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Research Prof Paul Hertzog - Researcher Profile

Address

Monash Institute of Medical Research
Monash Medical Centre, Clayton

Contact Details

Tel: +61 3 9594 7206

Email: Paul.Hertzog@monash.edu

Profile
Summary
Qualifications
Publications
Grants
Supervisions

Biography

Director - Centre for Innate Immunity & Infectious Disease

Monash Institute of Medical Research

"Innate immunity proves promising for fighting disease"

Professor Paul Hertzog believes our innate, or first-line, immune defence system offers great promise in a range of therapeutic areas. As Director of the Centre for Innate Immunity and Infectious Disease, Paul oversees research that aims to increase understanding of how immune cells operate. His facility is also using genome sequencing to find genetic signatures for a variety of diseases.

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Innate immunity is our natural ability to provide an immediate defence against infection. Unlike the instructive immunity that vaccination offers against specific viruses, our innate immune system responds in a generic way to provide an immediate defence against pathogens. Paul says they cannot lose sight of the fact that immune responses can sometimes be inadequate or too strong.

“Immune response is always about balance”, Paul says. “Whether you think about innate immunity, inflammation or vaccination, we know if things work well you get a burst of activity and resolve a disease. Depending on the disease, that might take two or three days.

“There’s a subtle balance of getting a fast and adequate immune response, both in strength and duration, but not so much that it creates acute disease such as septic shock, or chronic autoimmune disease. We try and understand those balances when we put in a molecule or remove it with therapeutic antibodies.”

Paul’s facility recently discovered a new cytokine molecule that regulates immune responses in the female reproductive tract.

“This is a particular type of cytokine called interferons, which are usually produced in response to a particular stress like an infection. They act locally if you get an infection by recruiting immune cells to the site of damage. They also get into the bloodstream and go to your major lymphoid organs such as your spleen or bone marrow. They can stop cells growing or modulate whether cells die or not. Cytokines have been used against cancers, hepatitis and autoimmune diseases like multiple sclerosis.

“Our recent discovery is being prepared for publication and we’ve taken out patents because we think it might have some translational benefits. It’s going to be relevant to a lot of STIs, like chlamydia, herpes, HIV and papillomavirus. We think our discovery will help treat those diseases, maybe detect them and formulate new vaccines. It might also be usable against gynaecological cancers and endometriosis,” Paul says.

Another of Paul’s interests incorporates the complex area of bioinformatics to understand how genes in the genome interact. This allows his facility to find genetic signatures for diseases, and they’re currently involved in exciting studies on infections and cancers.

“Current technologies enable us to examine how a cell responds by measuring the output of the genome. Fifteen years ago we could measure one gene at a time, whereas now we can measure all 30,000 and look at how they’ve changed.

“When we study innate immune responses, whether they are infections or cancers, we aim to look for signatures. We no longer look for a single marker, but groups of markers. It’s a simple indicator for some diseases, such as diabetes, but it’s more complicated for cancer and infections. A single molecule can’t account for all the changes so we have to use bioinformatics, because a signature disease might involve anything from 10 to 100 different genes being changed.

“We’re making good inroads into understanding innate responses as they contribute to breast cancer metastases or infections with HIV. Some of the work on cancer and infection signatures will probably see practical translational outcomes sooner than developing new molecules.”

Qualifications

PHD (SCHOOL OF PATHOLOGY): Institution: Melbourne University; Year awarded: 1977

BACHELOR OF SCIENCE (HONS): Institution: Melbourne University; Year awarded: 1972

BACHELOR OF SCIENCE: Institution: Melbourne University; Year awarded: 1971

Publications

Book Chapters

Wilson, T.J., Truman, D., Giudice, A., Hertzog, P.J., 2007, Rapid generation of gene-targeting constructs, in PCR: Methods Express Series, eds S Hughes and A Moody, Scion Publishing, Oxfordshire, UK, pp. 173-196.

Samarajiwa, S., Wilson, W., Hertzog, P.J., 2006, Type 1 interferons: genetics and structure, in The Interferons: Characterization and Application, eds Anthony Meager, Wiley-VCH, Weinheim Germany, pp. 3-34.

Samarajiwa, S.A., Wilson, W., Hertzog, P.J., 2006, Type 1 interferons: genetics and structure, in The Interferons Characterization and Applications, eds Anthony Meager, Wiley-VCH, UK, pp. 3-34.

Xu, D., Wilson, T.J., Hertzog, P.J., 2006, Ultraviolet-induced apoptosis in embryonic stem cells in vitro, in Embryonic Stem Cell Protocols. Volume 1: Isolation and Characterization, eds Kursad Turksen (Series Editor John M. Walker), Humana Press, Totowa NJ USA, pp. 327-338.

Lahoud, M.H., Wilson, T.J., Hertzog, P.J., 2001, Choice of mouse strains for gene targeting, in Methods in Molecular Biology: Gene Knockout Protocols, eds Martin J Tymms and Ismail Kola, Humana Press, Totowa New Jersey USA, pp. 107-119.

Hertzog, P.J., 2001, Isolation of embryonic fibroblasts and their use in the in vitro characterization of gene function, in Methods in Molecular Biology: Gene Knockout Protocols, eds Martin J. Tymms and Ismail Kola, Humana Press, Totowa New Jersey USA, pp. 205-215.

Hertzog, P.J., Kola, I., 2001, Overview: Gene Knockouts, in Methods in Molecular Biology: Gene Knockout Protocols, eds Martin J. Tymms and Ismail Kola, Humana Press, Totowa New Jersey USA, pp. 1-10.

Wilson, T.J., Lazner, F., Kola, I., Hertzog, P.J., 2000, The mouse and the genomic era, in Comparative genomics, Kluwer Academic Publishers, Norwell USA, pp. 97-121.

Journal Articles

Berry, C.M., Hertzog, P.J., Mangan, N., 2012, Interferons as biomarkers and effectors: lessons learned from animal models, Biomarkers In Medicine [P], vol 6, issue 2, Future Medicine Ltd, United Kingdom, pp. 159-176.

GreenHill, C., Gould, J.A., Ernst, M.R., Jarnicki, A.G., Hertzog, P.J., Mansell, A.S., Jenkins, B.J., 2012, LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling, Immunology And Cell Biology [P], vol 90, issue 5, Nature Publishing Group, United Kingdom, pp. 559-563.

Hertzog, P.J., 2012, Overview. Type I interferons as primers, activators and inhibitors of innate and adaptive immune responses, Immunology And Cell Biology [P], vol 90, issue 5, Nature Publishing Group, United Kingdom, pp. 471-473.

Bidwell, B., Slaney, C.Y., Withana, N.P., Forster, S., Cao, Y., Loi, S., Andrews, D.M., Mikeska, T., Mangan, N., Samarajiwa, S.A., De Weerd, N.A., Gould, J.A., Argani, P., Moller, A., Smyth, M., Anderson, R., Hertzog, P.J., Parker, B., 2012, Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape, Nature Medicine [P], vol 18, issue 8, Nature Publishing Group, United States, pp. 1224-1231.

Schuessler, A., Funk, A., Lazear, H.M., Cooper, D.A., Torres, S., Daffis, S., Jha, B.K., Kumagai, Y., Takeuchi, O., Hertzog, P.J., Silverman, R.H., Akira, S., Barton, D.J., Diamond, M.S., Khromykh, A.A., 2012, West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response, Journal Of Virology [P], vol 86, issue 10, American Society for Microbiology, United States, pp. 5708-5718.

Gantier, M., McCoy, C., Rusinova, I., Saulep, D., Wang, D., Xu, D., Irving, A., Behlke, M., Hertzog, P., Mackay-Fisson, F., Williams, B., 2011, Analysis of microRNA turnover in mammalian cells following Dicer1 ablation, Nucleic Acids Research [P], vol 39, issue 13, Oxford University Press, United Kingdom, pp. 5692-5703.

Vremec, D., O'Keeffe, M., Wilson, A., Ferrero, I., Koch, U., Radtke, F., Scott, B., Hertzog, P., Villadangos, J., Shortman, K., 2011, Factors determining the spontaneous activation of splenic dendritic cells in culture, Innate Immunity [P], vol 17, issue 3, Sage Publications Ltd, United Kingdom, pp. 338-352.

