Dr Sophia Zoungas - Researcher Profile

Biography

Associate Professor Sophia Zoungas is an academic endocrinologist with an emerging national and international reputation as a clinical researcher in the fields of diabetes and vascular risk.  Her current primary appointment is as the Head, Diabetes and Clinical Research Program, Monash Applied Research Stream, School of Public Health and Preventive Medicine, Monash University.  In this capacity she directs and supports projects on diabetes, cardiovascular health, kidney health and health care delivery, as well as advise on clinical epidemiological methods and trial design/conduct/reporting.

A/Prof Zoungas has a conjoint Professorial Research Fellow appointment at the George Institute for Global Health.  She is the current international clinical director of the ADVANCE-ON study (a post trial observational study of over 10,000 patients with type 2 diabetes) and the international coordinator/scientific lead of the Collaborators ON TRials Of glucose Lowering (CONTROL) project. 

A/Prof Zoungas is an associate editor for the journal Diabetic Medicine (UK) and is a serving member of the Australian Diabetes Society council.  She is also the current chairperson for the National Association for Diabetes Centres in Australia

Qualifications

DOCTOR OH PHILOSOPHY

Institution: Monash University

Year awarded: 2006

BACHELOR OF MEDICINE AND BACHELOR OF SURGERY

Institution: Monash University

Year awarded: 1993

Publications

Journal Articles

Zoungas, S., Chalmers, J., Ninomiya, T., Li, Q., Cooper, M.E., Colagiuri, S., Fulcher, G.R., De Galan, B.E., Harrap, S.B., Hamet, P., Heller, S.R., MacMahon, S., Marre, M., Poulter, N., Travert, F., Patel, A., Neal, B., Woodward, M., 2012, Association of HbA1c levels with vascular complications and death in patients with type 2 diabetes: evidence of glycaemic thresholds, Diabetologia [P], vol 55, issue 3, Springer, Heidelberg, Germany, pp. 636-643.

Dieren, S.v., Kengne, A., Chalmers, J.P., Beulens, J.W., Cooper, M.E., Grobbee, D.E., Harrap, S.B., Mancia, G., Neale, B., Patel, A., Poulter, N., Schouw, Y.T.v., Woodward, M., Zoungas, S., 2012, Effects of blood pressure lowering on cardiovascular outcomes in different cardiovascular risk groups among participants with type 2 diabetes, Diabetes Research and Clinical Practice [P], vol 98, issue 1, Elsevier Ireland Ltd, Ireland, pp. 83-90.

Morton, J., Zoungas, S., Li, Q., Patel, A., Chalmers, J., Woodward, M., Celermajer, D.S., Beulens, J.W., Stolk, R.P., Glasziou, P.P., Ng, M.K.C., 2012, Low HDL cholesterol and the risk of diabetic nephropathy and retinopathy: results of the ADVANCE study, Diabetes Care [P], vol 35, issue 11, American Diabetes Association, United States, pp. 2201-2206.

Wong, G., Zoungas, S., Lo, S., Chalmers, J.P., Cass, A., Neale, B., Woodward, M., Perkovic, V., Glasziou, P.P., Williams, B., Howard, K., Chapman, J.R., Craig, J.C., 2012, The risk of cancer in people with diabetes and chronic kidney disease, Nephrology Dialysis Transplantation [P], vol 27, issue 8, Oxford University Press, United Kingdom, pp. 3337-3344.

Zoungas, S., Lui, M., Kerr, P., Teede, H.J., McNeil, J.J., McGrath, B.P., Polkinghorne, K.R., 2011, Advanced chronic kidney disease, cardiovascular events and the effect of diabetes: Data from the Atherosclerosis and Folic Acid Supplementation Trial, Internal Medicine Journal [P], vol 41, issue 12, Wiley-Blackwell Publishing Asia, Australia, pp. 825-832.

