Prof Richard Harding - Researcher Profile

Biography

Professor Richard Harding is a NHMRC Senior Principal Research Fellow with the Department of Anatomy and Developmental Biology. His research focuses on Respiratory Development and Programming.

Related Links:

• Respiratory Development and Programming

Keywords

hypoxia, hyperoxia,, respiratory development, respiratory programming, respiratory illness,

Qualifications

DOCTOR OF SCIENCE

Institution: Monash University

Year awarded: 1992

DOCTOR OF PHILOSOPHY

Institution: University of Edinburgh

Year awarded: 1971

MASTER OF SCIENCE

Institution: University of Melbourne

Year awarded: 1968

BACHELOR OF SCIENCE

Institution: University of Melbourne

Year awarded: 1966

Publications

Books

Harding, R., Bocking, A.D. (eds), 2001, Fetal Growth and Development, Cambridge University Press, UK.

Book Chapters

Harding, R., Hooper, S.B., 2011, Physiologic mechanisms of normal and altered lung growth before and after birth, in Fetal and Neonatal Physiology, eds R.A. Polin, W.W. Fox and SH Abman, Saunders, USA, pp. 885-895.

Harding, R., Snibson, K.J., O'Reilly, M., Maritz, G.S., 2009, Early environmental influences on lung development: implications for lung function and respiratory health throughout life, in Early Life Origins of Human Health and Disease, eds DP Newnham & MG Ross, Karger, Switzerland, pp. 78-88.

Harding, R., Hooper, S.B., 2009, Lung growth and maturation, in Fetal Medicine: Basic Science and Clinical Practice, eds CH Rodeck & MJ Whittle, Churchill Livingstone, USA, pp. 133-146.

Harding, R., Hooper, S.B., Albuquerque, C.A., 2006, Fetal Breathing, in Encyclopedia of Respiratory Medicine, eds Geoffrey J Laurent and Steven D Shapiro, Elservier Ltd, Amsterdam Netherlands, pp. 242-246.

Hooper, S.B., Harding, R., 2006, Fetal Lung Liquid, in Encyclopedia of Respiratory Medicine, eds Geoffrey J. Laurent and Steven D. Shapiro, Elsevier Ltd, Amsterdam Netherlands, pp. 246-250.

Harding, R., Pinkerton, K.E., 2006, Lung Anatomy (including the Aging Lung), in Encyclopedia of Respiratory Medicine, eds G Laurent & S Shapiro, Academic Press, UK, pp. 606-613.

Harding, R., Hooper, S.B., Wallace, M.J., 2006, Lung development, in Encyclopedia of Respiratory Medicine, eds Geoffrey J Laurent and Steven D Shapiro, Elsevier Ltd, Amsterdam Netherlands, pp. 613-619.

Rees, S.M., Harding, R., Inder, T., 2006, The developmental environment and the origins of neurological disorders, in Developmental Origins of Health and Disease, eds Peter Gluckman and Mark Hanson, Cambridge University Press, New York USA, pp. 379-391.

Harding, R., Cock, M.L., Maritz, G.S., 2006, The developmental environment: effects on lung structure and function, in Developmental Origins of Health and Disease, eds Peter Gluckman; Mark Hanson, Cambridge University Press, New York USA, pp. 336-348.

Harding, R., Hooper, S.B., 2004, Physiologic mechanisms of normal and altered lung growth, in Fetal and Neonatal Physiology, eds RA Polin, WW Fox & SH Abman, Elsevier, USA, pp. 802-811.

Hooper, S.B., Harding, R., 2004, Pulmonary transition at birth, in The Lung: Development, Aging and the Environment, eds Richard Harding, Kent E Pinkerton and Charles G Plopper, Elsevier Academic Press, USA, pp. 201-211.

Harding, R., Cock, M.L., Albuquerque, C.A., 2004, Role of nutrition in the lung development before and after birth, in The Lung: Development, Aging and the Environment, eds Richard Harding, Kent E Pinkerton and Charles G Plopper, Elsevier Academic Press, USA, pp. 253-266.

Hooper, S.B., Harding, R., 2001, Respiratory System, in Fetal Growth and Development, eds Richard Harding, Alan D Bocking, Cambridge University Press, Cambridge United Kingdom, pp. 114-136.

Harding, R., Hooper, S.B., 1999, Lung development and maturation, in Fetal Medicine: Basic Science and Clinical Practice, eds -, Churchill Livingstone, London UK, pp. 181-196.

Harding, R., 1997, Fetal Pulmonary Development: The Role of Respiratory Movements, in Equine Veterinary Journal, eds -, Equine Veterinary Journal Ltd, UK, pp. 32-39.

Journal Articles

O'Reilly, M., Sozo, F., Harding, R., 2013, The impact of preterm birth and bronchopulmonary dysplasia on the developing lung: long-term consequences for respiratory health, Clinical and Experimental Pharmacology and Physiology [E], vol E-pub, Wiley-Blackwell Publishing Asia, Australia, pp. 1-25.

Kenna, K.R., Sozo, F., De Matteo, R.M., Hanita, T., Gray, S.P., Tare, M., Moritz, K.M., Bertram, J.F., Black, M.J., Brien, J.F., Parkington, H.C., Walker, D.W., Harding, R., 2012, Alcohol exposure during late gestation: multiple developmental outcomes in sheep, Journal of Developmental Origins of Health and Disease [P], vol 3, issue 4, Cambridge University Press, UK, pp. 224-236.

Crossley, K.J., Allison, B.J., Polglase, G., Morley, C.J., Harding, R., Davis, P.G., Moss, T.J.M., Hooper, S.B., 2012, Effects of caffeine on renal and pulmonary function in preterm newborn lambs, Pediatric Research [P], vol 72, issue 1, Nature Publishing Group, United States, pp. 19-25.

Atik, A.A., Sozo, F., Orgeig, S., Suri, L., Hanita, T., Harding, R., De Matteo, R.M., 2012, Long-term pulmonary effects of intrauterine exposure to endotoxin following preterm birth in sheep, Reproductive Sciences [P], vol 19, issue 12, Sage Publications, Inc., USA, pp. 1352-1364.

Harding, R., Maritz, G.S., 2012, Maternal and fetal origins of lung disease in adulthood, Seminars in Fetal and Neonatal Medicine [P], vol 17, issue 2, WB Saunders Co Ltd, UK, pp. 67-72.

Bensley, J.G., De Matteo, R.M., Harding, R., Black, J., 2012, Preterm birth with antenatal corticosteroid administration has injurious and persistent effects on the structure and composition of the aorta and pulmonary artery, Pediatric Research [P], vol 71, issue 2, Nature Publishing Group, USA, pp. 150-155.

Ishak, N., Hanita, T., Sozo, F., Maritz, G.S., Harding, R., De Matteo, R.M., 2012, Sex differences in cardiorespiratory transition and surfactant composition following preterm birth in sheep, American Journal of Physiology - Regulatory Integrative and Comparative Physiology [E], vol 303, issue 7, American Physiological Society, USA, pp. R778-R789.

Polglase, G., Hooper, S., Kluckow, M., Gill, A., Harding, R., Moss, T., 2012, The cardiopulmonary haemodynamic transition at birth is not different between male and female preterm lambs, Reproduction, Fertility and Development [P], vol 24, issue 3, C S I R O Publishing, Australia, pp. 510-516.

Muhlhausler, B., Hancock, S., Bloomfield, F., Harding, R., 2011, Are twins growth restricted?, Pediatric Research [P], vol 70, issue 2, Nature Publishing Group, USA, pp. 117-122.