Harman, A., Lai, J., Turville, S., Samarajiwa, S., Gray, L., Marsden, V., Mercier, S., Jones, K., Nasr, N., Rustagi, A., Cumming, H., Donaghy, H., Mak, J., Gale Jr, M., Churchill, M., Hertzog, P., Cunningham, A., 2011, HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production, Blood [P], vol 118, issue 2, American Society of Hematology, USA, pp. 298-308.

van Zuylen, W., Garceau, V., Idris, A., Schroder, K., Irvine, K., Lattin, J., Ovchinnikov, D., Perkins, A., Cook, A., Hamilton, J., Hertzog, P., Stacey, K., Kellie, S., Hume, D., Sweet, M., 2011, Macrophage activation and differentiation signals regulate schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis, PLoS ONE [P], vol 6, issue 1 (Art. No: e15723), Public Library of Science, United States, pp. 1-13.

Hertzog, P., Mansell, A., van Driel, I., Hartland, E., 2011, Sculpting the immune response to infection, Nature Immunology [P], vol 12, issue 7, Nature Publishing Group, United States, pp. 579-582.

Piganis, R., De Weerd, N., Gould, J., Schindler, C., Mansell, A., Nicholson, S., Hertzog, P., 2011, Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2, Journal Of Biological Chemistry [P], vol 286, issue 39, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 33811-33818.

Hertzog, P., Forster, S., Samarajiwa, S., 2011, Systems biology of interferon responses, Journal of Interferon and Cytokine Research [P], vol 31, issue 1, Mary Ann Liebert, Inc., USA, pp. 5-11.

Lapinskas, E., Svobodova, S., Davis, I., Cebon, J., Hertzog, P., Pritchard, M., 2011, The Ets transcription factor ELF5 functions as a tumor suppressor in the kidney, Twin Research and Human Genetics [P], vol 14, issue 4, Australian Academic Press Pty. Ltd, Australia, pp. 316-322.

Haque, A., Best, S., Ammerdorffer, A., Desbarrieres, L., Montes de Oca, M., Amante, F., de Labastida Rivera, F., Hertzog, P., Boyle, G., Hill, G., Engwerda, C., 2011, Type I interferons suppress CD4{+} T-cell-dependent parasite control during blood-stage Plasmodium infection, European Journal Of Immunology [P], vol 41, issue 9, Wiley - V C H Verlag GmbH & Co. KGaA, Germany, pp. 2688-2698.

Robb, R., Kreijveld, E., Kuns, R., Wilson, Y., Olver, S., Don, A., Raffelt, N., De Weerd, N., Lineburg, K., Varelias, A., Markey, K., Koyama, M., Clouston, A., Hertzog, P., MacDonald, K., Hill, G., 2011, Type I-IFNs control GVHD and GVL responses after transplantation, Blood [P], vol 118, issue 12, American Society of Hematology, United States, pp. 3399-3409.

Liaskos, M., Turnbull, L., Carneiro, L., Firth, S.D., Coleman, H.A., Parkington, H.C., Le Bourhis, L., Karrar, A., Viala, J., Mak J., Hutton, M.L., Davies, J.K., Crack, P.J., Hertzog, P.J., Philpott, D., Girardin, S.E., Whitchurch, C.B., Ferrero, R.L., 2010, Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells, Cellular Microbiology [P], vol 12, Wiley-Blackwell Publishing Ltd, UK, pp. 372-385.

Ang, D.K., Oates, C.V., Schuelein, R., Kelly, M.L., Sansom, F.M., Bourges, D., Boon, L., Hertzog, P.J., Hartland, E.L., van Driel, I.R., 2010, Cutting edge: Pulmonary Legionella pneumophila is controlled by plasmacytoid dendritic cells but not type I IFN, Journal Of Immunology [P], vol 184, issue 10, American Association of Immunologists, USA, pp. 5429-5433.

Gough, D.J., Messina, N.L., Hii, L., Gould, J.A., Sabapathy, K., Robertson, A.P.S., Trapani, J.A., Levy, D.E., Hertzog, P.J., Clarke, C.J., Johnstone, R.W., 2010, Functional crosstalk between type I and II interferon through the regulated expression of STAT1, PLoS Biology [E], vol 8, issue 4 (e1000361), Public Library Science, USA, pp. 1-12.

Greenhill, C., Rose-John, S., Lissilaa, R., Ferlin, W., Ernst, M., Hertzog, P.J., Mansell, A.S., Jenkins, B.J., 2010, IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3, Journal Of Immunology [P], vol 186, issue 2, American Association of Immunologists, United States, pp. 1199-1208.

Jones, G., Stumhofer, J., Foster, T., Twohig, J., Hertzog, P.J., Topley, N., Williams, A.S., Hunter, C., Jenkins, B.J., Wang, E., Jones, S.A., 2010, Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation, Faseb Journal [P], vol 25, issue 1, Federation of American Societies for Experimental Biology, United States, pp. 409-419.

Chehab Rogers, R., van Seuningen, I., Gould, J.A., Hertzog, P.J., Naylor, M.J., Pritchard, M.A., 2010, Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of elf5, PLoS ONE [P], vol 5, issue 10 (e13150), Public Library of Science, United States, pp. 1-10.

Fleetwood, A.J., Dinh, H., Cook, A.D., Hertzog, P.J., Hamilton, J.A., 2009, GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling, Journal of Leukocyte Biology [P], vol 86, issue 2, Federation of American Societies for Experimental Biology, US, pp. 411-421.

Forster, S., Samarajiwa, S., Auchettl, K., Hertzog, P., 2009, INTERFEROME: the database of interferon regulated genes, Nucleic Acids Research [P], vol 37, issue Database issue, Oxford University Press, United Kingdom, pp. D852-D857.

Verstak, B., Nagpal, K., Bottomley, S.P., Golenbock, D.T., Hertzog, P.J., Mansell, A.S., 2009, MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses, Journal Of Biological Chemistry [P], vol 284, issue 36, The American Society for Biochemistry and Molecular Biology, Inc, United States, pp. 24192-24203.

Carpenter, S., Carlson, T., Dellacasagrande, J., Garcia, A., Gibbons, S., Hertzog, P.J., Lyons, A., Lin, L., Lynch, M., Monie, T., Murphy, C., Seidl, K.J., Wells, C., Dunne, A., O'Neill, L., 2009, TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain, Journal Of Immunology [P], vol 183, issue 6, American Association of Immunologists, USA, pp. 3989-3995.

Crack, P.J., Gould, J.A., Bye, N., Ross, S., Ali, U., Habgood, M., Morganti-Kossmann, M.C., Saunders, N.R., Hertzog, P.J., 2009, The genomic profile of the cerebral cortex after closed head injury in mice: Effects of minocycline, Journal of Neural Transmission, vol 116, issue -, Springer Wien, Austria, pp. 1-12.

Thibault, D.L., Graham, K.L., Lee, L.Y., Balboni, I., Hertzog, P.J., Utz, P.J., 2009, Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus, Arthritis Research and Therapy [P], vol 11, issue R112, BioMed Central Ltd, UK, pp. 1-10.

Zhao, W., Lee, C., Piganis, R., Plumlee, C., De Weerd, N.A., Hertzog, P.J., Schindler, C., 2008, A conserved IFN-alpha receptor tyrosine motif directs the biological response to type I IFNs, Journal of Immunology, vol 180, issue 8, American Association of Immunologists, USA, pp. 5483-5489.

Hertzog, P.J., 2008, A notch in the toll belt, Immunity [P], vol 29, issue 5, Cell Press, USA, pp. 663-665.

Wong, C.H.Y., Bozinovski, S., Hertzog, P.J., Hickey, M.J., Crack, P.J., 2008, Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion, Journal of Neurochemistry, vol 107, issue 1, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 241-252.

Field, J., Alderuccio, F.P., Hertzog, P.J., Toh, B., 2008, GM-CSF-induced autoimmune gastritis in interferon alpha receptor deficient mice, Journal of Autoimmunity, vol 31, issue 3, Academic Press, United Kingdom, pp. 274-280.

Wu, J., Duan, R., Cao, H., Field, D., Newnham, C.M., Koehler, D.R., Zamel, N., Pritchard, M.A., Hertzog, P.J., Post, M., Tanswell, A.K., Hu, J., 2008, Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation, Cell Research [P], vol 18, issue 6, Nature Publishing Group, United Kingdom, China, pp. 649-663.

