Assoc Prof Mark Hedger - Researcher Profile

Biography

Mark works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as an Associate Professorial Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 1984

PHYSIOLOGY / BIOCHEMISTRY

Institution: Monash University

Year awarded: 1980

Publications

Book Chapters

Hedger, M.P., 2012, Immune Privilege of the Testis a: meaning, mechanisms and manifestations, in Infection, Immune Homeostasis and Immune Privilege, eds Joan Stein-Streilein, Springer, Basel, Switzerland, pp. 31-52.

Hedger, M., 2010, Immunology of the testis and male reproductive tract, in Comprehensive Toxicology: Reproductive and Endocrine Toxicology (Volume 11), eds John Richburg and Patricia Hoyer (Volume 11), Elsevier, US, pp. 189-230.

O'Bryan, M.K., Hedger, M.P., 2008, Inflammatory Networks in the Control of Spermatogenesis - Chronic Inflammation in a Immunologically Privileged Tissue?, in Molecular Mechanisms in Spermatogenesis (Volume 636), eds C Y Cheng, Landes Bioscience, USA, pp. 92-114.

Hedger, M.P., 2007, Immunologically privileged environments, in Cellular Transplantation: from Laboratory to Clinic, eds Craig Halberstadt amd Dwaine Emerich, Elsevier, California USA, pp. 567-590.

Hedger, M.P., Hales, D.B., 2006, Immunophysiology of the male reproductive tract, in Knobil and Neill's Physiology of Reproduction, eds Jimmy D Neill, Tony M Plant, Donald W Pfaff, John R Challis, David de Kretser, JoAnne Richards, Paul M Wassarman, Elsevier, London UK, pp. 1195-1286.

Hedger, M.P., de Kretser, D.M., 2000, Leydig cell function and its regulation, in The genetic basis of male infertility, Springer-Verlag, Berlin Germany, pp. 69-110.

Hedger, M., 1998, Hypophyseal-Gonadal Relationships in the Male, in Reproductive Endocrinology and Biology, JAI Pres Inc., Stamford Connecticut USA, pp. 25-55.

Journal Articles

Wu, H., Chen, Y., Winnall, W.R., Phillips, D.J., Hedger, M.P., 2012, Acute regulation of activin A and its binding protein, follistatin, in serum and tissues following lipopolysaccharide treatment of adult male mice, American Journal of Physiology - Regulatory Integrative and Comparative Physiology [E], vol 303, issue 6, American Physiological Society, United States, pp. R-665-R-675.

Craythorn, R., Winnall, W., Lederman, F., Gold, E., O'Connor, A., de Kretser, D., Hedger, M., Rogers, P., Girling, J., 2012, Progesterone stimulates expression of follistatin splice variants Fst288 and Fst315 in the mouse uterus, Reproductive Biomedicine Online [P], vol 24, issue 3, Elsevier Ltd, United Kingdom, pp. 364-374.

Hedger, M.P., Winnall, W.R., 2012, Regulation of activin and inhibin in the adult testis and the evidence for functional roles in spermatogenesis and immunoregulation, Molecular and Cellular Endocrinology [P], vol 359, issue 1-2, Elsevier Ireland Ltd, Ireland, pp. 30-42.

de Kretser, D., O'Hehir, R., Hardy, C., Hedger, M., 2012, The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair, Molecular and Cellular Endocrinology [P], vol 359, issue 1-2, Elsevier Ireland Ltd, Ireland, pp. 101-106.

Meinhardt, A., Hedger, M., 2011, Immunological, paracrine and endocrine aspects of testicular immune privilege, Molecular and Cellular Endocrinology [P], vol 335, issue 1, Elsevier Ireland Ltd, Ireland, pp. 60-68.

Hedger, M., 2011, Immunophysiology and pathology of inflammation in the testis and epididymis, Journal of Andrology [P], vol 32, issue 6, American Society of Andrology, USA, pp. 625-640.

Chen, Y., Phillips, D., McMillan, J., Bedford, P., Goldstein, J., Wu, H., Hedger, M., Smith, J., 2011, Pattern of activin A and follistatin release in a sheep model of cardiopulmonary bypass, Cytokine [P], vol 54, issue 2, Academic Press, United Kingdom, pp. 154-160.