Kenna, K., De Matteo, R., Hanita, T., Rees, S., Sozo, F., Stokes, V., Walker, D., Bocking, A., Brien, J., Harding, R., 2011, Daily ethanol exposure during late ovine pregnancy: Physiological effects in the mother and fetus in the apparent absence of overt fetal cerebral dysmorphology, American Journal Of Physiology-Regulatory Integrative And Comparative Physiology [P], vol 301, issue 4, American Physiological Society, USA, pp. R926-R936.

Loeliger, M.L., Mackintosh, A., De Matteo, R.M., Harding, R.L., Rees, S., 2011, Erythropoietin protects the developing retina in an ovine model of endotoxin-induced retinal injury, Investigative Ophthalmology and Visual Science [P], vol 52, issue 5, Association for Research in Vision and Ophthalmology, USA, pp. 2656-2661.

Brew, N., Hooper, S., Allison, B., Wallace, M., Harding, R., 2011, Injury and repair in the very immature lung following brief mechanical ventilation, American Journal Of Physiology-Lung Cellular And Molecular Physiology [P], vol 301, issue 6, American Physiological Society, USA, pp. L917-L926.

Cvejic, L., Harding, R., Churchward, T., Turton, A., Finlay, P., Massey, D., Bardin, P.G., Guy, P., 2011, Laryngeal penetration and aspiration in individuals with stable COPD, Respirology [P], vol 16, issue 2, Wiley-Blackwell Publishing Asia, Australia, pp. 269-275.

Maritz, G., Harding, R., 2011, Life-long programming implications of exposure to tobacco smoking and nicotine before and soon after birth: Evidence for altered lung development, International Journal of Environmental Research and Public Health [E], vol 8, issue 3, M D P I AG, Swizterland, pp. 875-898.

Rees, S., Harding, R., Walker, D., 2011, The biological basis of injury and neuroprotection in the fetal and neonatal brain, International Journal of Developmental Neuroscience [P], vol 29, issue 6, Pergamon, UK, pp. 551-563.

Nitsos, I., Newnham, J.P., Rees, S.M., Harding, R.L., Moss, T.J., 2011, The impact of chronic intrauterine inflammation on the physiologic and neurodevelopmental consequences of intermittent umbilical cord occlusion in fetal sheep, Reproductive Sciences [P], vol E, Sage Publications, Inc., USA, pp. 1-13.

Goh, J.M., Bensley, J.G., Kenna, K.R., Sozo, F., Bocking, A.D., Brien, J.F., Walker, D.W., Harding, R., Black, M.J., 2010, Alcohol exposure during late gestation adversely affects myocardial development with implications for postnatal cardiac function, American Journal Of Physiology-Heart And Circulator..., vol 300, issue 2, American Physiological Society, USA, pp. H645-H651.

Bensley, J.G.A., Stacy, V., De Matteo, R.M., Harding, R., Black, M.J., 2010, Cardiac remodelling as a result of pre-term birth: Implications for future cardiovascular disease, European Heart Journal [P], vol 31, issue 16, Oxford University Press, UK, France, pp. 2058-2066.

Sozo, F., Vela, M., Stokes, V., Kenna, K.R., Meikle, P.J., De Matteo, R.M., Walker, D.W., Brien, J.F., Bocking, A.D., Harding, R.L., 2010, Effects of prenatal ethanol exposure on the lungs of postnatal lambs, American Journal Of Physiology-Lung Cellular And Molecular Physiology [P], vol 300, issue 1, American Physiological Society, USA, pp. L139-L147.

Dijkstra, F., Jozwiak, M., De Matteo, R.M., Duncan, J., Hale, N., Harding, R., Rees, S.M., 2010, Erythropoietin ameliorates damage to the placenta and fetal liver induced by exposure to lipopolysaccharide, Placenta [P], vol 31, issue 4, Elsevier Ltd, UK, pp. 282-288.

Rees, S.M., Hale, N., De Matteo, R.M., Cardamone, L., Tolcos, M., Loeliger, M., Mackintosh, A., Shields, A., Probyn, M.E., Greenwood, D.L., Harding, R., 2010, Erythropoietin is neuroprotective in a preterm ovine model of endotoxin-induced brain injury, Journal of Neuropathology and Experimental Neurol..., vol 69, issue 3, Lippincott Williams & Wilkins, USA, pp. 306-319.

De Matteo, R.M., Blasch, N., Stokes, V., Davis, P., Harding, R., 2010, Induced preterm birth in sheep: A suitable model for studying the developmental effects of moderately preterm birth, Reproductive Sciences [P], vol 17, issue 8, Sage Publications, Inc., USA, pp. 724-733.

Probyn, M.E., Cock, M.L., Duncan, J.R., Tolcos, M., Hale, N., Shields, A., Rees, S.M., Harding, R., 2010, The anti-inflammatory agent N-acetyl cysteine exacerbates endotoxin-induced hypoxemia and hypotension and induces polycythemia in the ovine fetus, Neonatology [P], vol 98, issue 2, S. Karger AG, Switzerland, pp. 118-127.

De Matteo, R.M., Snibson, K., Thompson, B., Koumoundouros, E., Harding, R., 2009, Lung function in developing lambs: Is it affected by preterm birth?, Journal Of Applied Physiology [P], vol 107, issue 4, American Physiological Society, USA, pp. 1083-1088.

O'Reilly, M., Hooper, S.B., Allison, B.J., Flecknoe, S.J., Snibson, K., Harding, R., Sozo, F., 2009, Persistent bronchiolar remodeling following brief ventilation of the very immature ovine lung, American Journal Of Physiology-Lung Cellular And M..., vol 297, issue 5, American Physiological Society, USA, pp. L992-L1001.

Sozo, F., O'Day, L.D., Maritz, G., Kenna, K.R., Stacy, V., Brew, N., Walker, D.W., Bocking, A.D., Brien, J.F., Harding, R., 2009, Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung, American Journal of Physiology: Lung Cellular and Molecular Physiology, vol 296, American Physiological Society, United States, pp. 1-38.

Stacy, V., De Matteo, R.M., Brew, N., Sozo, F., Probyn, M.E., Harding, R., Black, M.J., 2009, The influence of naturally occuring differences in birthweight on ventricular cardiomyocyte number in sheep, The Anatomical Record, vol 292, John Wiley & Sons, Inc., United States, pp. 29-37.

Rees, S.M., Harding, R., Walker, D.W., 2008, An adverse intrauterine environment: implications for injury and altered development of the brain, International Journal of Developmental Neuroscience, vol 26, Pergamon-Elsevier Science Ltd, Oxford, England, UK, pp. 3-11.

Verbeek, M.M., Richardson, H.L., Parslow, P.M., Walker, A.M., Harding, R., Horne, R.S.C., 2008, Arousal and ventilatory responses to mild hypoxia in sleeping preterm infants, Journal of Sleep Research, vol 17, issue 3, Wiley-Blackwell Publishing Ltd., UK, pp. 344-353.

De Matteo, R.M., Stacy, V., Probyn, M.E., Brew, N., Blasch, N., Harding, R., 2008, Does moderate preterm birth lead to altered arterial pressure? Studies in sheep, Clinical and Experimental Pharmacology & Physiology, vol 35, issue 12, Wiley-Blackwell Publishing Asia, Australia, pp. 1426-1432.

Dalitz, P., Cock, M.L., Harding, R., Rees, S.M., 2008, Injurious effects of acute ethanol exposure during late gestation on developing white matter in fetal sheep, International Journal of Developmental Neuroscience, vol 26, issue 5, Pergamon, United Kingdom, pp. 391-399.

Snibson, K., Harding, R., 2008, Postnatal growth rate, but not mild preterm birth, influences airway structure in adult sheep challenged with house dust mite, Experimental Lung Research, vol 34, issue 2, Informa Healthcare, United Kingdom, pp. 69-84.

