Assoc Prof David Walker - Researcher Profile

Biography

Associate Professor David Walker is part of The Ritchie Centre’s Fetal, Neonatal and Child Health group. Associate Professor Walker is a physiologist with a long interest in fetal and neonatal development. Over the last five years his research has become centred on perinatal brain damage and the cause of cerebral palsy.

Brain damage which occurs during pregnancy, or which evolves soon after birth may be subtle, resulting in learning disabilities and behavioural problems in children, or it may be catastrophic and result in outcomes such as epilepsy, spasticity, and cerebral palsy.

Associate Professor Walker’s major research questions are around the basic chemical energy system employed by all body cells. Adenosine triphosphate (ATP) is an essential metabolite found inside every cell, and provides its energy source. Creatine is the precursor substance for maintaining the ATP in cells, and is either synthesized in the body or obtained from the diet. The finding that creatine had beneficial effects in the brain of adults recovering from stroke has led Associate Professor Walker to investigate its potential for preventing brain damage in the developing fetus and newborn.

 

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Qualifications

DSC

Institution: Monash University

Year awarded: 2001

PERINATAL PHYSIOLOGY

Institution: Monash University

Year awarded: 1978

Publications

Journal Articles

Pasco, R., Gardner, D.K., Walker, D.W., Dickinson, H., 2012, A superovulation protocol for the spiny mouse (Acomys cahirinus), Reproduction, Fertility and Development [P], vol 24, issue 8, C S I R O Publishing, Australia, pp. 1117-1122.

Kenna, K.R., Sozo, F., De Matteo, R.M., Hanita, T., Gray, S.P., Tare, M., Moritz, K.M., Bertram, J.F., Black, M.J., Brien, J.F., Parkington, H.C., Walker, D.W., Harding, R., 2012, Alcohol exposure during late gestation: multiple developmental outcomes in sheep, Journal of Developmental Origins of Health and Disease [P], vol 3, issue 4, Cambridge University Press, UK, pp. 224-236.

Miller, S.L., Sutherland, A.E., Supramaniam, V.G., Walker, D.W., Jenkin, G., Wallace, E.M., 2012, Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner, Reproduction, Fertility and Development [P], vol 24, issue 5, C S I R O Publishing, Australia, pp. 753-758.

Miller, S.L., Wallace, E.M., Walker, D.W., 2012, Antioxidant therapies: A potential role in perinatal medicine, Neuroendocrinology [P], vol 96, issue 1, S Karger AG, Switzerland, pp. 13-23.

Ratnayake, U., Quinn, T.A., Zakhem, M.E., Dickinson, H., Walker, D.W., 2012, Behaviour and hippocampus-specific changes in spiny mouse neonates after treatment of the mother with the viral-mimetic Poly I:C at mid-pregnancy, Brain Behavior And Immunity [P], vol 26, issue 8, Academic Press, Untied States, pp. 1288-1299.

Fleiss, B., Parkington, H.C., Coleman, H.A., Dickinson, H., Yawno, T., Zakhem, M., Hirst, J.J., Walker, D.W., 2012, Effect of maternal administration of allopregnanolone before birth asphyxia on neonatal hippocampal function in the spiny mouse, Brain Research [P], vol 1433, Elsevier BV, The Netherlands, pp. 9-19.

Baburamani, A.A., Lo, C.Y., Zakhem, M.E., Walker, D.W., 2012, Morphological evaluation of the cerebral blood vessels in the late gestation fetal sheep following hypoxia in utero, Microvascular Research [P], vol 85, issue 1, Academic Press, United States, pp. 1-9.

Ireland, Z., Zakhem, M., Dickinson, H., Snow, R., Walker, D., 2011, A maternal diet supplemented with creatine from mid-pregnancy protects the newborn spiny mouse brain from birth hypoxia, Neuroscience [P], vol 194, Pergamon, United Kingdom, pp. 372-379.

Cannata, D., Crossley, K., Barclay, C.J., Walker, D., West, J., 2011, Contribution of stretch to the change of activation properties of muscle fibers in the diaphragm at the transition from fetal to neonatal life, Frontiers in Physiology [E], vol 2, issue 109, Frontiers Research Foundation, Switzerland, pp. 1-13.

Kenna, K., De Matteo, R., Hanita, T., Rees, S., Sozo, F., Stokes, V., Walker, D., Bocking, A., Brien, J., Harding, R., 2011, Daily ethanol exposure during late ovine pregnancy: Physiological effects in the mother and fetus in the apparent absence of overt fetal cerebral dysmorphology, American Journal Of Physiology-Regulatory Integrative And Comparative Physiology [P], vol 301, issue 4, American Physiological Society, USA, pp. R926-R936.

Fleiss, B., Coleman, H., Zakhem, M.E., Ireland, Z., Walker, D., Parkington, H., 2011, Effects of birth asphyxia on neonatal hippocampal structure and function in the spiny mouse, International Journal of Developmental Neuroscience [P], vol 29, issue 7, Pergamon, UK, pp. 757-766.

Croitoru-Lamoury, J., Lamoury, F.M., Caristo, M., Suzuki, K., Walker, D.W., Takikawa, O., Taylor, R., Brew, B.J., 2011, Interferon-gamma regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO), PLoS ONE [P], vol 6, issue 2 (Art. No: e14698), Public Library of Science, USA, pp. 1-13.

Yawno, T., Yan, E., Hirst, J., Walker, D., 2011, Neuroactive steroids induce changes in fetal sheep behavior during normoxic and asphyxic states, Stress-The International Journal On The Biology Of Stress [P], vol 14, issue 1, Informa Healthcare, United Kingdom, France, pp. 13-22.

Kelleher, M.A., Palliser, H.K., Walker, D.W., Hirst, J.J., 2011, Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on foetal guinea pig brain development, Journal of Endocrinology [P], vol 208, issue 3, BioScientifica Ltd, UK, pp. 301-309.

Rees, S., Harding, R., Walker, D., 2011, The biological basis of injury and neuroprotection in the fetal and neonatal brain, International Journal of Developmental Neuroscience [P], vol 29, issue 6, Pergamon, UK, pp. 551-563.

O'Connell, B., Moritz, K., Roberts, C., Walker, D., Dickinson, H., 2011, The placental response to excess maternal glucocorticoid exposure differs between the male and female conceptus in spiny mice, Biology Of Reproduction [P], vol 85, issue 5, Society for the Study of Reproduction, United States, pp. 1040-1047.

Goh, J.M., Bensley, J.G., Kenna, K.R., Sozo, F., Bocking, A.D., Brien, J.F., Walker, D.W., Harding, R., Black, M.J., 2010, Alcohol exposure during late gestation adversely affects myocardial development with implications for postnatal cardiac function, American Journal Of Physiology-Heart And Circulator..., vol 300, issue 2, American Physiological Society, USA, pp. H645-H651.

Sozo, F., Vela, M., Stokes, V., Kenna, K.R., Meikle, P.J., De Matteo, R.M., Walker, D.W., Brien, J.F., Bocking, A.D., Harding, R.L., 2010, Effects of prenatal ethanol exposure on the lungs of postnatal lambs, American Journal Of Physiology-Lung Cellular And Molecular Physiology [P], vol 300, issue 1, American Physiological Society, USA, pp. L139-L147.