Razavian, M., Heeley, E., Perkovic, V., Zoungas, S., Weekes, A., Patel, A., Anderson, C., Chalmers, J., Cass, A., 2011, Cardiovascular risk management in chronic kidney disease in general practice (the AusHEART study), Nephrology Dialysis Transplantation [P], vol E, Oxford University Press, United Kingdom, pp. 1-7.

Ritchie, G., Kengne, A., Joshi, R., Chow, C., Neale, B., Patel, A., Zoungas, S., 2011, Comparison of near-patient capillary glucose measurement and a risk assessment questionnaire in screening for type 2 diabetes in a high-risk population in rural India, Diabetes Care [P], vol 34, issue 1, American Diabetes Association, United States, pp. 44-49.

Zoungas, S., Woodward, M., 2011, Diabetes. Insights from the extended follow-up of the ACCORD trial, Nature Reviews Cardiology [P], vol 8, issue 6, Nature Publishing Group, United Kingdom, pp. 308-310.

Woodward, M., Patel, A., Zoungas, S., Liu, L., Pan, C., Poulter, N., Januszewicz, A., Tandon, N., Joshi, P., Heller, S., Neale, B., Chalmers, J., 2011, Does glycemic control offer similar benefits among patients with diabetes in different regions of the world? Results from the ADVANCE trial, Diabetes Care [P], vol 34, issue 12, American Diabetes Association, United States, pp. 2491-2495.

Stefansdottir, G., Zoungas, S., Chalmers, J.P., Kengne, A., Knol, M.J., Leufkens, H.G.M., Patel, A., Woodward, M., Grobbee, D.E., De Bruin, M.L., 2011, Intensive glucose control and risk of cancer in patients with type 2 diabetes, Diabetologia [P], vol 54, issue 7, Springer, Germany, pp. 1608-1614.

Wolfe, R., Zoungas, S., Polkinghorne, K., 2011, Missing data and multiple imputation when predicting mortality in incident dialysis patients, American Journal Of Kidney Diseases [P], vol 58, WB Saunders Co-Elsevier Inc, United States, p. 679.

Jardine, M., Ninomiya, T., Perkovic, V., Cass, A., Turnbull, F., Gallagher, M., Zoungas, S., Heerspink, H.J.L., Chalmers, J., Zanchetti, A., 2010, Aspirin is beneficial in hypertensive patients with chronic kidney disease: A post-hoc subgroup analysis of a randomized controlled trial, Journal of the American College of Cardiology [P], vol 56, issue 12, Elsevier Inc., USA, pp. 956-965.

Zoungas, S., Patel, A., 2010, Cardiovascular outcomes in type 2 diabetes: The impact of preventative therapies, Annals of the New York Academy of Sciences [P], vol 1212, issue 1, Wiley-Blackwell Publishing, Inc., USA, pp. 29-40.

Czernichow, S., Kengne, A., Huxley, R., Batty, G., De Galan, B.E., Grobbee, D., Pillai, A., Zoungas, S., Marre, M., Woodward, M., Neal, B., Chalmers, J., 2010, Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: A prospective cohort study from ADVANCE, European Journal Of Cardiovascular Prevention & Rehabilitation [P], vol 18, Lippincott Williams & Wilkins, United State, pp. 312-319.

Heerspink, H.J.L., Ninomiya, T., Perkovic, V., Woodward, M., Zoungas, S., Cass, A., Cooper, M., Grobbee, D., Mancia, G., Mogensen, C., Neal, B., Chalmers, J., 2010, Effects of a fixed combination of perindopril and indapamide in patients with type 2 diabetes and chronic kidney disease, European Heart Journal [P], vol 31, issue 23, Oxford University Press, UK, pp. 2888-2896.

Ninomiya, T., Zoungas, S., Neal, B., Woodward, M., Patel, A., Perkovic, V., Cass, A., Cooper, M., Grobbee, D., Hamet, P., Harrap, S., Liu, L., Mancia, G., Mogensen, C., Poulter, N., Rodgers, A., Williams, B., MacMahon, S., Chalmers, J., 2010, Efficacy and safety of routine blood pressure lowering in older patients with diabetes: Results from the advance trial, Journal of Hypertension [P], vol 28, issue 6, Lippincott Williams & Wilkins, Ltd, UK, pp. 1141-1149.

