Prof Peter Stewart - Researcher Profile

Biography

Position

Professor of Pharmaceutics
Deputy Dean
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

Research & Supervision Interests

• Agglomeration of cohesive drug powders and consequences in drug delivery
• Respiratory drug delivery including the formulation of powders for inhalation
• Oral drug delivery, with focus on dissolution modelling of poorly-water soluble drugs and the development of dissolution enhancement strategies.

Keywords

Agglomeration of cohesive drug powders, dissolution modelling, drug delivery, disposition and dynamics, formulation, oral drug delivery, poorly-water soluble drugs, powders for inhalation, respiratory drug delivery

Qualifications

DOCTOR OF PHILOSOPHY

Institution: University of Queensland

Year awarded: 1976

Publications

Journal Articles

Zhou, Q., Qu, L., Gengenbach, T.R., Larson, I.C., Stewart, P.J., Morton, D.A.V., 2013, Effect of surface coating with magnesium stearate via mechanical dry powder coating approach on the aerosol performance of micronized drug powders from dry powder inhalers, Aaps Pharmscitech [P], vol 14, issue 1, Springer, New York USA, pp. 38-44.

Das, S.C., Stewart, P.J., 2012, Characterising surface energy of pharmaceutical powders by inverse gas chromatography at finite dilution, Journal of Pharmacy and Pharmacology [P], vol 64, issue 9, Wiley-Blackwell, Malden, Massachusetts USA, pp. 1337-1348.

Tay, T., Morton, D.A.V., Gengenbach, T.R., Stewart, P.J., 2012, Dissolution of a poorly water-soluble drug dry coated with magnesium and sodium stearate, European Journal of Pharmaceutics and Biopharmaceutics [P], vol 80, issue 2, Elsevier Science BV, Amsterdam Netherlands, pp. 443-452.

Behara, S.R.B., Larson, I.C., Kippax, P., Stewart, P.J., Morton, D.A.V., 2012, Insight into pressure drop dependent efficiencies of dry powder inhalers, European Journal of Pharmaceutical Sciences [P], vol 46, issue 3, Elsevier BV, Netherlands, pp. 142-148.

Jetmalani, K., Young, P.M., Smith, T., Stewart, P.J., Traini, D., 2012, Micronized drug powders in binary mixtures and the effect of physical properties on aerosolization from combination drug dry powder inhalers, Drug Development And Industrial Pharmacy [P], vol 38, issue 12, Informa Healthcare, London UK, pp. 1504-1511.

Das, S.C., Behara, S.R.B., Bulitta, J.B., Morton, D.A.V., Larson, I.C., Stewart, P.J., 2012, Powder strength distributions for understanding de-agglomeration of lactose powders, Pharmaceutical Research [P], vol 29, issue 10, Springer New York LLC, United States, pp. 2926-2935.

Behara, S., Larson, I., Kippax, P., Morton, D., Stewart, P., 2011, An approach to characterising the cohesive behaviour of powders using a flow titration aerosolisation based methodology, Chemical Engineering Sciences [P], vol 66, issue 8, Elsevier, Netherlands, pp. 1640-1648.

Zhou, Q., Denman, J., Gengenbach, T., Das, S., Qu, L., Zhang, H., Larson, I., Stewart, P., Morton, D., 2011, Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach, Journal of Pharmaceutical Sciences [P], vol 100, issue 8, John Wiley & Sons, Inc., United States, pp. 3421-3430.

Tay, T., Allahham, A., Morton, D., Stewart, P., 2011, Counter-intuitive enhancement in the dissolution of indomethacin with the incorporation of cohesive poorly water-soluble inorganic salt additives, European Journal of Pharmaceutics and Biopharmaceutics [P], vol 79, Elsevier, Netherlands, pp. 674-682.

Das, S., Larson, I., Morton, D., Stewart, P., 2011, Determination of the polar and total surface energy distributions of particulates by inverse gas chromatography, Langmuir [P], vol 27, issue 2, American Chemical Society, USA, pp. 521-523.

Zhou, Q., Qu, L., Larson, I., Stewart, P., Morton, D., 2011, Effect of mechanical dry particle coating on the improvement of powder flowability for lactose monohydrate: A model cohesive pharmaceutical powder, Powder Technology [P], vol 207, issue 1-3, Elsevier, The Netherlands, pp. 414-421.

Zhou, Q., Qu, L., Gegenbach, T., Denman, J., Larson, I., Stewart, P., Morton, D., 2011, Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties, International Journal of Pharmaceutics [P], vol 413, Elsevier/North-Holland Biomedical Press, Netherlands, pp. 36-43.

Behara, S., Kippax, P., Larson, I., Morton, D., Stewart, P., 2011, Kinetics of emitted mass - a study with three dry powder inhaler devices, Chemical Engineering Sciences [P], vol 66, Pergamon Press, United Kingdom, pp. 5284-5292.