Gray, S.P., Kenna, K.R., Bertram, J.F., Hoy, W.E., Yan, E.B., Bocking, A.D., Brien, J.F., Walker, D.W., Harding, R., Moritz, K.M., 2008, Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep, American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol 295, issue 2, American Physiological Society, USA, pp. 568-574.

Probyn, M.E., Stacy, V., Desai, M., Ross, M., Harding, R., 2008, Spontaneously occurring differences in fetal weight do not affect blood pressure, the hypothalamic-pituitary-adrenal axis or the renin-angiotensin system in the late-gestation ovine fetus, Reproduction, Fertility and Development, vol 20, issue 4, CSIRO, Australia, pp. 451-459.

De Matteo, R.M., Stacy, V., Probyn, M.E., Desai, M., Ross, M., Harding, R., 2008, The perinatal development of arterial pressure in sheep: Effects of low birth weight due to twinning, Reproductive Sciences, vol 15, issue 1, Sage Science Press (US), United States, pp. 66-74.

Allison, B.J., Crossley, K.J., Flecknoe, S.J., Davis, P.G., Morley, C.J., Harding, R., Hooper, S.B., 2008, Ventilation of the very immature lung in utero induces injury and BPD-like changes in lung structure in fetal sheep, Pediatric Research, vol 64, issue 4, Lippincott Williams & Wilkins, United States, pp. 387-392.

Gatford, K., Dalitz, P., Cock, M.L., Harding, R., Owens, J.A., 2007, Acute ethanol exposure in pregnancy alters the insulin-like growth factor axis of fetal and maternal sheep, American Journal of Physiology-Endocrinology and Metabolism, vol 292, issue 2, American Physiological Society, Bethesda USA, pp. 494-500.

Crossley, K.J., Morley, C.J., Allison, B.J., Polglase, G.R., Dargaville, P.A., Harding, R., Hooper, S.B., 2007, Blood gases and pulmonary blood flow during resuscitation of very preterm lambs treated with antenatal betamethasone and/or curosurf: Effect of positive end-expiratory pressure, Pediatric Reseaarch, vol 62, issue 1, Int Pediatric Research Foundation Inc, Baltimore MD USA, pp. 37-42.

Thompson, B., King, G., Harding, R., 2007, Commentary on 'The role of the large airways on smooth muscle contraction in asthma', Journal of Applied Physiology, vol 103, issue 4, American Physiological Society, USA, p. 1465.

Feltis, B.N., Wignarajah, D., Reid, D.W.F., Ward, C., Harding, R., Walters, E.H., 2007, Effects of inhaled fluticasone on angiogenesis and vascular endothelial growth factor in asthma, Thorax, vol 62, issue 4, BMJ Publishing Group, London England, pp. 314-319.

Bubb, K., Cock, M.L., Black, M.J., Dodic, M., Boon, W.M., Parkington, H.C., Harding, R., Tare, M., 2007, Intrauterine growth restriction delays cardiomyocyte maturation and alters coronary artery function in the fetal sheep, The Journal of Physiology-London, vol 578, issue 3, Blackwell Publishing Ltd, Oxord England, pp. 871-881.

Maritz, G.S., Probyn, M.E., De Matteo, R.M., Snibson, K.J., Harding, R., 2007, Lung parenchyma at maturity is influenced by postnatal growth but not by moderate preterm birth in sheep, Neonatology, vol 93, Karger, Basel Switzerland, pp. 28-35.

Richardson, H.L., Parslow, P.M., Walker, A.M., Harding, R., 2007, Maturation of the initial ventilatory response to hypoxia in sleeping infants, Journal of Sleep Research, vol 16, issue 1, Blackwell Publishing, Oxford, England, pp. 117-127.

Zohdi, V., Moritz, K.M., Bubb, K.J., Cock, M.L., Wreford, N.G., Harding, R., Black, M.J., 2007, Nephrogenesis and the renal renin-angiotensin system in fetal sheep: effects of intrauterine growth restriction during late gestation, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol 293, issue 3, Americal Physiological Society, Bethesda MD USA, pp. R1267-R1273.

Suzuki, K., Harding, R., 2007, Pulmonary circulation and pulmonary function in neonatal lung hypoplasia: treatment with corticosteroids, Current Pediatric Reviews, vol 3, issue 4, Bentham Science Publishers Ltd, The Netherlands, pp. 264-276.

Loeliger, M., Duncan, J., Cock, M.L., Harding, R., Rees, S.M., 2007, Vulnerability of dopaminergic amacrine cells and optic nerve myelination to prenatal endotoxin exposure, Investigative Ophthalmology and Visual Science, vol 48, issue 1, Associate Research Vision Ophthalmology Inc, Rockville MD USA, pp. 472-478.

Briscoe, T., Duncan, J., Cock, M.L., Choo, J., Rice, G.E., Harding, R., Scheerlinck, J., Rees, S.M., 2006, Activation of NF-kappaB transcription factor in the preterm ovine brain and placenta after acute LPS exposure, Journal of Neuroscience Research, vol 83, issue 4, John Wiley & Sons, Inc., Hoboken USA, pp. 567-574.

Snibson, K.J., Bischof, R.J., Koumoundouros, E., McMurtrie, L.S., Cock, M.L., Harding, R., 2006, Altered airway responsiveness in adult sheep born prematurely: effects of allergen exposure, Experimental Lung Research, vol 32, issue 6, Taylor and Francis Ltd, UK, pp. 215-228.

Sozo, F., Wallace, M.J., Hanna, M., Flecknoe, S.J., Cock, M.L., Maritz, G., Harding, R., Hooper, S.B., 2006, Alveolar epithelial cell differentiation and surfactant protein expression after mild preterm birth in sheep, Pediatric Research, vol 59, issue 1, Int. Pediartric Research Foundation, Inc., Baltimore USA, pp. 151-156.

Duncan, J., Cock, M.L., Suzuki, K., Scheerlinck, J., Harding, R., Rees, S.M., 2006, Chronic Endotoxin Exposure Causes Brain Injury in the Ovine Fetus in the Absence of Hypoxemia, Journal of the Society for Gynecologic Investigation, vol 13, issue 2, Elsevier Science Ltd, New York NY USA, pp. 87-96.

Nitsos, I., Rees, S.M., Duncan, J., Kramer, B.W., Harding, R., Newnham, J.P., Moss, T.J.M., 2006, Chronic exposure to intra-amniotic lipopolysaccharide affects the ovine fetal brain, Journal of The Society for Gynecologic Investigation, vol 13, issue 4, Elsevier, New York USA, pp. 239-247.

Suzuki, K., Hooper, S.B., Wallace, M.J., Probyn, M.E., Harding, R., 2006, Effects of antenatal corticosteroid treatment on pulmonary ventilation and circulation in neonatal lambs with hypoplastic lungs, Pediatric Pulmonology, vol 41, issue 9, John Wiley & Sons, Inc, Hoboken USA, pp. 844-854.

Feltis, B.N., Wignarajah, D., Zheng, L., Ward, C., Reid, D.W.F., Harding, R., Walters, E.H., 2006, Increased vascular endothelial growth factor and receptors: relationship to angiogenesis in asthma, American Journal of Respiratory and Critical Care Medicine, vol 173, issue 11, American Thoracic Society, New York USA, pp. 1201-1207.

Brace, R.A., Cheung, C.Y., Davis, L.E., Gagnon, R., Harding, R., Widness, J.A., 2006, Sources of amniotic fluid erythropoietin during normoxia and hypoxia in fetal sheep, American Journal of Obstetrics and Gynecology, vol 195, issue 1, Mosby-Elsevier, New York USA, pp. 246-254.