Teede, H., Meyer, C., Hutchison, S., Zoungas, S., McGrath, B., Moran, L., 2010, Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy, Fertility and Sterility [P], vol 93, issue 1, Elsevier Science Inc, United States, pp. 184-191.

Batty, D., Li, Q., Czernichow, S., Neal, B., Zoungas, S., Huxley, R., Patel, A., De Galan, B., Woodward, M., Hamet, P., Harrap, S., Poulter, N., Chalmers, J., 2010, Erectile dysfunction and later cardiovascular disease in men with type 2 diabetes: Prospective cohort study based on the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation) trial, Journal of the American College of Cardiology [P], vol 56, issue 23, Elsevier Inc., United States, pp. 1908-1913.

Wong, J., Zoungas, S., Wright, C., Teede, H., 2010, Evidence-based guidelines for perioperative management of diabetes in cardiac and vascular surgery, World Journal Of Surgery [P], vol 34, issue 3, Springer New York LLC, United States, pp. 500-513.

Jun, M., Zoungas, S., Perkovic, V., Webster, A., 2010, How to read a report of a randomized controlled trial, Nephrology [P], vol 15, issue 2, Wiley-Blackwell Publishing Inc, Malden, United States, pp. 153-157.

Moran, L., Meyer, C., Hutchison, S., Zoungas, S., Teede, H., 2010, Novel inflammatory markers in overweight women with and without polycystic ovary syndrome and following pharmacological intervention, Journal Of Endocrinological Investigation [P], vol 33, issue 4, Editrice Kurtis s.r.l., Italy, pp. 258-265.

Li, Q., Chalmers, J., Czernichow, S., Neal, B., Taylor, B., Zoungas, S., Poulter, N., Woodward, M., Patel, A., De Galan, B., Batty, D., 2010, Oral disease and subsequent cardiovascular disease in people with type 2 diabetes: A prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial, Diabetologia [P], vol 53, issue 11, Springer, Germany, pp. 2320-2327.

Zoungas, S., Patel, A., Chalmers, J., De Galan, B., Li, Q., Billot, L., Woodward, M., Ninomiya, T., Neal, B., MacMahon, S., Grobbee, D., Kengne, A., Marre, M., Heller, S., 2010, Severe hypoglycemia and risks of vascular events and death, New England Journal Of Medicine [P], vol 363, issue 15, Massachusetts Medical Society, United States, pp. 1410-1418.

Kengne, A., Patel, A., Colagiuri, S., Heller, S., Hamet, P., Marre, M., Pan, C., Zoungas, S., Grobbee, D., Neal, B., Chalmers, J., Woodward, M., 2010, The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: The action in diabetes and vascular disease: Pre, Diabetologia [P], vol 53, issue 5, Springer, Germany, pp. 821-831.

Zoungas, S., Chalmers, J., Kengne, A., Pillai, A., Billot, L., De Galan, B.E., Marre, M., Neal, B., Harrap, S., Poulter, N., Patel, A., 2010, The efficacy of lowering glycated haemoglobin with a gliclazide modified release-based intensive glucose lowering regimen in the ADVANCE trial, Diabetes Research and Clinical Practice [P], vol 89, issue 2, Elsevier Ireland Ltd, Ireland, pp. 126-133.

Moran, L.J., Hutchison, S.K., Meyer, C., Zoungas, S., Teede, H.J., 2009, A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome, Clinical Science [P], vol 116, issue 10, Portland Press Ltd, UK, pp. 761-770.