Cannata, D., Ireland, Z.J., Dickinson, H., Snow, R., Russell, A.P., West, J., Walker, D.W., 2010, Maternal creatine supplementation from mid-pregnancy protects the diaphragm of the newborn spiny mouse from intrapartum hypoxia-induced damage, Pediatric Research [P], vol 68, issue 5, Lippincott Williams & Wilkins, USA, pp. 393-398.

Ligam, P., Manuelpillai, U., Wallace, E., Walker, D., 2010, NFkappaB-dependent increase of kynurenine pathway activity in human placenta: Inhibition by sulfasalazine, Placenta [P], vol 31, issue 11, Elsevier Ltd, United Kingdom, pp. 997-1002.

McKendry, A.A., Palliser, H.K., Yates, D.M., Walker, D.W., Hirst, J.J., 2010, The effect of betamethasone treatment on neuroactive steroid synthesis in a foetal guinea pig model of growth restriction, Journal of Neuroendocrinology [P], vol 22, Wiley-Blackwell Publishing Ltd, UK, The Netherlands & USA, pp. 166-174.

Ireland, Z.J., Dickinson, H., Fleiss, B., Hutton, L.C., Walker, D.W., 2009, Behavioural effects of near-term acute fetal hypoxia in a small precocial animal, the spiny mouse (Acomys cahirinus), Neonatology [P], vol 97, S. Karger AG, Switzerland, pp. 45-51.

Geng, G., Johnston, L.A., Yan, E., Britto, J.M., Smith, D.W., Walker, D.W., Egan, G.F., 2009, Biomechanisms for modelling cerebral cortical folding, Medical Image Analysis, vol 13, issue 6, Elseiver BV, The Netherlands, pp. 920-930.

Miller, S.L., Supramaniam, V.G., Jenkin, G., Walker, D.W., Wallace, E.M., 2009, Cardiovascular responses to maternal betamethasone administration in the intrauterine growth-restricted ovine fetus, American Journal Of Obstetrics And Gynecology [P], vol 201, issue 6, Mosby, Inc., USA, pp. 613.e1-613.e8.

Yan, E.B., Baburamani, A.A., Walker, A.M., Walker, D.W., 2009, Changes in cerebral blood flow, cerebral metabolites, and breathing movements in the sheep fetus following asphyxia produced by occlusion of the umbilical cord, American Journal Of Physiology-Regulatory Integrat..., vol 297, issue 1, American Physiological Society, USA, pp. R60-R69.

Ireland, Z.J., Russell, A.P., Wallimann, T., Walker, D.W., Snow, R., 2009, Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse, BMC Developmental Biology [P], vol 9, BioMed Central Ltd, UK, pp. 1-12.

Hutton, L.C., Ratnayake, U., Shields, A., Walker, D.W., 2009, Neuropathology and functional deficits in a model of birth asphyxia in the precocial spiny mouse (Acomys cahirinus), Developmental Neuroscience [P], vol 31, issue 6, S. Karger AG, Switzerland, pp. 523-535.

Hutton, L.C., Abbasszadeh, M., Dickinson, H., Ireland, Z.J., Walker, D.W., 2009, Neuroprotective Properties of melatonin in a model of birth asphyxia in the spiny mouse (Acomys cahirinus), Developmental Neuroscience [P], vol 31, issue 5, S. Karger AG, Switzerland, pp. 437-451.

Sozo, F., O'Day, L.D., Maritz, G., Kenna, K.R., Stacy, V., Brew, N., Walker, D.W., Bocking, A.D., Brien, J.F., Harding, R., 2009, Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung, American Journal of Physiology: Lung Cellular and Molecular Physiology, vol 296, American Physiological Society, United States, pp. 1-38.

Yawno, T., Hirst, J.J., Zakhem, M.E., Walker, D.W., 2009, Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain, Neuroscience [P], vol 163, issue 3, Pergamon, UK, pp. 838-847.

Hirst, J.J., Walker, D.W., Yawno, T., Palliser, H.K., 2009, Stress in pregnancy: A role for neuroactive steroids in protecting the fetal and neonatal brain, Developmental Neuroscience [P], vol 31, issue 5, S Karger AG, Switzerland, pp. 363-377.

Rees, S.M., Harding, R., Walker, D.W., 2008, An adverse intrauterine environment: implications for injury and altered development of the brain, International Journal of Developmental Neuroscience, vol 26, Pergamon-Elsevier Science Ltd, Oxford, England, UK, pp. 3-11.

Dickinson, H., Griffiths, T., Walker, D.W., Jenkin, G., 2008, Application of clinical indices of fetal growth and wellbeing to a novel laboratory species, the spiny mouse, Reproductive Biology, vol 8, issue 3, Towarzystwo Biologil Rozrodu, Poland, pp. 229-243.

Westcott, K.T., Hirst, J.J., Ciurej, I.A., Walker, D.W., Wlodek, M.E., 2008, Brain allopregnanolone in the fetal and postnatal rat in response to uteroplacental insufficiency, Neuroendocrinology, vol 88, issue 4, S. Karger AG, Switzerland, pp. 287-292.

Owe-Young, R., Webster, N.L., Mukhtar, M., Pomerantz, R.J., Smythe, G., Walker, D.W., Armati, P.J., Crowe, S.M., Brew, B.J., 2008, Kynurenine pathway metabolism in human blood-brain-barrier cells: implications for immune tolerance & neurotoxicity, Journal of Neurochemistry, vol 105, issue 4, Wiley-Blackwell Publishing Ltd, UK, pp. 1346-1357.

Ireland, Z.J., Dickinson, H., Snow, R.J., Walker, D.W., 2008, Maternal creatine: Does it reach the fetus and improve survival after an acute hypoxic episode in the spiny mouse (Acomys cahirinus)?, American Journal of Obstetrics and Gynecology, vol 198, issue 4, Mosby, Inc., United States, pp. 431.e1-431.e6.

Hutton, L.C., Castillo-Melendez, M., Smythe, G.A., Walker, D.W., 2008, Microglial activation, macrophage infiltration, and evidence of cell death in the fetal brain after uteroplacental administration of lipopolysaccharide in sheep in late gestation, American Journal of Obstetrics and Gynecologyy, vol 198, issue 1, Mosby, Inc., United States, pp. 117.e1-117.e11.

Hirst, J.J., Palliser, H.K., Yates, D.H., Yawno, T., Walker, D.W., 2008, Neurosteroids in the fetus and neonate: Potential protective role in compromised pregnancies, Neurochemistry International, vol 52, Pergamon-Elsevier Science Ltd, Oxford, England,UK, pp. 602-610.

Dickinson, H., Walker, D.W., Zakhem, M.E., 2008, Onset of feeding at birth-Perinatal development of the hypothalamic mechanisms that induce appetite and feeding in the newborn, Neuroscience Letters, vol 436, issue 1, Elsevier Ireland Ltd, Ireland, pp. 1-6.

Gray, S.P., Kenna, K.R., Bertram, J.F., Hoy, W.E., Yan, E.B., Bocking, A.D., Brien, J.F., Walker, D.W., Harding, R., Moritz, K.M., 2008, Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep, American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol 295, issue 2, American Physiological Society, USA, pp. 568-574.

Dickinson, H., Moritz, K.M., Wintour-Coghlan, M.E., Walker, D.W., Kett, M.M., 2007, A comparative study of renal function in the desert-adapted spiny mouse and the laboratory-adapted C57BL/6 mouse: Response to dietary salt load, American Journal of Physiology - Renal Physiology, vol 293, issue 4, American Physiological Society, Bethesda MD USA, pp. F1093-F1098.