Behara, S., Kippax, P., McIntosh, M., Morton, D., Larson, I., Stewart, P., 2011, Structural influence of cohesive mixtures of salbutamol sulphate and lactose on aerosolisation and de-agglomeration behaviour under dynamic conditions, European Journal of Pharmaceutical Sciences [P], vol 42, issue 3, Elsevier, The Netherlands, pp. 210-219.

Behara, S., Larson, I., Kippax, P., Morton, D., Stewart, P., 2011, The kinetics of cohesive powder de-agglomeration from three inhaler devices, International Journal of Pharmaceutics [P], vol 421, Elsevier/North-Holland Biomedical Press, Netherlands, pp. 72-81.

Tay, T., Allahham, A., Morton, D., Stewart, P., 2011, Understanding improved dissolution of indomethacin through the use of cohesive poorly water-soluble aluminium hydroxide: Effects of concentration and particle size distribution, Journal of Pharmaceutical Sciences [P], vol 100, issue 10, Wiley - Liss, USA, pp. 4269-4280.

Das, S., Zhou, Q., Morton, D., Larson, I., Stewart, P., 2011, Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate, European Journal of Pharmaceutical Sciences [P], vol 43, Elsevier Science B.V, Netherlands, pp. 325-333.

Zhou, Q., Qu, L., Larson, I.C., Stewart, P.J., Morton, D.A.V., 2010, Improving aerosolization of drug powders by reducing powder intrinsic cohesion via a mechanical dry coating approach, International Journal of Pharmaceutics [P], vol 394, issue 1-Feb, Elsevier, Netherlands, pp. 50-59.

Zhou, Q., Armstrong, B., Larson, I.C., Stewart, P.J., Morton, D.A.V., 2010, Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating, Journal of Pharmaceutical Sciences [P], vol 99, issue 2, John Wiley & Sons, Inc, USA, pp. 969-981.

Tay, T., Das, S.C., Stewart, P.J., 2010, Magnesium stearate increases salbutamol sulphate dispersion: what is the mechanism?, International Journal of Pharmaceutics [P], vol 383, International Journal of Pharmaceutics, The Netherlands, pp. 62-69.

Zhou, Q., Armstrong, B., Larson, I., Stewart, P., Morton, D., 2010, Understanding the influence of powder flowability, fluidization and de-agglomeration characteristics on the aerosolization of pharmaceutical model powders, European Journal of Pharmaceutical Sciences [P], vol 40, issue 5, Elsevier BV, Netherlands, pp. 412-421.

Das, S.C., Larson, I.C., Young, P.M., Stewart, P.J., 2009, Agglomerate properties and dispersibility changes of salmeterol xinafoate from powders for inhalation after storage at high relative humidity, European Journal of Pharmaceutical Sciences [P], vol 37, issue 3-4, Elsevier BV, Netherlands, pp. 442-450.

Kale, K.P., Hapgood, K., Stewart, P.J., 2009, Drug agglomeration and dissolution - What is the influence of powder mixing?, European Journal of Pharmaceutics and Biopharmaceutics, vol 72, issue 1, Elsevier BV, The Netherlands, pp. 156-164.

Das, S.C., Larson, I.C., Young, P.M., Stewart, P.J., 2009, Influence of storage relative humidity on the dispersion of salmeterol xinafoate powders for inhalation, Journal of Pharmaceutical Sciences, vol 98, John-Wiley & Sons, Inc., USA, pp. 1015-1027.

Adi, H., Larson, I.C., Stewart, P.J., 2009, Influence of the polydispersity of the added fine lactose on the dispersion of salmeterol xinafoate from mixtures for inhalation, European Journal of Pharmaceutical Sciences, vol 36, issue 2-3, Elsevier BV, Netherlands, pp. 265-274.

Andreou, J., Stewart, P., Morton, D., 2009, Short-term changes in drug agglomeration within interactive mixtures following blending, International Journal of Pharmaceutics [P], vol 372, issue 1-2, Elsevier BV, Netherlands, pp. 1-11.

Das, S.C., Larson, I.C., Young, P.M., Stewart, P.J., 2009, Surface energy changes and their relationship with the dispersibility of salmeterol xinafoate powders for inhalation after storage at high RH, European Journal of Pharmaceutical Sciences [P], vol 38, issue 4, Elsevier BV, The Netherlands, pp. 347-354.

Adi, H., Young, P.M., Chan, H., Stewart, P.J., Agus, H., Traini, D., 2008, Cospray dried antibiotics for dry powder lung delivery, Journal of Pharmaceutical Sciences, vol 97, Wiley Inter Science and the American Pharmacists Association, US, pp. 3356-3366.

Marriott, J.L., Nation, R.L., Roller, L., Costelloe, M.T., Galbraith, K.J., Stewart, P.J., Charman, W.N., 2008, Pharmacy Education in the Context of Australian Practice, American Journal of Pharmaceutical Education, vol 72, issue 6, American Association of Colleges of Pharmacy, United States, pp. 1-12.

