Assoc Prof Katherine Denton - Researcher Profile

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Address

Department of Physiology
Faculty of Medicine, Nursing & Health Sciences, Clayton

Biography

Heart-felt understanding of blood pressure and kidneys

The renin-angiotensin system is one of our most intricate hormone systems in the human body. It controls our blood pressure and fluid balance, and its effectiveness is vital to our kidney function. Dr Kate Denton says a better understanding of the renin-angiotensin system will lead to significant improvements in blood pressure control. By extension, Kate believes it is an important step in the fight against heart disease and earlier detection of kidney disease. 

 

Hypertension and its associated complications affect men and women during different stages of their lives. Kate is focusing on what controls blood pressure in pregnant women, and what largely protects women from heart disease until menopause.

“One in 10 women experience hypertension during pregnancy,” Kate says. “It’s life-threatening for the mother and the child, and the only therapy we have at the moment is delivery. Blood pressure medication affects the baby, so you normally try to keep the pregnancy going for as long as possible without adversely affecting the mother. We’re trying to understand what controls blood pressure during pregnancy.”

“Blood pressure is very different in how it’s controlled in men and women. Females have lower blood pressure than males until menopause. Up until menopause, females are protected to a large extent from cardiovascular disease, but if you take the whole population, more women than men are affected. We want to understand why female hormones are protective and how they’re helping to regulate blood pressure, and whether we can keep that protection going past menopause,” she says.

Kate says there’s an intrinsic link between blood pressure and kidney disease. A healthy kidney consists of one million glomeruli, each of which filters a certain amount of blood, but patients often lose the majority of their kidney function before they have symptoms. Kate says it is important to understand how the individual filters work in order to detect kidney failure earlier.

“When you get down to between 25 and 50 per cent [glomeruli], you start to see signs of renal failure. We hope to work out how they’re functioning, what’s controlling them and work out methods of detecting renal damage earlier. Using a microscope and little glass pipettes about a micro in diameter at the tip, we can find a glomerulus, measure pressure and collect fluid in a single glomerulus and determine what’s happening,” Kate says. 

The method they use to do this is called renal micropuncture.

“If you’re filtering, the blood pressure in those capillaries determines how much fluid moves across. In healthy glomeruli, pressure is normally kept constant by the constriction of blood vessels. I’m interested in what controls the pressure in those filters, and I can measure that with micropuncture.”

Kate is also exploring how the renal nerves, or sympathetic nerves, control our kidneys and blood pressure. She is using techniques to directly record and stimulate nerve activity.

“There’s a lot of evidence in humans that suggests over-activity of the sympathetic nerves can change renal function and drive hypertension. One of the newest treatments for drug resistant hypertension is to sever the nerves around the kidney with laser surgery. I’m looking at how long it takes for nerves to regrow in the kidney once they have been severed,” Kate says. 

“The amazing thing about these studies in humans is that they’ve followed the subjects for up to five years and blood pressure is being kept down significantly. Yet we know the nerves regrow, so what this suggests is that they connect to the tissues differently. Our studies aim to understand how this is occurring.”

 

Qualifications

PHD - MEDICINE
Institution: Monash University
Year awarded: 1992
SCIENCE
Institution: Monash University
Year awarded: 1983
SCIENCE
Institution: Monash University
Year awarded: 1981

Publications

Book Chapters

Denton, K.M., Kett, M., Dodic, M., 2006, Programming hypertension - animal models: causes and mechanisms, in Advances in Experimental Medicine and Biology, eds E. Marelyn Wintour and Julie A Owens, Landes Bioscience, Georgetown USA, pp. 103-120.

Denton, K.M., 2000, Blood flow in the glomerular capillary network, in The Renal Circulation, JAI Press Inc, Stamford Connecticut USA, pp. 93-107.

Journal Articles

Hilliard, L.M., Sampson, A.K., Brown, R.D., Denton, K.M., 2013, The "His and Hers" of the Renin-Angiotensin System, Current Hypertension Reports [P], vol 15, issue 1, Springer Healthcare, USA, pp. 71-79.

