Dr Zane Andrews - Researcher Profile

Biography

 I completed my PhD in 2003 (1999-2003) from the University of Otago, Dunedin, New Zealand. During my PhD I worked with Dave Grattan on the neuroendocrine control of prolactin secretion.

 I received excellent postdoctoral training at Yale University, New Haven, Connecticut, USA (2004-2008) in the lab of Tamas Horvath, a world recognised expert on the hypothalamic mechanisms regulating energy balance. Yale University is considered one of the world’s leading universities through a proven ability to consistently recruit world-leading scientists/educators/academics that publish constantly in top class journals and develop breakthrough technologies.

In my career I have made a major contribution to the fields of the neural control of appetite and bodyweight, neurodegeneration in Parkinson’s disease and neuroendocrine actions of ghrelin. My work has been heavily cited for an Early Career Researcher with over 620 citations.

• Read the rest of the profile

Related Links:

Keywords

AMPK, CPT1, CRAT, GPx3, Ghrelin, energy balance, mitochondria, fat metabolism, hypothalamus, Neurodegeneration, Parkinson's Disease, Dopamine, Ventral Tegmental Area, Neuroendocrinology, des-acyl ghrelin; goat; acyl ghrelin; insulin sensitivity; goat; glucose; insulin; pancreas; , ghrelin receptor, GHSR, Growth hormone secretagogue receptor, transgenic mice, neuronal metabolism, , neuropeptide y; pro-opiomelanocortin; arcuate nucleus; diet-induced obesity; calorie restriction

Qualifications

ANATOMY AND STRUCTURAL BIOLOGY

Institution: University of Otago

Year awarded: 2003

BACHELOR OF SCIENCE (HONOURS)

Institution: University of Otago

Year awarded: 1999

Publications

Book Chapters

Bayliss, J., Stark, R., Reichenbach, A., Andrews, Z.B., 2011, Gut Hormones restrict neurodegeneration in Parkinson's Disease, in Advanced Understanding of Neurodegenerative Diseases, eds R Cheun-Chung Chang, InTech, Croatia, pp. 269-284.

Journal Articles

Stark, R., Ashley, S.E., Andrews, Z.B., 2013, AMPK and the neuroendocrine regulation of appetite and energy expenditure, Molecular and Cellular Endocrinology [P], vol 366, issue 2, Elsevier Ireland Ltd, Ireland, pp. 215-223.

Briggs, D.I., Lockie, S.K.H., Wu, Q., Lemus, M.B., Stark, R., Andrews, Z.B., 2013, Calorie-restricted weight loss reverses high-fat diet-induced ghrelin resistance, which contributes to rebound weight gain in a ghrelin-dependent manner, Endocrinology [P], vol 154, issue 2, The Endocrine Society, USA, pp. 709-717.

Reichenbach, A., Steyn, F.J., Sleeman, M.W., Andrews, Z.B., 2012, Ghrelin receptor expression and colocalization with anterior pituitary hormones using a GHSR-GFP mouse line, Endocrinology [P], vol 153, issue 11, The Endocrine Society, USA, pp. 5452-5466.

Spencer, S.J., Xu, L., Clarke, M.A., Lemus, M.B., Reichenbach, A., Geenen, B., Kozicz, T., Andrews, Z.B., 2012, Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress, Biological Psychiatry [P], vol 72, issue 6, Elsevier Inc., USA, pp. 457-465.

Clarke, S.D., Lee, K., Andrews, Z.B., Bischof, R., Fahri, F., Evans, R.G., Clarke, I.J., Henry, B.A., 2012, Postprandial heat production in skeletal muscle is associated with altered mitochondrial function and altered futile calcium cycling, American Journal of Physiology - Regulatory Integrative and Comparative Physiology [E], vol 303, issue 10, American Physiological Society, USA, pp. R1071-R1079.

Briggs, D., Andrews, Z., 2011, A recent update on the role of ghrelin in glucose homeostasis, Current Diabetes Reviews [P], vol 7, issue 3, Bentham Science Publishers Ltd, The Netherlands, pp. 201-207.

Henry, B., Andrews, Z., Rao, A., Clarke, I., 2011, Central leptin activates mitochondrial function and increases heat production in skeletal muscle, Endocrinology [P], vol 152, issue 7, Endocrine Society, USA, pp. 2609-2618.

Andrews, Z., 2011, Central mechanisms involved in the orexigenic actions of ghrelin, Peptides [P], vol 32, issue 11, Elsevier Inc., USA, pp. 2248-2255.

Briggs, D., Lemus, M., Kua, E., Andrews, Z., 2011, Diet-induced obesity attenuates fasting-induced hyperphagia, Journal of Neuroendocrinology [P], vol 23, issue 7, Wiley-Blackwell Publishing Ltd, UK, The Netherlands, USA, pp. 620-626.