Ernst, M.R., Najdovska, M., Grail, D., Lundgren-May, T., Buchert, M., Tye, Y.M.H., Matthews, V.B., Armes, J.E., Bhathal, P.S., Hughes, N.R., Marcusson, E.G., Karras, J.G., Na, S., Sedgwick, J., Hertzog, P.J., Jenkins, B.J., 2008, STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice, Journal of Clinical Investigation, vol 118, issue 5, American Society for Clinical Investigation, USA, pp. 1727-1738.

Wilson, T.J., Lacham, O., Gould, J.A., Holloway, A.J., Bertoncello, I., Hertzog, P.J., Trounson, A.O., 2007, Comparison of mice born after intracytoplasmic sperm injection with in vitro fertilization and natural mating, Molecular Reproduction and Development, vol 74, issue 1, Wiley-Liss, Div John Wiley & Sons Inc, Hoboken NJ USA, pp. 512-519.

Lari, R., Fleetwood, A.J., Kitchener, P.D., Cook, A.D., Pavasovic, D., Hertzog, P.J., Hamilton, J., 2007, Macrophage lineage phenotypes and osteoclastogenesis-Complexity in the control by GM-CSF and TGF-beta, Bone, vol 40, issue 2, Elsevier Science Inc., New York USA, pp. 323-336.

Flentjar, N.J., Chu, P., Ng, A.Y.N., Johnstone, C.N., Heath, J.K., Ernst, M.R., Hertzog, P.J., Pritchard, M.A., 2007, TGF-betaRII rescues development of small intestinal epithelial cells in Elf3-deficient mice, Gastroenterology, vol 132, WB Saunders Co, USA, pp. 1410-1419.

O'Leary, D.A., Noakes, P.G., Lavidis, N.A., Kola, I., Hertzog, P.J., Ristevski, S., 2007, Targeting of the ETS factor Gabpalpha disrupts neuromuscular junction synaptic function, Molecular and Cellular Biology, vol 27, issue 9, American Society for Microbiology, USA, pp. 3470-3480.

Noppert, S., Fitzgerald, K.A., Hertzog, P.J., 2007, The role of type 1 interferons in TLR responses., Immunology and Cell Biology, vol 85, Nature Publishing Group, New York, USA, pp. 446-457.

Noppert, S., Fitzgerald, K.A., Hertzog, P.J., 2007, The role of type I interferons in TLR responses, Immunology and Cell Biology, vol 85, Nature Publishing Group, United Kingdom, pp. 446-457.

Verstak, B., Hertzog, P.J., Mansell, A.S., 2007, Toll-like receptor signalling and the clinical benefits that lie within, Inflammation Research, vol 56, issue 1, Birkhaeuser Verlag AG, Basel, Switzerland, pp. 1-10.

De Weerd, N.A., Samarajiwa, S., Hertzog, P.J., 2007, Type 1 interferon receptors: Biochemistry and biological functions., Journal of Biological Chemistry, vol 282, issue 28, American Society of Biochemistry and Molecular Biology Inc, Bethesda, MD, USA, pp. 20053-20057.

Swann, J.B., Hayakawa, Y., Zerafa, N., Sheehan, K.C., Scott, B.M., Schreiber, R.D., Hertzog, P.J., Smyth, M.J., 2007, Type I IFN contributes to NK cell homeostasis, activation, and antitumor function, The Journal of Immunology, vol 178, issue 12, The American Association of Immunologists, USA, pp. 7540-7549.

Sheehan, K.C., Lai, K.S., Dunn, G.P., Bruce, A.T., Diamond, M.S., Heutel, J.D., Dungo-Arthur, C., Carrero, J.A., White, J.M., Hertzog, P.J., Schreiber, R.D., 2006, Blocking monoclonal antibodies specific for mouse IFN-alpha/beta receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfection, Journal of Interferon & Cytokine Research, vol 26, Mary Ann Liebert Inc., New Rochelle USA, pp. 804-819.

Crack, P.J., Cimdins, K., Ali, U., Hertzog, P.J., Iannello, R.C., 2006, Lack of glutathione peroxidase-1 exacerbates Abeta-mediated neurotoxicity in cortical neurons, Journal of Neural Transmission, vol 113, Springer Wien, Wien Austria, pp. 645-657.

Crack, P.J., Taylor, J.M., Ali, U., Mansell, A.S., Hertzog, P.J., 2006, Potential contribution of NF-kappaB in neuronal cell death in the glutathione peroxidase-1 knockout mouse in response to ischemia-reperfusion injury, Stroke, vol 37, issue 6, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1533-1538.

Mansell, A.S., Smith, R.A., Doyle, S.L., Gray, P., Fenner, J.E., Crack, P.J., Nicholson, S.E., Hilton, D.J., O'Neill, L., Hertzog, P.J., 2006, Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation, Nature Immunology, vol 7, issue 2, Nature Publishing Group, New York USA, pp. 148-155.

Fenner, J.E., Starr, R.J., Cornish, A.L., Zhang, J., Metcalf, D., Schreiber, R.D., Sheehan, K., Hilton, D.J., Alexander, W.S., Hertzog, P.J., 2006, Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity, Nature Immunology, vol 7, issue 1, Nature Publishing Group, New York USA, pp. 33-39.

Palmer, J., Ernst, M.R., Hammacher, A., Hertzog, P.J., 2005, Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo, The Prostrate, vol 62, issue 3, John Wiley & Sons, Inc., USA, pp. 282-289.

Taylor, J.M., Ali, U., Iannello, R.C., Hertzog, P.J., Crack, P.J., 2005, Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death, Journal of Neurochemistry, vol 92, Blackwell Publishing Ltd, UK, pp. 283-293.

Zhou, J., Chehab, R., Tkalcevic, J., Naylor, M.J., Harris, J., Wilson, T.J., Tsao, S.E., Tellis, I., Zavarsek, S., Xu, D., Lapinskas, E.J., Visvader, J., Lindeman, G.J., Thomas, R.S., Ormandy, C.J., Hertzog, P.J., Kola, I., Pritchard, M.A., 2005, Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation, The EMBO Journal, vol 24, issue 3, Nature Publishing Group, New York USA, pp. 635-644.

O'leary, D.A., Koleski, D., Kola, I., Hertzog, P.J., Ristevski, S., 2005, Identification and expression analysis of alternative transcripts of the mouse GA-binding protein (Gabp) subunits alpha and beta1, Gene, vol 344, Elsevier, The Netherlands, pp. 79-92.

De Haan-Klein, J.B., Stefanovic, N., Nikolic-Paterson, D.J., Scurr, L.L., Croft, K.D., Mori, T.A., Hertzog, P.J., Kola, I., Atkins, R.C., Tesch, G.H., 2005, Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy, American Journal of Physiology: Renal Physiology, vol 289, issue 3, American Physiological Society, USA, pp. F544-F551.

Mittaz, L., Ricardo, S.D., Martinez, G., Kola, I., Kelly, D.J., Little, M.H., Hertzog, P.J., Pritchard, M.A., 2005, Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis, Nephrology Dialysis Transplantation, vol 20, Oxford University Press, Oxford England, pp. 419-423.

Lapinskas, E.J., Palmer, J., Ricardo, S.D., Hertzog, P.J., Hammacher, A., Pritchard, M.A., 2004, A major site of expression of the ets transcription factor Elf5 is epithelia of exocrine glands, Histochemistry Cell Biology, vol 122, issue 6, Springer-Verlag, USA, pp. 521-526.

Mittaz, L., Russell, D.L., Wilson, T.J., Brasted, M., Tkalcevic, J., Salamonsen, L.A., Hertzog, P.J., Pritchard, M.A., 2004, Adamts-1 is essential for the development and function of the urogenital system, Biology of Reproduction, vol 70, issue 4, Soc Study Reproduction, Madison USA, pp. 1096-1105.

Taylor, J.M., Crack, P.J., Gould, J.A., Ali, U., Hertzog, P.J., Iannello, R.C., 2004, Akt phosphorylation and NFactivation are counterregulated under conditions of oxidative stress, Experimental Cell Research, vol 300, Academic Press Inc Elsevier, USA, pp. 463-475.

Hardy, M., Owczarek, C.M., Jermiin, L.S., Ejdeback, M., Hertzog, P.J., 2004, Characterization of the type I interferon locus and identification of novel genes, Genomics, vol 84, issue 2, Academic Press Inc Elsevier Science, USA, pp. 331-345.

Owczarek, C.M., Portbury, K.J., Hardy, M., O'leary, D., Kudoh, J., Shibuya, K., Shimizu, N., Kola, I., Hertzog, P.J., 2004, Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16, Gene, vol 325, Elsevier Science, Netherland, pp. 65-77.