Winnall, W., Muir, J., Hedger, M., 2011, Rat resident testicular macrophages have an alternatively activated phenotype and constitutively produce interleukin-10 in vitro, Journal of Leukocyte Biology [P], vol 90, issue 1, Federation of American Societies for Experimental Biology, United States, pp. 133-143.

Kazutaka, S., Winnall, W., Muir, J., Hedger, M., 2011, Regulation of Sertoli cell activin A and inhibin B by tumour necrosis factor a and interleukin 1a: Interaction with follicle-stimulating hormone/adenosine 3',5'-cyclic phosphate signalling, Molecular and Cellular Endocrinology [P], vol 335, issue 2, Elsevier Ireland Ltd, Ireland, pp. 195-203.

Hedger, M., Winnall, W., Phillips, D., de Kretser, D., 2011, The regulation and functions of activin and follistatin in inflammation and immunity, Vitamins And Hormones-Advances In Research And Applications [P], vol 85, Academic Press, United States, pp. 255-297.

Hedger, M., 2011, Toll-like receptors and signalling in spermatogenesis and testicular responses to inflammation - a perspective, Journal of Reproductive Immunology [P], vol 88, issue 2, Elsevier Ireland Ltd, Ireland, pp. 130-141.

Chen, Y., Wu, H., Winnall, W., Loveland, K., Makanji, Y., Phillips, D., Smith, J., Hedger, M., 2011, Tumour necrosis factor-alpha stimulates human neutrophils to release preformed activin A, Immunology And Cell Biology [P], vol 89, issue 8, Nature Publishing Group, United Kingdom, pp. 889-896.

Phillips, D.J., de Kretser, D.M., Hedger, M.P., 2009, Activin and related proteins in inflammation: Not just interested bystanders, Cytokine and Growth Factor Reviews [P], vol 20, issue 2, Elsevier, UK, pp. 153-164.

Craythorn, R.G., Girling, J.E., Hedger, M.P., Rogers, P.A.W., Winnall, W.R., 2009, An RNA spiking method demonstrates that 18S rRNA is regulated by progesterone in the mouse uterus, Molecular Human Reproduction [P], vol 15, issue 11, Oxford University Press, UK, pp. 757-761.

Winnall, W.R., Muir, J.A., Hedger, M.P., 2009, Differential responses of epithelial Sertoli cells of the rat testis to Toll-like receptor 2 and 4 ligands: implications for studies of testicular inflammation using bacterial lipopolysaccharides, Innate Immunity [P], vol E, Sage Publications Ltd, England, pp. 1-14.

Winnall, W.R., Muir, J.A., Liew, S., Hirst, J.J., Meachem, S.J., Hedger, M.P., 2009, Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide-treated rats, International Journal Of Andrology [P], vol 32, issue 5, Wiley-Blackwell Publishing Ltd, UK, pp. 542-555.

Krawetz, S.A., De Rooij, D.G., Hedger, M.P., 2009, Molecular aspects of male fertility, Embo Reports [P], vol 10, issue 10, Nature Publishing Group, UK, Germany, pp. 1087-1092.

Winnall, W.R., Okuma, Y., Saito, K., Muir, J.A., Hedger, M.P., 2009, Regulation of interleukin 1alpha, activin and inhibin by lipopolysaccharide in Sertoli cells from prepubertal rats, Molecular and Cellular Endocrinology [P], vol 307, issue 1-2, Elsevier Ireland Ltd, Ireland, pp. 169-175.

Foulds, L.M., Boysen, R.I., Crane, M., Yang, Y., Muir, J.A., Smith, A.I., de Kretser, D.M., Hearn, M.T.W., Hedger, M.P., 2008, Molecular Identification of lyso-glycerophosphocholines as endogenous immunosuppressives in bovine and rat gonadal fluids, Biology of Reproduction, vol 79, issue 3, Society for the Study of Reproduction, United States, pp. 525-536.

Liew, S.H.J., Meachem, S.J., Hedger, M.P., 2007, A stereological analysis of the response of spermatogenesis to an acute inflammatory episode in adult rats, Journal of Andrology, vol 28, issue 1, American Society Andrology, USA, pp. 176-185.