Adi, H., Larson, I.C., Chiou, H., Young, P.M., Traini, D., Stewart, P.J., 2008, Role of agglomeration in the dispersion of salmeterol xinafoate from mixtures for inhalation with differing drug to fine lactose ratios, Journal of Pharmaceutical Sciences, vol 97, issue 1, Wiley-Liss Inc, US, pp. 3140-3152.

Adi, H., Larson, I.C., Stewart, P.J., 2007, Adhesion and redistribution of salmeterol xinafoate particles in sugar-based mixtures for inhalation, International Journal of Pharmaceutics, vol 337, issue 1-2, Elsevier, Netherlands, pp. 229-238.

Allahham, A., Stewart, P.J., 2007, Enhancement of the dissolution of indomethacin in interactive mixtures using added fine lactose, European Journal of Pharmaceutics and Biopharmaceutics, vol 67, issue 3, Elsevier, Netherlands, pp. 732-742.

Adi, H., Larson, I.C., Stewart, P.J., 2007, Laser diffraction particle sizing of cohesive lactose powders, Powder Technology, vol 179, issue 1-2, Elsevier, Switzerland, pp. 90-94.

Adi, H., Larson, I.C., Stewart, P.J., 2007, Use of milling and wet sieving to produce narrow particle size distributions of lactose monohydrate in the sub-sieve range, Powder Technology, vol 179, issue 1-2, Elsevier, Switzerland, pp. 95-99.

Adi, H., Larson, I.C., Chiou, H., Young, P.M., Traini, D., Stewart, P.J., 2006, Agglomerate strength and dispersion of salmeterol xinafoate from powder mixtures for inhalation, Pharmaceutical Research, vol 23, issue 11, Springer New York LLC, USA, pp. 2556-2565.

Allahham, A., Stewart, P.J., Marriott, J.L., Mainwaring, D.E., 2005, Factors affecting shear thickening behavior of a concentrated injectable suspension of levodopa, Journal of Pharmaceutical Sciences, vol 94, issue 11, John Wiley & Sons, Inc., USA, pp. 2393-2402.

Islam, M.N., Stewart, P.J., Larson, I.C., Hartley, P., 2005, Surface roughness contribution to the adhesion force distribution of salmeterol xinafoate on lactose carriers by atomic force microscopy, Journal of Pharmaceutical Sciences, vol 94, issue 7, John Wiley & Sons, Inc., USA, pp. 1500-1511.

Stewart, P.J., Zhao, F., 2005, Understanding agglomeration of indomethacin during the dissolution of micronised indomethacin mixtures through dissolution and de-agglomeration modeling approaches, European Journal of Pharmaceutics and Biopharmaceutics, vol 59, issue 2, Elsevier, The Netherlands, pp. 315-323.

Allahham, A., Mainwaring, D.E., Stewart, P.J., Marriott, J.L., 2004, Development and application of a micro-capillary rheometer for in-vitro evaluation of parenteral injectability, Journal of Pharmacy and Pharmacology, vol 56, issue 6, Pharmaceutical Press, UK, pp. 709-716.

Islam, M.N., Stewart, P.J., Larson, I.C., Hartley, P., 2004, Effect of carrier size on the dispersion of salmeterol xinafoate from interactive mixtures, Journal of Pharmaceutical Sciences, vol 93, issue 4, Wiley-Liss, Inc., Hoboken USA, pp. 1030-1038.

Allahham, A., Stewart, P.J., Marriott, J.L., Mainwaring, D.E., 2004, Flow and injection characteristics of pharmaceutical parenteral formulations using a micro-capillary rheometer, International Journal of Pharmaceutics, vol 270, issue 1-2, Elsevier, The Netherlands, pp. 139-148.

Islam, M.N., Stewart, P.J., Larson, I.C., Hartley, P., 2004, Lactose surface modification by decantation: are drug-fine lactose ratios the key to better dispersion of slametereol xinafoate from lactose-intercative mixtures?, Pharmaceutical Research, vol 21, issue 3, Kluwer Academic/Plenum Publishers, Dordrecht The Netherlands, pp. 492-499.

Zhao, F., Stewart, P.J., 2004, Modeling the deagglomeration of micronised benzodiazepines from powder mixtures added to dissolution media, Journal of Pharmaceutical Sciences, vol 93, issue 6, John Wiley & Sons, Inc., USA, pp. 1618-1627.

Zhao, F., Stewart, P.J., 2003, De-agglomeration of micronized benzodiazepines in dissolution media measured by laser diffraction particle sizing, Journal of Pharmacy and Pharmacology, vol 55, issue 6, Pharmaceutical Press, UK, pp. 749-755.

Louey, M.D., Razia, S., Stewart, P.J., 2003, Influence of the physico-chemical carrier properties on the in vitro aerosol deposition from interactive mixtures, International Journal of Pharmaceutics, vol 252, Elsevier, The Netherlands, pp. 87-98.

Louey, M., Stewart, P.J., 2002, Particle interactions involved in aerosol dispersion of ternary interactive mixtures, Pharmaceutical Research, vol 19, issue 10, Kluwer Academic/Plenum Publishers, USA, pp. 1524-1531.