Hilliard, L.M., Mirabito, K., Denton, K.M., 2013, Unmasking The Potential Of The At(2) r As A Therapeutic Target In Hypertension In Men And Women: What We Know And What We Still Need To Find Out, Clinical and Experimental Pharmacology and Physiology [E], vol E-pub, Wiley-Blackwell Publishing Asia, Australia, pp. 1-27.

McCarthy, C.A., Widdop, R.E., Denton, K.M., Jones, E.S., 2013, Update on the Angiotensin AT(2) Receptor, Current Hypertension Reports [P], vol 15, issue 1, Springer Healthcare, USA, pp. 25-30.

Lankadeva, Y.R., Singh, R.R., Hilliard, L.M., Moritz, K.M., Denton, K.M., 2012, Blunted sodium excretion in response to a saline load in 5 year old female sheep following fetal uninephrectomy, PLoS ONE [P], vol 7, issue 10 (Art. No.: e47528), Public Library of Science, USA, pp. 1-10.

Bosnyak, S., Widdop, R.E., Denton, K.M., Jones, E.S., 2012, Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats, International Journal of Hypertension [E], vol 2012, issue 192567, Hindawi Publishing Corporation, USA, pp. 1-9.

Eppel, G.A., Head, G.A., Denton, K.M., Evans, R.G., 2012, Effects of tempol and candesartan on neural control of the kidney, Autonomic Neuroscience: Basic and Clinical [P], vol 168, issue 1-2, Elsevier BV, The Netherlands, pp. 48-57.

Singh, R.R., Jefferies, A.J., Lankadeva, Y.R., Lombardo, P., Schneider-Kolsky, M.E., Hilliard, L.M., Denton, K.M., Moritz, K.M., 2012, Increased cardiovascular and renal risk is associated with low nephron endowment in aged females: an ovine model of fetal unilateral nephrectomy, PLoS ONE [P], vol 7, issue 8 (Art. ID: e42400), Public Library of Science, USA, pp. 1-11.

Gallo, L.A., Denton, K.M., Moritz, K.M., Tare, M., Parkington, H.C., Davies, M.M., Tran, M., Jefferies, A.J., Wlodek, M.E., 2012, Long-term alteration in maternal blood pressure and renal function after pregnancy in normal and growth-restricted rats, Hypertension [P], vol 60, issue 1, Lippincott Williams & Wilkins, USA, pp. 206-213.

Sampson, A.K., Moritz, K.M., Denton, K.M., 2012, Postnatal ontogeny of angiotensin receptors and ACE2 in male and female rats, Gender Medicine [P], vol 9, issue 1, Excerpta Medica Inc., USA, pp. 21-32.

Singh, R.R., Moritz, K.M., Bertram, J.F., Denton, K.M., 2012, Renal responses to furosemide are significantly attenuated in male sheep at 6 months of age following fetal uninephrectomy, American Journal of Physiology - Regulatory Integrative and Comparative Physiology [E], vol 302, issue 7, American Physiological Society, USA, pp. R868-R875.

Safari, T., Nematbakhsh, M., Hilliard, L.M., Evans, R.G., Denton, K.M., 2012, Sex differences in the renal vascular response to angiotensin II involves the Mas receptor, Acta Physiologica [P], vol 206, issue 2, Wiley-Blackwell Publishing Ltd, UK, pp. 150-156.

Hilliard, L.M., Jones, E.S., Steckelings, U.M., Unger, T., Widdop, R.E., Denton, K.M., 2012, Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension, Hypertension [P], vol 59, issue 2, Lippincott Williams & Wilkins, USA, pp. 409-414.

Hilliard, L.M., Denton, K.M., 2012, The angiotensin type 2 receptor weighs in on obesity: a promising therapeutic target?, Hypertension Research [P], vol 35, issue 6, Nature Publishing Group, UK, pp. 582-584.

Sampson, A.K., Hilliard, L.M., Moritz, K.M., Thomas, M.C., Tikellis, C., Widdop, R.E., Denton, K.M., 2012, The arterial depressor response to chronic low-dose angiotensin II infusion in female rats is estrogen dependent, American Journal of Physiology - Regulatory Integrative and Comparative Physiology [E], vol 302, issue 1, American Physiological Society, USA, pp. R159-R165.

