Dr Tracy Heng - Researcher Profile

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Address

Monash Immunology & Stem Cell Labs
Faculty of Medicine, Nursing & Health Sciences, Clayton

Biography

Tracy works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

My postdoctoral research in the von Boehmer lab (Dana-Farber Cancer Institute, Boston) was directed at developing novel strategies for generating antigen-specific regulatory T cells in animal disease models. I continued my postdoctoral training in the Mathis/Benoist lab (Harvard Medical School, Boston), establishing standardised conditions for gene expression profiling of immune cell populations by high-throughput microarray technology for the Immunological Genome Project. Currently, my research in the Boyd lab is focussed on developing strategies to complement thymic and immune regeneration with emerging stem cell therapies for suppressing aberrant immune responses in animal models and humans.

Grants: Heng TSP, Boyd RL, Itescu S; Australian Research Council Linkage Project Grant LP110201169 (Partner Organisation: Mesoblast Limited) (2011-2014).

Qualifications

DOCTOR OF PHILOSOPHY
Institution: Monash University
Year awarded: 2006
BACHELOR OF SCIENCE (BIOMEDICAL) WITH HONOURS
Institution: Monash University
Year awarded: 2001

Publications

Journal Articles

Heng, T.S., Reiseger, J.J., Fletcher, A.L., Leggatt, G.R., White, O.J., Vlahos, K., Frazer, I.H., Turner, S.J., Boyd, R.L., 2012, Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice, PLoS ONE [P], vol 7, issue 8, Public Library of Science, USA, pp. e42677-1-e42677-11.

Heng, T.S.P., Chidgey, A.P., Boyd, R.L., 2010, Getting back at nature: Understanding thymic development and overcoming its atrophy, Current Opinion in Pharmacology [P], vol 10, issue 4, Elsevier Ltd, UK, pp. 425-433.

Goldberg, G.L., Dudakov, J.A., Reiseger, J.J., Seach, N.L., Ueno, T., Vlahos, K., Hammett, M.V., Young, L.F., Heng, T.S.P., Boyd, R.L., Chidgey, A.P., 2010, Sex steroid ablation enhances immune reconstitution following cytotoxic antineoplastic therapy in young mice, Journal Of Immunology [P], vol 184, issue 11, American Association of Immunologists, USA, pp. 6014-6024.

Heng, T.S.P., Dudakov, J.A., Khong, D.M.P., Chidgey, A.P., Boyd, R.L., 2009, Stem cells-meet immunity, Journal of Molecular Medicine [P], vol 87, issue 11, Springer, Germany, pp. 1061-1069.

Sutherland, J.S., Spyroglou, L.G., Muirhead, J.L., Heng, T.S.P., Prieto-Hinojosa, A., Prince, H.M., Chidgey, A.P., Schwarer, A.P., Boyd, R.L., 2008, Enhanced immune system regeneration in humans following allogeneic or autologous hemopoietic stem cell transplantation by temporary sex steroid blockade, Clinical Cancer Research, vol 14, issue 4, American Association for Cancer Research (A AC R), USA, pp. 1138-1149.

Heng, T.S., Painter, M.W., Immunological Genome Project, 2008, The Immunological Genome Project: networks of gene expression in immune cells, Nature Immunology [P], vol 9, issue 10, Nature Publishing Group, USA, pp. 1091-1094.

Kretschmer, K., Heng, T.S., von Boehmer, H., 2006, De novo production of antigen-specific suppressor cells in vivo, Nature Protocols [P], vol 1, issue 2, Nature Publishing Group, UK, pp. 653-661.

Sutherland, J.S., Goldberg, G.L., Hammett, M.V., Uldrich, A.P., Berzins, S.P., Heng, T.S.P., Blazar, B.R., Millar, J.L., Malin, M., Chidgey, A.P., Boyd, R.L., 2005, Activation of thymic regeneration in mice and humans following androgen blockade, The Journal of Immunology, vol 175, issue 4, The American Association of Immunologists, USA, pp. 2741-2753.

Heng, T.S.P., Goldberg, G.L., Gray, D.H.D., Sutherland, J.S., Chidgey, A.P., Boyd, R.L., 2005, Effects of castration on thymocyte development in two different models of thymic involution, The Journal of Immunology, vol 175, issue 5, American Association of Immunologists, USA, pp. 2982-2993.

Goldberg, G.L., Sutherland, J.S., Hammett, M.V., Milton, M.K., Heng, T.S.P., Chidgey, A.P., Boyd, R.L., 2005, Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation, Transplantation, vol 80, issue 11, Lippincott Williams & Wilkins, USA, pp. 1604-1613.

Postgraduate Research Supervisions

Current Supervision

Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Development of a safe, effective and clinically relevant protocol for the induction of allogenic tolerance through mixed chimerism.
Supervisors:
Boyd, R (Main), Chidgey, A (Associate), Heng, T (Associate).