Stewart, P.J., Liu, J., 2002, The influence of aggregate microenvironment on the dissolution of oxazepam in ternary surfactant interactive mixtures, Journal of Pharmacy and Pharmacology, vol 54, issue 9, Pharmaceutical Press, UK, pp. 1181-1187.

Louey, M.D., Mulvaney, P., Stewart, P.J., 2001, Characterisation of adhesional properties of lactose carriers using atomic force microscopy, Journal of Pharmaceutical and Biomedical Analysis, vol 25, Elsevier Science BV, The Netherlands, pp. 559-567.

Rhodes, M.J., Wang, X.S., Nguyen, M., Stewart, P.J., Liffman, K., 2001, Onset of cohesive behaviour in gas fluidized beds: a numerical study using DEM simulation, Chemical Engineering Science, vol 56, issue 14, Elsevier Science Ltd, Pergamon, UK, pp. 4433-4438.

Rhodes, M.J., Wang, X., Nguyen, M., Stewart, P.J., Liffman, K., 2001, Study of mixing in gas-fluidized beds using a DEM model, Chemical Engineering Science, vol 56, issue 8, Elsevier Science Ltd, Pergamon, UK, pp. 2859-2866.

Rhodes, M.J., Wang, S.S., Nguyen, M., Stewart, P.J., Liffman, K., 2001, Use of discrete element method simulation in studying fluidization characteristics: influence of interparticle force, Chemical Engineering Science, vol 56, issue 1, Elsevier Science Ltd, Pergamon, UK, pp. 69-76.

Liu, J., Stewart, P.J., 1998, Deaggregation during the dissolution of benzodiazepines in interactive mixtures, Journal of Pharmaceutical Sciences, vol 87 issue 12, American Chem Society & Am Pharmaceutical Assoc., Washington USA, pp. 1632-1638.

Conference Proceedings

Das, S.C., Behara, S.R.B., Bulitta, J.B., Morton, D.A.V., Larson, I.C., Stewart, P.J., 2012, Superiority of powder strength distribution for understanding de-agglomeration of lactose powders, Respiratory Drug Delivery 2012, May 13-17, 2012, Virginia Commonwealth University, United States, pp. 585-590.

Das, S., Zhou, Q., Morton, D., Stewart, P., 2011, Application of surface energy distributions by inverse gas chromatography to distinguish the effect of magnesium stearate on the surface energy of lactoses after conventional mixing and mechanofusion, DDL 22, 07-09/12/2011, The Aerosol Society, England, pp. 257-260.

Jetmalani, K., Stewart, P., Traini, D., Young, P., 2011, Formulation and characteristics of combination dry powder inhalation therapy, RDD Europe 2011, 03-06/05/2011, RDD online; Davis Healthcare, UK, pp. 523-526.

Behara, S., Larson, I., Kippax, P., Morton, D., Stewart, P., 2011, How important is powder structure on the kinetics of emptying and de-agglomeration from devices?, DDL 22, 07-09/12/2011, The Aerosol Society, UK, pp. 367-370.

Das, S., Behara, S., Morton, D., Larson, I., Stewart, P., 2011, Investigating the dispersibility of lactose powders by measuring the total surface energy distributions with an inverse gas chromatography method at finite dilution, Respiratory Drug Delivery 2011, 03-06/05/2011, Davis Healthcare, USA, pp. 359-362.

Jetmalani, K., Young, P., Smith, T., Stewart, P., Traini, D., 2011, Micronized drug powders in binary mixtures and the effect of physical properties on aerosolisation from combination drug dry powder inhalers, DDL 22, 07-09/12/2011, The Aerosol Society, England, pp. 305-307.

Behara, S., Kippax, P., Morton, D., Larson, I., Stewart, P., 2011, The effect of pressure drop on powder de-agglomeration, Respiratory Drug Delivery Europe 2011, 03-06/05/2011, Davis Healthcare International Publishing, USA, pp. 355-358.

Das, S., Behara, S., Morton, D., Larson, I., Stewart, P., 2011, Total surface energy distributions determined using inverse gas chromatography at finite dilution for understanding the de-agglomeration of lactose powders, Proceedings of Chemeca 2011 - Engineering a better world, 18-21/092011, Engineers Australia, Australia, pp. e1-e10.

Behara, S., Larson, I., Morton, D., Kippax, P., Stewart, P., 2010, Cohesive behaviour of lactose - its influence on aerosolisation under varying air flows, Lactose as a carrier for inhalation products, 26/09 - 28/09/2010, TEFARCO Innova, Italy, pp. 61-62.

Morton, D., Stewart, P., Das, S., Lifran, E., Vu, L., Sleigh, R., Hourigan, J., 2010, Controlled crystalisation of lactose carrier particles for improved interactive mixture flow, Lactose as a carrier for inhalation products, 26/09-28/09/2010, TEFARCO BiopharmaNet, Italy, pp. 1-2.

Zhou, Q., Armstrong, B., Larson, I., Stewart, P., Morton, D., 2010, Effect of host particle size on the modification of powder flow behaviours for lactose monohydrate following dry coating, Dairy Science and Technology, 15-17/04/2009, Springer France, France, pp. 237-251.