Singh, R., Moritz, K., Wintour-Coghlan, M., Jefferies, A., Iqbal, J., Bertram, J., Denton, K., 2011, Fetal uninephrectomy in male sheep alters the systemic and renal responses to angiotensin II infusion and AT1R blockade, American Journal of Physiology - Renal Physiology [P], vol 301, issue 2, American Physiological Society, USA, pp. F319-F326.

Hilliard, L.M., Nematbakhsh, M., Kett, M.M., Teichman, E., Sampson, A.K., Widdop, R.E., Evans, R.G., Denton, K.M., 2011, Gender differences in pressure-natriuresis and renal autoregulation: Role of the Angiotensin type 2 receptor, Hypertension [P], vol 57, issue 2, Lippincott Williams & Wilkins, USA, pp. 275-282.

Lim, K., Lombardo, P., Schneider-Kolsky, M., Hilliard, L., Denton, K., Black, M., 2011, Induction of hyperglycemia in adult intrauterine growth-restricted rats: Effects on renal function, American Journal of Physiology - Renal Physiology [P], vol 301, issue 2, American Physiological Society, USA, pp. F288-F294.

Brown, R.D., Hilliard, L.M., Head, G.A., Jones, E.S., Widdop, R.E., Denton, K.M., 2011, Sex differences in the pressor and tubuloglomerular feedback response to angiotensin II, Hypertension [P], vol E, Lippincott Williams & Wilkins, USA, pp. 1-7.

Denton, K., 2011, The renin-angiotensin system: new horizons, Journal of Hypertension [P], vol 29, issue 10, Lippincott Williams & Wilkins, USA, pp. 1857-1858.

Singh, R., Denton, K., Bertram, J., Dowling, J., Moritz, K., 2011, Urine-concentrating defects exacerbate with age in male offspring with a low-nephron endowment, American Journal of Physiology - Renal Physiology [P], vol 301, issue 6, American Physiological Society, USA, pp. F1168-F1176.

McArdle, A.M., Maduwegedera, D.W., Moritz, K.M., Flower, R.L., Denton, K.M., Roberts, C.T., 2010, Chronic maternal hypertension affects placental gene expression and differentiation in rabbits, Journal of Hypertension [P], vol 28, issue 5, Lippincott Williams & Wilkins, Ltd, UK, pp. 959-968.

McArdle, A.M., Roberts, C.T., Maduwegedera, D.W., Flower, R.L., Denton, K.M., 2010, Chronic maternal hypertension characterized by renal dysfunction is associated with reduced placental blood flow during late gestation in rabbits, American Journal Of Physiology-Regulatory Integrat..., vol 298, issue 4, American Physiological Society, USA, pp. R1043-R1049.

Ruta, L.M., Dickinson, H., Thomas, M.C., Denton, K.M., Anderson, W.P., Kett, M.M., 2010, High-salt diet reveals the hypertensive and renal effects of reduced nephron endowment, American Journal of Physiology - Renal Physiology [P], vol 298, issue 6, American Physiological Society, USA, pp. F1384-F1392.

Gray, S.P., Denton, K.M., Cullen-McEwen, L.A., Bertram, J.F., Moritz, K.M., 2010, Prenatal exposure to alcohol reduces nephron number and raises blood pressure in progeny, Journal Of The American Society Of Nephrology [P], vol 21, issue 11, American Society of Nephrology, USA, pp. 1891-1902.

Singh, R.R., Denton, K.M., Bertram, J.F., Jefferies, A.J., Moritz, K.M., 2010, Reduced nephron endowment due to fetal uninephrectomy impairs renal sodium handling in male sheep, Clinical Science [P], vol 118, issue 11/12, Portland Press Ltd, UK, pp. 669-680.

Kett, M.M., Denton, K.M., 2010, Renal programming: Cause for concern?, American Journal Of Physiology-Regulatory Integrat..., vol 300, American Physiological Society, USA, pp. 1-38.