Loh, K., Fukushima, A., Zhang, X.M., Galic, S., Briggs, D.I., Enriori, P., Simonds, S., Wiede, F., Reichenbach, A., Hauser, C., Sims, N.A., Bence, K.K., Zhang, S., Zhang, Z., Kahn, B., Neel, B., Andrews, Z.B., Cowley, M.A., Tiganis, T., 2011, Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance, Cell Metabolism [P], vol 14, issue 5, Cell Press, USA, pp. 684-699.

Wolff, E., Gao, X., Yao, K., Andrews, Z., Du, H., Elsworth, J., Taylor, H., 2011, Endometrial stem cell transplantation restores dopamine production in a Parkinson's disease model, Journal Of Cellular And Molecular Medicine [P], vol 15, issue 4, Wiley-Blackwell Publishing Ltd, UK, pp. 747-755.

Horvath, T., Erion, D., Elsworth, J., Roth, R., Shulman, G., Andrews, Z., 2011, GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function, Neurobiology Of Disease [P], vol 43, issue 1, Academic Press, USA, pp. 152-162.

Furness, J.B., Hunne, B., Matsuda, N., Yin, L., Russo, D., Kato, I., Fujimiya, M., Patterson, M., McLeod, J., Andrews, Z.B., Bron, R., 2011, Investigation of the presence of ghrelin in the central nervous system of the rat and mouse, Neuroscience [P], vol 193, Pergamon, UK, pp. 1-9.

Briggs, D.I., Andrews, Z.B., 2011, Metabolic status regulates ghrelin function on energy homeostasis, Neuroendocrinology [P], vol 93, issue 1, S. Kager AG, Switzerland, pp. 48-57.

Borg, M., Andrews, Z., Duh, E., Zechner, R., Meikle, P., Watt, M., 2011, Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase, Diabetes [P], vol 60, issue 5, American Diabetes Association, USA, pp. 1458-1466.

Andrews, Z.B., 2011, The extra-hypothalamic actions of ghrelin on neuronal function, Trends in Neurosciences [P], vol 34, issue 1, Elsevier Ltd, UK, pp. 31-40.

Briggs, D.I., Enriori, P.J., Lemus, M.B., Cowley, M.A., Andrews, Z.B., 2010, Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons, Endocrinology [P], vol 151, issue 10, The Endocrine Society, USA, pp. 4745-4755.

Andrews, Z.B., 2010, Uncoupling protein-2 and the potential link between metabolism and longevity, Current Aging Science [P], vol 3, issue 2, Bentham Science Publishers Ltd, The Netherlands, pp. 102-112.

Andrews, Z.B., Erion, D.M., Beiler, R., Choi, C.S., Shulman, G.I., Horvath, T.L., 2010, Uncoupling protein-2 decreases the lipogenic actions of ghrelin, Endocrinology [P], vol 151, issue 5, The Endocrine Society, USA, pp. 2078-2086.

Horvath, T., Andrews, Z.B., Diano, S., 2009, Fuel utilization by hypothalamic neurons: roles for ROS, Trends in Endocrinology & Metabolism, vol 20, Elsevier Ltd, UK, pp. 78-87.

Andrews, Z.B., Erion, D., Beiler, R., Liu, Z., Abizaid, A., Zigman, J., Elsworth, J.D., Savitt, J.M., DiMarchi, R., Tschoep, M., Roth, R.H., Gao, X., Horvath, T.L., 2009, Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism, Journal Of Neuroscience [P], vol 29, issue 45, Society for Neuroscience, USA, pp. 14057-14065.

Andrews, Z.B., Horvath, T., 2009, Uncoupling protein-2 regulates lifespan in mice, American Journal of Physiology: Endocrinology and Metabolism, vol 296, issue 4, American Physiological Society, USA, pp. E621-E627.

Dietrich, M.O., Andrews, Z.B., Horvath, T., 2008, Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation, The Journal of Neuroscience, vol 28, issue 42, Society for Neuroscience, United States, pp. 10766-10771.

Andrews, Z.B., Horvath, T., 2008, Tasteless Food Reward, Neuron, vol 57, issue 6, Cell Press, USA, pp. 806-808.

Andrews, Z.B., Liu, Z., Wallingford, N., Erion, D.M., Borok, E., Friedman, J., Tschop, M.H., Shanabrough, M., Cline, G., Shulman, G.I., Coppola, A., Gao, X., Horvath, T., Diano, S., 2008, UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals, Nature, vol 454, issue 7206, Nature Publishing Group, UK, pp. 846-851.