Richardson, H.L., Parslow, P.M., Walker, A.M., Harding, R., Horne, R.S.C., 2006, Variability of the initial phase of the ventilatory response to hypoxia in sleeping infants, Pediatric Research, vol 59, issue 5, Lippincott Williams & Wilkins, USA, pp. 700-704.

Tuladhar, R., Harding, R., Adamson, T.M., Horne, R.S.C., 2005, Comparison of postnatal development of heart rate responses to trigeminal stimulation in sleeping preterm and term infants, Journal of Sleep Research, vol 14, issue 1, Blackwell Publishing Ltd, Oxford England, pp. 29-36.

Maritz, G.S., Morley, C.J., Harding, R., 2005, Early developmental origins of impaired lung structure and function, Early Human Development, vol 81, issue 9, Elsevier Science Ireland Ltd, Ireland, pp. 763-771.

Suzuki, K., Hooper, S.B., Cock, M.L., Harding, R., 2005, Effect of lung hypoplasia on birth-related changes in the pulmonary circulation in sheep, Pediatric Research, vol 57, issue 4, Lippingcott Williams & Wilkins, USA, pp. 530-536.

Moss, T.J.M., Doherty, D.A., Nitsos, I., Sloboda, D., Harding, R., Newnham, J.P., 2005, Effects into adulthood of single or repeated antenatal corticosteroids in sheep, American Journal of Obstetrics and Gynecology, vol 192, issue 1, Mosby, Inc., USA, pp. 146-152.

Probyn, M.E., Hooper, S.B., Dargaville, P.A., McCallion, N., Harding, R., Morley, C.J., 2005, Effects of tidal volume and positive end-expiratory pressure during resuscitation of very premature lambs, Acta Paediatrica, vol 94, issue 12, Taylor & Francis Ltd, UK, pp. 1764-1770.

Loeliger, M., Duncan, J., Louey, S.C., Cock, M.L., Harding, R., Rees, S.M., 2005, Fetal growth restriction induced by chronic placental insufficiency has long-term effects on the retina but not the optic nerve, Investigative Ophthalmology & Visual Science (IOVS), vol 46, issue 9, Association for Research in Vision and Ophthamology, USA, pp. 3300-3308.

Harding, R., 2005, Fetal origins of postnatal health and disease, Early Human Development, vol 81, issue 9, Elsevier Ireland Ltd, Ireland, pp. 721-722.

Tuladhar, R., Harding, R., Adamson, T.M., Horne, R.S.C., 2005, Heart rate responses to non-arousing trigeminal stimulation in infants: Effects of sleep position, sleep state and postnatal age, Early Human Development, vol 81, Elsevier Ireland Ltd, Ireland, pp. 673-681.

Harding, R., Cock, M.L., Maritz, G.S., 2005, Impact of the intrauterine environment on respiratory health throughout life, Physiology News, vol 58, The Physiological Society, London UK, pp. 19-21.

Louey, S.C., Cock, M.L., Harding, R., 2005, Long term consequences of low birthweight on postnatal growth, adiposity and brain weight at maturity in sheep, Journal of Reproduction and Development, vol 51, issue 1, Japanese Society of Animal Reproduction, Japan, pp. 59-68.

Polglase, G.R., Morley, C.J., Crossley, K.J., Dargaville, P.A., Harding, R., Morgan, D.L., Hooper, S.B., 2005, Positive end-expiratory pressure differentially alters pulmonary hemodynamics and oxygenation in ventilated, very premature lambs, Journal of Applied Physiology, vol 99, issue 4, American Physiological Society, Bethesda USA, pp. 1453-1461.

Horne, R.S.C., Parslow, P.M., Harding, R., 2005, Postnatal development of ventilatory and arousal responses to hypoxia in human infants, Respiratory Physiology & Neurobiology, vol 149, issue 1-3, Elsevier BV, The Netherlands, pp. 257-271.

Camm, E.J., Gibbs, M.E., Harding, R., Mulder, T., Rees, S.M., 2005, Prenatal hypoxia impairs memory function but does not result in overt structural alterations in the postnatal chick brain, Developmental Brain Research, vol 160, issue 1, Elsevier, The Netherlands, pp. 9-18.

Cock, M.L., Hanna, M., Sozo, F., Wallace, M.J., Yawno, T., Suzuki, K., Maritz, G.S., Hooper, S.B., Harding, R., 2005, Pulmonary function structure following mild preterm birth in lambs, Pediatric Pulmonology, vol 40, issue 4, John Wiley & Sons, Inc., USA, pp. 336-348.

Hooper, S.B., Harding, R., 2005, Role of aeration in the physiological adaptation of the lung to air-breathing at birth, Current Respiratory Medicine Reviews, vol 1, issue 2, Bentham Science Publishers Ltd, The Netherlands, pp. 185-195.

Parslow, P.M., Cranage, S.M., Adamson, T.M., Harding, R., Horne, R.S.C., 2004, Arousal and ventilatory responses to hypoxia in sleeping infants: effects of maternal smoking, Respiratory Physiology & Neurobiology, vol 140, issue 1, Elsevier Science BV, Netherland, pp. 77-87.

Rees, S.M., Harding, R., 2004, Brain development during fetal life: influences of the intra-uterine environment, Neuroscience Letters, vol 361, issue 1-3, Elsevier Science Ireland, Ireland, pp. 111-114.

Boland, R.E., Joyce, B.J., Wallace, M.J., Stanton, H., Fosang, A.J., Pierce, R.A., Harding, R., Hooper, S.B., 2004, Cortisol enhances structural maturation of the hypoplastic fetal lung in sheep, Journal of Physiology, vol 554, issue 2, Blackwell Publishing, Oxford UK, pp. 505-517.

Parslow, P.M., Harding, R., Adamson, T.M., Horne, R.S.C., 2004, Effects of Sleep State and Postnatal Age on Arousal Responses Induced by mild Hypoxia in Infants, Sleep, vol 27, issue 1, American Academy Sleep Medicine, USA, pp. 77-87.

Duncan, J.R., Camm, E.J., Loeliger, M., Cock, M.L., Harding, R., 2004, Effects of umbilical cord occlusion in late gestation on the ovine fetal brain and retina, Journal of the Society for Gynecologic Investigation, vol 11, issue 6, Elsevier, New York USA, pp. 369-376.

Maritz, G.S., Cock, M.L., Louey, S.C., Suzuki, K., Harding, R., 2004, Fetal growth restriction has long-term effects on postnatal lung structure in sheep, Pediatric Research, vol 55, issue 2, International Pediatric Research Foundation, Inc., USA, pp. 287-295.

Albuquerque, C.A., Smith, K.R., Johnson, C., Chao, R., Harding, R., 2004, Influence of maternal tobacco smoking during pregnancy on uterine, umbilical and fetal cerebral artery blood flows, Early Human Development, vol 80, issue 1, Elsevier, Ireland, pp. 31-42.

Cheung, C.Y., Bogic, L., Gagnon, R., Harding, R., Brace, R.A., 2004, Morphologic alterations in ovine placenta and fetal liver following induced severe placental insufficiency, Journal of the Society for Gynecologic Investigation, vol 11, issue 8, Elsevier, New York USA, pp. 521-528.

Mitchell, E.K.L., Louey, S.C., Cock, M.L., Harding, R., Black, M.J., 2004, Nephron endowment and filtration surface area in the kidney after growth restriction of fetal sheep, Pediatric Research, vol 55, issue 5, International Pediatric Research Foundation, Inc., Baltimore USA, pp. 769-773.

Duncan, J.R., Cock, M.L., Harding, R., Rees, S.M., 2004, Neurotrophin expression in the hippocampus and cerebellum is affected by chronic placental insufficiency in the late gestational ovine fetus, Developmental Brain Research, vol 153, issue 2, Elsevier, Amsterdam The Netherlands, pp. 243-250.

