Dr Dion Kaiserman - Researcher Profile

Biography

Dion works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 2006

HONOURS DEGREE OF BACHELOR OF SCIENCE (BIOMEDICAL)

Institution: Monash University

Year awarded: 2001

BACHELOR OF SCIENCE (BIOMEDICAL)

Institution: Monash University

Year awarded: 1999

Publications

Book Chapters

Stewart, S.E., Mangan, M.S., Bird, P.I., Kaiserman, D., 2012, Detection of human and mouse granzyme B activity in cell extracts, in Methods in Molecular Biology - Leucocytes Methods and Protocols, eds JM Walker, Humana Press, USA, pp. 251-260.

Kaiserman, D., Hitchen, C.R., Levina, V., Bottomley, S.P., Bird, P.I., 2011, Intracellular production of recombinant serpins in yeast, in Methods in Enzymology, Volume 501: Serpin Structure and Evolution, eds James C Whisstock and Phillip I Bird, Academic Press, USA, pp. 1-12.

Song, J., Matthews, A., Reboul, C.F., Kaiserman, D., Pike, R.N., Bird, P.I., Whisstock, J.C., 2011, Predicting serpin/protease interactions, in Methods in Enzymology, Volume 501: Serpin Structure and Evolution, eds James C Whisstock and Philip I Bird, Academic Press, USA, pp. 237-273.

Irving, J.A., Cabrita, L., Kaiserman, D., Worrall, D.M., Whisstock, J., 2007, Evolution and classification of the serpin superfamily, in Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity, eds G.A. Silverman & D.A. Lomas, World Scientific, Singapore, pp. 1-33.

Journal Articles

Plasman, K., Van Damme, P., Kaiserman, D., Impens, F., Demeyer, K., Helsens, K., Goethals, M., Bird, P.I., Vandekerckhove, J., Gevaert, K., 2011, Probing the efficiency of proteolytic events by positional proteomics, Molecular & Cellular Proteomics [P], vol 10, issue 2 (Art. No: M110.003301), Amercian Society for Biochemistry and Molecular Biology, Inc., USA, pp. 1-10.

Kaiserman, D., Bird, P.I., 2010, Control of granzymes by serpins, Cell Death and Differentiation [P], vol 17, Nature Publishing Group, UK, pp. 586-595.

Silverman, G.A., Whisstock, J.C., Bottomley, S.P., Huntington, J.A., Kaiserman, D., Luke, C.J., Pak, S.C., Reichhart, J.-., Bird, P.I., 2010, Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems, Journal Of Biological Chemistry [P], vol 285, issue 32, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 24299-24305.

Whisstock, J.C., Silverman, G.A., Bird, P.I., Bottomley, S.P., Kaiserman, D., Luke, C.J., Pak, S.C., Reichhart, J.-., Huntington, J.A., 2010, Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions, Journal Of Biological Chemistry [P], vol 285, issue 32, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 24307-24312.

Northfield, S., Roberts, K., Mountford, S., Hughes, R., Kaiserman, D., Mangan, M., Pike, R., Bird, P., Thompson, P., 2010, Synthesis of "difficult" fluorescence quenched substrates of granzyme C, International Journal of Peptide Research and Therapeutics [E], vol 16, Springer, New York New York USA, pp. 159-165.

Levina, V., Dai, W., Knaupp, A.S., Kaiserman, D., Pearce, M.C., Cabrita, L.D., Bird, P.I., Bottomley, S.P., 2009, Expression, purification and characterization of recombinant Z alpha1-Antitrypsin-The most common cause of alpha1-Antitrypsin deficiency, Protein Expression And Purification [P], vol 68, issue 2, Academic Press, USA, pp. 226-232.

Kaiserman, D., Buckle, A.M., Van Damme, P., Irving, J.A., Law, R.H.P., Matthews, A.Y., Bashtannyk-Puhalovich, T.A., Langendorf, C., Thompson, P., Vandekerckhove, J., Gevaert, K., Whisstock, J.C., Bird, P.I., 2009, Structure of granzyme C reveals an unusual mechanism of protease autoinhibition, Proceedings of the National Academy of Sciences of the United States of America, vol 106, issue 14, National Academy of Sciences, USA, pp. 5587-5592.