Palmer, J., Hertzog, P.J., Hammacher, A., 2004, Differential expression and effects of gp 130 cytokines and receptors in prostate cancer cells, The International Journal of Biochemistry & Cell Biology, vol 36, Pergamon-Elsevier Science Ltd, UK, pp. 2258-2269.

Schroder, K., Hertzog, P.J., Ravasi, T., Hume, D.A., 2004, Interferon- : An overview of signals, mechanisms and functions, Journal of Leukocyte Biology, vol 75, issue 2, Federation of American Soc Exp Biol, USA, pp. 163-189.

Mansell, A.S., Brint, E., Gould, J.A., O'Neill, L., Hertzog, P.J., 2004, Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kB activation by Toll-like receptor (TLR)-2 and TLR4, The Journal of Biological Chemistry, vol 279, issue 36, The American Society for Biochemistry and Molecular Biology,c, USA, pp. 37227-37230.

Ristevski, S., O'leary, D., Thornell, A.P., Owen, M.J., Kola, I., Hertzog, P.J., 2004, The ETS transcription factor GABPis essential for early embryogenesis, Molecular and Cellular Biology, vol 24, issue 13, American Society for Microbiology, USA, pp. 5844-5849.

O'leary, D., Pritchard, M.A., Xu, D., Kola, I., Hertzog, P.J., Ristevski, S., 2004, Tissue-specific overexpression of the HSA21 gene GABP Implications for DS, Biochimica et biophysica Acta, vol 1739, Elsevier Science BV, Netherland, pp. 81-87.

de Haan, J.B., Crack, P.J., Flentjar, N.J., Iannello, R.C., Hertzog, P.J., Kola, I., 2003, An imbalance in antioxidant defense affects cellular function: The pathophysiological consequences of a reduction in antioxidant defense in the glutathione peroxidase-1 (Gpx1) knockout mouse, Redox Report, vol 8, issue 2, Maney Publishing, Leeds England, pp. 69-79.

Sanij, E., Scott, B.M., Wilson, T.J., Xu, D., Hertzog, P.J., Wolvetang, E.J., 2003, Characterization of monoclonal antibodies specific to the transcription factor ETS-2 protein, Immunology Letters, vol 86, issue 1, Elsevier, The Netherlands, pp. 63-70.

Field, J., Marshall, A.C.J., Hertzog, P.J., Wells, T.N., Alderuccio, F.P., Toh, B., 2003, Chemokine receptor CCR5 is not required for development of experimental autoimmune gastritis, Clinical Immunology, vol 109, issue 2, Academic Press Inc Elsevier Science, San Diego USA, pp. 238-247.

O'Keeffe, M., Hochrein, H., Vremec, D., Scott, B.M., Hertzog, P.J., Tatarczuch, L., Shortman, K., 2003, Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human bolood plasmacytoid pre-DC2 and CD11c+ DC1 precursors, Blood, vol 101, issue 4, The American Society of Hematology, USA, pp. 1453-1459.

Wolvetang, E.J., Wilson, T.J., Sanij, E., Busciglio, J., Hatzistavrou, T., Seth, A., Hertzog, P.J., Kola, I., 2003, ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway, Human Molecular Genetics, vol 12, issue 3, Oxford University Press, UK, pp. 247-255.

Ohtani, N., Brennan, P., Gaubatz, S., Sanij, E., Hertzog, P.J., Wolvetang, E.J., Ghysdael, J., Rowe, M., Hara, E., 2003, Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5, The Journal of Cell Biology, vol 162, issue 2, Rockfeller University Press, New York USA, pp. 173-183.

Yong, Y., Zhang, Y., Zhang, W., Shen, L., Hertzog, P.J., Wilson, T.J., Xu, D., 2003, Ets1 as a marker of malignant potential in gastric carcinoma, World Journnal of Gastroenterology, vol 9, issue 10, WJG Press, Beijing Peoples Republic of China, pp. 2154-2159.

Trajanovska, S., Owczarek, C.M., Stanton, P.G., Hertzog, P.J., 2003, Generation and characterization of recombinant unmodified and phosphorylatable murine IFN-1 in the methylotropic yeast Pichia pastoris, Journal of Interferon & Cytokine Research, vol 23, issue 12, Mary Ann Liebert Inc. Publishing, New York USA, pp. 351-358.

Wolvetang, E.J., Bradfield, O.M., Hatzistavrou, T., Crack, P.J., Busciglio, J., Kola, I., Hertzog, P.J., 2003, Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis, Neurobiology of Disease, vol 14, issue 6, Academic Press Inc Elsevier Science, San Diego USA, pp. 349-356.

Wolvetang, E.J., Bradfield, O.M., Tymms, M.J., Zavarsek, S., Hatzistavrou, T., Kola, I., Hertzog, P.J., 2003, The chromosome 21 transcription factor ETS2 transactivates the beta-APP promoter: Implications for Down syndrome, Biochimica et Biophysica Acta, vol 1628, issue 2, Elsevier Science BV, Amsterdam The Netherlands, pp. 105-110.

Hertzog, P.J., O'Neill, L.A., Hamilton, J.A., 2003, The interferon in TLR signaling: more than just antiviral, TRENDS in immunology, vol 24, issue 10, Elsevier Science Ltd, Oxford UK, pp. 534-539.

Chan, D., Wilson, T.J., Xu, D., Cowdery, H.E., Sanij, E., Hertzog, P.J., Kola, I., 2003, Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1, British Journal of Cancer, vol 88, Nature Publishing Group, London UK, pp. 137-145.

Wilson, T.J., Cowdery, H.E., Xu, D., Kola, I., Hertzog, P., 2002, A Human CD2 minigene directs CRE-mediated recombination in T cells in vivo, Genesis, vol 33, issue 4, Wiley-Liss, New York NY USA, pp. 181-184.

Bonder, C.S., Davies, K.V., Liu, X., Hertzog, P., Woodcock, J.M., Finlay-Jones, J.J., Hart, P.H., 2002, Endogenous interferon-reduces c expression and blocks IL-4 regulation of TNF production of human monocyte-derived macrophages, Cytokine, vol 17, issue 4, Academic Press ltd Elsevier Science, Ltd, London UK, pp. 187-196.

Xu, D., Wilson, T.J., Chan, D., De Luca, E., Zhou, J., Hertzog, P., Kola, I., 2002, Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells, European Molecular Biology Organization Journal, vol 21, issue 15, Oxford University Press, UK, pp. 4081-4093.

Ristevski, S., Tam, P., Hertzog, P., Kola, I., 2002, Ets2 is expressed during morphogenesis of the somite and limb in the mouse embryo, Mechanisms of Development, vol 116, issue 1-Feb, Elsevier, Amsterdam Netherlands, pp. 165-168.

Ng, A.Y., Waring, P., Ristevski, S., Wang, C., Wilson, T.J., Pritchard, M.A., Hertzog, P.J., Kola, I., 2002, Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium, Gastroenterology, vol 122, WB Saunders Co., Philadelphia USA, pp. 1455-1466.

Flentjar, N.J., Crack, P.J., Boyd, R.M., Malin, M.A., De Haan, J., Hertzog, P., Kola, I., Iannello, R., 2002, Mice lacking glutathione peroxidase-1 activity show increased tunel staining and an accelerated inflammatory response in brain following a cold induced injury, Experimental Neurology, vol 177, Elsevier Science,, San Diego CA USA, pp. 9-20.

O'Keeffe, M., Hochrein, H., Vremec, D., Caminschi, I., Miller, J.L., Anders, M.L., Wu, L., Mahoud, M.H., Henri, S., Scott, B.M., Hertzog, P., Tatarczuch, L., Shortman, K., 2002, Mouse Plasmacytoid Cells: Long-lived Cells, Heterogeneous in Surface Phenotype and Function, that Differentiate Into CD8+ Dendritic Cells Only after Microbial Stimulus, Journal of Experimental Medicine, vol 196, issue 10, The Rockefeller University Press, New York NY USA, pp. 1307-1319.

Hardy, M.P., Hertzog, P., Owczarek, C.M., 2002, Multiple regions within the promoter of the murine Ifnar-2 gene confer basal and inducible expression, Biochem Journal, vol 365, Biochemical Society, Portland Place London England, pp. 355-367.

Owczarek, C., Treutlein, H., Portbury, K.J., Gulluyan, L.M., Kola, I., Hertzog, P., 2001, A novel member of the STOMATIN/EPB72/mec-2 family, stomatin-like2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1, Cytogenetics and Cell Genetics, vol 92, Karger, Basel Switzerland, pp. 196-203.

