Dr Jerome Le Nours - Researcher Profile

Biography

Jerome works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

PHD OF PROTEIN CHEMISTRY

Institution: University of Copenhagen

Year awarded: 2005

Publications

Journal Articles

Kjer-Nielsen, L., Patel, O.G., Corbett, A.J., Le Nours, J., Meehan, B., Liu, L., Bhati, M., Chen, Z., Kostenko, L., Reantragoon, R., Williamson, N.A., Purcell, A.W., Dudek, N.L., McConville, M.J., O'Hair, R.A., Khairallah, G.N., Godfrey, D.I., Fairlie, D.P., Rossjohn, J., McCluskey, J., 2012, MR1 presents microbial vitamin B metabolites to MAIT cells, Nature [P], vol 491, issue 7426, Nature Publishing Group, UK, pp. 717-723.

Patel, O.G., Pellicci, D.G., Gras, S., Sandoval Romero, M.L., Uldrich, A.P., Mallevaey, T., Clarke, A.J., Le Nours, J., Theodossis, A., Cardell, S.L., Gapin, L., Godfrey, D.I., Rossjohn, J., 2012, Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor, Nature Immunology [P], vol 13, issue 9, Nature Publishing Group, USA, pp. 857-863.

Torpenholt, S., Le Nours, J., Christensen, U., Jahn, M., Withers, S., Ostergaard, P., Borchert, T., Poulsen, J., Leggio, L., 2011, Activity of three beta-1,4-galactanases on small chromogenic substrates, Carbohydrate Research [P], vol 346, issue 13, Elsevier Science Ltd, UK, pp. 2028-2033.

Pellicci, D., Clarke, A., Patel, O., Mallevaey, T., Beddoe, T., Le Nours, J., Uldrich, A., McCluskey, J., Besra, G., Porcelli, S., Gapin, L., Godfrey, D., Rossjohn, J., 2011, Recognition of beta-linked self glycolipids mediated by natural killer T cell antigen receptors, Nature Immunology [P], vol 12, issue 9, Nature Publishing Group, USA, pp. 827-833.

Le Nours, J., Bulloch, E., Zhang, Z., Greenwood, D., Middleditch, M., Dickson, J., Baker, E., 2011, Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide, Journal Of Biological Chemistry [P], vol 286, issue 47, American Society of Biochemistry & Molecular Biology Inc., USA, pp. 40706-40716.

Vivian, J., Riedmaier, P., Ge, H., Le Nours, J., Sansom, F.M., Wilce, M.C.J., Byres, E., Dias, M., Schmidberger, J., Cowan, P.J., d'Apice, A.J., Hartland, E.L., Rossjohn, J., Beddoe, T.C., 2010, Crystal Structure of a Legionella pneumophila Ecto -Triphosphate Diphosphohydrolase, A Structural and Functional Homolog of the Eukaryotic NTPDases, Structure [P], vol 18, issue 2, Cell Press, USA, pp. 228-238.

Scoble, J.A., McAlister, A.D., Fulton, Z.J., Troy, S.T., Byres, E., Vivian, J., Brammananth, R., Wilce, M.C.J., Le Nours, J., Zaker-Tabrizi, L., Coppel, R.L., Crellin, P., Rossjohn, J., Beddoe, T.C., 2010, Crystal structure and comparative functional analyses of a Mycobacterium aldo-keto reductase, Journal of Molecular Biology [P], vol 398, issue 1, Academic Press, UK, pp. 26-39.

Beddoe, T.C., Paton, A.W., Le Nours, J., Rossjohn, J., Paton, J.C., 2010, Structure, biological functions and applications of the AB5 toxins, Trends In Biochemical Sciences [P], vol 35, issue 7, Elsevier Ltd, UK, Switzerland, pp. 411-418.

Crellin, P., Vivian, J., Scoble, J.A., Chow, F.M., West, N.P., Brammananth, R., Proellocks, N.I., Shahine, A.E., Le Nours, J., Wilce, M.C., Britton, W.J., Coppel, R.L., Rossjohn, J., Beddoe, T.C., 2010, Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability, Journal Of Biological Chemistry [P], vol 285, issue 39, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 30050-30060.

Le Nours, J., De Maria, L., Welner, D., Jorgensen, C.T., Christensen, L.L.H., Borchert, T.V., Larsen, S., Lo Leggio, L., 2009, Investigating the binding of beta-1,4-galactan to Bacillus licheniformis beta-1,4-galactanase by crystallography and computational modeling, Proteins-Structure Function And Bioinformatics [P], vol 75, issue 4, John Wiley & Sons, Inc., USA, pp. 977-989.

Le Nours, J., Anderson, L., Stoll, D., Stalbrand, H., Leggio, L.L., 2005, The structure and characterization of a modular endo-beta-1,4-mannanase from Cellulomonas fimi, Biochemistry, vol 44, issue 38, American Chemical Society, USA, pp. 12700-12708.

Hansen, M., Le Nours, J., Johansson, E., Antal, T., Ullrich, A., Loffler, M., Larsen, S., 2004, Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain, Protein Science, vol 13, issue 4, Cold Spring Harbor Laboratory Press, USA, pp. 1031-1042.

Ryttersgaard, C., Le Nours, J., Leggio, L.L., Jorgensen, C.T., Christensen, L.L.H., Bjornvad, M., Larsen, S., 2004, The structure of endo-beta-1,4-galactanase from Bacillus licheniformis in complex with two oligosaccharide products, Journal of Molecular Biology, vol 341, issue 1, Academic Press, UK, pp. 107-117.

Le Nours, J., Ryttersgaard, C., Leggio, L.L., Ostergaard, P.R., Borchert, T.V., Christensen, L.L.H., Larsen, S., 2003, Structure of two fungal beta-1,4-galactanases: searching for the basis for temperature and pH optimum, Protein Science, vol 12, issue 6, Cold Spring Harbor Laboratory Press, USA, pp. 1195-1204.