Yawno, T., Yan, E.B., Walker, D.W., Hirst, J.J., 2007, Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep, Neuroscience, vol 146, issue 4, Pergamon-Elsevier Science Ltd, Oxford England UK, pp. 1726-1733.

Hutton, L.C., Yan, E.B., Yawno, T., Castillo-Melendez, M., Hirst, J.J., Walker, D.W., 2007, Injury of the developing cerebellum: A brief review of the effects of endotoxin and asphyxial challenges in the late gestation sheep fetus, Cerebellum, vol E-Pub, Taylor & Francis Ltd, Abingdon, England, UK, pp. 1-10.

Dickinson, H., Walker, D.W., Wintour-Coghlan, M.E., Moritz, K.M., 2007, Maternal dexamethasone treatment at midgestation reduces nephron number and alters renal gene expression in the fetal spiny mouse, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, vol 292, issue 1, American Physiological Society, Bethesda USA, pp. 453-461.

Hirst, J., Yawno, T., Nguyen, P., Walker, D.W., 2007, Stress in pregnancy activates neurosteroid production in the fetal brain, Neuroendocrinology, vol 84, issue 4, S Karger AG, Switzerland, pp. 264-274.

Miller, S.L., Chai, M., Loose, J.M., Castillo-Melendez, M., Walker, D.W., Jenkin, G., Wallace, E.M., 2007, The effects of maternal betamethasone administration on the intrauterine growth-restricted fetus, Endocrinology, vol 148, issue 3, The Endocrine Society, Chevy Chase USA, pp. 1288-1295.

Hutton, L.C., Castillo-Melendez, M., Walker, D.W., 2007, Uteroplacental inflammation results in blood brain barrier breakdown, increased activated caspase 3 and lipid peroxidation in the late gestation ovine fetal cerebellum, Developmental Neuroscience, vol 29, issue 4-5, Karger, Basel, Switzerland, pp. 341-354.

Billiards, S.S., Nguyen, P., Scheerlinck, J., Phillips, D.J., Canny, B.J., Walker, D.W., Hirst, J.J., 2006, Hypoxia potentiates endotoxin-induced allopregnanolone concentrations in the newborn brain, Biology of the Neonate, vol 90, issue 4, S Karger AG, Switzerland, pp. 258-267.

McClure, L., O'Connor, A.E., Hayward, S., Jenkin, G., Walker, D.W., Phillips, D.J., 2005, Effects of age and pregnancy on the circulatory activin response of sheep to acute inflammatory challenge by lipopolysaccharide, Journal of Endocrinology, vol 185, issue 1, Society for Endocrinology, UK, pp. 139-149.

Castillo-Melendez, M.E., Yan, E.B., Walker, D.W., 2005, Expression of erythropoietin and its receptor in the brain of late-gestation fetal sheep, and responses to asphyxia caused by umbilical cord occlusion, Developmental Neuroscience, vol 27, issue 2-4, S Karger AG, Switzerland, pp. 220-227.

Manuelpillai, U.C., Ligam, P., Smythe, G., Wallace, E.M., Hirst, J.J., Walker, D.W., 2005, Identification of kynurenine pathway enzyme mRNAs and metabolites in human placenta: up-regulation by inflammatory stimuli and with clinical infection, American Journal of Obstetrics & Gynaecology, vol 192, issue 1, Mosby, Inc., USA, pp. 280-288.

Ligam, P., Manuelpillai, U.C., Wallace, E.M., Walker, D.W., 2005, Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: implications for role of the kynurenine pathway in pregnancy, Placenta, vol 26, issue 6, W B Saunders Co. Ltd, UK, pp. 498-504.

Miller, S.L., Yan, E.B., Castillo-Melendez, M.E., Jenkin, G., Walker, D.W., 2005, Melatonin provides neuroprotection in the late-gestation fetal sheep brain in response to umbilical cord occlusion, Developmental Neuroscience, vol 27, issue 2-4, S Karger AG, Switzerland, pp. 200-210.

Yan, E.B., Unthank, J.K., Castillo-Melendez, M.E., Miller, S.L., Langford, S.J., Walker, D.W., 2005, Novel method for in vivo hydroxyl radical measurement by microdialysis in fetal sheep brain in utero, Journal of Applied Physiology, vol 98, issue 6, American Physiological Society, USA, pp. 2304-2310.

Yan, E., Zakhem, M., Smythe, G., Walker, D., 2005, Quinolinic acid promotes albumin deposition in Purkinje cell, astrocytic activation and lipid peroxidation in fetal brain, Neuroscience [P], vol 134, issue 3, Pergamon, United Kingdom, pp. 867-875.

Dickinson, H., Walker, D.W., Cullen-McEwen, L.A., Wintour, E., Moritz, K.M., 2005, The spiny mouse (Acomys cahirinus) completes nephrogenesis before birth, American journal of Physiology - Renal Physiology, vol 289, issue 2, Amer Physiological Society, Bethesda USA, pp. F273-F279.

Nguyen, P., Young, I.R., Walker, D.W., Hirst, J.J., 2004, Allopregnanolone in the brain and blood after disruption of the hypothalamic-pituitary-adrenal axis in fetal sheep, Journal of Endocrinology, vol 182, issue 1, Society for Endocrinology, Bristol UK, pp. 81-88.

Yan, E.B., Castillo-Melendez, M.E., Nicholls, T.A., Hirst, J.J., Walker, D.W., 2004, Cerebrovascular responses in the fetal sheep brain to low-dose endotoxin, Pediatric Research, vol 55, issue 5, International Pediatric Research Foundation, Inc., Baltimore USA, pp. 855-863.

Nguyen, P., Yan, E.B., Castillo-Melendez, M.E., Walker, D.W., Hirst, J.J., 2004, Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion, Journal of Physiology, vol 560, issue 2, Blackwell Publishing Ltd, Oxford UK, pp. 593-602.

Castillo-Melendez, M.E., Chow, J.M., Walker, D.W., 2004, Lipid peroxidation, caspase-3 immunoreactivity, and pyknosis in late-gestation fetal sheep brain after umbilical cord occlusion, Pediatric Research, vol 55, issue 5, International Pediatric Research Foundation, Inc., USA, pp. 864-871.

Nguyen, P.N., Billiards, S.S., Walker, D.W., Hirst, J.J., 2003, Changes in 5alpha-Pregnane Steroids and Neurosteroidogenic Enzyme Expression in Fetal Sheep with Umbilicoplacental Embolization, Pediatric Research, vol 54, issue 6, International Pediatric Research Foundation, Inc., Baltimore USA, pp. 840-847.

Nguyen, P.N., Billiards, S.S., Walker, D.W., Hirst, J.J., 2003, Changes in 5alpha-pregnane steroids and neurosteroidogenic enzyme expression in the perinatal sheep, Pediatric Research, vol 53, issue 6, International Pediatric Research Foundation, Inc., Baltimore USA, pp. 956-964.

Manuelpillai, U.C., Nicholls, T.A., Wallace, E.M., Phillips, D.J., Guillemin, G., Walker, D.W., 2003, Increased mRNA expression of kynurenine pathway enzymes in human placentae exposed to bacterial endotoxin, Advances in Experimental Medicine and Biology, vol 527, Kluwer Academic/Plenum Publishers, USA, pp. 85-89.