Probyn, M.E., Hooper, S.B., Dargaville, P.A., McCallion, N., Crossley, K.J., Harding, R., Morley, C.J., 2004, Positive end expiratory pressure during resuscitation of premature lambs rapidly improves blood gases without adversely affecting arterial pressure, Pediatric Research, vol 56, issue 2, International Pediatric Research Foundation, Inc., Baltimore USA, pp. 198-204.

Cock, M.L., Hooper, S.B., Wallace, M.J., Gagnon, R., Brace, R.A., Louey, S.C., Harding, R., 2004, Pulmonary elastin synthesis and deposition in developing and mature sheep: effects of intrauterine growth restriction, Experimental Lung Research, vol 30, issue 5, Taylor & Francis Inc., Philadelphia USA, pp. 405-418.

Flecknoe, S.J., Boland, R.E., Wallace, M.J., Harding, R., Hooper, S.B., 2004, Regulation of alveolar epithelial cell phenotypes in fetal sheep: roles of cortisol and lung expansion, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol 287, issue 6, American Physiological Society, Bethesda USA, pp. 1207-1214.

Horne, R.S.C., Parslow, P.M., Harding, R., 2004, Respiratory control and arousal in sleeping infants, Paediatric Respiratory Reviews [P], vol 5, issue 3, Elsevier Ltd, UK, pp. 190-198.

Camm, E.J., Harding, R., Lambert, G.W., Gibbs, M.E., 2004, The role of catecholamines in memory impairment in chicks following reduced gas exchange in ovo, Neuroscience, vol 128, issue 3, Pergamon-Elsevier Science Ltd, Oxford UK, pp. 545-553.

Parslow, P.M., Harding, R., Cranage, S.M., Adamson, T.M., Horne, R.S., 2003, Arousal responses to somatosensory and mild hypoxic stimuli are depressed during quiet sleep in healthy term infants, Sleep, vol 26, issue 6, American Academy of Sleep Medicine, Westchester USA, pp. 739-744.

Flecknoe, S.J., Wallace, M.J., Cock, M.L., Harding, R., Hooper, S.B., 2003, Changes in alveolar epithelial cell proportions during fetal and postnatal development in sheep, American Journal of Physiology, Lung Cellular and Molecular Physiology, vol 285, issue 3, American Physiological Society, Bethesda USA, pp. 664-670.

Loeliger, M., Louey, S., Cock, M.L., Harding, R., Rees, S.M., 2003, Chronic placental insufficiency and foetal growth restriction lead to long-tem effects on postnatal retinal structure, Clinical and Experimental Opthalmology, vol 31, issue 3, Blackwell Publishing Asia, Carlton Vic Australia, pp. 250-253.

Moss, T.J., Nitsos, I., Harding, R., Newnham, J.P., 2003, Differential effects of maternal and fetal betamethasone injections in late-gestation fetal sheep, Journal of the Society for Gynecologic Investigation, vol 10, issue 8, Elsevier, New York USA, pp. 474-479.

Tuladhar, R., Harding, R., Cranage, S.M., Adamson, T.M., Horne, R.S., 2003, Effects of sleep position, sleep state and age on heart rate responses following provoked arousal in term infants, Early Human Development, vol 71, issue 2, Elsevier Science Ireland Ltd, Clare Ireland, pp. 157-169.

Loeliger, M., Watson, C.S., Reynolds, J.D., Penning, D.H., Harding, R., Bocking, A.D., Rees, S.M., 2003, Extracellular glutamate levels and neuropathology in cerebral white matter following repeated umbilical cord occlusion in the near term fetal sheep, Neuroscience, vol 116, issue 3, Pergamon-Elsevier Science Ltd, Oxford UK, pp. 705-714.

Moss, T.J., Doherty, D.A., Nitsos, I., Harding, R., Newnham, J.P., 2003, Pharmacokinetics of betamethasone after maternal or fetal intramuscular administration, American Journal of Obstetrics and Gynecology, vol 189, issue 6, Mosby, Inc., St Louis USA, pp. 1751-1757.

Dalitz, P., Harding, R., Rees, S.M., Cock, M.L., 2003, Prolonged reductions in placental blood flow and cerebral oxygen delivery in preterm fetal sheep exposed to endotoxin: possible factors in white matter injury after acute infection, Journal of the Society for Gynecologic Investigation, vol 10, issue 5, Elsevier, New York USA, pp. 283-290.

Joyce, B.J., Wallace, M.J., Pierce, R.A., Harding, R., Hooper, S.B., 2003, Sustained changes in lung expansion alter tropoelastin mRNA levels and elastin content in fetal sheep lungs, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol 284, issue 4, American Physiological Society, Bethesda USA, pp. 643-649.

Duncan, J.R., Cock, M.L., Rees, S.M., Harding, R., 2003, The effects of repeated endotoxin exposure on placental structure in sheep, Placenta, vol 24, issue 7, W B Saunders Co. Ltd, London UK, pp. 786-789.

Tolcos, M., Harding, R., Loeliger, M., Breen, S., Cock, M.L., Duncan, J., Rees, S.M., 2003, The fetal brainstem is relatively spared from injury following intrauterine hypoxemia, Developmental Brain Research, vol 143, issue 1, Elsevier, Amsterdam The Netherlands, pp. 73-81.

Parslow, P.M., Harding, R., Cranage, S.M., Adamson, T.M., Horne, R.S., 2003, Ventilatory responses preceding hypoxia-induced arousal in infants: effects of sleep-state, Respiratory Physiology & Neurobiology, vol 136, issue 2-3, Elsevier Science BV, Amsterdam The Netherlands, pp. 235-247.

Gagnon, R., Harding, R., Brace, R.A., 2002, Amniotic fluid and fetal urinary responses to severe placental insufficiency in sheep, American Journal of Obstetrics and Gynecology, vol 186, issue 5, Mosby Inc, St Louis USA, pp. 1076-1084.

Flecknoe, S.J., Wallace, M.J., Harding, R., Hooper, S.B., 2002, Determination of alveolar epithelial cell phenotypes in fetal sheep: evidence for the involvement of basal lung expansion, Journal of Physiology, vol 542-1, Cambridge University Press, New York NY USA, pp. 245-253.

Watson, C.S., Schafer, R., White, S.E., Homan, J.H., Fraher, L.L., Harding, R., Bocking, A.D., 2002, Effect of intermittent umbilical cord occulsion on fetal respiratory activity and brain adenosine in late-gestation sheep, Reproduction, Fertility and Development, vol 14, CSIRO Publishing, Collingwood Vic Australia, pp. 35-42.

Moss, T.J.M., Davey, M.G., Harding, R., Newnham, J.P., 2002, Effects of Intra-amniotic endotoxin on lung structure and function two months after term birth in sheep, Journal of the Society for Gynecological Investigation, vol 9, issue 4, Elsevier Science Inc, New York NY USA, pp. 220-225.

Nitsos, I., Moss, T.J.M., Cock, M.L., Harding, R., Newnham, J.P., 2002, Fetal responses to intra-amniotic endotoxin in sheep, Journal of the Society for Gynecological Investigation, vol 9, issue 2, Elsevier Science Inc, New York NY USA, pp. 80-85.

Brown, J., Briscoe, T., Harding, R., Cock, M.L., Bertram, J.F., Black, J.M., 2002, Glomerular number and capillary dimensions in the normal lamb kidney, Image Analysis and Stereology, vol 21, International Society for Stereology, Ljubljana Slovenia, pp. 157-164.

Wignarajah, D., Cock, M.L., Pinkerton, K.E., Harding, R., 2002, Influence of intrauterine growth restriction on airway development in fetal and postnatal sheep, Pediatric Research, vol 51, issue 6, International Pediatric Research Foundation, Baltimore MD USA, pp. 681-688.

