June98, Lippincott-Raven Publishers, London UK, p. S112.

Widdop, R.E., Paull, J.R., 1998, Great inhibitions of angiotensin I - than angiotensin II-induced press or response on withdrawal of the AT1 antagonist TCV-116, Journal of Vascular Research, Mol, Belgium, June 1998, Karger, Denmark, p. 28 p53.

Hannan, R.E., Zwart, A.S., Davis, E.A., Widdop, R.E., 1998, Interactions between angiotensin AT2 receptors, Bradykinin b2receptors and nitric oxide in modulating AT1 receptor - mediated contraction in the rat uterine artery, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart, TAS, December 1998, ASCEPT, Sydney NSW Australia, p. 135.

Li, X.C., Widdop, R.E., 1998, Regional vascular reactivity to angiotensin II in conscious spontaneously hypertensive and normotensive Wistar-Kyoto rats, Proceedings of the Australian Physiological and Pharmacological Society, Brisbane, QLD, September 1998, Blackwell Scientific Publications, Carlton Vic Australia, p. 345P.

Paull, J.R., Widdop, R.E., 1998, Regression of cardiovascular hypertrophy following chronic candesartan cilexetil treatment in spontaneously hypertensive rats, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart, TAS, December 1998, ASCEPT, Sydney NSW Australia, p. 182.

Barber, M.N., Sampey, D.B., Widdop, R.E., 1998, The potential role of the AT2 receptor in blood pressure regulation in conscious rats, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart, December 1998, ASCEPT, Sydney NSW Australia, p. 183.

Roulston, C.L., Lawrence, A.J., Paull, J.R., Bunting, M.W., Watkins, D., Jarrott, B., Widdop, R.E., 1998, The selective AT2 ligand[125I)CGP42112 reveals AT2 receptors in nucleus of the solitary tract of adult rats, Naunyn-Schmiedeberg's Archives of Pharmacology, Munchen, Germany, July 1998, Springer, Berlin, p. R293.

Paull, J.R., Widdop, R.E., 1998, Withdrawal of AT1 receptor antagonist TCV-116, affects return of angiotensin 1 and 11 responses differentially in hypertensive rats, Journal of Hypertension, Amsterdam, Netherlands, June 98, Lippincott-Raven, London UK, p. S120.

Sampey, D.B., Widdop, R.E., 1997, Cardiovascular effects of angiotensin-(1-7) in conscious rats, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 30 November - 3 December, 1997, ASCEPT, Sydney NSW Australia, p. 73.

Paull, J.R., Widdop, R.E., 1997, Cardiovascular effects of chronic hypertensive treatment with the AT1 receptor antagonist, TCV-116, in adult spontaneously hypertensive rats, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 30 November - 3 December, 1997, ASCEPT, Sydney NSW Australia, p. 29.

Beart, P.M., Li, X.C., Monn, J.A., Widdop, R.E., Jones, N.M., 1997, Roles for metabotropic glutamate receptors (mGLURs) in the lateral sympthatic column, Journal of the Autonomic Nervous System, 14-19 September, 1997, Elsevier, Netherland, p. 97.

Zwart, A.S., Davis, E.A., Widdop, R.E., 1997, The effect of AT2 ligands (PD123319 and CGP42112) on Ang II mediated contractile responses in the rat uterine artery, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 30 November - 3 December, 1997, ASCEPT, Sydney NSW Australia, p. 71.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

AT4R/ IRAP AS A TARGET FOR PROTECTION IN CARDIOVASCULAR DISEASE.

Supervisors:

Gaspari, T (Main), Widdop, R (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Identify the specific functional roles of T cell and leukocytes during hypertension.

Supervisors:

Widdop, R (Main), Vinh, A (Associate).

Completed Supervision

Student:

Barber, M.

Program of Study:

VASCULAR ACTIONS OF NATRIURETIC PEPTIDES IN ATHEROSCLEROSIS. (PHD) 2003.

Supervisors:

Widdop, R (Main), Woods, R (Associate).

Student:

Bosnyak, S.

Program of Study:

Cardiovascular studies of AT2 receptor in various pathophysiological settings. (PHD) 2011.

Supervisors:

Widdop, R (Main), Jones, E (Associate).

Student:

Hannan, R.

Program of Study:

FUNCTIONAL MODULATION OF UTERINE VASCULAR TONE BY ANGIOTENSIN II RECEPTORS:ROLE OF AT2 RECEPTORS. (PHD) 2003.

Supervisors:

Davis, E (Joint), Widdop, R (Joint-Co).

Student:

Irvine, J.

Program of Study:

The regulation of cardiovascular function by nitroxyl (HNO). (PHD) 2007.

Supervisors:

Widdop, R (Main), Kemp, B (Associate).

Student:

Jones, E.

Program of Study:

ANGIOTENSIN AT2 RECEPTOR FUNCTION: CHRONIC INFLUENCE ON CARDIOVASCULAR REMODELLING IN HYPERTENSION AND SENESCENCE. (PHD) 2004.

Supervisors:

Widdop, R (Main).

Student:

Mccarthy, C.

Program of Study:

Role of angiotensin AT2 receptor in stroke. (PHD) 2009.

Supervisors:

Widdop, R (Main).

Student:

Mcdougall, S.

Program of Study:

CENTRAL CONTROL OF THE CARDIOVASCULAR SYSTEM DURING STRESS. (PHD) 2004.

Supervisors:

Lawrence, A (Main), Widdop, R (Joint).

Student:

Paull, J.

Program of Study:

CHRONIC INHIBITION OF THE RENIN-ANGIOTENSIN SYSTEM: EFFECTS ON CARDIOVASCULAR FUNCTION AND STRUCTURE IN ADULT SPONTANEOUSLY HYPERTENSIVE RATS. (PHD) 2000.

Supervisors:

Widdop, R (Main), Jarrott, B (Associate).

Student:

Roulston, C.

Program of Study:

LOCALISATION OF BOTH TYPE 2 ANGIOTENSIN II RECEPTORS AND A NON-ANGIOTENSIN II BINDING SITE BY [125 I] CGP42112 IN RAT BRAIN STEM. (PHD) 2001.

Supervisors:

Jarrott, B (Main), Widdop, R (Associate).

Student:

Simonds, L.

Program of Study:

ROLE OF ANGIOTENSIN AT1 AND AT2 RECEPTORS IN REGULATION OF BLOOD PRESSURE, REGIONAL HAEMODYNAMICS AND RENAL FUNCTION. (PHD) 2004.

Supervisors:

Evans, R (Joint-Co), Widdop, R (Joint).

Student:

Tesanovic Kljajic, S.

Program of Study:

Vaso- and athero- protective effects of non-AT1 receptors in apolipoprotein-E deficient mice. (PHD) 2009.

Supervisors:

Widdop, R (Main), Gaspari, T (Associate).

Student:

Vinh, A.

Program of Study:

Angiotensin IV-evoked modulation of vascular function and atherogenesis in ApoE-deficient mice. (PHD) 2008.

Supervisors:

Gaspari, T (Joint), Widdop, R (Joint-Co), Dear, A (Associate).

Student:

Walters, P.

Program of Study:

Angiotensin peptides: cardiovascular function in hypertension. (PHD) 2005.

Supervisors:

Widdop, R (Main).