Jones, K.L., Mansell, A.S., Patella, S., Scott, B.M., Hedger, M.P., de Kretser, D.M., Phillips, D.J., 2007, Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia, Proceedings of the National Academy of Sciences of the USA, vol 104, issue 41, Nationall Academy of Sciences, United States, pp. 16239-16244.

Winnall, W.R., Ali, U., O'Bryan, M.K., Hirst, J.J., Whiley, P.A.F., Muir, J.A., Hedger, M.P., 2007, Constitutive expression of prostaglandin-endoperoxide synthase 2 by somatic and spermatogenic cells is responsible for prostaglandin E2 production in the adult rat testis, Biology of Reproduction, vol 76, issue 5, Soc Study Reproduction, Madison USA, pp. 759-768.

Shehu-Xhilaga, M., Kent, S.J., Batten, J., Ellis, S., Van der Meulen, J.D., O'Bryan, M.K., Cameron, P.U., Lewin, S.R., Hedger, M.P., 2007, The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infection, Retrovirology, vol 4, issue 1, BioMed Central Ltd, United Kingdom, pp. 1-13.

Girling, J.E., Hedger, M.P., 2007, Toll-like receptors in the gonads and reproductive tract: emerging roles in reproductive physiology and pathology, Immunology and Cell Biology, vol 85, issue 6, Nature Publishing Group, UK, Australia, pp. 481-489.

Okuma, Y., O'Connor, A., Hayashi, T., Loveland, K.A.L., de Kretser, D.M., Hedger, M.P., 2006, Regulated production of activin A and inhibin B throughout the cycle of the seminiferous epithelium in the rat, Journal of Endocrinology, vol 190, issue 2, Society for Endocrinology, Bristol England, pp. 331-340.

Ochsenkuhn, R., O'Connor, A.E., Hirst, J.J., Baker, H.W.G., de Kretser, D.M., Hedger, M.P., 2006, The relationship between immunosuppressive activity and immunoregulatory cytokines in seminal plasma: influence of sperm autoimmunity and seminal leukocytes, Journal of Reproductive Immunology, vol 71, issue 1, Elsevier Ireland Ltd, Ireland, pp. 57-74.

O'Bryan, M.K., Gerdprasert, O., Nikolic-Paterson, D.J., Meinhardt, A., Muir, J.A., Foulds, L.M., Phillips, D.J., de Kretser, D.M., Hedger, M.P., 2005, Cytokine profiles in the testes of rats treated with lipopolysaccharide reveal localized suppression of inflammatory responses, American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol 288, issue 6, Amercan Physiological Society, USA, pp. R1744-R1755.

Webster, K.E., O'Bryan, M.K., Fletcher, S., Crewther, P.E., Aapola, U., Craig, J., Harrison, D.K., Aung, H., Phutikanit, N., Lyle, R., Meachem, S.J., Antonarakis, S.E., de Kretser, D.M., Hedger, M.P., Peterson, P., Carroll, B.J., Scott, H.S., 2005, Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis, Proceedings of the National Academy of Sciences, vol 102, issue 11, National Academy Sciences, USA, pp. 4068-4073.

Okuma, Y., Saito, K., O'Connor, A., Phillips, D.J., de Kretser, D.M., Hedger, M.P., 2005, Reciprocal regulation of activin A and inhibin B by interleukin-1 (IL-1) and follicle-stimulating hormone (FSH) in rat Sertoli cells in vitro, Journal of Endocrinology, vol 185, issue 12, Society for Endocrinology, Bristol UK, pp. 99-110.

Okuma, Y., O'Connor, A.E., Muir, J.A., Stanton, P.G., de Kretser, D.M., Hedger, M.P., 2005, Regulation of activin A and inhibin B secretion by inflammatory mediators in adult rat Sertoli cell cultures, Journal of Endocrinology, vol 187, issue 1, Society for Endocrinology, UK, pp. 125-134.

Hedger, M.P., Klug, J., Frohlich, S., Muller, R., Meinhardt, A., 2005, Regulatory cytokine expression and interstitial fluid formation in the normal and inflamed rat testis are under Leydig cell control, Journal of Andrology, vol 26, issue 3, American Society of Andrology, USA, pp. 379-386.