Moritz, K.M., Cuffe, J.S.M., Wilson, L.B., Dickinson, H., Wlodek, M.E., Simmons, D.G., Denton, K.M., 2010, Review: Sex specific programming: A critical role for the renal renin-angiotensin system, Placenta [P], vol 31, issue Suppl 1, Elsevier Ltd, UK, pp. S40-S46.

Singh, R.R., Denton, K.M., Bertram, J.F., Jefferies, A.J., Head, G.A., Lombardo, P., Schneider-Kolsky, M.E., Moritz, K.M., 2009, Development of cardiovascular disease due to renal insufficiency in male sheep following fetal unilateral nephrectomy, Journal of Hypertension, vol 27, issue 2, Lippincott Williams & Wilkins, Ltd, UK, USA, pp. 386-396.

Moritz, K.M., Singh, R.R., Probyn, M.E., Denton, K.M., 2009, Developmental programming of a reduced nephron endowment: More than just a baby's birth weight, American Journal of Physiology: Renal Physiology, vol 296, American Physiological Society, United States, pp. 1-9.

Shweta, A., Cullen-McEwen, L.A., Kett, M.M., Evans, R.G., Denton, K.M., Fitzgerald, S.M., Anderson, W.P., Bertram, J.F., 2009, Glomerular surface area is normalized in mice born with a nephron deficit: no role for AT1 receptors, American Journal of Physiology - Renal Physiology [P], vol 296, issue 3, American Physiological Society, USA, pp. F583-F589.

McArdle, A.M., Denton, K.M., Maduwegedera, D.W.K., Moritz, K.M., Flower, R.L., Roberts, C.T., 2009, Ontogeny of placental structural development and expression of the renin-angiotensin system and 11beta-HSD2 genes in the rabbit, Placenta [P], vol 30, issue 7, Elsevier Ltd, UK, pp. 590-598.

Sampson, A.K., Moritz, K.M., Jones, E.S., Flower, R.L., Widdop, R.E., Denton, K.M., 2008, Enhanced angiotensin II type 2 receptor mechanisms mediate decreases in arterial pressure attributable to chronic low-dose angiotensin II in female rats, Hypertension, vol 52, issue 4, Lippincott Williams & Wilkins, United States, pp. 666-671.

Abdelkader (Shweta), A., Cullen-McEwen, L.A., Kett, M.M., Evans, R.G., Denton, K.M., Fitzgerald, S.M., Anderson, W.P., Bertram, J.F., 2008, Glomerular surface area is normalized in mice born with a nephron deficit: No role for AT(1) receptors, American Journal of Physiology: Renal Physiology, vol E, American Physiological Society, USA, pp. F583-F589.

Denton, K.M., Barnett, A.G., 2008, Postnatal growth and the tracking of blood pressure, Journal of Hypertension, vol 26, issue 3, Lippincott Williams & Wilkins, Ltd., UK, USA, pp. 392-393.

Sampson, A.K., Widdop, R.E., Denton, K.M., 2008, Sex-differences in circadian blood pressure variations in response to chronic angiotensin II infusion in rats, Clinical and Experimental Pharmacology & Physiology, vol 35, issue 4, Wiley-Blackwell Publishing Asia, Australia, pp. 391-395.

Denton, K.M., Baylis, C., 2007, Physiological and molecular mechanisms governing sexual dimorphism of kidney, cardiac, and vascular function, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, vol 292, issue 2, American Physiological Society, USA, pp. 697-699.

Maduwegedera, D.W.K., Kett, M.M., Flower, R.L., Lambert, G.W., Bertram, J.F., Wintour, M.E., Denton, K.M., 2007, Sex differences in postnatal growth and renal development in offspring of rabbit mothers with chronic secondary hypertension, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, vol 292, issue 2, American Physiological Society, Bethesda USA, pp. 706-714.

Zimanyi, M.A., Denton, K.M., Forbes, J.M., Thallas-Bonke, V., Thomas, M.C., Poon, F., Black, M.J., 2006, A developmental nephron deficit in rats is associated with increased susceptibility to a secondary renal injury due to advanced glycation end-products, Diabetologia, vol 49, issue 4, Springer, New York NY USA, pp. 801-810.

