Dr Lauren May - Researcher Profile

Biography

Position
Research Fellow
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Qualifications

MEDICINE, DENTISTRY & HEALTH SCIENCES

Institution: University of Melbourne

Year awarded: 2010

BACHELOR OF SCIENCE (HON)

Institution: The University of Melbourne

Year awarded: 2002

BACHELOR OF BIOMEDICAL SCIENCE

Institution: The University of Melbourne

Year awarded: 2001

Publications

Journal Articles

Wootten, D.L., Savage, E.E., Valant, C., May, L.T., Sloop, K.W., Ficorilli, J., Showalter, A.D., Willard, F.S., Christopoulos, A., Sexton, P.M., 2012, Allosteric modulation of endogenous metabolites as an avenue for drug discovery, Molecular Pharmacology [P], vol 82, issue 2, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 281-290.

May, L.T., Leach, K., Sexton, P.M., Christopoulos, A., 2007, Allosteric modulation of G protein-coupled receptors, The Annual Review of Pharmacology and Toxicology, vol 47, Annual Reviews, Palo Alto USA, pp. 1-51.

Bisson, W.H., Cheltsov, A.V., Bruey-Sedano, N., Lin, B., Chen, J., Goldberger, N., May, L.T., Christopoulos, A., Dalton, J.T., Sexton, P., Zhang, X., Abagyan, R., 2007, Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs, Proceedings of the National Academy of Sciences of the United States of America, vol 104, issue 29, National Academy of Sciences, Washington DC USA, pp. 11927-11932.

May, L.T., Avlani, V.A., Langmead, C.J., Herdon, H.J., Wood, M.D., Sexton, P., Christopoulos, A., 2007, Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors, Molecular Pharmacology, vol 72, issue 2, American Society for Pharmacology & Experimental Therapeutics, Bethesda MD USA, pp. 463-476.

May, L.T., Sexton, P.M., Christopoulos, A., 2005, Effects of urea pretreatment on the binding properties of adenosine A 1 receptors, British Journal of Pharmacology, vol 146, issue 8, Nature Publishing Group, UK, pp. 1119-1129.

May, L.T., Lin, Y., Sexton, P.M., Christopoulos, A., 2005, Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators, The Journal of Pharmacology and Experimental Therapeutics, vol 312, issue 1, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 382-390.

Avlani, V.A., May, L.T., Sexton, P., Christopoulos, A., 2004, Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors, The Journal of Pharmacology and Experimental Therapeutics, vol 308, issue 3, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 1062-1072.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Adenosine Receptor-Mediated Attenuation of Organ Transplant Rejection.

Supervisors:

Christopoulos, A (Main), May, L (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Biased adenosine receptor agonists as cardioprotective agents - in vivo evaluation.

Supervisors:

White, P (Main), May, L (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigating the modulation of adenosine A1 receptor-mediated cardioprotection by A2 receptors.

Supervisors:

May, L (Joint), White, P (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Structure-function analysis of allosteric binding sites on adenosine A1 receptors.

Supervisors:

Christopoulos, A (Main), May, L (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

What makes the alpha1A-adrenoceptor gene express the alpha1L-adrenoceptor functional phenotype?.

Supervisors:

Evans, B (Joint), Ventura, S (Joint-co), May, L (Associate), Summers, R (Associate).