Shehu-Xhilaga, M., de Kretser, D.M., Dejucq-Rainsford, N., Hedger, M.P., 2005, Standing in the way of eradication: HIV-1 infection and treatment in the male genital tract, Current HIV Research, vol 3, issue 4, Bentham Science Publishers Ltd., The Netherlands, pp. 345-359.

O'Bryan, M.K., Foulds, L.M., Cannon, J.F., Winnall, W.R., Muir, J.A., Sebire, K.L., Smith, A.I., Keah, H.H., Hearn, M.T.W., de Kretser, D.M., Hedger, M.P., 2004, Identification of a Novel Apolipoprotein, ApoN, in Ovarian Follicular Fluid, Endocrinology, vol 145, issue 11, The Endocrine Society, USA, pp. 5231-5242.

Douglas, G.C., O'Bryan, M.K., Hedger, M.P., Lee, D.K.L., Yarski, M.A., Smith, A.I., Lew, R., 2004, The Novel Angiotensin-Converting Enzyme (ACE) Homolog, ACE2, Is Selectively Expressed by Adult Leydig Cells of the Testis, Endocrinology, vol 145, issue 10, The Endocrine Society, USA, pp. 4703-4711.

de Kretser, D.M., Buzzard, J.J., Okuma, Y., O'Connor, A.E., Hayashi, T., Lin, S., Morrison, J.R., Loveland, K.A.L., Hedger, M.P., 2004, The role of activin, follistatin and inhibin in testicular physiology, Mollecular Cell Endocrinology, vol 225, Elsevier Sci Ireland Ltd, Netherland, pp. 57-64.

Hedger, M.P., Meinhardt, A., 2003, Cytokines and the immune-testicular axis, Journal of Reproductive Immunology, vol 58, issue 1, Elsevier Science Ireland Ltd, Shannon Ireland, pp. 1-26.

Gerdprasert, O., O'Bryan, M.K., Nikolic-Paterson, D.J., Sebire, K.L., de Kretser, D.M., Hedger, M.P., 2002, Expression of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor in normal and inflamed rat testis, Molecular Human Reproduction, vol 8, issue 6, Oxford University Press, Oxford UK, pp. 518-524.

de Kretser, D.M., Hedger, M.P., Loveland, K.L., Phillips, D.J., 2002, Inhibins, activins and follistatin in reproduction, Human Reproduction Update, vol 8, issue 6, Oxford University Press, Oxford UK, pp. 529-541.

Hedger, M.P., 2002, Macrophages and the immune responsiveness of the testis, Journal of Reproductive Immunology, vol 57, Elsevier Science, Amsterdam Netherlands, pp. 19-34.

Gerdprasert, O., O'Bryan, M.K., Muir, J.A., Caldwell, A.M., Schlatt, S., de Kretser, D.M., Hedger, M.P., 2002, The response of testicular leukocytes to lipopolysaccharide-induced inflammation: further evidence for heterogeneity of the testicular macrophage population, Cell and Tissue Research, vol 308, issue 2, Springer-Verlag, New York NY USA, pp. 277-285.

Gow, R.M., O'Bryan, M., Canny, B., Ooi, G.T., Hedger, M., 2001, Differential effects of dexamethasone treatment on lipopolysaccharide-induced testicular inflammation and reproductive hormone inhibition in adult rats, Journal of Endocrinology, vol 168, issue 1, Society for Endocrinology, Stokebristol England, pp. 193-201.

Phillips, D.J., Jones, K.L., Scheerlinck, J., Hedger, M., de Kretser, D.M., 2001, Evidence for activin A and follistatin involvement in the systemic inflammatory response, Molecular and Cellular Endocrinology, vol 180, Elsevier Science Ireland Ltd, Coclare Ireland, pp. 155-162.

O'Bryan, M.K., Schlatt, S., Phillips, D.J., de Kretser, D.M., Hedger, M., 2000, Bacterial lipopolysaccharide-induced inflammation compromises testicular function at multiple levels in vivo, Endocrinology, vol 141 issue 1, Endocrine Society, Bethesda USA, pp. 238-246.