Lazner, F., Wolvetang, E., Lazner, D., Hertzog, P., 2001, Bone disease - Current knowledge and future propects, Current Genomics, vol 2, issue 2, Bentham Science Publishers, Netherland, pp. 91-124.

Ristevski, S., Tam, P., Kola, I., Hertzog, P., 2001, Desrt, an AT-rich interaction domain family transcription factor gene, is an early marker for nephrogenic mesoderm and is expressed dynamically during mouse limb development, Mechanisms of Development, vol 104, Elsevier Science Ireland Ltd, Ireland, pp. 139-142.

Hochrein, H., Shortman, K., Vremec, D., Scott, B.M., Hertzog, P., O'Keeffe, M., 2001, Differential production of IL-12, IFN-a and IFN-g by mouse dendritic cell subsets, Journal of Immunology, vol 166, American Association of Immunologists, Bethesda MD USA, pp. 5448-5455.

Sanij, E., Hatzistavrou, T., Hertzog, P., Kola, I., Wolvetang, E., 2001, Ets-2 is induced by oxidative stress and sensitizes cells to H2O2 -induced apoptosis: implications for Down's Syndrome, Biochemical and Biophysical Reserach Communications, vol 287, issue 4, Academic Press inc, San Diego California USA, pp. 1003-1008.

Lahoud, M.H., Ristevski, S., Venter, D., Jermiin, L.S., Bertoncello, I., Zavarsek, S., Hasthorpe, S., Drago, J., de Kretser, D.M., Hertzog, P., Kola, I., 2001, Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs, Genome Research, vol 11, Cold Spring Harbor Lab Press, New York NY USA, pp. 1327-1334.

Giudice, A., Gould, J., Freeman, K., Rastan, S., Hertzog, P., Kola, I., Iannello, R., 2001, Identification and characterization of alternatively spliced murine Rgs11 isoforms: genomic structure and gene analysis, Cytogenetics and Cell Genetics, vol 94, issue 3-4, Karger, Basel Switzerland, pp. 216-224.

Crack, P.J., Taylor, J.M., Flentjar, N.J., De Haan-Klein, J., Hertzog, P., Iannello, R., Kola, I., 2001, Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury, Journal of Neurochemistry, vol 78, Blackwell Science Ltd, Oxford England, pp. 1389-1399.

Hardy, M., Owczarek, C., Trajanovska, S., Liu, X., Kola, I., Hertzog, P., 2001, The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties, Blood, vol 97, issue 2, American Society of Hematology, Washington DC USA, pp. 473-482.

Owczarek, C.M., Portbury, K.J., Kola, I., Hertzog, P.J., 2000, Assignment of protein kinase C mu (PRKCM) to human chromosome band 14q11 with somatic cell hybrids and radiation hybrids, Cytogenetics and Cell Genetics, vol 89, Karger, Basel Switzerland, pp. 240-241.

Vadiveloo, P.K., Vairo, G., Hertzog, P.J., Kola, I., Hamilton, J.A., 2000, Role of type I interferons during macrophage activation by lipopolysaccharide, Cytokine, vol 12 issue 11, WB Saunders, Philadelphia USA, pp. 1639-1646.

Vadiveloo, P.K., Christopoulos, H., Novak, U., Kola, I., Hertzog, P.J., Hamilton, J.A., 2000, Type I interferons mediate the lipopolysaccharide induction of macrophage cyclin D2, Journal of Interferon and Cytokine Research, vol 20 issue 4, Mary Ann Liefert Inc Pub, Larchmont USA, pp. 355-359.

Gowen, M., Lazner, F., Dodds, R., Kapadia, R., Feild, J., Tavaria, M., Bertoncello, I., Drake, F., Zavarsek, S., Tellis, I., Hertzog, P.J., Debouck, C., Kola, I., 1999, Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization, Journal of Bone and Mineral Research, vol 14, Amer Soc Bone & Mineral Res, Durham USA, pp. 1654-1663.

Alexander, W., Starr, R.J., Fenner, J., Scott, C.L., Handman, E., Sprigg, N.S., Corbin, J.E., Cornish, A.L., Darwiche, R., Owczarek, C.M., Kay, T.W., Nicola, N.A., Hertzog, P.J., Metcalf, D., Hilton, D., 1999, SCCS1 is a critical inhibitor of interferon Y signaling and prevents the potentially fatal neonatal actions of this cytokine, Cell, vol 98, Cell Press, Cambridge MA USA, pp. 597-608.

Goldstein, D., Hertzog, P.J., Tomkinson, E., Couldwell, D., McCarville, S., Parrish, S., Cunningham, P., Newell, M., Owens, M., Cooper, D.A., 1998, Administration of Imiquimod, an Interferon Inducer, in Asymptomatic Human Immunodeficiency Virus - Infected Persons to Determine Safety and Biologic Response Modification, The Journal of Infectious Diseases, vol 178, Infectious Diseases Society of America, USA, pp. 858-861.

Kola, I., Hertzog, P.J., 1998, Down syndrome and mouse models, Current Opinion in Genetics & Development, vol 8, Current Biology Ltd, USA, pp. 316-321.

De Haan, J.B., Bladier, C., Griffiths, P.I., Kelner, M.J., Bronson, R.T., Silvestro, M.J., Wild, S., Zheng, S., Hertzog, P.J., Kola, I., O'Shea, R.D., Sang Cheung, N., Beart, P.M., 1998, Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide, Journal of Biological Chemistry, vol 273,35, The American Soc for Biochemistry & Molecular Biol, USA, pp. 22528-22536.

De Haan, J.B., Bladier, C., Griffiths, P.I., Kelner, M.J., O'Shea, R.D., Cheung, N.S., Bronson, R.T., Silvestro, M.J., Wild, S., Zheng, S.S., Beart, P.M., Hertzog, P.J., Kola, I., 1998, Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptability to the oxidative stress-inducing agents parquat and hydrogen peroxide, Journal of Biological Chemistry, vol 273 (35), American society for biochemistry and Molecular By, Bethesda USA, pp. 22528-22536.

Rubinstein, M., Dinarello, C.A., Oppenheim, J.J., Hertzog, P.J., 1998, Recent advances in cytokines, Cytokine Receptors and Signal Transduction, Cytokine & Growth Factor Reviews, vol prof michael b sporn, Elsevier Science Ltd, UK, pp. 175-181.

McKinlay, L.H., Tymms, M.J., Thomas, R.S., Seth, A., Hasthorpe, S., Hertzog, P.J., Kola, I., 1998, The Role of Ets-1 in Mast Cell Granulocyte-Macrophage Colony-Stimulating Factor Expression and Activation, The Journal of Immunology, vol 161, The American Association of Immunologists, USA, pp. 4099-4105.

Luft, T., Pang, K.C., Thomas, E., Hertzog, P.J., Hart, D.N.J., Trapani, J.A., Cebon, J., 1998, Type I IFNs Enhance the Terminal Differentiation of Dendritic Cells, Journal of Immunology, vol 161, The American Association of Immunologists, USA, pp. 1947-1953.

Holland, K.A., Owczarek, C.M., Hwang, S.Y., Tymms, M.J., Constantinescu, S., Pfeffer, L.M., Kola, I., Hertzog, P.J., 1997, A type I interferon signaling factor, ISF21, encoded on chromosome 21 is distinct from receptor components and their down-regulation and is necessary for transcritpional activation of interferon-regulated genes, Jouirnal of Biological Chemistry, vol 272, American Soc for Biochemistry & Molecular Biology, USA, pp. 21045-21051.

Hwang, S.Y., Owczarek, C.M., Holland, K.A., Weaver, B., Reich, N.C., Kola, I., Hertzog, P.J., Gulluyan, L., 1997, Cloning and characterisation of a novel component of the murine type I interferon receptor, IFNAR2, Journal of Biological Chemistry, vol 272, American Society for Biochemistry & Molecular Biol, USA, pp. 23865-23870.

Conference Proceedings

Owczarek, C.M., Hardy, M., Kola, I., Hertzog, P.J., 1998, Analysis of a secreted form of the murine type I interferon receptor, IFNAR2, 10th Lorne Cancer Conference, Lorne Victoria. February 12-15, 1998, The Australian Cancer Society, Melbourne Vic Australia.

