Assoc Prof Anna Roujeinikova - Researcher Profile

Biography

Anna works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as an Associate Professor.

Qualifications

GRADUATE CERTIFICATE IN HIGHER EDUCATION

Institution: Monash University

Year awarded: 2011

LEVEL 3 AWARD IN FIRST LINE MANAGEMENT

Institution: Institute of Leadership and Management (United Kingdom)

Year awarded: 2009

PHD, STRUCTURAL BIOLOGY

Institution: The University of Sheffield (United Kingdom)

Year awarded: 2002

MSC, BIOLOGY PHYSICS

Institution: Moscow Institute of Physics and Technology (Russia)

Year awarded: 1997

BSC, NATURAL SCIENCES

Institution: Moscow Institute of Physics and Technology (Russia)

Year awarded: 1994

Publications

Journal Articles

Andrews, D., Xie, M., Hughes, V.A., Wilce, M.C.J., Roujeinikova, A., 2013, Design, purification and characterization of a soluble variant of the integral membrane protein MotB for structural studies, Journal Of The Royal Society Interface [P], vol 10, issue 79, The Royal Society Publishing, UK, pp. 1-10.

Alonso, H., Roujeinikova, A., 2012, Characterization and two-dimensional crystallization of membrane component AlkB of the medium-chain alkane hydroxylase system from Pseudomonas putida GPo1, Applied And Environmental Microbiology [P], vol 78, issue 22, American Society for Microbiology, USA, pp. 7946-7953.

Xie, M., Alonso, H., Roujeinikova, A., 2011, An improved procedure for the purification of catalytically active alkane hydroxylase from Pseudomonas putida GPo1, Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology [P], vol 165, issue 3-4, Humana Press Inc., USA, pp. 823-831.

Reboul, C., Andrews, D., Nahar, M., Buckle, A., Roujeinikova, A., 2011, Crystallographic and molecular dynamics analysis of loop motions unmasking the peptidoglycan-binding site in stator protein MotB of flagellar motor, PLoS ONE [P], vol 6, issue 4 (Art. No: e18981), Public Library of Science, USA, pp. 1-7.

Aydin, I., Dimitropoulos, A., Chen, S., Thomas, C., Roujeinikova, A., 2011, Purification, crystallization and preliminary X-ray crystallographic analysis of the putative Vibrio parahaemolyticus resuscitation-promoting factor YeaZ, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 67, issue Part 5, Wiley-Blackwell Publishing, Inc., USA, UK, pp. 604-607.

O'Neill, J., Xie, M., Hijnen, M., Roujeinikova, A., 2011, Role of the MotB linker in the assembly and activation of the bacterial flagellar motor, Acta Crystallographica Section D-Biological Crystallography [P], vol 67, issue Part 12, Wiley-Blackwell Publishing, Inc., USA, pp. 1009-1016.

Aydin, I., Saijo-Hamano, Y., Namba, K., Thomas, C., Roujeinikova, A., 2011, Structural analysis of the essential resuscitation promoting factor YeaZ suggests a mechanism of nucleotide regulation through dimer reorganization, PLoS ONE [P], vol 6, issue 8 (Art. No: e23245), Public Library of Science, USA, pp. 1-8.

Nahar, M., Roujeinikova, A., 2010, Structural basis of resistance of Helicobacter pylori DnaK to antimicrobial peptide pyrrhocoricin, World Academy of Science, Engineering and Technology. Proceedings [E], vol 65, World Academy of Science, Engineering and Technology (W A S E T), Turkey, pp. 168-171.

Liebscher, M., Roujeinikova, A., 2009, Allosteric coupling between the lid and interdomain linker in DnaK revealed by inhibitor binding studies, Journal Of Bacteriology [P], vol 191, issue 5, American Society for Microbiology, USA, pp. 1456-1462.

O'Neill, J., Roujeinikova, A., 2008, Cloning, purification and crystallization of MotB, a stator component of the proton-driven bacterial flagellar motor, Acta Crystallographica Section F: Structural Biology..., vol 64, issue Pt. 6, Wiley-Blackwell Publishing, Inc., UK, USA, pp. 561-563.

Roujeinikova, A., 2008, Cloning, purification and preliminary X-ray analysis of the C-terminal domain of Helicobacter pylori MotB, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 64, issue Pt 4, Wiley-Blackwell Munksgaard, Denmark, USA, pp. 277-280.

Roujeinikova, A., 2008, Crystal structure of the cell wall anchor domain of MotB, a stator component of the bacterial flagellar motor: Implications for peptidoglycan recognition, Proceedings Of The National Academy Of Sciences O..., vol 105, issue 30, National Academy of Sciences, USA, pp. 10348-10353.

Hothi, P., Hay, S., Roujeinikova, A., Sutcliffe, M.J., Lee, M., Leys, D., Cullis, P.M., Scrutton, N.S., 2008, Driving force analysis of proton tunnelling across a reactivity series for an enzyme-substrate complex., Chembiochem [P], vol 9, issue 17, Wiley - VCH Verlag GmbH & Co. KGaA, Germany, pp. 2839-2845.

Toogood, H.S., Fryszkowska, A., Hare, V., Fisher, K., Roujeinikova, A., Leys, D., Gardiner, J.M., Stephens, G.M., Scrutton, N.S., 2008, Structure-based insight into the asymmetric bioreduction of the C=C double bond of alpha,beta-unsaturated nitroalkenes by pentaerythritol tetranitrate reductase, Advanced Synthesis and Catalysis [P], vol 350, issue 17, Wiley - VCH Verlag GmbH & Co. KGaA, Germany, pp. 2789-2803.