Denton, K.M., 2006, Can adult cardiovascular disease be programmed in utero?, Journal of Hypertension, vol 24, issue 7, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1245-1247.

Denton, K.M., 2006, Intricacies of brain angiotensin II signalling pathways, Journal of Hypertension, vol 24, issue 1, Lippincott Williams & Wilkins, Philadelphia USA, pp. 39-41.

Eppel, G.A., Ventura, S., Denton, K.M., Evans, R.G., 2006, Lack of contribution of P2X receptors to neurally mediated vasoconstriction in the rabbit kidney in vivo, Acta Physiologica, vol 186, issue 3, Blackwell Publishing, Oxford UK, pp. 197-207.

Eppel, G.A., Luff, S.E., Denton, K.M., Evans, R.G., 2006, Type 1 neuropeptide Y receptors and alpha1-adrenoceptors in the neural control of regional renal perfusion, American Journal of Physiology-Regulatory Integrative And Comparative Physiology, vol 290, issue 2, American Physiological Society, USA, pp. R331-R340.

Evans, R.G., Kett, M.M., Shweta, A., Fitzgerald, S.M., Denton, K.M., Eppel, G.A., Edgley, A.J., Anderson, W.P., 2005, New physiological targets within the kidney for antihypertensive therapy, Drug Design Reviews, vol 2, Bentham Science Publishers Ltd, The Netherlands, pp. 167-178.

Shweta, A., Denton, K.M., Kett, M.M., Bertram, J.F., Lambert, G.W., Anderson, W.P., 2005, Paradoxical structural effects in the unilaterally denervated spontaneously hypertensive rat kidney, Journal of Hypertension, vol 23, Lippincott Williams & Wilkins, Philadelphia USA, pp. 851-859.

Denton, K.M., Luff, S.E., Shweta, A., Anderson, W.P., 2004, Differential neural control of glomerular ultrafiltration, Clinical and Experimental Pharmacology and Physiology, vol 31, issue 5-6, Blackwell Publishing Asia, Carlton Vic Australia, pp. 380-386.

Denton, K.M., Shweta, A., Finkelstein, L., Flower, R.L., Evans, R.G., 2004, Effect of endothelin-1 on regional kidney blood flow and renal arteriole calibre in rabbits, Clinical and Experimental Pharmacology and Physiology, vol 31, issue 8, Blackwell Publishing Asia, Carlton Vic Australia, pp. 494-501.

Kett, M.M., Denton, K.M., Boesen, E.I., Anderson, W.P., 2004, Effects of early carvedilol treatment and withdrawal on the development of hypertension and renal vascular narrowing, American Journal of Hypertension, vol 17, issue 2, Elsevier, New York USA, pp. 161-166.

Evans, R.G., Eppel, G.A., Anderson, W.P., Denton, K.M., 2004, Mechanisms underlying the differential control of blood flow in the renal medulla and cortex, Journal of Hypertension, vol 22, issue 8, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1439-1451.

Eppel, G.A., Malpas, S.C., Denton, K.M., Evans, R.G., 2004, Neural control of renal medullary perfusion, Clinical and Experimental Pharmacology and Physiology, vol 31, issue 5-6, Blackwell Publishing, Carlton Vic Australia, pp. 387-396.

Denton, K.M., Shweta, A., Flower, R.L., Anderson, W.P., 2004, Predominant postglomerular vascular resistance response to reflex renal sympathetic nerve activation during ANG II clamp in rabbits, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol 287, issue 4, American Physiological Society, Bethesda USA, pp. 780-786.

Rajapakse, N.W., Flower, R.L., Eppel, G.A., Denton, K.M., Malpas, S.C., Evans, R.G., 2004, Prostaglandins and nitric oxide in regional kidney blood flow responses to renal nerve stimulation, Pflugers Archiv-European Journal of Physiology, vol 449, issue 2, Springer, New York USA, pp. 143-149.