Hardy, M., Owczarek, C.M., Kola, I., Hertzog, P.J., 1998, Characterisation of a novel soluble interferon receptor, Australasian Society for Immunology 28th Annual Conference, Melbourne, Victoria Nov 29-Dec 4 98, Australasian Society for Immunology, Vic Australia.

Hertzog, P.J., Young, J., Holland, K.A., Hardy, M., Bertoncello, I., Owczarek, C.M., Kola, I., 1998, Different functions of the two type I interferon receptor components revealed by IFNAR1 and IFNAR 2 knockout mice, 2nd Joint Meeting of the International Cytokine Society and the International Society for Interferon and Cytokine Research, Jerusalem, Israel, October 25 - 30, 1998, ICS & ISICR, USA, p. 38.

Ng, A.Y., Thomas, R.S., Tymms, M.J., Zhou, J., Hertzog, P.J., Kola, I., 1998, ELF3, a new member of the ETS family of transcription factors, is epithelial expressed and maps to 1q32.2, a region frequently amplified in breast cancer, Functional Genomics: New Horizons in Genetics and Disease, Melbourne, Australia. March 15-17, 1998, SmithKline Beecham Pharmaceuticals, Melbourne Vic Australia.

Hertzog, P.J., Holland, K.A., Owczarek, C.M., Trajanovska, S., Gulluyan, L., Hardy, M., Zheng, S., Kola, I., 1998, Genetic analysis of the function of interferon receptor components in IFNAR1 and IFNAR2 knockout mice, 10th Lorne Cancer Conference, Lorne, Victoria. February 12-15, 1998, The Australian Cancer Society, Melbourne Vic Australia.

Hertzog, P.J., Owczarek, C.M., Hardy, M., Gulluyan, L., Young, J., Kola, I., 1998, Genetic analysis of the interferon system, Functional Genomics: New Horizons in Genetics & Disease, Melbourne, Australia. March 15-17, 1998, SmithKline Beecham Pharmaceuticals, Vic Australia.

Lahoud, M.H., Ristevski, S., Zavarsek, S., Hertzog, P.J., Kola, I., 1998, Identification and characterisation of a new murine member of the ARID family of DNA binding proteins, 10th Lorne Cancer Conference, Lorne Victoria, 12-15 February 1998, Australian Cancer Society, Vic Australia, p. 1007.

De Haan, J.B., Bladier, C., Griffiths, P.I., Kelner, M.J., Bronson, R.T., Silvestro, M.J., Wild, S., Zheng, S., Beart, P.M., Hertzog, P.J., Kola, I., O'Shea, R.D., Sang Cheung, N., 1998, Mice with a homozygous null mutation for Gpx1 show increased susceptibility to the oxidative stress-inducing agents, paraquat and hydrogen peroxide, Radiation 98, Melbourne November 15-17, 1998, Aust Institute of Nuclear Science & Engineering, Vic Australia, p. 16.

Fenner, J., Owczarek, C.M., Alexander, W., Starr, R.J., Hilton, D., Hertzog, P.J., 1998, Regulation of interferon responses by SOCS, Australasian Society for Immunology 28th Annual Conference, Melbourne, Victoria 29/11-4/12/98, A'asian Society for Immunology, Vic Australia.

Hertzog, P.J., Owczarek, C.M., Holland, K.A., Hardy, M., Fenner, J., Bertoncello, I., Young, J., Kola, I., 1998, The function of type I interferons based on mice deficient in both receptor components, 28th Conference of the A'asian Society for Immunology, Melbourne, Victoria, The Australian Society for Immunology, Vic Australia.

Hertzog, P.J., Fenner, J., Owczarek, C.M., Alexander, W., Starr, R.J., Hilton, D., 1998, The involvement of the SOCS family in the interferon system, 2nd Joint Meeting of the International Cytokine Society and the International Society for Interferon and Cytokine Research, Jerusalem, Israel October 25-30, 1998, ICS & ISICR, USA, p. 35.

Other

Kola, I., Hertzog, P.J., 1997, Animal models in the study of the biological function of genes on human chromosome 21 and their role in the pathophysiology of Down syndrome, Human Molecular Genetics, vol 6, issue 10, Oxford University Press, UK, pp. 1713-1727.

Grants

Title:: ARC Small 2000- Dr P J Hertzog- Dr P J Hertzog.
Investigators:: Hertzog, P
Funding:: (2000 - ). Australian Research Council (ARC).

Title:: Animal Models for Immune Diseases and Cancer.
Investigators:: Hertzog, P
Funding:: (2001 - 2001). CYTOPIA.

Title:: Application for NHMRC Research Fellowship.
Investigators:: Hertzog, P
Funding:: (2004 - 2008). National Health & Medical Research Council (NHMRC).; (2007 - 2011). National Health & Medical Research Council (NHMRC).; (2012 - 2016). National Health & Medical Research Council (NHMRC).

Title:: CRC Chronic Inflammatory Diseases.
Investigators:: Hertzog, P, Holdsworth, S, Wilson, T
Funding:: (2003 - 2007). Cooperative Research Centres (CRC).

Title:: CRC Oral Health Science.
Investigators:: Hertzog, P, Pike, R
Funding:: (2005 - 2009). Cooperative Research Centres (CRC).

Title:: Characterising the novel signalling mechanism for a new interferon.
Investigators:: Hertzog, P
Funding:: (2013 - 2017). National Health & Medical Research Council (NHMRC).

Title:: Characterization o an interferon signalling molecule encoded by a gene on chromosome 21.
Investigators:: Hertzog, P
Funding:: (1996 - 2000). National Health & Medical Research Council (NHMRC).

Title:: Chromosome 21 in Down Syndrome and Related Genes in Disease.
Investigators:: Kola, I, Hertzog, P, Wolvetang, E, Pritchard, M
Funding:: (1999 - 2003). National Health & Medical Research Council (NHMRC).

Title:: Covaris E-series/Agilent bioanalyzer 2100.
Investigators:: Williams, B, Hertzog, P, Watkins, D, Risbridger, G, Jenkins, B, Wallace, E, Mackay-Fisson, F, Mackay, C
Funding:: (2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:: Cryopreservation of Ejaculated and Epididymal Sperm for Mouse Mutants and Analyses of the Safety of Such Methodology.
Investigators:: Trounson, A, Shaw, J, Hertzog, P, Lacham-Kaplan, O
Funding:: (1999 - 2003). National Institutes of Health (NIH), USA.; (2000 - 2003). National Institutes of Health (NIH), USA.; (2002 - 2009). National Institutes of Health (NIH), USA.

Title:: Development of a signature for early response to influenza strains that determine/correlate with severity of infection, vacine response and changes in virulence.
Investigators:: Hertzog, P, Visvanathan, K, Mansell, A, Sasaduesz, J, Williams, B
Funding:: (2009 - 2013). National Health & Medical Research Council (NHMRC).; (2009 - 2014). National Health & Medical Research Council (NHMRC).

Title:: Development of new antivirals.
Investigators:: Hertzog, P, Sullivan, M
Funding:: (2012 - 2015). National Health & Medical Research Council (NHMRC).

Title:: ETS2 and ERG in down syndrome and mormal development.
Investigators:: Kola, I, Tymms, M, Wilson, T, Hertzog, P
Funding:: (1996 - 2013). National Health & Medical Research Council (NHMRC).

Title:: Effect of protease-adhesins from porphyromonas gingivalis on cells of the oral cavity.
Investigators:: Pike, R, Quinsey, N, Pagel, C, Hertzog, P, O'Brien-Simpson, N
Funding:: (2005 - 2009). The University of Melbourne.; (2005 - 2009). Victorian Department of Innovation, Industry & Regional Development (DIIRD).

Title:: Establish the Australian Cancer Research Foundation (ACRF) Centre for Cancer Genomic Medicine.
Investigators:: Williams, B, Hertzog, P, Watkins, D, Jenkins, B, Williams, E, Risbridger, G
Funding:: (2012 - 2016). Australian Cancer Research Foundation.

Title:: Establishment of a Core Sequencing Facility for the Study of Gene Function And/or Disease.
Investigators:: Hertzog, P, Fuller, P, Iannello, R, Owczarek, C, Wilson, T
Funding:: (1998 - 2001). Wellcome Trust (UK).

Title:: EtS2 and ERG as transcription factors and their role in down syndrome.
Investigators:: Tymms, M, Hertzog, P, Kola, I
Funding:

Title:: Fluorescence activated cell sorting module.
Investigators:: Tipping, P, Hertzog, P, Kola, I, Hedger, M
Funding:: (1997 - 2001). National Health & Medical Research Council (NHMRC).