Craig, A., Luo, N.L., Beardsley, D.J., Wingate-Pearse, N., Walker, D.W., Hohimer, A.R., Back, S.A., 2003, Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human, Experimental Neurology, vol 181, issue 2, Academic Press, San Diego USA, pp. 231-240.

Crossley, K.J., Nitsos, I., Walker, D.W., Lawrence, A.J., Beart, P.M., Hirst, J.J., 2003, Steroid-sensitive GABAA receptors in the fetal sheep brain, Neuropharmacology, vol 45, issue 4, Pergamon-Elsevier Science Ltd, Oxford UK, pp. 461-472.

Smythe, G.A., Braga, O., Brew, B.J., Grant, R.S., Guillemin, G.J., Kerr, S.J., Walker, D.W., 2002, Concurrent Quantification of Quinolinic, Picolinic, and Nicotinic Acids Using Electron-Capture Negative-Ion Gas Chromatography-Mass Spectrometry, Analytical Biochemistry, vol 301, issue 1, Elsevier Science Ltd, USA, pp. 21-26.

Tolcos, M., Rees, S.M., McGregor, H.P., Walker, D.W., 2002, Consequences of intauterine growth restriction on ventilatory and thermoregulatory responses to asphyxia and hypercapnia in the newborn guinea-pig, Reproduction, Fertility and Development, vol 14, issue 2, CSIRO Publishing, Australia, pp. 85-92.

Billiards, S.S., Walker, D.W., Canny, B., Hirst, J.J., 2002, Endotoxin increases sleep and brain alloprenanolone concentrations in newborn lambs, Pediatric Research, vol 52, issue 6, Lippincott, Williams and Wilkins, USA, pp. 892-899.

Santoso, D., Rogers, P., Wallace, E.M., Manuelpillai, U.C., Walker, D.W., Bekti Subakir, S., 2002, Localization of Indoleamine 2,3-Dioxygenase and 4-Hydroxynonenal in Normal and Pre-eclamptic Placentae, Placenta, vol 23, issue 5, WB Saunders, Elsevier Science Ltd, London UK, pp. 373-379.

Lee, B., Hirst, J.J., Walker, D.W., 2002, Prostaglandin D Synthase in the Prenatal Ovine Brain and Effects of Its Inhibition with Selenium Chloride on Fetal Sleep/Wake Activity In Utero, The Journal of Neuroscience, vol 22, issue 13, Society for Neuroscience, USA, pp. 5679-5687.

Nardo, L., Soong, Y., Wu, D., Young, I., Walker, D.W., Szeto, H.H., 2002, Site and mechanism of action of dynorphin A-(1-13) and N-methyl-D-aspartate on ACTH release in fetal sheep, American Journal of Physiology-Endocrinology and Metabolism, vol 282, issue 6, American Physiological Society, USA, pp. E1301-E1307.

Nicol, M.B., Hirst, J.J., Walker, D.W., 2001, Effect of finasteride on behavioural arousal and somatosensory evoked potentials in fetal sheep, Neuroscience Letters, vol 306, issue 1-2, Elsevier Science Ltd, Oxford UK, pp. 13-16.

Nicholls, T.A., Nitsos, I., Smythe, G.A., Walker, D.W., 2001, Kynurenine production and catabolism in fetal sheep with embolized or nonembolized placentas, American Journal of Obstetrics and Gynecology, vol 185, issue 4, Mosby Inc, St Louis MO USA, pp. 988-995.

Nicholls, T.A., Lacey, B.M., Nitsos, I., Smythe, G.A., Walker, D.W., 2001, Regional changes in kynurenic acid, quinolinic acid, and glial fibrillary acidic protein concentrations in the fetal sheep brain after experimentally induced placental insufficiency, American Journal of Obstetrics and Gynecology, vol 184, issue 2, Mosby Inc, St Louis MO USA, pp. 203-208.

Crossley, K.J., Walker, D.M., Beart, P.M., Hirst, J.J., 2000, Characterisation of GABAA receptors in fetal, neonatal and adult ovine brain: region and age related changes and the effects of allopregnanolone, Neuropharmacology, vol 39, Pergamon-Elsevier, Oxford England, pp. 1514-1522.

Hirst, J.J., Egodagamage, K.C., Walker, D.M., 2000, Effect of a neuroactive steroid infused into the cerebral ventricles of fetal sheep in utero using small infusion volumes, Journal of neuroscience methods, vol 97, Elsevier Science, www.elsevier.nl, pp. 37-44.

West, J.M., Williams, N.A., Luff, A.R., Walker, D.M., 2000, Effect of tibial bone resection on the development of fast- and slow-twitch skeletal muscles in foetal sheep, Journal of Muscle Research and CellMotility, vol 21, Kluwer Academic Publishers, Dordrecht Netherland, pp. 209-222.

Miller, S., Jenkin, G., Walker, D.M., 2000, Effects of hyperthermia on uterine blood flow and shunting through uterine arteriovenous anastomoses in the late-pregnant ewe, Reproduction Fertility and Development, vol 11 issue 45, CSIRO Publications, Melbourne Vic Australia, pp. 201-209.

Walker, D.M., Lee, B., Nitsos, I., 2000, Effects of hypoxia on respiratory activity in the foetus, Clinical and Experimental Pharmacology and Physiology, vol 27, Blackwells, Melbourne Vic Australia, pp. 110-113.

Tolcos, M., Mallard, C., McGregor, H.P., Walker, D.M., Rees, S., 2000, Exposure to prenatal carbon monoxide and postnatal hyperthermia: short and long term effects pmneurochemicals and neuroglia in the developing brain, Experimental neurology, vol 162 issue 2, Academic Press, San Diego California USA, pp. 235-246.

Petratos, S., Hirst, J.J., Mendis, S., Anikijenko, P., Walker, D.M., 2000, Localization of P450scc and 5alpha-reductase type-2 in the cerebellum of fetal and newborn sheep, Developmental Brain Research, vol 123, Elsevier Science, www.elsevier.nl, pp. 81-86.

Nitsos, I., Walker, D.M., 1999, Characterisation of pontine neurons which respond to hypoxia in fetal sheep, Neuroscience Letters, vol 266 issue 1, Elsevier Science, http://www.elsevier.com, pp. 33-36.

Walker, D.M., Curtis, B., Lacey, B., Nitsos, I., 1999, Concentrations of Kynurenic acid in the brain and cerebrospinal fluid of fetal, newborn and adult sheep, Pediatric Research, vol 45, International Pediatric Research Foundation Inc, Baltimore MD USA, pp. 820-826.

West, J.M., Barclay, C.J., Luff, A.R., Walker, D.M., 1999, Developmental changes in the activation properties and ultrastructure of fast- and slow-twitch muscles from fetal sheep, Journal of Muscle Research and Cell Motility, vol 20 issue 3, Kluwer Academic Publishers, Dordrecht Netherland, pp. 249-264.

Nicol, M., Hirst, J.J., Walker, D.M., 1999, Effects of pregnanolone on behaviour parameters and the response to GABA-A receptor antagonists in the late gestation fetal sheep, Neuropharmacology, vol 38 issue 1, Elsevier Science, http://www.elsevier.com, pp. 49-63.

Lee, B., Nitsos, I., Walker, D.M., 1999, Effects of the respiratory stimulant Almitrine on breathing and FOS expression in the brain of fetal and newborn sheep, Pediatric Research, vol 45 issue 4, International Pediatric Research Foundation Inc, Baltimore MD USA, pp. 531-543.