Roujeinikova, A., Simon, W.J., Gilroy, J., Rice, D.W., Rafferty, J.B., Slabas, A.R., 2007, ABSTRACT: Structures of fatty acyl-(acyl carrier protein) thioesters reveal a binding cavity that expands to fit longer substrates, The Febs Journal [P], vol 274, issue Suppl 1, Wiley-Blackwell Publishing Ltd, UK, Denmark, p. 223.

Hothi, P., Roujeinikova, A., Khadra, K.A., Lee, M., Cullis, P.M., Leys, D., Scrutton, N.S., 2007, Isotope effects reveal that para-substituted benzylamines are poor reactivity probes of the quinoprotein mechanism for aromatic amine dehydrogenase, Biochemistry [P], vol 46, issue 32, American Chemical Society, USA, pp. 9250-9259.

Roujeinikova, A., Hothi, P., Masgrau, L., Sutcliffe, M.J., Scrutton, N.S., Leys, D., 2007, New insights into the reductive half-reaction mechanism of aromatic amine dehydrogenase revealed by reaction with carbinolamine substrates, Journal Of Biological Chemistry [P], vol 282, issue 33, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 23766-23777.

Roujeinikova, A., Simon, W.J., Gilroy, J., Rice, D.W., Rafferty, J.B., Slabas, A.R., 2007, Structural studies of fatty acyl-(acyl carrier protein) thioesters reveal a hydrophobic binding cavity that can expand to fit longer substrates, Journal of Molecular Biology [P], vol 365, issue 1, Academic Press, UK, pp. 135-145.

Masgrau, L., Roujeinikova, A., Johannissen, L.O., Hothi, P., Basran, J., Ranaghan, K.E., Mulholland, A.J., Sutcliffe, M.J., Scrutton, N.S., Leys, D., 2006, Atomic description of an enzyme reaction dominated by proton tunneling, Science [P], vol 312, issue 5771, American Association for the Advancement of Science, USA, pp. 237-241.

Roujeinikova, A., Scrutton, N.S., Leys, D., 2006, Atomic level insight into the oxidative half-reaction of aromatic amine dehydrogenase, Journal Of Biological Chemistry [P], vol 281, issue 52, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 40264-40272.

Xu, L., Muench, S.P., Roujeinikova, A., Sedelnikova, S.E., Rice, D.W., 2006, Cloning, purification and preliminary crystallographic analysis of the Bacillus subtilis GTPase YphC-GDP complex, Acta Crystallographica Section F: Structural Biology..., vol 62, issue Pt 5, Wiley-Blackwell Munksgaard, Denmark, USA, pp. 435-437.

Seward, H.E., Roujeinikova, A., McLean, K.J., Munro, A.W., Leys, D., 2006, Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode, Journal Of Biological Chemistry [P], vol 281, issue 51, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 39437-39443.

Sutcliffe, M.J., Masgrau, L., Roujeinikova, A., Johannissen, L.O., Hothi, P., Basran, J., Ranaghan, K.E., Mulholland, A.J., Leys, D., Scrutton, N.S., 2006, Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: Flavoprotein and quinoprotein systems, Philosophical Transactions of the Royal Society of London Series B Biological Sciences [P], vol 361, issue 1472, The Royal Society Publishing, UK, pp. 1375-1386.

Levy, C.W., Roujeinikova, A., Sedelnikova, S.E., Baker, P.J., Stuitje, A.R., Slabas, A.R., Rice, D.W., Rafferty, J.B., 1999, Molecular basis of triclosan activity, Nature [P], vol 398, issue 6726, Nature Publishing Group, UK, pp. 383-384.

Conference Proceedings

Roujeinikova, A., 2011, Structural basis of resistance of Helicobacter pylori DnaK to antimicrobial peptide pyrrhocoricin, Antimicrobial Peptides in Innate Immunity - New Insights on an Ancient System, 15-20 May 2011, Gordon Research Conferences, USA, p. 1.

Roujeinikova, A., 2010, Dissecting of three-dimensional structure of the power-generating mechanism of the bacterial flagellar motor, BIT Life Sciences 3rd Annual Protein and Peptide Conference, 21/03/2010 to 24/03/2010, China Medicinal Biotech Association, China, p. 1.

Roujeinikova, A., 2008, PP3D-22 (Poster): Crystal structure of the cell wall anchor domain of MotB, the stator component of the bacterial flagellar motor: Implications for peptidoglycan recognition, Febs Journal [P], June 28 - July 3, 2008, Wiley-Blackwell Publishing Ltd, UK, Denmark, p. 205.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Bacterial flagellar motor: how is the power-generating part assembled and activated?.

Supervisors:

Roujeinikova, A (Main), Kwok-Schuelein, T (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Dynamic characterisation of motility protein B.

Supervisors:

Roujeinikova, A (Main), Buckle, A (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

RpoH-Sigma 32 mediated control of stress response in Gram negative bacteria..

Supervisors:

Davies, J (Joint), Roujeinikova, A (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Structural and functional characterization of the Helicobacter pylori protein CagA.

Supervisors:

Roujeinikova, A (Main), Kwok-Schuelein, T (Associate).