Coppola, A., Liu, Z., Andrews, Z.B., Paradis, E., Roy, M., Friedman, J., Ricquier, D., Richard, D., Horvath, T., Gao, X., Diano, S., 2007, A Central Thermogenic-like Mechanism in Feeding Regulation: An Interplay between Arcuate Nucleus T3 and UCP2, Cell Metabolism, vol 5, issue 1, Cell Press, USA, pp. 21-33.

Abizaid, A., Liu, Z., Andrews, Z.B., Shanabrough, M., Borok, E., Elsworth, J.D., Roth, R.H., Sleeman, M.W., Picciotto, M.R., Tschop, M.H., Gao, X., Horvath, T.L., 2006, Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite, Journal of Clinical Investigation, vol 116, issue 12, American Society for Clinical Investigation, USA, pp. 3229-3239.

Andrews, Z.B., Zhao, H., Frugier, T., Meguro, R., Grattan, D.R., Koishi, K., McLennan, I.S., 2006, Transforming growth factor beta2 haploinsufficient mice develop age-related nigrostriatal dopamine deficits, Neurobiology of Disease, vol 21, issue 3, Academic Press, USA, pp. 568-575.

Andrews, Z.B., Rivera, A., Elsworth, J.D., Roth, R., Agnati, L., Gago, B., Abizaid, A., Schwartz, M., Fuxe, K., Horvath, T.L., 2006, Uncoupling protein-2 promotes nigrostriatal dopamine neuronal function, European Journal of Neuroscience, vol 24, issue 1, Wiley-Blackwell Publishing Ltd, UK, pp. 32-36.

McGeachie, A.B., Koishi, K., Andrews, Z.B., McLennan, I.S., 2005, Analysis of mRNAs that are enriched in the post-synaptic domain of the neuromuscular junction, Molecualr and Cellular Neuroscience, vol 30, issue 2, Academic Press, USA, pp. 173-185.

Andrews, Z.B., Diano, S., Horvath, T.L., 2005, Mitochondrial uncoupling proteins in the CNS: in support of function and survival, Nature Reviews Neuroscience, vol 6, issue 11, Nature Publishing Group, UK, pp. 829-840.

Andrews, Z.B., 2005, Neuroendocrine regulation of prolactin secretion during late pregnancy: Easing the transition into lactation, Journal of Neuroendocrinology, vol 17, issue 7, Wiley-Blackwell Publishing Ltd., UK, pp. 466-473.

Conti, B., Sugama, S., Lucero, J., Winsky-Sommerer, R., Wirz, S.A., Maher, P., Andrews, Z.B., Barr, A.M., Morale, M.C., Paneda, C., Pemberton, J., Gaidarova, S., Behrens, M.M., Beal, F., Sanna, P.P., Horvath, T., Bartfai, T., 2005, Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity, Journal of Neurochemistry, vol 93, issue 2, Wiley-Blackwell Publishing Ltd., UK & USA, pp. 493-501.

Andrews, Z.B., Horvath, B., Barnstable, C., Elsworth, J.D., Yang, L., Beal, M.F., Roth, R., Matthews, R.T., Horvath, T.L., 2005, Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease, The Journal of Neuroscience, vol 25, issue 1, Society for Neuroscience, USA, pp. 184-191.

Andrews, Z.B., Grattan, D.R., 2003, Opioid receptor subtypes involved in the regulation of prolactin secretion during pregnancy and lactation, Journal of Neuroendocrinology, vol 15, issue 3, Wiley-Blackwell Publishing Ltd, UK, pp. 227-236.

Augustine, R.A., Kokay, I.C., Andrews, Z.B., Ladyman, S.R., Grattan, D.R., 2003, Quantitation of prolactin receptor mRNA in the maternal rat brain during pregnancy and lactation, Journal of Molecular Endocrinology, vol 31, issue 1, Society for Endocrinology, UK, pp. 221-232.

Andrews, Z.B., Grattan, D.R., 2002, Opioid control of prolactin secretion in late pregnant rats is mediated by tuberoinfundibular dopamine neurons, Neuroscience Letters, vol 328, issue 1, Elsevier Ireland Ltd, Ireland, pp. 60-64.

Andrews, Z.B., Kokay, I.C., Grattan, D.R., 2001, Dissociation of prolactin secretion from tuberoinfundibular dopamine activity in late pregnant rats., Endocrinology, vol 142, issue 6, The Endocrine Society, USA, pp. 2719-2724.

Grattan, D.R., Pi, J., Andrews, Z.B., Augustine, R.A., Kokay, I.C., Summerfield, M.R., Todd, B., Bunn, S.J., 2001, Prolactin receptors in the brain during pregnancy and lactation: Implications for behavior, Hormones and Behavior, vol 40, issue 2, Academic Press, USA, pp. 115-124.