Nitsos, I., Walker, D.M., 1999, The distribution of FOS-immunoreactive neurons in the brainstem, midbrain and diencephalon of fetal sheep in response to acute hypoxia in mid and late gestation fetal sheep, Developmental Brain Research, vol 114 issue 1, Elsevier Science, http://www.elsevier.com, pp. 9-26.

Miller, S., Jenkin, G., Walker, D.M., 1999, The effects of nitric oxide synthase inhibition on the uterine vasculature of the late pregnant ewe, American Journal of Obstetrics and Gynaecology, vol 180, Mosby-Year Book Inc, St Louis MO USA, pp. 1138-1145.

Nicholls, T., Walker, D.M., Nitsos, I., 1999, Tryptophan metabolism in pregnant sheep: increased fetal kynurenine production in response to maternal tryptophan loading, American Journal of Obstetrics and Gynecology, vol 181, Mosby, http://www.mosby.com, pp. 1452-1460.

Walsh, J.P., Clarke, I.J., 1998, Blockade of the oestrogen-induced luteinizing hormone surge in ovariectomized ewes by a highly selective opioid receptor agonist: Evidence for site of action, Neuro Endorinonology, vol 67, Blackwell Science, UK, pp. 164-170.

Read, P.A., Horne, R.S., Cranage, S.M., Walker, A.M., Walker, D.M., Adamson, T.M., 1998, Dynamic changes in arousal threshold during sleep in the human infant, Pediatric Research, vol 43 (5), American Pediatric Society, Baltimore USA, pp. 697-703.

Read, P.A., Horne, R.K., Cranage, S.M., Walker, A.M., Walker, D.M., Adamson, M.M., 1998, Dynamic changes in arousal threshold during sleep in the human infant, Pediatric Research, vol 43 no 5, Williams & Wilkins, Baltimore USA, pp. 697-703.

Read, P.A., Horne, R.S., Cranage, S.M., Walker, A.M., Walker, D.M., Adamson, T.M., 1998, Dynamic changes in arousal threshold during sleep in the human infant, Pediatric Research, vol 43 (5), American Pediatric Society, Baltimore USA, pp. 697-703.

Read, P.A., Horne, R.K., Cranage, S.M., Walker, A.M., Walker, D.M., Adamson, T.M., 1998, Dynamic changes in the arousal threshold during sleep in the human infant, PEDIATRIC RESEARCH, vol 43 (5), WILLIAMS & WILKINS COMPANY, HTTP://WWW.WWILKINS.COM/PDR, pp. 1-7.

Nicol, M., Hirst, J.J., Walker, D.M., 1998, Effect of pregnane steroids on electrocortical activity and somatosensory evoked potentials in fetal sheep, Neuroscience Letters, vol 253, Elsevier Science Ltd, Amsterdam Netherlands, pp. 111-114.

Kazda, H., Taylor, N., Healy, D.W., Walker, D.M., 1998, Maternal umbilical and amniotic fluid concentrations of tryptophan and kynurenine after labour or caesarian section, Pediatric Research, vol 44 (3), American Pediatric Society, Baltimore USA, pp. 368-373.

Miller, S., Dickson, K.A., Jenkin, G., Walker, D.M., 1998, Physiological evidence for arterioivenous anastomoses in the unterine circulation of late pregnant ewes, Clinical and Experimental Pharmacology and Physiology, vol 25, Blackwell Science, Melbourne Vic Australia, pp. 92-98.

Walsh, J.P., Simmons, D.M., Clarke, I.J., 1998, Proopiomelanocortin mRNA levels in ovine hypothalamus are not reduced at the time of the preovulatory luteinising hormone surge, Journal of Neuroendocrinology, vol 10, Blackwell Science, UK, pp. 803-808.

McGregor, H.P., Walker, D.M., 1998, The effect of prenatal exposure to carbon monoxide on breathing and growth of the newborn guinea pig, Pediatric Research, vol 43 (1), American Pediatric Society, Baltimore USA, pp. 126-131.

Nicol, M., Hirst, J.J., Walker, D.M., Thorburn, G.D., 1997, Effect of alteration of maternal plasma progesterone concentrations on fetal behavioural state during late gestation, Journal of Endocrinology, vol 152, Journal of Endocrinology ltd, UK, pp. 379-386.

Breen, S., Rees, S.M., Walker, D.M., 1997, Identification of brainstem neurons responding to hypoxia in fetal and neonatal sheep, Brain Research, vol 748, Elsevier Science BV, Amsterdam Netherlands, pp. 107-121.

Conference Proceedings

Manuelpillai, U.C., Ligam, P., Walker, D.W., Wallace, E.M., 2006, Effects of betamethasone and sulfasalazine on placental production of the neurotoxin quinolinic acid, Journal of The Society for Gynecologic Investigation, 22-25 March, Elsevier Science Inc, New York NY USA, p. 182A.

Luff, A.R., West, J.M., Walker, D.M., 1999, Effect of tibial section on the development of fast- and slow-twitch skeletal muscles in fetal sheep, An Annual Meeting of Professional Research Scientists: Experimental Biology 99, Washington DC USA 17-20 April 1999, Federation American Society of Experimental Bioloy, Danvers MA USA, p. 1009A.

Crossley, K.J., Walker, D.M., Beart, P.M., Hirst, J.J., 1999, Modulation of GABAa receptors in the fetal sheep brain by neuroactive steroids, Proceedings of the Australian Neuroscience Society, Hobart, TAS, Jan 1999, Aust Neurosci Society, Melbourne Vic Australia, pp. 29-Oral 2-5.

Nitsos, I., Walker, D.M., 1998, Characterisation of pontine neurons with cervical projections which express FOS protein in response to hypoxia in fetal sheep, Proceedings of the Australian Neuroscience Society, Canberra ACT 27-30 January 1998, Australian Neuroscience Society, Sydney NSW Australia, p. 75.

Lacey, B., Nitsos, I., Walker, D.M., 1998, Does carbon monoxide exposure during pregnancy ablate the postpartum decrease of glial fibrillary acidic protein (GFAP) in the brains of maternal and newborn guinea pigs?, Proceedings of the 2nd Annual Perinatal Society of Australia and New Zealand Congress, Alice Springs NT 29 March - 1 April 1998, Wyeth Clinical Services, Sydney NSW Australia, p. 198.

Nicol, M., Hirst, J.J., Walker, D.M., 1998, Effects of pregnanolone and iso-pregnanolone on fetal cortical evoked potentials during high- and low-voltage ECoG, Proceedings of the Australian Neuroscience Society, Canberra ACT 27-30 January 1998, Australian Neuroscience Society, Melbourne Vic Australia, p. 75.

Walsh, J.P., Wood, C., Maher, P., 1998, Establishment of fibroid clinic, Australian Gynaecological Endoscopy Society 1998 Scientific Meeting, Melbourne, 3-6 June 1998, Australian Gynaecological Endoscopy Society, Melbourne Vic Australia, p. 10.

Crossley, K.J., Walker, D.M., Beart, P.M., Hirst, J.J., 1998, GABAA receptors in the fetal and neonatal bovine brain, Proceedings of the Australian Neuroscience Society, Canberra ACT 27-30 January 1998, Australian Neuroscience Society, Melbourne Vic Australia, p. 142.

Crossley, K.J., Walker, D.M., Beart, P.M., Hirst, J.J., 1998, GABAA receptors in the fetal and neonatal ovine brain, Proceedings of the Australian Neuroscience Society, Canberra, ACT, Jan. 1998, Australian Neuroscience Society, Canberra ACT Australia, p. 142.