Zhou, Q., Qu, L., Armstrong, B., Larson, I., Stewart, P., Morton, D., 2010, Effect of surface modifaction via mechanical dry coating on the aerosolisattion of a range of milled drug powders, Lactose as a carrier for inhalation products, TEFARCO Innova, Italy, p. 1.

Zhou, Q., Qu, L., Armstrong, B., Larson, I., Stewart, P., Morton, D., 2010, Effect of surface modifaction via mechanical dry coating on the flowability and fluidization of a range of milled lactose powders, Lactose as a carrier for inhalation products, 26/09/2010-28/09/2010, TEFARCO Innova, Italy, p. 1.

Zhou, Q., Armstrong, B., Stewart, P., Morton, D., 2010, Effect of surface modification via mechanical dry coating on the aerosolisation of a range of milled drug powders, Lactose as a carrier for inhalation products, 26/09 - 28/09/2010, TEFARCO Innova, Italy, pp. 1-2.

Behara, S., Larson, I., Morton, D., Stewart, P., 2010, Effect of time on concentration, de-agglomeration and particle size distributions of aerosol cloud generated by a simple marketed device, Lactose as a carrier for inhalation products, 26/09 - 28/09/2010, University of Parma, Italy, pp. 1-2.

Tay, T., Stewart, P., 2010, Enhancement of particle de-agglomeration during dissolution using agglomerate modifiers, WCPT6, 26/04 - 29/04/2010, NurembergMesse, Germany, pp. 1-3.

Das, S., Larson, I., Morton, D., Young, P., Stewart, P., 2010, Further understanding of surface energy of lactoses showing different behaviours in formulation, Lactose as a carrier for inhalation products, 26/09 - 28/09/2010, Consortium TEFARCO Innova, BioPharmaNet, University of Parma, Italy, pp. 1-2.

Morton, D., Qu, L., Zhou, Q., Stewart, P., Larson, I., 2010, Improving the flow and dispersion properties of several micronized drug powders using an innovative dry coating approach, World Congress on Particle Technology 6, Nuremberg, Germany, 2010, 26/04/2010, Society of Chemical Industry, Nuremberg, Germany, pp. 1-2.

Stewart, P., Morton, D., Zhou, Q., Larson, I., 2010, The influence of dry powder coating methods, including mechanofusion, on the flow properties of inhalable grades of lactose monohydrate., World Congress on Particle Technology 6, Nuremberg, Germany, 2010, 26/04/2010, Society of Chemical Industry, Germany, pp. 1-2.

Larson, I., Morton, D., Stewart, P., Behara, S., 2010, The influence of structure of cohesive binary mixtures on dispersibility behavior under varying flow conditions, World Congress on Particle Technology 6, Nuremberg, Germany, 2010, Society of Chemical Industry, Germany, pp. 1-2.

Das, S., Morton, D., Zhou, Q., Stewart, P., 2010, Understanding the dry coating process of lactose surface by surface energy analysis, Lactose as a carrier for inhalation products, 26/09/2010-28/09/2010, TEFARCO Innova, Italy, p. 1.

Das, S., Morton, D., Zhou, Q., Stewart, P., 2010, Understanding the dry coating process of lactose surface by surface energy analysis, Lactose as a carrier for inhalation products, 26/09 - 28/09/2010, TEFARCO Innova, Italy, pp. 21-22.

Morton, D., Stewart, P., Zhou, Q., Larson, I., Das, S., 2010, Understanding the surface energy changes of mechanofused pharmaceutical powders., World Congress on Particle Technology 6, Nuremberg, Germany, 2010, 26/04/2010, Society of Chemical Industry, Germany, pp. 1-2.

Das, S.C., Morton, D.A.V., Vu, L.T., Hourigan, J.A., Stewart, P.J., 2009, A novel ternary component for dry powder inhaler formulations, Respiratory Drug Delivery 2009, 19/05-22/05/2009, Davis Healthcare International Publishing, USA, pp. 327-332.

Islam, M.N., Stewart, P.J., Larson, I.C., Hartley, P., 2009, Adhesion and dispersion of salmeterol xinafoate from lactose interactive mixtures for inhalation - can surface roughness of carriers determine performance, CHEMECA 2009, 27/09-30/09/2009, Engineers Australia, Australia, pp. 1-10.

Morton, D.A.V., Stewart, P.J., Das, S.C., Lifran, E.V., Vu, L.T., Sleigh, R.W., Hourigan, J.A., 2009, Engineered lactose carrier partciles: does latered microstructure give improved performance?, Respiratory Drug Delivery 2009, 19/05/2009-22/05/2009, Davis Healthcare International Publishing, USA, pp. 333-336.

Stewart, P.J., 2009, Influence of mixing and formulation on agglomeration and functionality of micronised drug powders, CHEMECA 2009, 27Septermber 2009 to 30 September 2009, Engineers Australia, Australia, pp. 1-11.