Moss, T.J.M., Harding, R., Newnham, J.P., 2002, Lung function, arterial pressure and growth in sheep during early postnatal life following single and repeated prenatal corticosteroid treatments,, Early Human Development, vol 66, Elsevier Science Ltd, Coclare Ireland, pp. 11-24.

Albuquerque, C.A., Smith, K.R., Saywers, T.E., Johnson, C., Cock, M.L., Harding, R., 2002, Relation between oligohydramnios and spinal flexion in the human fetus, Early Human Development, vol 68, issue 2, Elsevier Science Ltd, Coclare Ireland, pp. 119-126.

Duncan, J., Cock, M.L., Scheerlinck, J., Westcott, K.T., McLean, C., Harding, R., Rees, S.M., 2002, White matter injury after repeated endotoxin exposure in the preterm ovine fetus, Pediatric Research, vol 52, issue 6, International Pediatric Research Foundation, Baltimore MD USA, pp. 941-949.

Rees, S., Harding, R., 2001, Brain development during fetus life: what happens when things go wrong?, Today's Life Science, vol 13, Vertical Markets Operations Pty Ltd, NSW Australia, pp. 36-44.

Joyce, B.J., Louey, S., Davey, M.G., Cock, M., Hooper, S.B., Harding, R., 2001, Compromised respiratory function in postnatal lambs after placental insufficiency and intrauterine growth restriction, Pediatric Research, vol 50, issue 5, INT Pediatric Research Foundation, Baltimore MD USA, pp. 641-649.

Maritz, G., Cock, M., Louey, S., Joyce, B.J., Albuquerque, C.A., Harding, R., 2001, Effects of fetal growth restriction on lung development before and after birth: A morphometric analysis, Pediatric Pulmonology, vol 32, Wiley-Liss, New York NY USA, pp. 201-210.

Cock, M., Albuquerque, C.A., Joyce, B.J., Hooper, S.B., Harding, R., 2001, Effects of intrauterine growth restriction on lung liquid dynamics and lung development in fetal sheep, American Journal of Obstetrics and Gynecology, vol 184, Mosby Inc, St Louis MO USA, pp. 209-216.

Cock, M., Camm, E.J., Louey, S., Joyce, B.J., Harding, R., 2001, Postnatal outcomes in term and preterm lambs following fetal growth restriction, Clinical and Experimental Pharamacology and Physiology, vol 28, Blackwell Science Asia, Carlton Vic Australia, pp. 931-937.

Moss, T.J., Sloboda, D., Gurrin, L., Harding, R., Challis, J.R., Newnham, J.P., 2001, Programming effects in sheep of prenatal growth restriction and glucocorticoid exposure, American Journal of Physiology - Regulatory Intergrative and Comparative Physiology, vol 281, American Physiological Society, Bethesda MD USA, pp. R960-R970.

Camm, E.J., Gibbs, M.E., Harding, R., 2001, Restriction of prenatal gas exchange impairs memory consolidation in the chick, Developmental Brain Research, vol 132, issue 2, Elsevier Science BV, Amsterdam Netherlands, pp. 141-150.

Davey, M.G., Hooper, S.B., Cock, M., Harding, R., 2001, Stimulation of lung growth in fetuses with lung hypoplasia leads to altered postnatal lung structure in sheep, Pediatric Pulmonology, vol 32, issue 4, Wiley-Liss, New York NY USA, pp. 267-276.

Moss, T.J., Harding, R., 2001, Ventilatory and arousal responses to respiratory stimuli of full term, intrauterine growth restricted lambs, Respiration Physiology, vol 124, Elsevier, Amsterdam The Netherlands, pp. 195-204.

Johns, D., Wilson, J., Harding, R., Walters, E.H., 2000, Airway distensibility in healthy and asthmatic subjects: effect of lung volume history, Journal of Applied Physiology, vol 88, Amercian Physiology Society, Bethesda MD USA, pp. 1413-1420.

Camm, E.J., Gibbs, M.E., Cock, M., Rees, S., Harding, R., 2000, Assessment of learning ability and behaviour in low birthweight lambs following intrauterine growth restriction, Reproduction, Fertility and Development, vol 12, CSIRO Publishing, Melbourne Vic Australia, pp. 165-172.

Nardo, L., Maritz, G., Harding, R., Hooper, S.B., 2000, Changes in lung structure and cellular division induced by tracheal obstruction in fetal sheep, Experimental lung research, vol 26, Hemipshere publishing corporation, Bristol PA USA, pp. 105-119.

Harding, R., Tester, M., Moss, T.J., Davey, M.G., Louey, S., Joyce, B.J., Hooper, S.B., Maritz, G., 2000, Effects of intra-uterine growth restriction on the control of breathing and lung development after birth, Clinical & Experimental Pharmacology and Physiology, vol 27 issue 1, Blackwell Science Asia, Melbourne Vic Australia, pp. 114-119.

Flecknoe, S.J., Harding, R., Maritz, G., Hooper, S.B., 2000, Increased lung expansion alters the proportions of type I and type II alveolar epithelial cells in fetal sheep, American Journal of Physiology: Lung cell and molecular physiology, vol 278, American Physiology Society, Bethesda MD USA, pp. L1180-L1185.

Louey, S., Cock, M., Steveson, K.M., Harding, R., 2000, Placental insufficiency and fetal growth restriction lead to postnatal hypotension and altered postnatal growth in sheep, Pediatric Research, vol 48 issue 6, International Pediatric Research Foundation, Baltimore MD USA, pp. 808-814.

Duncan, J., Cock, M., Harding, R., Rees, S., 2000, Relation between damage to the placenta and the fetal brain after late-gestation placental embolization and fetal grwoth restriction in sheep, American Journal of Obstetrics & Gynacology, vol 183, Mosby Inc, St Louis MO USA, pp. 1013-1022.

Harding, R., Cock, M.L., Louey, S., Joyce, B.J., Davey, M.G., Albuquerque, C.A., Hooper, S.B., Maritz, G.S., 2000, The compromised intra-uterine environment: implications for futrue lung health, Clinical and Experimental Pharmacology and Physiology, vol 27 issue 12, Blackwell Science Asia, Melbourne Vic Australia, pp. 965-974.

Moss, T.J., Harding, R., 2000, Ventilatory and arousal responses of sleeping lambs to respiratory challenges: effect of prenatal maternal anemia, Journal of Applied Physiology, vol 88, American Physiological Society, Bethesda MD USA, pp. 641-648.

Roufail, E., Harding, R., Tester, M., Rees, S., 1999, Chronic hypoxemia effects on developing nitrergic and dopaminergic amacrine cells, Investigative Opthalmology and Visual Science, vol 40, JP Lippincott, Philadelphia PA USA, pp. 1467-1476.

Rees, S., Loeliger, M., McCrabb, G., Harding, R., 1999, Hypoxemia near mid-gestation has long term effects on fetal brain development, Journal of Neuropathology and Experimental Neurology, vol 58, American Association of Neuropathologists Inc, Lawrence KS USA, pp. 932-945.

Harding, R., Albuquerque, C.A., 1999, Pulmonary hypoplasia; role of mechanical factors in prenatal lung growth, Lung Development, vol -, American Physiological Society/Oxford Univ Press, New York NY USA, pp. 364-394.

Davey, M.G., Hooper, S.B., Tester, M., Johns, D.P., Harding, R., 1999, Respiratory function in lambs after "in utero" treatment of lung hypoplasia by tracheal obstruction, Journal of Applied Physiology, vol 87 issue 6, American Physiological Society, Bethesda MD USA, pp. 2296-2304.