Hirst, J.J., Minekus, M.P., Nitsos, I., Walker, D.M., 1998, GABAA subunit expression in the fetal brain: evidence for pregnant esteroid regulation of fetal behavioural activity, Proceedings of the 2nd Annual Congress of the Perinatal Society of Australia and New Zealand, Alice Springs NT 29 March - 1 April 1998, Perinatal Society of Australia and New Zealand, Paramatta NSW, p. 29.

Nitsos, I., Walker, D.M., 1998, Increased production of the neuroactive precursor kynurenine from tryptophan in late gestation fetal sheep, Proceedings of the 2nd Perinatal Society of Australia and New Zealand Congress, Alice Springs NT 29 March-1 April 1998, Wyeth Clinical Services, Sydney NSW Australia, p. 31.

Lee, B., Hirst, J.J., Walker, D.M., 1998, Prostaglandin D2 and E2 in hypothalamus and cortex of fetal and neonatal sheep, Proceedings of the Australian Neuroscience Society, Canberra ACT 27-30 January 1998, Australian Neuroscience Society, Melbourne Vic Australia, p. 190.

Crossley, K.J., Walker, D.M., Beart, P.M., Hirst, J.J., 1998, Region specific and age-related changes in GABAA receptor binding parameters in fetal sheep, Journal of Sleep Research, Madrid,Spain Sept.1998, Blackwell Science, London UK, p. 52 A103.

West, J.M., Luff, A.R., Walker, D.M., 1998, The effect of hypophysectomy on the activation profiles of developing fast- and slow-twitch hindlimb muscles of fetal sheep, Proceedings of the Australian Physiological and Pharmacological Society, Brisbane Queensland 27 September - 1 October 1998, Aust Physiological and Pharmacological Society, Vic Australia, p. 349P.

Rees, S.M., Tolcos, M., Mallard, C., McGregor, H.P., Walker, D.M., 1997, Brain Development and the consequences of prenatal exposure to carbon monoxide and nicotine, 11th Australian SIDS Conference - Programme and Abstracts, Melbourne, 20-22 June 1997, National SIDS Council of Australia, Melbourne Vic Australia, p. 304.

West, J.M., Barclay, C.J., Luff, A.R., Walker, D.M., 1997, Ca2+ -and Sr2+ - activation poperties of fase - and slow-twitch muscles in fetal sheep: contrast with the developmental changes of isometric contractions, Fetal and Neonatal Physiology Symposium, Cambridge UK, 25-29 June 1997, R & W Publications Ltd, Cambridge UK, p. 118.

Nitsos, I., Rajan, R., Walker, D.M., 1997, Characterisation of spinal projecting neurons in the pons which express Fos immunoreactivity during hypoxia in fetal sheep, Proceedings Society for Neuroscience, New Orleans USA,25-30 October, Society for Neuroscience, USA, p. 436.

Curtis, B., Nitsos, I., Walker, D.M., 1997, Concentrations of kynurenic acid in brain and cerebrospinal fluid of fetal, newborn and adult sheep, Symposium on Fetal and Neonatal Physiology, Cambridge UK, 25-29 June 1997, R & W Publications Ltd, Cambridge UK, p. 85.

Kazda, H., Taylor, N., Healy, D.W., Walker, D.M., 1997, Concentrations of tryptophan and kynurenine in umbilical vein blood and amniotic fluid after vaginal or caesarean delivery, Fetal and Neonatal Physiological Society, St Margherita Ligure Italy,15-18 June 1997, Fetal and Neonatal Physiological Society, Genoa Italy, p. 68.

Nicol, M., Hirst, J.J., Aumann, T.D., Walker, D.M., 1997, Effects of pregnanolone and trilostane on fetal spinal reflexes and cortical evoked potentials, Proceedings Society of Neuroscience, New Orleans USA, 25-30 October, Society for Neuroscience, USA, p. 312.

Nicol, M., Hirst, J.J., Thorburn, G.D., Walker, D.M., 1997, Effects of pregnanolone and trilostane on fetal spinal reflexes and evoked potentials, Fetal and Neonatal Physiological Society Proceedings, S Margherita Ligure Genoa Italy, 15-18 June 1997, Fetal & Neonatal Physiological Society, Genoa Italy, p. 70.

Nitsos, I., Walker, D.M., 1997, FOS-immunoreactive neurons in the brain of fetal sheep in response to acute hypoxia at 100 and 133 days gestation, 24th Annual Meeting, Fetal & Neonatal Physiological Society, St Margherita Ligure Genoa Italy, 15-18 June 1997, Fetal & Neonatal Physiological Society, Genoa Italy, p. 88.

Tolcos, M., Mall, E., McGregor, H.P., Walker, D.M., Rees, S.M., 1997, Is the brainstem vulnerable to prenatal carbon monoxide exposure?, Proceedings of the Society for Neuroscience, New Orleans USA,25-30 October, Society for Neuroscience, Washington DC USA, p. 2252.

Miller, S., Jenkin, G., Walker, D.M., 1997, Physiological evidence for the presence of arteriovenous anastomoses in the uterine circulation of late pregnant sheep, Fetal and Neonatal Physiological Society, St Margherita Ligure Genoa Italy,15-18 June 1997, Fetal and Neonatal Physiological Society, Genoa Italy, p. 69.

Miller, S., Jenkin, G., Walker, D.M., 1997, Physiological evidence for the presence of arteriovenous anastomoses in the uterine circulation of late-pregnant ewes, Fetal & Neonatal Physiology Symposium/IUPS Congress Abstract Handbook, Cambridge UK, 25-29 June 1997, R & W Publications, Cambridge UK, p. 97.

Tolcos, M., McGregor, H.P., Walker, D.M., Rees, S.M., 1997, Prenatal carbon monoxide exposure affects brainstem development, Australian Neuroscience Society, Newcastle Australia, 2-5 February 1997, Australian Neuroscience Society, Australia, p. 35.

Tolcos, M., McGregor, H.P., Walker, D.M., Rees, S.M., 1997, Structural and neurochemical development of the brainstem following prenatal exposure to carbon monoxide, 11th Australian SIDS Conference - Programme & Abstracts, Melbourne, 20-22 June 1997, National SIDS Council of Australia, Melbourne Vic Australia, p. 103.

Nitsos, I., Walker, D.M., 1997, The distribution fos-immunoreactive neurons in the brain of fetal sheep in response to acute hypoxia, 11th Australian SIDS Conference 1997, Melbourne,20-22 June 1997, National SIDS Council of Australia, Melbourne Vic Australia, p. 134.

Miller, S., Jenkin, G., Walker, D.M., 1997, The effects of nitric oxide inhibition of the uterine vasculature of the late-pregnant ewe, Fetal and Neonatal Physiological Society, Santa Margherito, Genoa, Italy, 15-18 June, Fetal and Neonatal Physiological Society, Italy, p. 9.

Mallard, E., Tolcos, M., McGregor, H.P., Walker, D.M., Rees, S.M., 1997, The effects of prenatal exposure to carbon monoxide on neuroglial and tyrosine hydroxylase expression in the brain, 11th Australian SIDS Conference 1997 - Programme & Abstracts, Melbourne,20-22 June 1997, National SIDS Council of Australia, Melbourne Vic Australia, p. 104.

Grants

Title:

Autoclave.