Kengne, A., Czernichow, S., Huxley, R., Grobbee, D.E., Woodward, M., Neal, B., Zoungas, S., Cooper, M.E., Glasziou, P.P., Hamet, P., Harrap, S.B., Mancia, G., Poulter, N., Williams, B., Chalmers, J., 2009, Blood pressure variables and cardiovascular risk: New findings from advance, Hypertension [P], vol 54, issue 2, Lippincott Williams & Wilkins, USA, pp. 399-404.

De Galan, B.E., Zoungas, S., Chalmers, J., Anderson, C., Dufouil, C., Pillai, A., Cooper, M.E., Grobbee, D.E., Hackett, M., Hamet, P., Heller, S.R., Lisheng, L., MacMahon, S., Mancia, G., Neal, B., Pan, C.Y., Patel, A., Poulter, N., Travert, F., Woodward, M., 2009, Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: The action in diabetes and vascular disease: Preterax and diamicron modified release controlled evaluation (ADVANCE) trial, Diabetologia [P], vol 52, issue 11, Springer, Germany, pp. 2328-2336.

Zoungas, S., De Galan, B., Ninomiya, T., Grobbee, D., Hamet, P., Heller, S., MacMahon, S., Marre, M., Neal, B., Patel, A., Woodward, M., Chalmers, J., 2009, Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial, Diabetes Care [P], vol 32, issue 11, American Diabetes Association, United States, pp. 2068-2074.

Heerspink, H.J.L., Ninomiya, T., Zoungas, S., de Zeeuw, D., Grobbee, D.E., Jardine, M.J., Gallagher, M., Roberts, M.A., Cass, A., Neal, B., Perkovic, V., 2009, Effect of lowering blood pressure on cardiovascular events and mortality in patients on dialysis: a systematic review and meta-analysis of randomised controlled trials, Lancet [P], vol 373, issue 9668, The Lancet Publishing Group, UK, pp. 1009-1015.

Deeks, A., Zoungas, S., Teede, H.J., 2008, Risk perception in women: a focus on menopause, Menopause, vol 15, issue 2, Lippincott Williams & Wilkins, US, pp. 304-309.

Zoungas, S., Kerr, P.G., Lui, M., Teede, H.J., 2008, The impact of glycaemic control on outcomes in patients with end-stage renal disease and type 2 diabetes, Nephrology, vol 13, issue 2, Wiley-Blackwell Publishing Asia, Australia, pp. 124-127.

Zoungas, S., Asmar, R.P., 2007, Arterial stiffness and cardiovascular outcome, Clinical And Experimental Pharmacology And Physiology [P], vol 34, issue 7, Wiley-Blackwell Publishing Asia, Australia, pp. 647-651.

Zoungas, S., Cameron, J.D., Kerr, P.G., Wolfe, R.S.J., Muske, C., McNeil, J.J., McGrath, B.P., 2007, Association of carotid intima-medial thickness and indices of arterial stiffness with cardiovascular disease outcomes in CKD, American Journal of Kidney Diseases, vol 50, issue 4, WB Saunders Co., United States, pp. 622-630.

Hutchinson, S., Zoungas, S., Teede, H.J., 2007, Insulin levels, insulin resistance and the use of metformin in polycystic ovary syndrome, Medical Journal Australia, vol 186, issue 5, Australasian Medical Publishing Company Pty Ltd, Australia, pp. 268-269.

Teede, H.J., Hutchinson, S., Zoungas, S., 2007, The management of insulin resistance in polycystic ovary syndrome, Trends in Endocrinology and Metabolism, vol 18, issue 7, Elsevier Ltd, UK, pp. 273-279.

Zoungas, S., McGrath, B.P., Branley, P., Kerr, P., Muske, C., Wolfe, R.S., Atkins, R.C., Nicholls, K., Fraenkel, M., Hutchison, B.G., Walker, R., McNeil, J.J., 2006, Cardiovascular Morbidity and Mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: A multicenter, randomized, controlled trial, Journal of the American College of Cardiology, vol 47, issue 6, Elsevier Inc., USA, pp. 1108-1116.