Title:: Function of a novel interferon in reproduction and development. ID: 384261.
Investigators:: Hertzog, P
Funding:: (2006 - 2010). National Health & Medical Research Council (NHMRC).

Title:: Genetic modification of cell lines for in vitro growth of viruses.
Investigators:: Trounson, A, Hertzog, P
Funding:: (2003 - 2007). CLS Ltd.

Title:: Genetic research by Gene Expression analysis (Equipment grant).
Investigators:: Hertzog, P, Williams, B, Vasic, V
Funding:: (2011 - 2015). Rebecca L. Cooper Medical Research Foundation Ltd.

Title:: High Performance Liquid Chromatography (hplc) System - Equipment Grant 2000.
Investigators:: de Kretser, D, Phillips, D, Hedger, M, Loveland, K, O'Bryan, M, Morrison, J, Risbridger, G, Pera, M, Hertzog, P
Funding:: (2000 - 2000). National Health & Medical Research Council (NHMRC).

Title:: High throughput analysis and screening facility.
Investigators:: Sexton, P, Christopoulos, A, Whisstock, J, Rossjohn, J, Scammells, P, Drummond, G, Beddoe, T, Mackay, C, Charman, W, Hertzog, P
Funding:: (2009 - 2014). National Health & Medical Research Council (NHMRC).

Title:: Importance of Socs Dependent and Independent Interferon Signaling Pathways.
Investigators:: Hertzog, P
Funding:: (2000 - 2000). Australian Research Council (ARC).

Title:: Inhibition of certain SOCS molecules, in particular SOCS-1 using SOCS-1 antisense or RNAi approaches.
Investigators:: Hertzog, P
Funding:: (2005 - 2009). Amrad Limited.

Title:: Investigation of Macrophage Function in an Immunologically Privileged Site.
Investigators:: Hedger, M, Hertzog, P
Funding:: (2006 - 2010). Australian Research Council (ARC).

Title:: Lightcycler Instument.
Investigators:: Kola, I, de Kretser, D, Holdsworth, S, Hertzog, P
Funding:: (1999 - 1999). National Health & Medical Research Council (NHMRC).

Title:: MONMAN Initiative - Mouse Modelling in Human Disease.
Investigators:: Hertzog, P, Jenkins, B
Funding:: (2008 - 2012). Victorian Department of Innovation, Industry & Regional Development (DIIRD).

Title:: Micro-array plate reader.
Investigators:: Hertzog, P
Funding:: (2002 - 2007). National Health & Medical Research Council (NHMRC).; (2002 - 2011). Monash University.

Title:: Mouse Knockout Technology.
Investigators:: Hertzog, P
Funding:: (2004 - 2008). CopyRat Pty Ltd.; (2008 - 2012). CopyRat Pty Ltd.

Title:: NHMRC 1996 Project - Dr P Hertzog.
Investigators:: Hertzog, P
Funding:: (1999 - ). National Health & Medical Research Council (NHMRC).

Title:: NHMRC 1996 Project - Dr P Hertzog.
Investigators:: Hertzog, P
Funding:: (1999 - ). National Health & Medical Research Council (NHMRC).

Title:: NHMRC Research Fellowship - Continuing 143804.
Investigators:: Hertzog, P
Funding:: (2001 - 2003). National Health & Medical Research Council (NHMRC).; (2003 - 2007). National Health & Medical Research Council (NHMRC).

Title:: NHMRC Standard Equipment Grant 2007.
Investigators:: Hertzog, P, Adler, B, Rossjohn, J, Williams, B, Boyd, R, Berndt, M
Funding:: (2008 - 2012). National Health & Medical Research Council (NHMRC).

Title:: New Mechanisms of mediating interferon responses by trans-signaling.
Investigators:: Hertzog, P
Funding:: (2008 - 2011). National Health & Medical Research Council (NHMRC).

Title:: Pre-clinical studies of a novel therapeutic strategy for malignant mesothelioma.
Investigators:: Scott, B, Hertzog, P
Funding:: (2005 - 2009). Mesothelioma Applied Research Foundation.

Title:: Regulating Interferon signalling in innate immunity.
Investigators:: Hertzog, P
Funding:: (2007 - 2011). National Health & Medical Research Council (NHMRC).

Title:: Research into Cpn10, its peptide fragments, Cpn10 mutants, receptors, cellular interactions, agonist sustained release formulations, preclinical and clinical development.
Investigators:: Hertzog, P
Funding:: (2005 - 2009). CBio Limited.

Title:: Structual characterisation function analyses of type I interferon-receptor interactions.
Investigators:: Hertzog, P, Reid, H
Funding:: (2010 - 2013). National Health & Medical Research Council (NHMRC).

Title:: The Biological Function of Genes on Human Chromosome 21 and Their Role in the Pathophysiology of Down Syndrome.
Investigators:: Kola, I, Hertzog, P, Iannello, R
Funding:: (1997 - 1997). The Jack Brockhoff Foundation.

Title:: The Biological Function of the Intersectin Gene and Its Role in the Pathophysiology of Downs Syndrome.
Investigators:: Hertzog, P, Pritchard, M, Tkalcevic, J
Funding:: (2000 - 2000). Jerome Lejeunne Foundation.

Title:: The Opposing Roles of STAT1 and STAT3 Signalling by IL-6 Family Cytokines in Inflammation and Tumourigenesis ; ID: 384268.
Investigators:: Jenkins, B, Ernst, M, Hertzog, P
Funding:: (2006 - 2010). National Health & Medical Research Council (NHMRC).

Title:: The Role of Irf3 in Tumourigenesis.
Investigators:: Hertzog, P
Funding:: (1998 - 2000). Cancer Council Victoria.

Title:: The Role of the Ews/fli-1gene in Ewings Sarcoma An Dthe Biological Function of the Ews Gene.
Investigators:: Hertzog, P, Kola, I
Funding:: (1998 - 2000). Cancer Council Victoria.

Title:: The interferon receptor normal function and role in Down Syndrome.
Investigators:: Hertzog, P, Tymms, M, Kola, I
Funding:

Title:: The involvement of the chromosome 21 transcription factor ETS-2 in the regulation of APP & the development of Down's Syndrome neuropathology.
Investigators:: Wolvetang, E, Hertzog, P
Funding:: (2002 - 2006). Jerome Lejeunne Foundation.

Title:: The role of BAFF, its recptor TACI and Toll-like receptors in Autoimmunity and Tolerance.
Investigators:: Mackay-Fisson, F, Hertzog, P
Funding:: (2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:: To Understand and Determine What Are the Essential Components That Determine An Effective Anti-tumour Immune Response.
Investigators:: Scott, B, Hertzog, P
Funding:: (2002 - 2006). William Angliss (Victoria) Charitable Fund.

Title:: Traumatic injury to the brain & spinal cord: Limiting the damage.
Investigators:: Hertzog, P
Funding:: (2003 - 2007). Victorian Trauma Foundation.

Title:: Cloning and Characterisation of a Novel Chromosome 21 Gene Involved in Antiviral Responses (990193) - (this Grant Has Been Subsumed With Program Grant 993207).
Investigators:: Owczarek, C, Hertzog, P, Pritchard, M
Funding:: (1999 - 2001). National Health & Medical Research Council (NHMRC).

Title:: Ets2,erg and Gabpa in Normal Development and in Down Syndrome (990511) - (this Grant Has Been Subsumed With Program Grant 993207).
Investigators:: Kola, I, Wilson, T, Wolvetang, E, Hertzog, P
Funding:: (1999 - 2001). National Health & Medical Research Council (NHMRC).

Title:: The Role of Type I Interferons in Regulating Physiological and Pathological Processes - Prf1 (991549) - (this Grant Has Been Subsumed With Program Grant 993207).
Investigators:: Hertzog, P
Funding:: (1999 - 2004). National Health & Medical Research Council (NHMRC).

Title:: A novel reproductive tract factor that protects against chlamydia.
Investigators:: Hertzog, P, Hansbro, P
Funding:: (2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:: The role of interferon signalling in the regulation of stroke.
Investigators:: Hertzog, P, Crack, P
Funding:: (2010 - 2014). National Health & Medical Research Council (NHMRC).

Title:: Understanding pathogenicity and immunity in an encephalitic mouse model of Hendra virus infection.
Investigators:: Hertzog, P, Stambas, J
Funding:: (2012 - 2017). National Health & Medical Research Council (NHMRC).