Das, S.C., Larson, I.C., Young, P.M., Stewart, P.J., 2009, Influence of moisture on surface energy determination by inverse gas chromatography, CHEMECA 2009, 27 September 2009 to 30 September 2009, Engineers Australia, Australia, p. 0.

Morton, D.A.V., Zhou, Q., Armstrong, B., Larson, I.C., Stewart, P.J., 2009, Surface engineering to improve the flowability and fluidization of a cohesive powder, CHEMECA 2009, 27 September 2009 to 30 September 2009, Engineers Australia, Australia, p. CD.

Das, S.C., Larson, I.C., Young, P.M., Stewart, P.J., 2008, Change in surface energy of lactoses after storage at high relative humidity deterined by inverse gas chromatography, Proceedings of Respiratory Drug Delivery, 11 May to 15 May 2008, Virginia Commonwealth University, USA, pp. 645-648.

Morton, D.A.V., Stewart, P.J., Zhou, T.Q., 2008, Investigating the flow modification of fine lactose carrier particles, RDD 2008, 11-15 May 2008, RDD, USA, pp. 655-660.

Zhou, T.Q., Armstrong, B., Morton, D.A.V., Stewart, P.J., 2008, Investigation of Fundamental Powder Flow Properties of Fine Lactose Particles Following Mechanical Surface Modification, DDL 19 Proceedings, 11/12/2008-15/12/2008, The Aerosol Society, UK, pp. 49-51.

Zhou, Q., Roberts, B.A., Morton, D.A.V., Stewart, P.J., 2008, Investigation of fundamental powder flow properties of fine lactose particles following mechanical surface modification, DDL 19, 10 -12/2008, DDL, UK, pp. 49-51.

Andreou, J.G., Stewart, P.J., Morton, D.A.V., 2008, Investigation of physical changes in drug-carrier interactive mixtures on blending, DDl 19, 10-12 December 2008, DDL 19, UK, pp. 2-5.

Das, S.C., Larson, I.C., Young, P.M., Stewart, P.J., 2008, The Changes in Dispersion of Salmeterol Xinafoate-lactose Mixtures During Storage at Different Relative Humidities, DDL 19 Proceedings, 11/12/2008-15/12/2008, The Aerosol Society, UK, pp. 128-131.

Das, S.C., Larson, I.C., Stewart, P.J., 2008, The changes in dispersion of salmeterol xinafoate-lactose mixtures during storage at different relative humidities, Proceedings of the Drug Delivery to the Lungs 19 Conference (DDL19), 10/12/2008 - 12/12/2008, DDL, UK, pp. 128-131.

Traini, D., Young, P.M., Chan, H., Stewart, P.J., Adi, H., 2007, Co-sprayed dried antibiotics for dry powder inhalation delivery, RDD Europe 2007, 17 April 2007 to 20 April 2007, Virginia Commonwealth University, United States of America, pp. 369-372.

Kale, K.P., Hapgood, K., Stewart, P.J., 2007, Effect of mixing speed and time on dispersion of cohesive drug powder mixtures measured during drug dissolution, Proceedings of CHEMECA 2007: Academia and Industry Strenghtening the Profession, 23 September 2007 to 26 September 2007, Engineers Australia, Australia, pp. 475-484.

Das, S.C., Larson, I.C., Young, P.M., Stewart, P.J., 2007, The relationship between the performance and surface energy of salmeterol xinafoate powders for inhalation during long term storage at different relative humidity, Proceedings of CHEMECA 2007: Academia and Industry Strengthening the Profession, 23 September 2007 to26 September 2007, Engineers Australia, Australia, pp. 468-474.

Islam, M.N., Stewart, P.J., Larson, I.C., Hartley, P., 2006, Measurement of surface roughness of lactose powders by AFM and confocal microscopy, 33rd Australasian Chemical Engineering conference, 17 September 2006 to 20 September 2006, Institute of Chemical Engineers, Auckland NZ, pp. 1-6.

Stewart, P.J., 2006, The importance of 'fines' control in carrier lactose, Proceedings of The Respiratory Drug Delivery 2006, 23 April 2006 to 27 April 2006, Davis Healthcare International Publishing, River Grove USA, pp. 333-341.

Adi, H., Larson, I.C., Stewart, P.J., 2005, Fractionation of narrow particle size distributions of micronised lactose by milling and wet sieving techniques, Chemeca 2005, 25/09/2005 to 28/09/2005, Institute of Chemical Engineers, Australia, pp. 1-6.

Adi, H., Larson, I.C., Stewart, P.J., 2005, Influence of cohesive properties of micronised lactose powders on particle size analysis by laser diffraction, CHEMECA 2005, 25 September 2005 to 28 September 2005, Institution of Chemical Engineers, IChemE, SCENZ, RACI, Australia, pp. 1-6.

Allahham, A., Stewart, P.J., 2005, The effect of lactose properties on the in vitro dissolution of micronised indomethacin from interactive mixtures, Chemeca 2005, 25/09/2005 to 28/09/2005, Institute of Chemical Engineers, Australia, pp. 1-6.

