Dr Maithili Sashindranath - Researcher Profile

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Address

Australian Centre for Blood Diseases
6th Floor, Burnet Tower, The Alfred Hospital

Biography

Maithili works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow, where she is an expert in the field of traumatic brain injury. Maithili is interested in understanding the mechanisms of brain trauma in rodents, and in how laboratory based findings can be translated to improving outcome in patients who sustain trauma. 

Dr Sashindranath is a Post-Doctoral researcher at the Australian Centre for Blood Diseases (ACBD), where she has been employed since June 2008. Her research interests pertain to blood-brain barrier damage following head trauma, apart from which she is also supervising a PhD project involving the study of long term effects of traumatic brain injury on the immune system. High impact publications in specialised journals such as Epilepsy Research, Laboratory Investigation and Brain are testimony to her achievements in the scientific arena thus far. As a specialist in neurotrauma research, Dr Sashindranath has developed novel methods of gait analysis and blood-brain barrier damage in rodents subjected to brain trauma. Having gained recognition by presenting her work at several national and international conferences, Dr Sashindranath received a bursary from the International Society for Fibrinolysis and Proteolysis in 2011 to spend one week carrying out important experiments at a laboratory at the University of Michigan, USA.  Her committee memberships include the International Society for Fibrinolysis and Proteolysis and the Women in Neurotrauma Research Society.  As an active member of the Central Clinical School (CCS) Early Career Researcher (ECR) Committee Dr Sashindranath is also a major stakeholder in the mentoring program for ECRs within the CCS. Dr Sashindranath's interest in mentoring underpins her involvement in university student teaching and evaluation since 2005. She graduated with a PhD from the University of Melbourne in December 2009 during which she studied seizure induced brain damage in epilepsy. Dr Sashindranath was the recipient of the Melbourne Research Scholarship (2004-2008) as well as the Leslie Eric Paddle scholarship for Neurology (2006 and 2007) and the RJ Gleghorn scholarship (2007) for PhD studies. She completed a BSc Hons degree from the University of Cape Town, South Africa in 2003.

Qualifications

PHD
Institution: University of Melbourne
Year awarded: 2009
BACHELOR OF SCIENCE IN MEDICINE (HONS)
Institution: University of Cape Town
Year awarded: 2003
BACHELOR OF SCIENCE IN CHEM, MOL & CELL SCIENCES
Institution: University of Cape Town
Year awarded: 2002

Publications

Journal Articles

Samson, A.L., Knaupp, A.S., Sashindranath, M., Borg, R.J., Au, A.E., Cops, E.J., Saunders, H.M., Cody, S.H., McLean, C., Nowell, C.J., Hughes, V.A., Bottomley, S.P., Medcalf, R.L., 2012, Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin, Cell Reports [E], vol 2, issue 4, Cell Press, USA, pp. 889-901.

Sashindranath, M., Sales, E., Daglas, M., Freeman, R., Samson, A.L., Cops, E., Beckham, S.A., Galle, A.A., McLean, C., Morganti-Kossmann, M.C., Rosenfeld, J.V., Madani, R., Vassalli, J., Su, E.J., Lawrence, D.A., Medcalf, R.L., 2012, The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans, Brain [P], vol 135, issue Part 11, Oxford University Press, United Kingdom, pp. 3251-3264.

Tan, M., Ng, A.Q.P., Pandher, P., Sashindranath, M., Hamilton, J.A., Davis, S.M., O'Brien, T.J., Medcalf, R.L., Yan, B., Jones, N., 2012, Tissue plasminogen activator does not alter development of acquired epilepsy, Epilepsia [P], vol 53, issue 11, Wiley-Blackwell Publishing, Inc., United States, pp. 1998-2004.

Sashindranath, M., Samson, A., Downes, C.E., Crack, P., Lawrence, A.J., Li, Q., Ng, A.Q.P., Jones, N.C., Farrugia, J., Abdella, E., Vassalli, J., Madani, R., Medcalf, R., 2011, Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation, Laboratory Investigation [P], vol 91, issue 7, Nature Publishing Group, United Kingdom, pp. 1079-1091.

Sashindranath, M., Mclean, K., Trounce, I.A., Cotton, R., Cook, M., 2010, Early hippocampal oxidative stress is a direct consequence of seizures in the rapid electrical amygdala kindling model, Epilepsy Research [P], vol 90, issue 3, Elsevier BV, Netherlands, pp. 285-294.

Postgraduate Research Supervisions

Current Supervision

Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Investigating the long term effects of TBI on the immune and fibrinolytic system..
Supervisors:
Medcalf, R (Main), Alderuccio, F (Associate), Sashindranath, M (Associate).