Dr Joshua Ooi - Researcher Profile

Biography

Joshua works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

PHD

Institution: Monash University

Year awarded: 2010

HONOURS DEGREE OF BACHELOR OF BIOMEDICAL SCIENCE

Institution: Monash University

Year awarded: 2005

BACHELOR OF BIOMEDICAL SCIENCE

Institution: Monash University

Year awarded: 2003

Publications

Journal Articles

Yang, Y.H., Song, W., Deane, J.A., Kao, W., Ooi, J., Ngo, D., Kitching, A.R., Morand, E.F., Hickey, M.J., 2013, Deficiency of annexin A1 in CD4+ T cells exacerbates T cell-dependent inflammation, Journal Of Immunology [P], vol 90, issue 3, American Association of Immunologists, United States, pp. 997-1007.

Summers, S.A., Gan, P., Dewage, L.T., Ma, F., Ooi, J., O'Sullivan, K., Nikolic-Paterson, D.J., Kitching, A.R., Holdsworth, S.R., 2013, Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction, Kidney International [P], vol 82, Nature Publishing Group, United Kingdom, pp. 676-685.

Ooi, J., Kitching, A.R., 2012, CD4+ Th1 cells are effectors in lupus nephritis--but what are their targets?, Kidney International [P], vol 82, issue 9, Nature Publishing Group, United Kingdom, pp. 947-949.

Gan, P.Y., Summers, S.A., Ooi, J., O'Sullivan, K., Tan, D.S.Y., Muljadi, R.C.M., Odobasic, D., Kitching, A.R., Holdsworth, S.R., 2012, Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis, Journal Of The American Society Of Nephrology [P], vol 23, issue 12, American Society of Nephrology, United States, pp. 1955-1966.

Snelgrove, S., Kausman, J., Lo, C., Lo, C., Ooi, J.D., Coates, P., Hickey, M., Holdsworth, S., Kurts, C., Engel, D., Kitching, A., 2012, Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis, American Journal Of Pathology [P], vol 180, issue 1, Elsevier Inc., United States, pp. 91-103.

Ooi, J., Chang, J., Hickey, M.J., Borza, D., Fugger, L., Holdsworth, S.R., Kitching, A.R., 2012, The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 109, issue 39, National Academy of Sciences, United Statess, pp. E2615-E2624.

Ooi, J., Snelgrove, S., Engel, D., Hochheiser, K., Ludwig-Portugall, I., Nozaki, Y., O'Sullivan, K., Hickey, M., Holdsworth, S., Kurts, C., Kitching, A., 2011, Endogenous foxp3{+} T-regulatory cells suppress anti-glomerular basement membrane nephritis, Kidney International [P], vol 79, issue 9, Nature Publishing Group, United Kingdom, United States, pp. 977-986.

Summers, S., Phoon, R., Ooi, J., Holdsworth, S., Kitching, A., 2011, The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses, American Journal Of Pathology [P], vol 178, issue 2, American Society for Investigative Pathology, United States, pp. 580-590.

Summers, S., Steinmetz, O., Gan, P., Ooi, J., Odobasic, D., Kitching, A., Holdsworth, S., 2011, Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis, Arthritis & Rheumatism-Arthritis Care & Research [P], vol 63, issue 4, John Wiley & Sons, Inc., United States, pp. 1124-1135.

Summers, S.A., van der Veen, B.S., O'Sullivan, K., Gan, P., Ooi, J., Heeringa, P., Satchell, S.C., Mathieson, P.W., Saleem, M.A., Visvanathan, K., Holdsworth, S.R., Kitching, A.R., 2010, Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis, Kidney International [P], vol 78, issue 12, Nature Publishing Group, United Kingdom, pp. 1263-1274.

Ooi, J., Kitching, A.R., Holdsworth, S.R., 2010, Review: T helper 17 cells: their role in glomerulonephritis, Nephrology [P], vol 15, issue 5, Wiley-Blackwell Publishing Asia, Australia, pp. 513-521.

Summers, S.A., Hoi, A., Steinmetz, O., O'Sullivan, K., Ooi, J., Odobasic, D., Akira, S., Kitching, A.R., Holdsworth, S.R., 2010, TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy, Journal Of Autoimmunity [P], vol 35, issue 4, Academic Press, United Kingdom, pp. 291-298.

Gan, P., Steinmetz, O., Tan, D.S.Y., O'Sullivan, K., Ooi, J., Iwakura, Y., Kitching, A.R., Holdsworth, S.R., 2010, Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis, Journal Of The American Society Of Nephrology [P], vol 21, issue 6, American Society of Nephrology, United States, pp. 925-931.

Summers, S.A., Steinmetz, O., Ooi, J., Gan, P., O'Sullivan, K., Visvanathan, K., Akira, S., Kitching, A.R., Holdsworth, S.R., 2010, Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis, American Journal Of Pathology [P], vol 177, issue 5, American Society for Investigative Pathology, United States, pp. 2234-2244.

Kuligowski, M.P., Kwan, R., Lo, C., Wong, C., James, W.G.M., Bourges, D., Ooi, J.D., Abeynaike, L., Hall, P.H., Kitching, A.R., Hickey, M.J., 2009, Antimyeloperoxidase antibodies rapidly induce alpha4-integrin-dependent glomerular neutrophil adhesion, Blood [P], vol 113, issue 25, American Society of Hematology, United States, pp. 6485-6494.

Ooi, J.D., Phoon, R.K.S., Holdsworth, S.R., Kitching, A.R., 2009, IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen, Journal Of The American Society Of Nephrology [P], vol 20, American Society of Nephrology, United States, pp. 980-989.

Ooi, J., Holdsworth, S.R., Kitching, A.R., 2008, Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells, Journal of Autoimmunity, vol 31, issue 3, Academic Press, United Kingdom, pp. 295-300.

Ruth, A., Kitching, A.R., Kwan, R.Q., Odobasic, D., Ooi, J.D.K., Timoshanko, J.R., Hickey, M.J., Holdsworth, S.R., 2006, Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis, Journal of the American Society of Nephrology, vol 17, issue 7, Lippincott Williams & Wilkins, USA, pp. 1940-1949.

Apostolopoulos, J., Ooi, J.D.K., Odobasic, D., Holdsworth, S.R., Kitching, A.R., 2006, The isolation and purification of biologically active recombinant and native autoantigens for the study of autoimmune disease, Journal of Immunological Methods, vol 308, issue 1-2, Elsevier BV, Netherlands, pp. 167-178.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of T-lymphocytes in autoimmune glomerulonephritis.

Supervisors:

Kitching, A (Joint), Ooi, J (Joint-co).

Completed Supervision

Student:

Chang, J.

Program of Study:

Autoimmunity - an Important Cause of Renal Failure. 2009.

Supervisors:

Kitching, A (Main), Ooi, J (Associate), Holdsworth, S (Associate).