Adi, H., Larson, I.C., Stewart, P.J., 2004, Influence of particle size of the fine lactose in the dispersion of salmeterol xinafoate from lactose mixtures for inhalation, Respiratory Drug Delivery, 25 April 2004 to 29 April 2004, Davis Healthcare International Publishing, River Grove USA, pp. 553-556.

Zhao, F., Stewart, P.J., 1999, Bioavailability study of indomethacin interactive mixtures in rats, Proceedings of the Australasian Pharmaceutical Science Association, Fremantle WA 28 November - 1 December 1999, Curtin University of Technology, Perth WA Australia, p. 67.

Louey, M.D., Mulvaney, P., Stewart, P.J., 1999, Distributions in adhesion force of lactose carriers by atomic force microscopy, AAPS PharmSci Supplement, New Orleans USA 14-18 November 1999, American Association of Pharmaceutical Sciences, USA, p. S-540.

Louey, M.D., Stewart, P.J., 1999, Fine particle effects on drug deposition from dry powder inhalers, AAPS PharmSci Supplement, New Orleans USA 14-18 November 1999, American Association of Pharmaceutical Sciences, USA, p. S-545.

Nguyen, M., Rhodes, M.J., Wang, S.S., Stewart, P.J., Liffman, K., 1999, Investigation of the influence of interparticle force on fluidized bed behaviour using DEM simulation, CHEMECA '99 - Particle Technology W'shop, Newcastle, NSW, 26-29 Sept 1999, Inst of Engrs Aust, Canberra ACT Australia.

Zhao, F., Stewart, P.J., 1999, Particle dispersion and dissolution study of indomethacin interactive mixtures, Proceedings of the Australasian Pharmaceutical Science Association, Fremantle WA 28 November - 1 December 1999, Curtin University of Technology, Perth WA Australia, p. 67.

Louey, M.D., Mulvaney, P., Stewart, P.J., 1998, Adhesion force measurements of pharmaceutical powders by atomic force microscopy, Proceedings of ASCEPT: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart Tas, 13-16 December 1998, Australasian Soc of Clinical & Exp Pharm & Toxicol, Sydney NSW Australia, p. 96.

Zhao, F., Stewart, P.J., 1998, Monitoring the particle dispersion of interactive mixtures of benzodiazepines in non-sink conditions using laser diffraction, AAPS PharmSci? Supplement, San Franscio USA, 15-19 November 1998, American Association of Pharmaceutical Scientists, Virgina USA, p. S317.

Zhao, F., Stewart, P.J., 1998, Using laser diffraction to monitor drug particle dispersion behaviour of benzodiazephine interactive mixtures, Proceedings of ASCEPT: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart Tas, 13-16 December 1998, Australasian Soc of Clinical & Exp Pharm & Toxicol, Sydney NSW Australia, p. 62.

Andreou, J.G., Stewart, P.J., 1997, Changes in dissolution rate following the preparation of interactive mixtures of nitrazepam, Pharmaceutical Research, Boston USA, 2-6 November, Plenum Press, New York NY USA, p. S523.

Zhao, F., Stewart, P.J., 1997, Particle size distribution changes during the dissolution of interactive mixtures, Australasian Pharmaceutical Science Association 1997 Conference, Sydney Australia, 26-28 Novemb, APSA 1997 Organising Committee, Sydney NSW Australia, p. 69.

Louey, M.D., Stewart, P.J., 1997, The effect of carrier type and drug concentration on the fine particle fraction of dry powder aerosol formulations, Australasian Pharmaceutical Science Association 1997 Conference, Sydney Australia, 26-28 November, APSA 1997 Organising Committee, Sydney NSW Australia, p. 60.

Other

Das, S.C., Larson, I.C., Young, P.M., Stewart, P.J., 2008, Investigation into the mechanism of dispersibility changes of salmeterol xinafoate powders for inhalation using a spraytec, Poster Presentation as listed in the APSA 2008: Handbook, APSA, Australia.

Teaching Commitment

• Teaching expertise in physical pharmacy and drug delivery

Activities

Affiliations with research centres

Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

Positions on advisory boards

Member
Health and Medicine Peer Review Panel
Performance-Based Research Fund in New Z

Grants

Title:

Bio-rad Excalibur Series Ft-ir Spectrophotometer to Provide Enhanced Analytical Capabilities Across a Number of Research Groups.

Investigators:

Stewart, P, Von Itzstein, M, Charman, W, Charman, S, Reed, B, Finnin, B, McLeish, M, Crosby, I, Thiel, W, Campbell, M, Kiefel, M

Funding:

(1998 - 1998). Australian Research Council (ARC). $27,500.00

Title:

Simulation of Pharmaceutical Fluidized Bed Processes Using a Discrete Element Method.

Investigators:

Rhodes, M, Stewart, P

Funding:

(1999 - 2001). Australian Research Council (ARC). $139,257.00

Title:

Upgrade of College Centrifuge Facilities.