Teede, H.J., Hutchinson, S., Zoungas, S., Meyer, C., 2006, Insulin resistance, the metabolic syndrome, diabetes, and cardiovascular disease risk in women with PCOS, Endocrine, vol 30, issue 1, Humana Press, Inc., USA, pp. 45-53.

Zoungas, S., Teede, H.J., 2005, Does metformin treatment really improve arterial structure in women with polycystic ovarian syndrome, Clinical Endocrinology & Metabolism, vol 90, issue 11, The Endocrine Society, US, pp. 6072-6076.

Zoungas, S., Kerr, P., Chadban, S.J., Muske, C., Ristevski, S., Atkins, R.C., McNeil, J.J., McGrath, B.P., 2004, Arterial function after successful renal transplantation, Kidney International, vol 65, Blackwell Publishing Inc, USA, pp. 1882-1889.

Zoungas, S., Branley, P., Kerr, P., Ristevski, S., Muske, C., Demos, L.L., Atkins, R.C., Becker, G., Fraenkel, M., Hutchison, B.G., Walker, R., McNeil, J.J., McGrath, B.P., 2004, Atherosclerosis and folic acid supplementation trial in chronic renal failure: Baseline results, Nephrology, vol 9, issue 3, Blackwell Publishing Asia, Australia, pp. 130-141.

Polkinghorne, K.R., Zoungas, S., Branley, P., Villanueva, E.V., McNeil, J.J., Atkins, R.C., McGrath, B.P., Kerr, P.G., 2003, Randomized, placebo-controlled trial of intramuscular vitamin B12 for the treatment of hyperhomocysteinaemia dialysis patients, Internal Medicine Journal, vol 33, Blackwell Publishing Asia, Carlton Vic Australia, pp. 489-494.

Teede, H.J., Liang, Y., Kotsopoulos, D., Zoungas, S., McGrath, B.P., 2002, Placebo-controlled trial of transdermal estrogen therapy alone in postmenopausal women: effects on arterial compliance and endothelial function, Climacteric, vol 5, Parthenon Publishing Group, Lancaster England, pp. 160-169.

Teede, H.J., Liang, Y., Kotsopoulos, D., Zoungas, S., Craven, R., McGrath, B.P., 2001, A placebo-controlled trial of long-term oral combined continuous hormone replacement therapy in postmenopausal women: effects on arterial compliance and endothelial function, Clinical Endocrinology, vol 55, Blackwell Science Ltd, Oxford England, pp. 673-682.

Zoungas, S., Ristevski, S., Lightfoot, P., Liang, Y., Branley, P., Shiel, L.M., Kerr, P., Atkins, R.C., McNeil, J.J., McGrath, B.P., 2000, Carotid Artery intima-Medial Thickness is increased in Chronic Renal Failure, Clinical and Experimental Pharmacology and Physiology, vol 27, Blackwell Scientific Asia, Carlton Vic Australia, pp. 639-641.

Conference Proceedings

Zoungas, S., Liang, Y., Ristevski, S., Branley, P., 1999, Arterial stiffness and IMT are increased in patients with chronic renal failure, High Blood Pressure Research Council aust Inc 21st Annual Scientiic Meeting Program and Abstracts, Melbourne, Vic, 9-11th Dec, 1999, High Blood Pressure Research Council Ast Inc., Melbourne Vic Australia, p. 95.

Clinical Activity

A/Prof Zoungas’ current clinical appointment is as a senior staff specialist in Endocrinology and Diabetes at Monash Medical Centre and Dandenong Hospital, Southern Health, Victoria where she has led provision and development of ambulatory diabetes services (mainly over the last 6 years). 

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Obesity insulin resistance and polycystic ovary syndrome.

Supervisors:

Teede, H (Main), Zoungas, S (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Statistical risk prediction of the course of renal disease.

Supervisors:

Wolfe, R (Main), Zoungas, S (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Towards optimal diabetes care in patients with type 2 diabetes and chronic kidney disease..

Supervisors:

Zoungas, S (Main), Teede, H (Associate).