O'Bryan, M.K., Sebire, K.L., Gerdprasert, O., Hedger, M., Hearn, M.T.W., de Kretser, D.M., 2000, Cloning and regulation of the rat activin betaE subunit, Journal of Molecular Endocrinology, vol 24, Society for Endocrinology, Bristol UK, pp. 409-418.

Hedger, M., Muir, J.G., 2000, Differential actions of gonadotropin-releasing hormone and human chorionic gonadotropin on interstitial fluid volume and immunoglobulin G concentrations in adult rat testis, Journal of Andrology, vol 21 issue 5, American Soc of Andrology Inc, C/o Allen Press, Lawrence USA, pp. 747-752.

Hedger, M., Phillips, D.J., de Kretser, D.M., 2000, Divergent cell-specific effects of activin-A on thymocyte proliferation stimulated by phytohemagglutinin, and interleukin 1beta or interleukin 6 in vitro, Cytokine, vol 12 issue 6, WB Saunders Co, Philadelphia USA, pp. 595-602.

O'Bryan, M.K., Schlatt, S., Gerdprasert, O., Phillips, D.J., de Kretser, D.M., Hedger, M., 2000, Inducible nitric oxide synthase in the rat testis: Evidence for potential roles in both normal function and inflammation-mediated infertility, Biology of Reproduction, vol 63, Soc Study Reproduction, Madison USA, pp. 1285-1293.

Hedger, M., Meinhardt, A., 2000, Local regulation of T cell numbers and lyphocyte-inhibiting activity in the interstitial tissue of the adult rat testis, Journal of Reproductive Immunology, vol 48, Elsevier Science Ireland Ltd, Co Clare Ireland, pp. 69-80.

Phillips, D.J., Brauman, J., Mason, T., de Kretser, D.M., Hedger, M., 1999, A sensitive and specific in vitro bioassay for activin using a mouse plasmacytoma cell line, MPC-11, Journal of Endocrinology, vol 162, Society for Endocrinology, Bradley Stoke UK, pp. 111-116.

Meinhardt, A., Bacher, M., O'Bryan, M.K., McFarlane, J.R., Mallidis, C., Lehmann, C., Metz, C.N., de Kretser, D.M., Bucala, R., Hedger, M., 1999, A switch in the cellular localization of macrophage migration inhibitory factor in the rat testis after ethane dimethane sulfonate treatment, Journal of Cell Science, vol 112, Company of Biologists Ltd, Cambridge UK, pp. 1337-1344.

de Kretser, D.M., Hedger, M., Phillips, D.J., 1999, Activin A and follistatin: their role in the acute phase reaction and inflammation, Journal of Endocrinology, vol 161, Soc for Endocrinology, Bradley Stoke UK, pp. 195-198.

Russell, C., Hedger, M., Brauman, J., de Kretser, D.M., Phillips, D.J., 1999, Activin A regulates growth and acute phase proteins in the human liver cell line HepG2, Molecular and Cellular Endocrinology, vol 148, Elsevier Science Ireland Ltd, Coclare Ireland, pp. 129-136.

Schlatt, S., de Kretser, D.M., Hedger, M., 1999, Mitosis of resident macrophages in the adult rat testis, Journal of Reproduction and Fertility, vol 116, Journals of Reproduction & Fertility Inc, Cambridge UK, pp. 223-228.

Tompkins, A.B., Hutchinson, P., de Kretser, D.M., Hedger, M., 1998, Characterization of lymphocytes in the adult rat testis by flow cytometry: effects of activin and transforming growth factor beta on lymphocyte subsets in vitro, BIOLOGY OF REPRODUCTION, vol 58, Society for the Study of Reproduction Inc, MADISON WI USA, pp. 943-951.

Hedger, M., Wang, J., Lan, H.Y., Atkins, R.C., Wreford, N.G., 1998, Immunoregulatory activity in adult rat testicular interstitial fluid: Relationship with intratesticular CD8+ lymphocytes following treatment with ethane dimethane sulfonate and testosterone implants, Biology of Reproduction, vol 58 (4), Society for the Study of Reproduction, Madison Wisconcin USA, pp. 935-942.