Ng, N.M., Quinsey, N.S., Matthews, A.Y., Kaiserman, D., Wijeyewickrema, L.C., Bird, P.I., Thompson, P.E., Pike, R.N., 2009, The effects of exosite occupancy on the substrate specificity of thrombin, Archives Of Biochemistry And Biophysics [P], vol 489, issue 1-2, Academic Press, USA, pp. 48-54.

Buzza, M.S., Dyson, J.M., Choi, H., Gardiner, E.E., Andrews, R.K., Kaiserman, D., Mitchell, C.A., Berndt, M.C., Dong, J., Bird, P.I., 2008, Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor, Journal of Biological Chemsitry, vol 283, issue 33, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 22498-22504.

Kerr, F.K., Thomas, A.R., Wijeyewickrema, L.C., Whisstock, J., Boyd, S.E., Kaiserman, D., Matthews, A.Y., Bird, P.I., Thielens, N.M., Rossi, V., Pike, R.N., 2008, Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor, Molecular Immunology, vol 45, Pergamon-Elsevier Science Ltd, Oxford England UK, pp. 670-677.

Mangan, M., Kaiserman, D., Bird, P.I., 2008, The role of serpins in vertebrate immunity, Tissue Antigens, vol 72, issue 1, Wiley-Blackwell Munksgaard, Denmark, pp. 1-10.

Kaiserman, D., Whisstock, J.C., Bird, P.I., 2006, Mechanisms of serpin dysfunction in disease, Expert Reviews in Molecular Medicine, vol 8, issue 31, Cambridge University Press, New York USA, pp. 1-19.

Kaiserman, D., Bird, C.H., Sun, J., Matthews, A.Y., Ung, K.S., Whisstock, J.C., Thompson, P.E., Trapani, J.A., Bird, P.I., 2006, The major human and mouse granzymes are structurally and functionally divergent, The Journal of Cell Biology, vol 175, issue 4, Rockefeller University Press, USA, pp. 619-630.

Kaiserman, D., Bird, P.I., 2005, Analysis of vertebrate genomes suggests a new model for clade B serpin evolution, BMC Genomics, vol 6, issue 167, Biomed Central Ltd, London England, pp. 1-10.

Kerr, F.K., O'Brien, G., Quinsey, N.S., Whisstock, J., Boyd, S.E., Garcia De La Banda, M.J., Kaiserman, D., Matthews, A.Y., Bird, P.I., Pike, R.N., 2005, Elucidation of the substrate specificity of the C1s protease of the classical complement pathway, Journal of Biological Chemistry, vol 280, issue 47, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 39510-39514.

Kim, T.W., Hung, C., Boyd, D.A.K., He, L., Lin, C., Kaiserman, D., Bird, P.I., Wu, T.C., 2004, Enhancement of DNA vaccine potency by coadministration of a tumor antigen gene and DNA encoding serine protease inhibitor-6, Cancer Research, vol 64, issue 1, American Association Cancer Research, Philadelphia USA, pp. 400-405.

Kaiserman, D., Knaggs, S., Scarff, K.L., Gillard, A., Mirza, G., Cadman, M., McKeone, R., Denny, P., Cooley, J., Benarafa, C., Remold-O'Donnell, E., Ragoussis, J., Bird, P.I., 2002, Comparison of human chromasome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repetoire in the mouse, Genomics, vol 79, issue 3, Academic Press Inc Elsevier Science, San Diego CA USA, pp. 349-362.

Conference Proceedings

Ng, N., Boyd, S.E., Bird, P.I., Thompson, P., Matthews, A.Y., Kaiserman, D., Pike, R.N., 2007, The effects of thrombomodulin on the substrate specificity of thrombin, 5th General Meeting of the International Proteolysis Society Book of Abstracts, 20 October 2007 to 24 October 2007, Novartis Pharma A, Basel Switzerland, p. 375.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Granzyme structure and function during vertebrate evolution.

Supervisors:

Bird, P (Main), Kaiserman, D (Associate).