Dr Michelle Halls - Researcher Profile

Biography

Position
NHMRC Overseas Biomedical Fellow
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 2007

BACHELOR OF BIOMEDICAL SCIENCE ( HON)

Institution: Monash University

Year awarded: 2003

Publications

Journal Articles

Bathgate, R., Halls, M.L., Van Der Westhuizen, E.T., Callander, G., Kocan, M., Summers, R.J., 2013, Relaxin family peptides and their receptors, Physiological Reviews [P], vol 93, issue 1, The American Physiological Society, Bethesda Maryland USA, pp. 405-480.

Willoughby, D., Halls, M.L., Everett, K.L., Ciruela, A., Skroblin, P., Klussmann, E., Cooper, D.M.F., 2012, A key phosphorylation site in AC8 mediates regulation of Ca2+-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex, Journal of Cell Science [E], vol Online, Company of Biologists Ltd, Cambridge England, pp. 1-30.

Ayling, L.J., Briddon, S.J., Halls, M.L., Hammond, G.R.V., Vaca, L., Pacheco, J., Hill, S.J., Cooper, D.M.F., 2012, Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu, Journal Of Cell Science [P], vol 125, issue 4, Company of Biologists Ltd, Cambridge England, pp. 869-886.

Halls, M.L., 2012, Constitutive formation of an RXFP1-signalosome: A novel paradigm in GPCR function and regulation, British Journal of Pharmacology [P], vol 165, issue 6, Wiley-Blackwell, Malden, Massachusetts, pp. 1644-1658.

Willoughby, D., Everett, K.L., Halls, M.L., Pacheco, J., Skroblin, P., Vaca, L., Klussmann, E., Cooper, D.M.F., 2012, Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling, Science signaling [P], vol 5, issue 219, Amer Assoc Advancement Science, Washington, DC, pp. 1-11.

Sato, M., Hutchinson, D.S., Halls, M.L., Furness, S.G.B., Bengtsson, T., Evans, B.A., Summers, R.J., 2012, Interaction with caveolin-1 modulates G protein coupling of the mouse beta3-adrenoceptor, Journal Of Biological Chemistry [P], vol 287, issue 24, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 20674-20688.

Shen, J.X., Wachten, S., Halls, M.L., Everett, K.L., Cooper, D.M.F., 2012, Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas GI?I? subunits exert opposing effects depending on the G-protein source, Biochemical Journal [P], vol 447, issue 3, Portland Press Ltd, London, England, pp. 393-405.

Halls, M.L., Cooper, D.M.F., 2011, Regulation by Ca2+-signaling pathways of adenylyl cyclases, Cold Spring Harbor Perspectives in Biology [E], vol 3, issue 1, Cold Spring Harbor Lab Press, Publications Dept, Cold Spring Harbor NY USA, p. a004143.

Willoughby, D., Masada, N., Wachten, S., Pagano, M., Halls, M., Everett, K., Ciruela, A., Cooper, D., 2010, AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems, Journal Of Biological Chemistry [P], vol 285, issue 26, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 20328-20342.

Halls, M., Cooper, D., 2010, Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex, Embo Journal [P], vol 29, issue 16, Nature Publishing Group, United Kingdom, pp. 2772-2787.

Samuel, C.S., Mookerjee, I., Halls, M.L., Summers, R.J., Chew, E., Bathgate, R.A.D., Tregear, G.W., Hewitson, T.D., 2009, Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation, Annals of the New York Academy of Sciences [P], vol 1160, Wiley-Blackwell Publishing Inc, USA, pp. 294-299.

Halls, M.L., Papaioannou, M., Wade, J.D., Evans, B.A., Bathgate, R.A.D., Summers, R.J., 2009, RXFP1 couples to the Galphai3-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail, Annals of the New York Academy of Sciences [P], vol 1160, Wiley-Blackwell Publishing, Inc., USA, pp. 117-120.

Halls, M.L., Hewitson, T.D., Moore, X., Du, X., Bathgate, R.A.D., Summers, R.J., 2009, Relaxin activates multiple cAMP signaling pathway profiles in different target cells, Annals of the New York Academy of Sciences [P], vol 1160, Wiley-Blackwell Publishing, Inc., USA, pp. 108-111.