Mallard, C., Rees, S., Stringer, M., Cock, M., Harding, R., 1998, Effects of chronic placental insufficiency on brain development in fetal sheep, Pediatric Research, vol 43 (2), American Pediatric Society, Baltimore USA, pp. 262-270.

Wlodek, M.E., Hooper, S.B., Thorburn, G.D., Tester, M., Harding, R., 1998, Effects of prostaglandin E2 on renal function and lung liquid dynamics in foetal sheep, Clinical and Experimental Pharmacology and Physiology, vol 25, Blackwell Science Asia, Carlton Vic Australia, pp. 805-812.

Rees, S., Mallard, C., Breen, S., Stringer, M., Cock, M., Harding, R., 1998, Fetal brain injury following prolonged hypoxemia and placental insufficiency; A review, Comparative Biochemistry and Physiology, vol 119a (3), Elsevier Science Inc, NY USA, pp. 653-660.

Davey, M.G., Harding, R., Johns, D., 1998, Postnatal development of respiratory function in lambs studied serially between birth and 8 weeks, Respiration Physiology, vol 113, Elsevier Science, Oxford UK, pp. 83-93.

Davey, M.G., Johns, D.P., Harding, R., 1998, Postnatal development of respiratory function in lambs studied serially between birth and 8 weeks, Respiratory Physiology, vol 113, Elsevier Science, NY USA, pp. 83-93.

Nardo, L., Hooper, S.B., Harding, R., 1998, Stimulation of growth by tracheal obstruction in fetal sheep: relation to luminal pressure and lung liquid volume, Pediatric Research, vol 43 (2), American Pediatric Society, Baltimore USA, pp. 184-190.

Moss, T.J., Harding, R., 1998, Ventilatory responsiveness to asphyxia during sleep in newborn lambs: effects of maternal anemia during pregnancy, Sleep Research On Line, vol 1, World Federation of Sleep Research Society, http:\\www.sro.org, pp. 75-79.

Harding, R., Jakubowska, A.E., McCrabb, G., 1997, Arousal and cardiorespiratory responses to airflow obstruction in sleeping lambs: Effects of sleep state, age and repeated obstruction, Sleep, vol 20, Am Sleep Dis Assoc & Sleep Research Society, USA, pp. 693-701.

McCrabb, G., Harding, R., 1997, Cerebral oxygen delivery is reduced during the acidaemia associated with prolonged hypoxemia in the immature ovine fetus, Biology of the Neonate, vol 71, Karger, Switzerland, pp. 385-394.

Cock, M., McCrabb, G., Wlodek, M.E., Harding, R., 1997, Effects of prolonged hypoxemia on fetal renal function and amniotic volume in sheep, American Journal of Obstetrics & Gynecology, vol 176, Mosby-Yearbook, USA, pp. 320-326.

Dickson, K.A., Harding, R., 1997, Fetal and maternal fluid balance in sheep during hyperthermia with and without water deprivation, Experimental Physiology, vol 82, Physiological Society, UK, pp. 777-789.

Lines, A., Hooper, S.B., Harding, R., 1997, Lung liquid production rates and volumes do not decrease before labour in healthy fetal sheep, Journal of Applied Physiology, vol 82, American Physiological Society, Bethesda MD USA, pp. 927-932.

Cock, M., Harding, R., 1997, Renal and amniotic fluid responses to umbilicoplacental embolisation for 20 days in fetal sheep, American Journal of Physiology, vol 273, American Physiological Society, USA, pp. 1094-1102.

Rees, S., Stringer, M., Just, Y., Hooper, S.B., Harding, R., 1997, The vulnerability of the fetal sheep brain to hypoxemia at mid gestation, Developmental Brain Research, vol 103, Elsevier, Amsterdam Netherlands, pp. 103-118.

Conference Proceedings

Harding, R., Cock, M.L., Joyce, B.J., Louey, S.C., Wignarajah, D., Suzuki, K., Albuquerque, C.A., Maritz, G., Wallace, M.J., Hooper, S.B., 2003, Immediate and long-term consequences of induced low birthweight in sheep, Havemeyer Foundation Monograph Series No. 8, 13 March 2002 - 15 March 2002, R & W Publications (Newmarket) Limited, Newmarket UK, pp. 29-31.

Duncan, J., Mallard, C., Tester, M., Harding, R., Rees, S., 1999, Alterations to hippocampal brain-derived neurotrophic factor protein following chronic hypoxemia in the fetus, Proceedings of the Australian Neuroscience Society, Hobart, Tas, 31 January-3 February 1999, AUstralian Neuroscience Society, Canberra ACT Australia, p. 63.

Moss, T.J., Newnham, J.P., Braekevelt, C.R., Harding, R., 1999, Blood pressure in 3 month old lambs is not affected by repeated prenatal betamethasone treatments, Perinatal Society of Australia and New Zealand 3rd Annual Congress, Melbourne, Victoria, 21-24 March 1999, The Perinatal Society of Ausstralia and New Zealad, Parramatta NSW, p. 266.

Lines, A., Davey, M.G., Harding, R., Hooper, S.B., 1999, Continuous positive airway pressure (CPAP) at 10cm H<2O does not alter surfactant protein mRNA levels in 2 week old lambs, Perinatal Society of Australia and New Zealand 3rd Annual Congress, Melbourne, Victoria, 21-24 March 1999, The Perinatal Society of Australia and New Zealand, Parramatta NSW, p. 110.

Lines, A., Davey, M.G., Harding, R., Hooper, S.B., 1999, Continuous positive airway pressure (CPAP) does not alter surfactant protein MRNA levels in 2 week old lambs, Respiratory and Critical Care Medicine, San Diego, CA, USA, 23-28 April 1999, American Thoracic Society, New York NY USA, p. 731A.

Harding, R., 1999, Control of lung development: roles of physical and metabolic factors, New Frontiers in Neonatology, Wurzburg, Germany, Wurzburg Germany, p. 13.

Roufail, E., Harding, R., Tester, M., Rees, S., 1999, Differential effects on developing nitrergic and dopaminergic amacrine cells in the retina in fetal growth restriction, Perinatal Society of Australia and New Zealand 3rd Annual Congress, Melbourne, Victoria, 21-24 March 1999, The Perinatal Society of Australia and New Zealand, Parramatta NSW, p. 17.

Louey, S., Tester, M., Joyce, B.J., Steveson, K.M., Harding, R., 1999, Effects of late gestational intrauterine growth restriction on fetal and postnatal arterial pressure, Perinatal Society of Ausstralia and New Zealand 3rd Annual Congress, Melbourne, Victoria, 21-24 March 1999, The Perinatal Society of Australia and New Zealand, Parramatta NSW, p. 297.

Joyce, B.J., Tester, M., Lines, A., Louey, S., Hooper, S.B., Harding, R., 1999, Effects of late gestational placental insufficiency on lung growth and pulmonary surfactant proteins in fetal sheep and 8 week old lambs, Perinatal Society of Australia and New Zealand 3rd Annual Congress, Melbourne VIC 21-24 March 1999, Perinatal Society of Australia and New Zealand, Parramatta NSW, p. 295.

Duncan, J., Tester, M., Harding, R., Rees, S., 1999, Effects of late gestational umbilico-placental embolisation on placental structure and fetal growth, Perinatal Society of Australia and New Zealand 3rd Annual Congrerss, Melbourne VIC 12-24 March 1999, The Perinatal Society of Australia and New Zealand, Parramatta NSW, p. 67.

Roufail, E., Harding, R., Tester, M., Rees, S., 1999, Fetal growth restriction: differential effects on developing nitrergic and dopaminergic amacrine cells in the retina, Proceedings of the Australian Neuroscience Society, Hobart, Tas, 31 January-3 February 1999, Austrailan Neuroscience Society, Canberra ACT Australia, p. 84.

