Dr Kip Gabriel - Researcher Profile

Biography

Kip works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Senior Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: University of Melbourne

Year awarded: 2004

Publications

Journal Articles

Hewitt, V.L., Heinz, E., Shingu-Vazquez, M.A., Qu, Y., Jelicic, B., Lo, T.L., Beilharz, T.H., Dumsday, G., Gabriel, K., Traven, A., Lithgow, T.J., 2012, A model system for mitochondrial biogenesis reveals evolutionary rewiring of protein import and membrane assembly pathways, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 109, issue 49, National Academy of Sciences, USA, pp. E3358-E3366.

Sim, C., Gabriel, K., Mills, R.D., Culvenor, J.G., Cheng, H., 2012, Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1), Human Mutation [P], vol 33, issue 10, John Wiley & Sons, Inc., USA, pp. 1408-1422.

Gabriel, K., 2012, Connecting the Points: Revealing the Bigger Picture, Journal of Molecular Biology [P], vol 422, issue 2, Academic Press, UK, pp. 181-182.

Jiang, J., Tong, J.H.S., Tan, K.S., Gabriel, K., 2012, From evolution to pathogenesis: the link between beta-barrel assembly machineries in the outer membrane of mitochondria and gram-negative bacteria, International Journal of Molecular Sciences [P], vol 13, issue 7, M D P I AG, Switzerland, pp. 8038-8050.

Jiang, J., Tong, J., Gabriel, K., 2012, Hijacking mitochondria: bacterial toxins that modulate mitochondrial function, Iubmb Life [P], vol 64, issue 5, Wiley-Blackwell Publishing Ltd, UK, pp. 397-401.

Dolezal, P., Aili, M., Tong, J., Jiang, J., Marobbio, C.M., Lee, S., Schuelein, R., Belluzzo, S., Binova, E., Mousnier, A., Frankel, G.M., Giannuzzi, G., Palmieri, F., Gabriel, K., Naderer, T., Hartland, E.L., Lithgow, T.J., 2012, Legionella pneumophila secretes a mitochondrial carrier protein during infection, Plos Pathogens [P], vol 8, issue 1 (Art. ID: e1002459), Public Library of Science, USA, pp. 1-13.

Tong, J.H.S., Dolezal, P., Selkrig, J., Crawford, S.A., Simpson, A.G., Noinaj, N., Buchanan, S.K., Gabriel, K., Lithgow, T.J., 2011, Ancestral and derived protein import pathways in the mitochondrion of Reclinomonas americana, Molecular Biology And Evolution [P], vol 28, issue 5, Oxford University Press, USA, pp. 1581-1591.

Jiang, J., Davies, J.K., Lithgow, T.J., Strugnell, R.A., Gabriel, K., 2011, Targeting of Neisserial PorB to the mitochondrial outer membrane: An insight on the evolution of beta-barrel protein assembly machines, Molecular Microbiology [P], vol 82, issue 4, Wiley-Blackwell Publishing Ltd, UK, pp. 976-987.

Palframan, S.L., Kwok-Scheulein, T., Gabriel, K., 2011, Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesis, Frontiers in Cellular and Infection Microbiology [E], vol 2, issue Art. No.: 92, Frontiers Research Foundation, Switzerland, pp. 1-9.

Anwari, K., Poggio, S., Perry, A., Gatsos, X., Ramarathinam, S.H., Williamson, N.A., Noinaj, N., Buchanan, S., Gabriel, K., Purcell, A.W., Jacobs-Wagner, C., Lithgow, T., 2010, A modular BAM complex in the outer membrane of the alpha-proteobacterium caulobacter crescentus, PLoS ONE [P], vol 5, issue 1 (e8619), Public Library of Science, USA, pp. 1-8.

Foo, J.H., Culvenor, J., Ferrero, R.L., Kwok-Schuelein, T., Lithgow, T.J., Gabriel, K., 2010, Both the p33 and p55 subunits of the Helicobacter pylori VacA toxin are targeted to mammalian mitochondria, Journal of Molecular Biology [P], vol 401, issue 5, Academic Press, UK, pp. 792-798.