Halls, M.L., van der Westhuizen, E.T., Wade, J.D., Evans, B.A., Bathgate, R.A.D., Summers, R.J., 2009, Relaxin family peptide receptor (RXFP1) coupling to Galphai3, involves the C-terminal Arg752 and localization within membrane raft microdomains, Molecular Pharmacology [P], vol 75, issue 2, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 415-428.

Mookerjee, I., Hewitson, T.D., Halls, M.L., Summers, R.J., Mathai, M.L., Bathgate, R., Tregear, G.W., Samuel, C.S., 2009, Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2, The FASEB Journal, vol 23, Federation of American Societies for Experimental Biology, USA, pp. 1219-1229.

Summers, R.J., Bathgate, R.A.D., Wade, J.D., van der Westhuizen, E.T., Halls, M.L., 2009, Roles of the receptor, the ligand, and the cell in the signal transduction pathways utilized by the relaxin family peptide receptors 1-3, Annals of the New York Academy of Sciences [P], vol 1160, Wiley-Blackwell Publishing, Inc., USA, pp. 99-104.

Van Der Westhuizen, E.T., Halls, M.L., Samuel, C.S., Bathgate, R., Unemori, E.N., Sutton, S.W., Summers, R.J., 2008, Relaxin family peptide receptors - from orphans to therapeutic targets, Drug Discovery Today, vol 13, issue 15-16, Elsevier Ltd., United Kingdom, pp. 640-651.

Halls, M.L., Bathgate, R., Summers, R.J., 2007, Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes, Journal of Pharmacology and Experimental Therapeutics, vol 320, issue 1, The American Society for Pharmacology and Experimental Therapeutics, Bethesda USA, pp. 281-290.

Halls, M.L., Van Der Westhuizen, E.T., Bathgate, R., Summers, R.J., 2007, Relaxin family peptide receptors - Former orphans reunite with their parent ligands to activate multiple signalling pathways, British Journal of Pharmacology, vol 150, issue 6, Nature Publishing Group, London England UK, pp. 677-691.

Van Der Westhuizen, E.T., Summers, R.J., Halls, M.L., Bathgate, R., Sexton, P., 2007, Relaxin receptors - new drug targets for multiple disease states, Current Drug Targets, vol 8, issue 1, Bentham Science Ltd, Sharjah UAE, pp. 91-104.

Halls, M.L., Bathgate, R.A.D., Summers, R.J., 2006, Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms, Molecular Pharmacology, vol 70, issue 1, The American Society for Pharmacology and Experimental Therapeutics, Bethesda Maryland USA, pp. 214-226.

Halls, M.L., Bond, C.P., Sudo, S., Kumagai, J., Ferraro, T., Layfield, S., Bathgate, R.A.D., Summers, R.J., 2005, Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8), The Journal of Pharmacology and Experimental Therapeutics, vol 313, issue 2, The American Society for Pharmacology and Experimental Therapeutics, Bethesda USA, pp. 677-687.

Conference Proceedings

Halls, M.L., Bathgate, R., Summers, R.J., 2006, Differential G protein coupling of the relaxin family peptide receptors RXFP1 and RXFP2 is due to differences in the C-terminal tail, Acta Pharmacologica Sinica, 2-7/7/2006, Blackwell Publishing, Oxford England, p. 395.

Halls, M.L., Bathgate, R., Sudo, S., Kumagai, J., Bond, C.P., Summers, R.J., 2005, Identification of binding sites with differing affinity and potency for relaxin analogues on LGR7 and LGR8 receptors, Relaxin and Related Peptides: Fourth International Conference, 05 September 2004 to 10 September 2004, New York Academy of Sciences, New York USA, pp. 17-21.

Halls, M.L., Bathgate, R., Summers, R.J., 2005, Signal switching after stimulation of LGR7 receptors by human relaxin 2, Relaxin and Related Peptides: Fourth International Conference, 05 September 2004 to 10 September 2004, New York Academy of Sciences, New York USA, pp. 288-291.

Halls, M.L., Bathgate, R., Roche, P.J., Summers, R.J., 2005, Signaling pathways of the LGR7 and LGR8 receptors determined by reporter genes, Relaxin and Related Peptides: Fourth International Conference, 5 September 2004 to 10 September 2004, New York Academy of Sciences, New York USA, pp. 292-295.