Title:: Victorian node of the Australian Phenomics Network (APN-VIC).
Investigators:: O'Bryan, M, Hilton, D, Hertzog, P, Furness, J, Holland, M
Funding:: (2007 - 2011). Victorian Department of Innovation, Industry & Regional Development (DIIRD).; (2008 - 2012). Victorian Department of Innovation, Industry & Regional Development (DIIRD).; (2009 - 2013). Victorian Department of Innovation, Industry & Regional Development (DIIRD).

Title:: A Biomolecular Small Angle X-ray Scattering Facility.
Investigators:: Wilce, M, Beddoe, T, Bottomley, S, Hertzog, P, Rossjohn, J, Whisstock, J, Williams, B, Cowieson, N, Hearn, M, Rood, J
Funding:: (2010 - 2014). Australian Research Council (ARC).; (2010 - 2014). Monash University.

Title:: Fluorescence Lifetime Imaging Facility.
Investigators:: Prescott, M, Devenish, R, Mercer, J, Beech, P, Mitchell, C, Coppel, R, Hertzog, P
Funding:: (2002 - 2006). Australian Research Council (ARC).; (2002 - 2006). Monash University.; (2002 - 2009). Deakin University.

Title:: High Content Cell Signaling Discovery and Screening Facility.
Investigators:: Hertzog, P, Williams, B, Rossjohn, J, Adler, B, Trounson, A, Sexton, P, Berndt, M
Funding:: (2008 - 2012). Australian Research Council (ARC).; (2008 - 2012). Monash University.; (2008 - 2012). Victorian Infectious Diseases Reference Laboratory.

Title:: The Role of a Soluble Type I Interferon Receptor in Regulating Interferon Responses (991221) - (this Grant Has Been Subsumed With Program Grant 993207).
Investigators:: Hertzog, P, Owczarek, C, Wilson, T
Funding:: (1999 - 2001). National Health & Medical Research Council (NHMRC).

Postgraduate Research Supervisions

Current Supervision

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Innate immunity to Henipavirus infection in mice.
Supervisors:: Hertzog, P (Main).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Systems biology of the Type 1 interferon response..
Supervisors:: Hertzog, P (Main).

Completed Supervision

Student:: Chan, W.
Program of Study:: THE ROLE OF EWS/FLI-1 FUSION GENE IN EWING'S SARCOMA. (PHD) 2001.
Supervisors:: Hertzog, P (Joint-Co), Wilson, T (Joint).
Student:: Fenner, J.
Program of Study:: REGULATION OF TYPE I INTERFERON RESPONSES. (PHD) 2003.
Supervisors:: Hertzog, P (Main), Owczarek, C (Associate), Scott, B (Associate).
Student:: Fung, K.
Program of Study:: Characterization of the novel type I IFN - Ifn-epsilon. (PHD) 2010.
Supervisors:: Hertzog, P (Main).
Student:: Giudice, A.
Program of Study:: MOLECULAR AND FUNCTIONAL ANALYSIS OF THE MURINE REGULATOR OF G PROTEIN SIGNALLING, RGS11. (PHD) 2002.
Supervisors:: Hertzog, P (Main), Iannello, R (Associate).
Student:: Hardy, M.
Program of Study:: THE MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF SOLUBLE IFNAR-2. (PHD) 2001.
Supervisors:: Hertzog, P (Joint-Co), Owczarek, C (Joint).
Student:: Khoo, J.
Program of Study:: The role of Mul1 in the regulation of RIG-I-Like Receptor (RLR) mediated inflammatory and antiviral response. (PHD) 2012.
Supervisors:: Mansell, A (Main), Hertzog, P (Associate), Nagley, P (Associate).
Student:: Lang, T.
Program of Study:: The human hepatitis B e antigen targets and suppresses Toll-like receptor signalling pathways. (PHD) 2011.
Supervisors:: Mansell, A (Main), Hertzog, P (Associate).
Student:: Lapinskas, E.
Program of Study:: ELF5 IS AN EPITHELIAL-SPECIFIC MEMBER OF THE ETS ONCOGENE/TUMOUR SUPPRESSOR GENE FAMILY. (PHD) 2003.
Supervisors:: Pritchard, M (Main), Hertzog, P (Associate).
Student:: Lazner, D.
Program of Study:: THE ROLE OF ETS. 2 IN APOPTOSIS. (PHD) 2000.
Supervisors:: Wolvetang, E (Main), Hertzog, P (Associate).
Student:: Mittaz Crettol, L.
Program of Study:: GENERATION AND CHARACTERISATION OF MOUSE MODELS FOR THE HUMAN CHROMOSOME 21 GENES ADAMST-1 AND DSCR1. (PHD) 2002.
Supervisors:: Pritchard, M (Main), Hertzog, P (Associate).
Student:: Ng, A.
Program of Study:: MOLECULAR CLONING AND FUNCTIONAL STUDY OF THE TRANSCRIPTION FACTOR, ELF3, IN EPITHELIAL CELLS.. (PHD) 2001.
Supervisors:: Pritchard, M (Main), Hertzog, P (Associate).
Student:: Noppert, S.
Program of Study:: Role of type 1 interferon in LPS-mediated inflammation. (PHD) 2007.
Supervisors:: Deacon, N (Main), Hertzog, P (Associate), Mansell, A (Associate).
Student:: O'Leary, D.
Program of Study:: CHARACTERISATION OF GENE STRUCTURE AND FUNCTION OF THE ETS TRANSCRIPTION FACTOR GABP-ALPHA IN MOUSE. (PHD) 2003.
Supervisors:: Hertzog, P (Main), Ristevski, S (Joint).
Student:: Palmer, J.
Program of Study:: THE IL-6 TYPE CYTOKINE FAMILY IN PROSTATE CANCER. (PHD) 2003.
Supervisors:: Hertzog, P (Joint-Co), Wolvetang, E (Joint).
Student:: Pavasovic, D.
Program of Study:: Factors involved in bone metabolism and osteoclast function. (PHD) 2011.
Supervisors:: Hertzog, P (Main), Pritchard, M (Associate).
Student:: Samarajiwa, S.
Program of Study:: The role of soluble IFNAR2 in modifying interferon responses in vivo. (PHD) 2005.
Supervisors:: Hertzog, P (Joint-Co), Owczarek, C (Joint).
Student:: Sanij, E.
Program of Study:: ETS2 AND p53, NOVEL PARTNERS IN GENE REGULATION AND APOPTOSIS. (PHD) 2003.
Supervisors:: Wolvetang, E (Main), Hertzog, P (Associate).
Student:: Taylor, J.
Program of Study:: CHARACTERISATION OF THE MOLECULAR PATHWAYS INVOLVING GPX1: IMPLICATIONS FOR NEURONAL CELL SURVIVAL. (PHD) 2003.
Supervisors:: Hertzog, P (Joint-Co), Iannello, R (Joint).
Student:: Trajanovska, S.
Program of Study:: Production and characterisation of murine interferon alpha-1. (Masters) 2001.
Supervisors:: Hertzog, P (Main), Owczarek, C (Associate).
Student:: Verstak, B.
Program of Study:: Characterisation of the interaction between Mal and TRAF6 in Toll-like receptor signalling. (PHD) 2008.
Supervisors:: Mansell, A (Main), Hertzog, P (Associate).
Student:: Wong, C.
Program of Study:: Oxidative stress and the cerebral microvasculature: a role for glutathione peroxidase-1. (PHD) 2008.
Supervisors:: Hertzog, P (Joint), Hickey, M (Joint-Co).
Student:: Zaker-Tabrizi, L.
Program of Study:: STRUCTURE FUNCTION STUDIES OF INTERFERON-RECEPTOR INTERACTIONS. 2011.
Supervisors:: Hertzog, P (Main), De Weerd, N (Associate).
Student:: Zavarsek, S.
Program of Study:: THE GENERATION AND CHARACTERISATION OF MICE WITH A TARGETED MUTATION IN THE BREAST REGRESSING PROTEIN 39 GENE. (PHD) 2002.
Supervisors:: Hertzog, P (Main), Lazner, F (Associate).
Student:: Zhou, J.
Program of Study:: CHARACTERIZATION & FUNCTIONAL STUDY OF A NOVEL EPITHELIAL-SPECIFIC ETS TRANSCRIPTION FACTOR-ELF5. (PHD) 2001.
Supervisors:: Hertzog, P (Main), Pritchard, M (Associate).