Veldhuis, N.A., Gaeth, A.P., Pearson, R.B., Gabriel, K., Camakaris, J., 2009, The multi-layered regulation of copper translocating P-type ATPases, Biometals, vol 22, issue 1, Springer Netherlands, The Netherlands, pp. 177-190.

Chacinska, A., Guiard, B., Muller, J.M., Schulze-Specking, A., Gabriel, K., Kutik, S., Pfanner, N., 2008, Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40, Journal Of Biological Chemistry [P], vol 283, issue 44, American Society for Biochemistry & Molecular Biology Inc, USA, pp. 29723-29729.

Stojanovski, D., Milenkovic, D., Muller, J.M., Gabriel, K., Schulze-Specking, A., Baker, M.J., Ryan, M.T., Guiard, B., Pfanner, N., Chacinska, A., 2008, Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase, The Journal of Cell Biology, vol 183, issue 2, Rockefeller University Press, USA, pp. 195-202.

Milenkovic, D., Gabriel, K., Guiard, B., Schulze-Specking, A., Pfanner, N., Chacinska, A., 2007, Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: Site-specific recognition of cysteine residues by the intermembrane space receptor Mia40, Journal of Biological Chemistry, vol 282, issue 31, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 22472-22480.

Gabriel, K., Milenkovic, D., Chacinska, A., Muller, J.M., Guiard, B., Pfanner, N., Meisinger, C., 2007, Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway, Journal of Molecular Biology, vol 365, issue 3, Academic Press, UK, pp. 612-620.

Rissler, M., Wiedemann, N., Pfannschmidt, S., Gabriel, K., Guiard, B., Pfanner, N., Chacinska, A., 2005, The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins, Journal of Molecular Biology, vol 353, issue 3, Academic Press, UK, pp. 485-492.

Gentle, I., Gabriel, K., Beech, P.L., Waller, R., Lithgow, T.J., 2004, The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria, The Journal of Cell Biology, vol 164, issue 1, Rockefeller University Press, USA, pp. 19-24.

Gabriel, K., Egan, B., Lithgow, T.J., 2003, Tom40, the import channel of the mitochondrial outer membrane, plays an active role in sorting imported proteins, EMBO Journal, vol 22, issue 10, Nature Publishing Group, UK & Germany, pp. 2380-2386.

Allen, R., Egan, B., Gabriel, K., Beilharz, T., Lithgow, T.J., 2002, A conserved proline residue is present in the transmembrane-spanning domain of Tom7 and other tail-anchored protein subunits of the TOM translocase, FEBS Letters, vol 514, issue 2-3, Elsevier BV, The Netherlands & Denmark, pp. 347-350.

Gabriel, K., Buchanan, S.K., Lithgow, T.J., 2001, The alpha and the beta: protein translocation across mitochondrial and plastid outer membranes, Trends in Biochemical Sciences, vol 26, issue 1, Elsevier Ltd, UK & Swizterland, pp. 36-40.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Helicobacter pylori Vacuolating cytotoxin (VacA) - examining its role at mitochondria.

Supervisors:

Gabriel, K (Joint-co), Kwok-Schuelein, T (Joint), Lithgow, T (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The architecture of the SAM complex: a molecular machine that drives membrane assembly..

Supervisors:

Lithgow, T (Main), Gabriel, K (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of Neisserial "blebs" on host cell biology during infection.

Supervisors:

Gabriel, K (Main), Lithgow, T (Associate), Naderer, T (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Understanding the toxic activity of Neisserial outer membrane vesicles on host cells.

Supervisors:

Gabriel, K (Joint-co), Lithgow, T (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Understanding the trafficing of pathogenic proteins to mitochondria and their effects on mitochondrial function.

Supervisors:

Gabriel, K (Joint-co), Lithgow, T (Joint).