Investigators:

Perkins, A, Proske, U, Walker, D, Hooper, S

Funding:

(1999 - 1999). National Health & Medical Research Council (NHMRC).

Title:

Cerebrovascular Effects of Intrauterine Hypoxia: Contribution to Perinatal Brain Injury.

Investigators:

Walker, D, Zakhem, M

Funding:

(2009 - 2012). National Health & Medical Research Council (NHMRC).

(2010 - 2014). National Health & Medical Research Council (NHMRC).

Title:

Contribution of disturbed blood flow and cerebral metabolism to white matter damage in the perinatal brain ID: 334074.

Investigators:

Walker, D, Hirst, J, Walker, A, Zakhem, M

Funding:

(2005 - 2009). National Health & Medical Research Council (NHMRC).

(2010 - 2014). National Health & Medical Research Council (NHMRC).

Title:

Creatine Synthesis and Transport in the Fetus - Critical Regulation of Energy Supply for Fetal Growth and Survival?.

Investigators:

Walker, D, Snow, R, Young, R

Funding:

(2007 - 2011). National Health & Medical Research Council (NHMRC).

(2010 - 2014). National Health & Medical Research Council (NHMRC).

Title:

Creatine supplementation during pregnancy as a means of improving outcomes from preterm birth.

Investigators:

Walker, D, Snow, R, De Matteo, R, Wong, F, Dickinson, H, Polglase, G

Funding:

(2013 - 2017). National Health & Medical Research Council (NHMRC).

Title:

Creatine, a multi-organ protectant against hypoxic injury in the neonate.

Investigators:

Dickinson, H, Walker, D, Snow, R, Wong, F

Funding:

(2013 - 2017). National Health & Medical Research Council (NHMRC).

Title:

DEXA body composition and bone density analysis suite.

Investigators:

Clarke, I, Mitchell, C, Cowley, M, Tiganis, T, Oldfield, B, Rosa, M, Walker, D, Lackmann, M, Watt, M, Armitage, J, Denton, K, Evans, R, Kett, M, Brown, R, Tilbrook, A, Andrews, Z, Smith, J, Spencer, S, Strauss, B, Simpson, E, Williams, B

Funding:

(2009 - 2013). National Health & Medical Research Council (NHMRC).

Title:

Endothelial progenitor cells in fetal blood and brain: Role in repair and recovery from developmental brain injury.

Investigators:

Zakhem, M, Gargett, C, Walker, D

Funding:

(2011 - 2015). Heart Foundation.

Title:

Essential Protective Role of Neuroactive Steroids in the Fetal and Neonatal Brain - Research Fellowship.

Investigators:

Hirst, J, Walker, D

Funding:

(2001 - 2005). National Health & Medical Research Council (NHMRC).

Title:

Hypoxia-induced bleeding in the fetal and newborn brain: a cause of cerebral palsy preventable by supplementing the mother's diet with creatine?.

Investigators:

Walker, D

Funding:

(2010 - 2014). Cerebral Palsy Foundation.

Title:

Identifying regulatory and therapeutic target in perinatal white matter injury following intrauterine growth restriction.

Investigators:

Tolcos, M, Walker, D, Rowitch, D

Funding:

(2012 - 2017). Research Foundation of Cerebral Palsy Alliance.

Title:

Maternal Infection and Perinatal Brain Damage - the Role of the Placenta in Protecting Or Damaging the Developing Brain.

Investigators:

Walker, D, Hirst, J, Phillips, I, Wallace, E

Funding:

(2001 - 2005). March Of Dimes Birth Defects Foundation.

(2001 - 2009). March Of Dimes Birth Defects Foundation.

Title:

NHMRC 1995 Project - Walker.

Investigators:

Walker, D

Funding:

(1999 - ). National Health & Medical Research Council (NHMRC).

Title:

NHMRC 1997 Project - Hirst/Walker.

Investigators:

Hirst, J, Walker, D

Funding:

(1999 - ). National Health & Medical Research Council (NHMRC).

Title:

NHMRC Research Fellowship.

Investigators:

Walker, D

Funding:

(2001 - 2004). National Health & Medical Research Council (NHMRC).

(2005 - 2010). National Health & Medical Research Council (NHMRC).

(2006 - 2014). National Health & Medical Research Council (NHMRC).

(2007 - 2011). National Health & Medical Research Council (NHMRC).

(2010 - 2014). National Health & Medical Research Council (NHMRC).

(2012 - 2016). National Health & Medical Research Council (NHMRC).

(2013 - 2017). National Health & Medical Research Council (NHMRC).

Title:

Neuro-protection in the Preterm Brain - A New Role for Dopamine Therapy?.

Investigators:

Wong, F, Walker, D, Miller, S

Funding:

(2012 - 2016). National Health & Medical Research Council (NHMRC).

Title:

Neuroactive Steroids in the Fetal Brain: Role in the Regulation of Behaviour and Protection Against Hypoxia - Application Also for a Research Fellowship- Bridging Funding (gms Id 000426).

Investigators:

Hirst, J, Walker, D, Von Itzstein, M

Funding:

(2000 - 2004). National Health & Medical Research Council (NHMRC).

Title:

Neurochemical control of fetal breathing movements and other muscle acitvity.

Investigators:

Walker, D

Funding:

(1991 - 1995). National Health & Medical Research Council (NHMRC).

Title:

Oxylite Tm 2 Channel System Plus Oxydata Tm Recording System - Equipment Grant 2000.

Investigators:

Jarrott, B, Walker, D, Callaway, J

Funding:

(2001 - 2001). National Health & Medical Research Council (NHMRC).

(2001 - 2015). Monash University.

Title:

Potential for creatine or melatonin as dietary supplements in pregnancy to prevent perinatal brain damage ; ID: 384167.

Investigators:

Walker, D, Zakhem, M

Funding:

(2006 - 2010). National Health & Medical Research Council (NHMRC).

(2010 - 2014). National Health & Medical Research Council (NHMRC).

Title:

Pre-pulse inhibition setup.

Investigators:

Hutton, L, Walker, D

Funding:

(2007 - 2011). Collier Charitable Fund.

Title:

Preventing Prenatal Brain Injury in Fetal Growth Restriction.

Investigators:

Wallace, E, Miller, S, Jenkin, G, Drummond, G, Walker, D

Funding:

(2009 - 2012). National Health & Medical Research Council (NHMRC).

(2010 - 2014). National Health & Medical Research Council (NHMRC).

Title:

Pulse voltametry system for on-line detection of transmitters.

Investigators:

Lawrence, A, Walker, D, Jarrott, B, Beart, P

Funding:

(1995 - 1999). National Health & Medical Research Council (NHMRC).

Title:

Pulse voltammetry system for on-line detection of transmitters.

Investigators:

Lawrence, A, Walker, D, Jarrott, B, Beart, P

Funding:

Title:

Reducing cerebral palsy by improving immediate resuscitation at preterm delivery.

Investigators:

Polglase, G, Kluckow, M, Miller, S, Moss, T, Hooper, S, Walker, D

Funding:

(2011 - 2014). Cerebral Palsy Foundation.

Title:

Refrigerated Microvial Fraction Collector.

Investigators:

Walker, D

Funding:

(2006 - 2010). Collier Charitable Fund.

(2006 - 2010). Monash University.

Title:

Regulation of myelination in intrauterine growth restriction: identification of potential therapeutic targets.