Hedger, M., Wang, J., Lan, H., Atkins, R.C., Wreford, N.G., 1998, Immunoregulatory activity in adult rat testicular interstitial fluid: relationship with intratesticular CD8+ lymphocytes following treatment with ethane dimethane sulfonate and testosterone implants, Biology of Reproduction, vol 58 issue 4, Society for the Study of Reproduction, Champagne Illinois USA, pp. 935-942.

Hedger, M., Nikolic-Paterson, D.J., Hutchinson, P., Atkins, R.C., de Kretser, D.M., 1998, Immunoregulatory activity in adult rat testicular interstitial fluid: roles of interleukin-1 and transforming growth factor beta1, BIOLOGY OF REPRODUCTION, vol 58, Society for the Study of Reproduction, MADISON WI USA, pp. 927-934.

Meinhardt, A., Bacher, M., Metz, C.N., Bucala, R., Wreford, N.G., Lan, H., Atkins, R.C., Hedger, M., 1998, Local regulation of macrophage subsets in the adult rat testis: examination of the roles of the seminiferous tubules, testosterone, and macrophage-migration inhibitory factor, Biology of Reproduction, vol 59 issue 2, Society for the study of reproduction, CHAMPAGNE ILLINOIS USA, pp. 371-378.

Hedger, M., Culler, M.D., 1997, Comparison of LHRH-peptidase and plasminogen activator activity in rat testis extracts, Reproduction Fertility & Development, vol 9, CSIRO, Melbourne Vic Australia, pp. 659-664.

Duckett, R., Wreford, N.G., Meachem, S.J., McLachlan, R.I., Hedger, M., 1997, Effect of Chorionic Gonadotropin and Flutamide in Leydig Cell and Macrophage Populations in the Testosterone-Estradiol-Implanted Adult Rat, Journal of Andrology, vol 18, American Society of Andrology, USA, pp. 656-662.

Duckett, R., Wreford, N.G., Meachem, S.J., Hedger, M., McLachlan, R.D., 1997, Effect of Chorionic Gonadotropin and Flutamide on Leydig Cell and Macrophage Populations in the Testosterone-Estradiol-Implanted Adult Rat, Journal of Andrology, vol 18, American Society of Andrology, San Francisco, pp. 656-662.

Imade, G., Baker, G.H., de Kretser, D.M., Hedger, M., 1997, Immunosuppressive activities in the seminal plasma of infertile men: relationship to sperm antibodies and autoimmunity, Human Reproduction, vol 12, Oxford University Press, Oxford UK, pp. 256-262.

Iannello, R., Young, J., Sumarsono, S.H., Tymms, M.J., Dahl, H.M., Gould, J., Hedger, M., Kola, I., 1997, Regulation of Pdha-2 Expression is mediated byproximal promoter sequences and CpG Methylation, Molecular and Cellular Biology, vol 17, American Society for Microbiology, Washington DC USA, pp. 612-617.

Hedger, M., 1997, Testicular leukocytes: what are they doing?, Reviews of Reproduction, vol 2, Journals of Reproduction and Fertility Ltd, Cambridge UK, pp. 38-47.

Duckett, R., Hedger, M., McLachlan, R.I., Wreford, N.G., 1997, The Effects of Gonadotropin-Releasing Hormone Immunization and Recombinant Follicle-Stimulating Hormone on the Leydig Cell and Macrophage Populations of the Adult Rat Testis, Journal of Andrology, vol 18, American Society of Andrology, USA, pp. 417-423.

Duckett, R., Hedger, M., Wreford, N.G., McLachlan, R.D., 1997, The effects of Gonadotropin-Releasing Hormone Immunization and Recombinant Follicle-Stimulating Hormone on the Leydig Cell and Macrophage Populations of the Adult Rat Testis, Journal of Andrology, vol 18, American Society of Andrology, Inc, San Francisco, pp. 417-423.

Conference Proceedings

Gow, R.D., O'Bryan, M.K., Canny, B., Ooi, G.T., Hedger, M., 1999, Dexamethosone ameliorates the effects of lipopolysaccharide on systemic inflammation and hormone production in the rat but not local testicular inflammation, The Endocrine Society of Australia Proceedings 1999, Melbourne VIC 26-29 September 1999, Endocrine Society of Australia, Adelaide SA Australia, p. 158.