Investigators:

Stewart, P, Von Itzstein, M, Mitchelson, F

Funding:

(1997 - 1997). Australian Research Council (ARC). $30,000.00

Title:

Particulate Characterisation for Pharmaceutical and Engineering Applications.

Investigators:

Chan, H, Stewart, P, Romagnoli, J, Amal, R, Valix, M, Coombes, A, Yang, R, Yang, R, Langrish, T

Funding:

(2004 - 2015). University of New South Wales. $0.00

(2005 - 2015). Australian Research Council (ARC). $0.00

(2005 - 2015). Monash University. $0.00

(2005 - 2015). University of Sydney. $0.00

Title:

State of the art high resolution nanoscale thermal analysis suite for the life and material sciences.

Investigators:

Chan, H, Stewart, P, Larson, I, Young, P, Traini, D, Weiss, A, Murray, M, Dehghani, F, Hibbs, D, Warr, G

Funding:

(2007 - 2011). Australian Research Council (ARC). $0.00

(2007 - 2011). Monash University. -$30,000.00

(2007 - 2011). Monash University. -$60,000.00

Title:

Characterising particulate laden flow in the lung airways: from drug delivery to primary anthropogenic sources.

Investigators:

Stewart, P, Soria, J, Honnery, D, Chan, H, Thompson, B, Larson, I, Young, P

Funding:

(2006 - 2010). Australian Research Council (ARC). $230,000.00

(2006 - 2010). Monash University. $10,000.00

(2006 - 2010). Monash University. $50,000.00

(2006 - 2010). Monash University. $60,000.00

(2006 - 2010). University of Sydney. $55,000.00

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Effect of surface coating via mechanical dry coating on the functionality of pharmaceutical powders.

Supervisors:

Morton, D (Main), Stewart, P (Associate), Hapgood, K (Associate).

Program of Study:

(MASTER'S BY RESEARCH).

Thesis Title:

Insight into de-agglomeration of mechanofused salbutamol sulphate powders for inhalation.

Supervisors:

Stewart, P (Main), Larson, I (Associate), Morton, D (Associate).

Completed Supervision

Student:

Adi, H.

Program of Study:

Understanding the role of fine excipients on the dispersion of salmeterol xinafoate from powder mixtures for inhalation. (PHD) 2006.

Supervisors:

Stewart, P (Main), Larson, I (Associate).

Student:

Al Lahham, A.

Program of Study:

Development, validation and application of an in vitro method of evaluating injectability using a micro-capillary rheometer.. (Masters) 2003.

Supervisors:

Stewart, P (Main).

Student:

Al Lahham, A.

Program of Study:

Effect of micronised excipients on the in vitro dissolution of indomethacin from interactive mixtures. (PHD) 2007.

Supervisors:

Stewart, P (Main).

Student:

Behara, S.

Program of Study:

Insight into mechanisms of de-agglomeration of pharmaceutical powders for inhalation. (PHD) 2011.

Supervisors:

Larson, I (Joint), Stewart, P (Joint-Co), Morton, D (Associate).

Student:

Das, S.

Program of Study:

Understanding the changes in dispersion of salmeterol xinafoate-lactose mixtures during storage at different relative humidities. (PHD) 2008.

Supervisors:

Stewart, P (Main), Larson, I (Associate).

Student:

Heinicke, I.

Program of Study:

The role of capillary forces in the dispersion of dry powder interactive mixtures. (Masters) 2007.

Supervisors:

Larson, I (Main), Stewart, P (Associate).

Student:

Islam, M.

Program of Study:

THE INFLUENCE OF SURFACE CHARACTERISTICS OF LACTOSE CARRIERS ON THE RESPIRATORY DELIVERY OF SALMETEROL XINAFOATE FROM INTERACTIVE MIXTURES. (PHD) 2004.

Supervisors:

Stewart, P (Main), Larson, I (Associate).

Student:

Kale, K.

Program of Study:

Influence of mixing parameters on dispersion and de-agglomeration within indomethacin interactive mixtures.. (Masters) 2007.

Supervisors:

Stewart, P (Main), Hapgood, K (Associate).

Student:

Louey, M.

Program of Study:

PARTICLE INTERACTIONS IN POWDER MIXTURES FOR INHALATION. (PHD) 2000.

Supervisors:

Stewart, P (Main).

Student:

Tay Mei Yee, T.

Program of Study:

Novel formulation strategies with a mechanistic approach to improving the dissolution of a poorly water-soluble drug. (PHD) 2011.

Supervisors:

Stewart, P (Main), Morton, D (Associate).

Student:

Zhao, F.

Program of Study:

CORRELATION BETWEEN PHYSICOCHEMICAL PROPERTIES OF DRUG AND ITS BIOAVAILABILITY. (PHD) 2001.

Supervisors:

Stewart, P (Main).

Student:

Zhou, Q.

Program of Study:

Surface modification of pharmaceutical powders. (PHD) 2011.

Supervisors:

Morton, D (Joint), Stewart, P (Joint-Co), Larson, I (Associate).