Denton, K.M., Flower, R.L., Stevenson, K.M., Anderson, W.P., 2003, Adult rabbit offspring of mothers with secondary hypertension have increased blood pressure, Hypertension, vol 41, issue 3, Lippincott Williams & Wilkins, Philadelphia USA, pp. 634-639.

Eppel, G.A., Denton, K.M., Malpas, S.C., Evans, R.G., 2003, Nitric oxide in responses of regional kidney perfusion to renal nerve stimulation and renal ischaemia, Pflugers Archiv - European Journal of Physiology, vol 447, issue 2, Springer-Verlag, New York USA, pp. 205-213.

Denton, K.M., Shweta, A., Anderson, W.P., 2002, Preglomerular and Postglomerular Resistance Responses to Different Level of Sympathetic Activation of Hypoxia, Journal of the American Society of Nephrology, vol 13, Lippincott, Williams & Wilkins, USA, pp. 27-34.

Denton, K.M., Lamden, M.D., Shweta, A., Alcorn, D., Anderson, W.P., 2001, Chronic angiotensin converting enzyme inhibition enhances renal vascular responsiveness to acetylocholine in anaesthetized rabbits, Journal of Hypertension, vol 19, issue 8, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1497-1503.

Leonard, B.L., Malpas, S.C., Denton, K.M., Madden, A.C., Evans, R.G., 2001, Differential control of intrarenal blood flow activity during reflex increases in sympathetic nerve activity, American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol 280, issue 1, American Physiological Society, Bethesda USA, pp. R62-R68.

Correia, A.G., Denton, K.M., Evans, R.G., 2001, Effects of activation of vasopressin-V1 -receptors on regional kidney blood flow and glomerular arteriole diameters, Journal of Hypertension, vol 19, issue 3, Lippincott Williams & Wilkins, Philadelphia USA, pp. 649-657.

Denton, K.M., Li, M., Anderson, W.P., Whitworth, J.A., 2001, Glomerular hypertension and hyperfiltration in adrenocorticotrophin-induced hypertension in rats: the role of nitric oxide, Journal of Hypertension, vol 19, issue 2, Lippincott Williams & Wilkins, Philadelphia USA, pp. 327-334.

Norman, M., Lew, R., Smith, A., Denton, K.M., Evans, R.G., 2001, Metalloendopeptidases EC 3.4.24.15 and EC 3.4.24.16 and bradykinin B2 receptors do not play important roles in renal wrap hypertension in rabbits, Clinical and Experimental Pharmacology and Physiology, vol 28, issue 10, Blackwell Science Asia, Carlton Vic Australia, pp. 836-841.

Evans, R.G., Madden, A.C., Denton, K.M., 2000, Diversity of responses of renal cortical and medullary blood flow to vasoconstrictors in conscious rabbits, Acta Physiologica Scandinavica, vol 169, Blackwell Sci/Scandinavian Physiological Society, Onsey Mead Oxford UK, pp. 297-308.

Denton, K.M., Anderson, W.P., Sinniah, R., 2000, Effects of angiotensin II on regional afferent and efferent arteriole dimensions and the golmerurlar pole, Amercan Journal of Physiology: Integrative and Comparative Phsysiology, vol 279, American Physiological Society, www.ajpregu.org, pp. R629-R638.

Evans, R.G., Steveson, K.M., Bergstrom, G., Denton, K.M., Madden, A.C., Gribben, R.L., Weekes, S.R., Anderson, W.P., 2000, Sex differences in pressure diuresis/natriuresis in rabbits, Acta Physiologica Scandinavica, vol 169, Scandinavian Physiological Society/Blackwell Sci, Onsey Mead Oxford UK, pp. 309-316.

Conference Proceedings

Anderson, W.P., Kett, M.M., Steveson, K.M., Edgley, A.J., Denton, K.M., Fitzgerald, S.M., 2000, Renovascular Hypertension: Structural changes in the renal vasculature, Hypertension, Lorne, Victoria: 22-24 March 2000, American Heart Foundation, www.hypertensionaha.org, pp. 648-652.