Phillips, D.J., Brauman, J., Mason, T., de Kretser, D.M., Hedger, M., 1998, A sensitive and specific in vitro bioassay for activin using a mouse plasmacytoma cell line, mpc-11, Proceedings Of The Endocrine Society Of Australia, PERTH, WA 23.8.98, The Endocrine Society of Australia, Perth WA Australia, p. 111.

Hedger, M., Phillips, D.J., de Kretser, D.M., 1998, Activin is not a universal inhibitor of interleukin-6 action, The Endocrine Society Of Australia Proceedings, PERTH, W.A. 23.8.98, THE ENDOCRINE sOCIETY OF AUSTRALIA, Melbourne Vic Australia, p. 95.

Meinhardt, A., Bacher, M., McFarlane, J.R., Metz, C.N., O'Bryan, M.K., de Kretser, D.M., Bucala, R., Hedger, M., 1998, Compensatory production of MIF in rat testis after EDS treatment, 10th European Workshop On Molecular And Cellular Endocrinology Of The Testis, CAPRI, ITALY 28.3.98, THE ARES-SERONO FOUNDATION, ROME ITALY, p. 23.

O'Bryan, M.K., Schlatt, S., Phillips, D.J., de Kretser, D.M., Hedger, M., 1998, Endotoxin-induced inflammation causes a biphasic inhibition of testicular function: possible roles for nitric oxide?, 10th European Workshop On Molecular And Cellular Endocrinology Of The Testis, CAPRI, ITALY 28.3.98, THE ARES-SERONO FOUNDATION, ROME ITALY, p. 10.

de Kretser, D.M., Hedger, M., Jones, K.L., Groome, N.P., Phillips, D.J., 1998, Follistatin and activin: changes in inflammation and the acute phase reaction, Journal Of Endocrinology Volume 159 Supplement, LONDON, UK, SOCIETY FOR ENDOCRINOLOGY, BRISTOL UK, p. 6.

Hedger, M., Duckett, R., Gerdprasert, O., Meinhardt, A., O'Bryan, M.K., 1998, Immunology of the male reproductive tract, Proceedings Of The Aust Physiological & Pharmacological Society, BRISBANE - 27.9.98, ICMS AUSTRALASIA, Sydney NSW Australia, p. 402.

Hedger, M., Meinhardt, A., 1998, Local Regulation of Intratesticular lymphocytes in the rat, Proceedings of the 29th Annual Conference of the Australian Society for Reproductive Biology, perth WA, Australian Society for Reproductive Biology, Perth WA Australia, p. 40.

Hedger, M., Schlatt, S., 1998, Mitosis of resident macrophages in the adult rat testis, The Australian Society For Medical Research, HOBART 22.11.98, LILLY AUSTRALIA, HTTP://WWW.LILLY.COM.AU, p. 67.

O'Bryan, M.K., Phillips, D.J., Schlatt, S., de Kretser, D.M., Hedger, M., 1998, Nitric oxide modulates steroidogenesis in the normal rat testis but is not the primary cause of reduced testosterone production during systemic inflammation, The Endocrine Society Of Australia Proceedings 1998 Volume 41, PERTH, 23.8.98, The Endocrine Society of Australia, Melbourne Vic Australia, p. 95.

Meinhardt, A., Bacher, M., McFarlane, J.R., Mallidis, C., Lehmann, C., Metz, C.N., de Kretser, D.M., Bucala, R., Hedger, M., 1997, A switch in the cellular localization of macrophage migration inhibitory factor (MIF) in rat testis after ethane dimethane sulfonate treatment, Journal of Reproductive Immunology, 30/9-3/10/97 Virginia USA, Elsevier, New York NY USA, pp. 35-36.

Russell, C., Hedger, M., de Kretser, D.M., Phillips, D.J., 1997, Activin regulates growth and haptoglobin production in the human liver cell line, HepG2, The Endocrine Society of Australia - Proceedings, 28/9-2/10/97 Canberra, Endocrine Society of Australia - Proceedings, Prahran, p. 54.