Languages

• English

Citizenship

• Australian citizen
• Citizen of New Zealand

Grants

Title:

AMP-activated kinase (AMPK) prevents dopamine cell degeneration in models of Parkinson's disease.

Investigators:

Andrews, Z

Funding:

(2012 - 2015). ANZ Charitable Trusts: Medical Research & Technology Grant.

Title:

CPT1c in hypothalamic POMC neurons regulates energy metabolism and glucose homeostasis.

Investigators:

Andrews, Z

Funding:

(2010 - 2014). Australian Research Council (ARC).

Title:

Carnitine Palmitoyl Transferase 1 in POMC neurons controls glucose homeostasis and body weight.

Investigators:

Andrews, Z

Funding:

(2012 - 2016). National Health & Medical Research Council (NHMRC).

Title:

DEXA body composition and bone density analysis suite.

Investigators:

Clarke, I, Mitchell, C, Cowley, M, Tiganis, T, Oldfield, B, Rosa, M, Walker, D, Lackmann, M, Watt, M, Armitage, J, Denton, K, Evans, R, Kett, M, Brown, R, Tilbrook, A, Andrews, Z, Smith, J, Spencer, S, Strauss, B, Simpson, E, Williams, B

Funding:

(2009 - 2013). National Health & Medical Research Council (NHMRC).

Title:

Diet-induced obesity causes ghrelin resistance.

Investigators:

Andrews, Z, Spencer, S

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Digital Stereology Confocal System to test therapeutic treatments in Parkinson's disease.

Investigators:

Andrews, Z

Funding:

(2011 - 2015). Equity Trustees - Harold and Cora Brennen Benevolent Trust.

Title:

Endogenous and environmental regulation of energy expenditure in skeletal muscle.

Investigators:

Clarke, I, Henry, B, Hickford, J, Andrews, Z

Funding:

(2012 - 2016). Australian Research Council (ARC).

Title:

Ghrelink's novel neuroprotective effects in Parkinson's disease are mediated by AMP-activated protein kinase (AMPK).

Investigators:

Andrews, Z

Funding:

(2009 - 2013). National Health & Medical Research Council (NHMRC).

Title:

Is the xenomitochondrial mouse an 'ideal' PD model?.

Investigators:

Andrews, Z, Trounce, I

Funding:

(2012 - 2016). Michael J Fox Foundation for Parkinson's Research via Centre for Eye Research Australia.

Title:

Muscle thermogenesis in models of predisposition to obesity.

Investigators:

Henry, B, Clarke, I, Andrews, Z

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Physical activity restores energy homeostasis in obesity through hypothalamic neurogenesis.

Investigators:

Watt, M, Andrews, Z, Oldfield, B

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

(2011 - 2016). National Health & Medical Research Council (NHMRC).

Title:

Plasma ghrelin concentrations in human Parkinson's disease patients.

Investigators:

Andrews, Z

Funding:

(2010 - 2014). The Andrews Foundation.

Title:

Seahorse XF24 Extracellular Flux Analyser.

Investigators:

Watt, M, Mitchell, C, Tiganis, T, Currie, P, Andrews, Z, Clarke, I, O'Bryan, M, Cowley, M, Sleeman, M, Dowling, D, Gabriel, K, Risbridger, G, Bruce, C, Brown, K, Johns, T, Sobey, C, Henry, B

Funding:

(2012 - 2016). National Health & Medical Research Council (NHMRC).

Title:

The novel neuroprotective effects of ghrelin in parkinsons disease are mediated by AMPK-activated kinase (AMPK).

Investigators:

Andrews, Z

Funding:

(2008 - 2012). Monash University.

Title:

Thermo Scientific LTO Orbitrap Elite ETD High Resolution Hybridi Mass Spectrometer.

Investigators:

Tiganis, T, Smith, A, Kleifeld, O, Lithgow, T, Whisstock, J, Jans, D, Bird, P, Mitchell, C, Lackmann, M, Pike, R, Wilce, J, Boag, P, Borg, N, Traven, A, Coppel, R, Adler, B, Cowley, M, Watt, M, Andrews, Z, Nice, E

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Hormonal regulation of NPY neurons in the arcuate nucleus of the hypothalamus.

Investigators:

Andrews, Z, Zigman, J

Funding:

(2012 - 2016). National Health & Medical Research Council (NHMRC).

Postgraduate Research Supervisions

Completed Supervision

Student:

Briggs, D.

Program of Study:

Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons. (PHD) 2012.

Supervisors:

Andrews, Z (Main), Oldfield, B (Associate).