Correia, A., Denton, K.M., Evans, R.G., 1999, Do cortical vascular sites mediate reduced medullary perfusion during activation of vasopressin V<1-receptors in the kidney?, High Blood Pressure Research Council of Australia 21st Scientific Meeting, Melbourne VIC 9-11 December 1999, High Blood Pressure Council of Australia Inc, Melbourne Vic Australia, p. 11.

Denton, K.M., Lamden, M., Shweta, A., Anderson, W.P., 1999, The effects of chronic angiotensin converting enzyme inhibition on renal vascular reactivity to vasoactive agents, High Blood Pressure Research Council of Australia 21st Scientific Meeting, Melbourne VIC 9-11 December 1999, High Blood Pressure Research Council, Vic Australia, p. 30.

Shweta, A., Denton, K.M., Anderson, W.P., 1999, The vascular effects of chronic unilateral renal denervation on renal vasculature of spontaneously hypertensive rats, High Blood Pressure Research Council of Australia 21st Scientific Meeting, Melbourne VIC 9-11 December 1999, High Blood Pressure Research Council, Vic Australia, p. 41.

Evans, R.G., Madden, A.C., Denton, K.M., 1999, Vasoconstrictor agents differentially affect renal cortical and medullary perfusion in conscious rabbits, High Blood Pressure Research Council of Australia 21st Annual Scientific Meeting, Melbourne VIC 9-11 December 1999, High Blood Pressure Council of Australia, Vic Australia, p. 26.

Denton, K.M., Sinniah, R., 1998, Renal vessel diameter responses to graded intrarenal infusions of ANG II in anaesthetised rabbits, The FASEB Journal Abstracts Part II Experimental Biology 98, San Francisco CA USA 18-22 April 1998, FASEB, Bethesda MD USA, p. 5763.

Denton, K.M., Li, M., Anderson, W.P., Whitworth, J.A., 1998, Role of nitric oxice in the control of glomerular filtration dynamics in hypertension induced by ACTH in rats, Proceedings of the High Blood Pressure Research Council of Australia, Melbourne Victoria 10-12 December 1998, High Blood Pressure Council of Australia, Melbourne Vic Australia, p. 86.

Denton, K.M., Sinniah, R., 1997, Renal arteriole diameter responses to graded intrarenal infusions of angiotensin II in anaesthetised rabbits, XIVth International Congress of Nephrology Abstracts, Sydney,25-29 May 1997, Blackwell Science Asia, Australia, p. S139.

Denton, K.M., Anderson, W.P., Whitworth, J.A., 1997, Renal cortical pressure profile in ACTH hypertensive rats, High Blood Pressure Research Council of Australia, 19th Scientific Meeting Abstracts, Melbourne,11-3 December 1997, High Blood Pressure Research Council of Aust, Australia, p. 78.

Postgraduate Research Supervisions

Current Supervision

Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Functional regrowth of the sympathetic nerves following renal denervation.
Supervisors:
Denton, K (Main), Tare, M (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Mechanisms underlying the perturbations in cardiovascular and renal function in 5-year old female sheep following fetal uninephrectomy.
Supervisors:
Denton, K (Main).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Sex differences in the vasodepressor axis of the renin angiotensin system in the regulation of arterial pressure..
Supervisors:
Denton, K (Main), Hilliard, L (Associate).

Completed Supervision

Student:
Maduwegedera, D.
Program of Study:
Chronic hypertension in pregnancy: impact on prenatal and postnatal growth and development of offspring. (PHD) 2006.
Supervisors:
Anderson, W (Main), Denton, K (Associate).
Student:
Mcardle, A.
Program of Study:
Placental development in a mild and moderate model of maternal chronic hypertension. (PHD) 2009.
Supervisors:
Denton, K (Main).
Student:
Sampson, A.
Program of Study:
Sex differences in arterial pressure regulation; the role of the renin angiotensin system. (PHD) 2008.
Supervisors:
Denton, K (Main), Anderson, W (Associate).
Student:
Shweta, A.
Program of Study:
THE RENAL SYMPATHETIC NERVES: IMPLICATIONS FOR VASCULAR REMODELLING IN THE SHR KIDNEY. (PHD) 2001.
Supervisors:
Anderson, W (Joint-Co), Denton, K (Joint).