O'Bryan, M.K., Schlatt, S., Phillips, D.J., de Kretser, D.M., Hedger, M., 1997, Inhibition of testicular function during lipopolysaccharide-induced inflammation, The Endocrine Society of Australia - Proceedings, 28/9-2/10/97 Canberra, Endocrine Society of Australia, Prahran, p. 64.

Duckett, R., Wreford, N.G., Meachem, S.J., Hedger, M., McLachlan, R.D., 1997, Regulation of Leydig cell and macrophage number in the rat testis : role of androgen and non-androgenic leydig cell factors, Aust Society for Reproductive Biology program and miniposters of abstracts, 29/9-1/10/97 Canberra, Vertebrate Biocontrol Cooperative Research Centre, Canberra ACT Australia, p. 64.

Duckett, R., Wreford, N.G., Meachem, S.J., McLachlan, R.I., Hedger, M., 1997, Regulation of Leydig cell and macrophage number in the rat testis: role of androgen and non-androgenic leydig cell factors, Australian Society for Reproductive Biology Program and Miniposters of Abstracts, Canberra 29/9-1/10/1997, Vertebrate Biocontrol Cooperative Research Centre, Canberra ACT Australia, p. 64.

Duckett, R., Wreford, N.G., Meachem, S.J., McLachlan, R.I., Hedger, M., 1997, Regulation of leydig cell and macrophage number in the rat testis: role of angrogen and non-androgenic leydig cell factors, Australian Society for Reproductive Biology, Canberra, 29 Sept - 1 Oct 1997, Australian Society for Reproductive Biology, ACT Australia, p. 64.

Gerdprasert, O., O'Bryan, M.K., Schlatt, S., Phillips, D.J., de Kretser, D.M., Hedger, M., 1997, Regulation of macrophages in the testis during endotoxin-induced imflammation, Australian Society for Medical Research Program and Abstracts, 23-26 November, Adelaide, Australian Society for Medical Research, Adelaide SA Australia, p. P23.B.

Hedger, M., Baker, G.H., de Kretser, D.M., 1997, Testicular Immunology and Sperm antibodies, Hormones & Men's Health Programme and Abstract Book, 19-21 March 1997 Clayton, IRD & PHIMR, Clayton Vic Australia, p. 39.

Hedger, M., O'Bryan, M.K., Phillips, D.J., Schlatt, S., de Kretser, D.M., 1997, The effects of lipopolysaccharide on testicular androgen secretion are preceded by changes in the testicular vasculature, Journal of Reproductive Immunology, 30/9-3/10/97 Virginia, USA, Elsevier, New York NY USA, p. 35.

Other

Hedger, M., 1997, Immunology of the Testis and Sperm, Comprehensive Toxicology, vol 10, issue 1, Pergamon/Elsevier Science Inc, New York NY USA, pp. 203-215.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Activin A: expression and potential sources in cardiopulmonary bypass and myocardial ischaemia-reperfusion injury.

Supervisors:

Hedger, M (Joint), Smith, J (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Role of Follistatin in wound healing and repair after cutaneous injury in the mouse..

Supervisors:

Temple-Smith, P (Main), Hedger, M (Associate), De Kretser, D (Associate).

Completed Supervision

Student:

Ali, U.

Program of Study:

Expression and regulation of cyclooxygenase isoforms in the rat testis.. (Masters) 2002.

Supervisors:

Hedger, M (Main).

Student:

Aridi, D.

Program of Study:

Analysis of lymphocyte subsets in the rat and mouse testis and their immunoregulatory properties. (PHD) 2007.

Supervisors:

Hedger, M (Main).

Student:

Crane, M.

Program of Study:

Characterisation of immunosuppressive molecules of gonadal origin. (PHD) 2006.

Supervisors:

Hedger, M (Main), De Kretser, D (Associate).

Student:

Craythorn, R.

Program of Study:

Follistatin isoforms in the female mouse reproductive tract. (PHD) 2010.

Supervisors:

Hedger, M (Joint), Rogers, P (Joint-Co).

Student:

Okuma, Y.

Program of Study:

STUDIES ON THE REGULATION OF ACTIVIN AND INHIBIN SECRETION BY THE RAT SERTOLI CELL. (PHD) 2003.

Supervisors:

Hedger, M (Main), De Kretser, D (Associate).