Investigators:

Tolcos, M, Wallace, E, Walker, D

Funding:

(2011 - 2015). Financial Markets Foundation for Children.

Title:

Role of Kynurenine Metabolites in Causing and Preventing Excitotoxic Brain Damage in the Fetus - Application Is Also for a Research Fellowship - Bridging Funding (gms Id 000410).

Investigators:

Walker, D, Nichols, N, Smythe, G

Funding:

(2000 - 2004). National Health & Medical Research Council (NHMRC).

Title:

Single Fibre and Whole Muscle Studies of Contraction Mechanisms in Fetal Sheep.

Investigators:

West, J, Luff, A, Walker, D

Funding:

(1998 - 2000). National Health & Medical Research Council (NHMRC).

Title:

The Fetal Response to Infection, With Particular Reference to Alterations of Tryptophan - Research Fellowship.

Investigators:

Walker, D, Smythe, G, Dziegielewska, K

Funding:

(2001 - 2005). National Health & Medical Research Council (NHMRC).

Title:

The Tryptophan - Kynurenic Acid Pathway in the Foetal and Newborn Brain.

Investigators:

Walker, D, Rees, S, Barfield, C

Funding:

(1995 - 1999). National Health & Medical Research Council (NHMRC).

Title:

The effects of maternal glucocorticoid administration in growth restricted fetuses.

Investigators:

Wallace, E, Miller, S, Jenkin, G, Walker, D, Parkington, H

Funding:

(2007 - 2011). National Health & Medical Research Council (NHMRC).

(2008 - 2012). National Health & Medical Research Council (NHMRC).

(2010 - 2014). National Health & Medical Research Council (NHMRC).

Title:

Ultrastructural & Contractile Properties of Skeletal Muscles During Development.

Investigators:

West, J, Luff, A, Walker, D

Funding:

(1997 - 1998). Anz Trustees.

Title:

Who determines gestation length - mother or fetus?.

Investigators:

Walker, D, Dickinson, H

Funding:

(2009 - 2013). Australian Research Council (ARC).

(2010 - 2014). Australian Research Council (ARC).

Title:

Clinical and experimental indices of fetal growth restriction - role of activin A ID: 334157.

Investigators:

Miller, S, Jenkin, G, Wallace, E, Walker, D

Funding:

(2005 - 2009). National Health & Medical Research Council (NHMRC).

Title:

Pathways of neurosteroid-mediated protection following compromised pregnancy and preterm birth.

Investigators:

Walker, D, Hirst, J, Parkington, H

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Neuroactive steroids in the developing brain: potential for preventing prenatal brain damage.

Investigators:

Hirst, J, Walker, D

Funding:

(2004 - 2008). National Health & Medical Research Council (NHMRC).

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Birth Asphyxia and Acute kidney Failure: the Protective Capacity of Maternal creatine Supplements.

Supervisors:

Dickinson, H (Main), Kett, M (Associate), Walker, D (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Birth asphyxia, the neonatal musculature and the protective capacity of maternal creatine supplementation..

Supervisors:

Dickinson, H (Main), Black, M (Associate), Walker, D (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Can maternal creatine and/or melatonin supplementation protect the fetus against hypoxic injury?.

Supervisors:

Harding, R (Joint-co), Walker, D (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Is the control of gestation length maternal, placental or fetal in origin?.

Supervisors:

Dickinson, H (Joint), Walker, D (Joint-co).

Completed Supervision

Student:

Baburamani, A.

Program of Study:

An investigation into the effect of in utero hypoxia on cerebral blood vessels and brain activity in late gestation fetal sheep. (PHD) 2011.

Supervisors:

Walker, D (Main), Zakhem, M (Associate).

Student:

Billiards, S.

Program of Study:

NEUROSTEROID AND SOMNOGENIC RESPONSES TO ENDOTOXIN AND HYPOXIA TREATMENTS IN LAMBS. (PHD) 2003.

Supervisors:

Hirst, J (Main), Walker, D (Associate), Canny, B (Associate).

Student:

Davis, L.

Program of Study:

Studies on the Prevention and Treatment of perinatal brain injury. 2011.

Supervisors:

Walker, D (Main).

Student:

Dickinson, H.

Program of Study:

A new model for perinatal and renal research - the spiny mouse. (PHD) 2006.

Supervisors:

Walker, D (Main), Moritz, K (Associate).

Student:

Fleiss, B.

Program of Study:

Studies on hippocampal function and structure in neonatal spiny mice following asphyxia at birth. (PHD) 2009.

Supervisors:

Coleman, H (Joint), Walker, D (Joint-Co).

Student:

Hutton, L.

Program of Study:

Fetel brain damage in sheep following administration of lipopolysaccharide into the utero-placental circulation. (PHD) 2006.

Supervisors:

Walker, D (Main).

Student:

Ireland, Z.

Program of Study:

Studies on the significance of creatine for fetal and neonatal development. (PHD) 2009.

Supervisors:

Walker, D (Main).

Student:

Kenna, K.

Program of Study:

Maternal ethanol consumption in late gestation: effects on vascular physiology in the offspring. (PHD) 2010.

Supervisors:

Parkington, H (Main), Walker, D (Associate).

Student:

Lee, B.

Program of Study:

PROSTAGLANDIN D2 AND THE DEVELOPMENT OF SLEEP IN THE OVINE FETUS. (PHD) 2000.

Supervisors:

Walker, D (Main).

Student:

Ligam, P.

Program of Study:

The role of the Kynurenine Pathway in human placenta-implications in pregnancy. (PHD) 2006.

Supervisors:

Walker, D (Main), Wallace, E (Joint).

Student:

Mcgregor, H.

Program of Study:

VENTILATION AND METABOLISM IN THE NEONATAL GUINEA PIG FOLLOWING PRENATAL EXPOSURE TO NICOTINE AND/OR CARBON MONOXIDE. (PHD) 2002.

Supervisors:

Walker, D (Main), Harding, R (Associate).

Student:

Nguyen, P.

Program of Study:

DEVELOPMENTAL AND PATHOPHYSIOLOGICAL REGULATION AND NEUROSTEROID SYNTHESIS IN THE FETAL AND NEONATAL SHEEP BRAIN. (PHD) 2005.

Supervisors:

Hirst, J (Main), Walker, D (Associate), Young, I (Associate).

Student:

Nicol, M.

Program of Study:

Effect of pregnane steroids on behavioural parameters and evoked responses in the fetal sheep. (PHD) 1999.

Supervisors:

Hirst, J (Main), Walker, D (Joint).

Student:

O'Connell, B.

Program of Study:

The effect of fetal sex and antenatal glucocorticoid exposure on placental development in the spiny mouse (Acomys cahirinus). (PHD) 2012.

Supervisors:

Dickinson, H (Main), Walker, D (Associate).

Student:

Pasco, R.

Program of Study:

Embryo development in the spiny mouse. 2011.

Supervisors:

Dickinson, H (Main), Walker, D (Associate).

Student:

Yan, E.

Program of Study:

FETAL BRAIN DAMAGE IN THE SHEEP FOLLOWING LIPOPOLYSACCHARIDE OR ASPHYXIAL INSULT. (PHD) 2005.

Supervisors:

Walker, D (Main), Nichols, N (Associate).

Student:

Yawno, T.

Program of Study:

Protective role of neurosteroids in the developing brain: studies in fetal sheep. (PHD) 2008.

Supervisors:

Walker, D (Main), Nichols, N (Associate).