Hooper, S.B., Flecknoe, S.J., Maritz, G., Harding, R., 1999, Increased fetal lung expansion changes the proportion of alveolar epithelial cells (AEC); evidence for type-II to type-I cell differentiation, Respiratory and Critical Care Medicine, San Diego, CA, USA, 23-28 April 1999, American Thoracic Society, New York NY USA, p. 669A.

Tester, M., Louey, S., Joyce, B.J., Davey, M.G., Maritz, G., Harding, R., 1999, Lung development following intrauterine growth restriction, Perinatal Society of Australia and New Zealand 3rd Annual Congress, Melbourne, Victoria, 21-24 March 1999, The Perinatal Society of Australia and New Zealand, Parramatta NSW, p. 119.

Flecknoe, S.J., Harding, R., Maritz, G., Hooper, S.B., 1999, The effect of altered lung expansion on the proportion of alveolar epithelial cells in fetal sheep, Perinatal Society of Australia and New Zealand 3rd Annual Congress, Melbourne, Victoria, 21-24 March 1999, The Perinatal Society of Australia and New Zealand, Parramatta NSW, p. 117.

Camm, E.J., Gibbs, M.E., Tester, M., Rees, S., Harding, R., 1999, The effects of placental insufficiency on learning and behaviour in postnatal lambs, Perinatal Society of Australia and New Zealand 3rd Annual Congress, Melbourne, Victoria, 21-24 March 1999, The Perinatal Society of Australia and New Zealand, Parramatta NSW, p. 298.

Harding, R., Cock, M., Hooper, S.B., Maritz, G., 1998, The effects of intrauterine compromise on respiratory development, Equine Veterinary Journal, Sydney Australia 9-11 February 1998, Equine Veterinary Journal Ltd, Newmarket UK, pp. 459-460.

Nardo, L., Hooper, S.B., Harding, R., 1997, Analysis of pulmonary cell types undergoing DNA synthesis following obstruction of the fetal trachea in sheep, First Annual Congress Perinatal Society of Australia and New Zealand, Femantle WA,16-24 March 1997, Perinat Soc of A&NZ, Wyeth Clin Meet Services, Parramatta NSW, p. A8.

Davey, M.G., Hooper, S.B., Johns, D.P., Harding, R., 1997, Measurements of lung function during early postnatal life in lambs with normal and hypoplastic lungs, First Annual Congress Perinatal Society of Australia & New Zealand Proceedings, Fremantle WA,16-24 March 1997, The Perinatal Soc of A&NZ, Wyeth Clin. Meet Serv, Paramatta NSW, p. A92.

Other

Harding, R., Snibson, K., O'Reilly, M., Maritz, G.S., 2009, Early Environmental Influences on Lung Development: Implications for Lung Function and Respiratory Health throughout Life, Early Life Origins of Human Health and Disease, vol monograph, S Karger AG, Switzerland, pp. 78-88.

Harding, R., Hooper, S.B., 2009, Lung growth and maturation, Fetal Medicine, vol monograph, Elsevier Ltd, UK, pp. 133-146.

Grants

Title:

Early Developmental Compromises: Effects on Postnatal Respiratory and Cardiovascular Function - Sprf.

Investigators:

Harding, R, Cock, M, Adamson, T, Stevenson, K, Anderson, W, Hooper, S, Henderson-Smart, D, Parkington, H, Horne, R, Walker, D

Funding:

(1999 - 2003). National Health & Medical Research Council (NHMRC).

Title:

Fetal alcohol syndrome: oxidative stress and innovative therapies.

Investigators:

Harding, R

Funding:

(2005 - 2009). Canadian Institutes of Health Research.

(2010 - 2014). Canadian Institutes of Health Research.

Title:

Maternal alcohol in pregnancy: arterial stiffness and endothelial dysfunction in the offspring.

Investigators:

Parkington, H, Tare, M, Morley, R, Harding, R

Funding:

(2009 - 2012). Heart Foundation.

Title:

NHMRC 1995 Project - Dr R Harding.

Investigators:

Harding, R

Funding:

(1999 - ). National Health & Medical Research Council (NHMRC).

Title:

NHMRC Research Fellowship.

Investigators:

Harding, R

Funding:

(2001 - 2005). National Health & Medical Research Council (NHMRC).

(2002 - 2003). National Health & Medical Research Council (NHMRC).

(2004 - 2008). National Health & Medical Research Council (NHMRC).

(2004 - 2011). National Health & Medical Research Council (NHMRC).

(2005 - 2013). National Health & Medical Research Council (NHMRC).

(2007 - 2013). National Health & Medical Research Council (NHMRC).

(2010 - 2013). National Health & Medical Research Council (NHMRC).

(2010 - 2014). National Health & Medical Research Council (NHMRC).

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Novel strategies for improving respiratory support and outcomes for preterm babies: ID 384100.

Investigators:

Harding, R, Morley, C, Hooper, S, Davis, P, Cole, T

Funding:

(2006 - 2010). National Health & Medical Research Council (NHMRC).

(2006 - 2012). National Health & Medical Research Council (NHMRC).

(2010 - 2014). National Health & Medical Research Council (NHMRC).

Title:

Oligohydramnios, fetal lung expansion and lung development.

Investigators:

Harding, R

Funding:

Title:

Postnatal Effects of Prenatal Brain Injury: a Structural, Neurochemical and Behavioural Study.

Investigators:

Harding, R, Rees, S

Funding:

(1998 - 1998). National Health & Medical Research Council (NHMRC).

Title:

Postnatal respiratory function following sub-optimal intra-uterine conditions.

Investigators:

Harding, R, Cock, M

Funding:

(1995 - 1999). National Health & Medical Research Council (NHMRC).

Title:

Role of Physical Forces in the Determination of Pulmonary Epithelial Cell Phenotypes (990478).

Investigators:

Hooper, S, Harding, R

Funding:

(1999 - 2001). National Health & Medical Research Council (NHMRC).

Title:

The role of fetal fluid sacs in fluid balance and nutrition of the fetus.

Investigators:

Thorburn, G, Harding, R

Funding:

Title:

Mechanisms of programmed hypertension in twin offspring.

Investigators:

Ross, M, Harding, R

Funding:

(2005 - 2009). Los Angeles Biomedical Research Institute.

Title:

Protecting the preterm fetal brain from hypoxia and infection: A healthy start to life.

Investigators:

Rees, S, Harding, R, Cock, M, Rice, G

Funding:

(2005 - 2009). National Health & Medical Research Council (NHMRC).

(2006 - 2010). National Health & Medical Research Council (NHMRC).

Title:

Improved respiratory support and outcomes for very preterm babies.

Investigators:

Hooper, S, Davis, P, Doyle, L, Harding, R, Cole, T, Moss, T

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

(2011 - 2015). The University of Melbourne.

(2012 - 2016). The University of Melbourne.

Title:

Can erythropoietin provide long-term protection against inflammation-induced brain injury? Relevance to Cerebral Palsy.

Investigators:

Tolcos, M, Harding, R, De Matteo, R

Funding:

(2010 - 2014). Cerebral Palsy Foundation.

(2011 - 2015). Cerebral Palsy Foundation.

Title:

Does caffeine affect the development of the very immature brain: dose response relationship?.

Investigators:

Tolcos, M, De Matteo, R, Cheong, J, Harding, R, Rees, S

Funding:

(2010 - 2014). National Health & Medical Research Council (NHMRC).

(2011 - 2015). National Health & Medical Research Council (NHMRC).

(2012 - 2015). National Health & Medical Research Council (NHMRC).

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Can maternal creatine and/or melatonin supplementation protect the fetus against hypoxic injury?.

Supervisors:

Harding, R (Joint-co), Walker, D (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Programming effects of neonatal exposure to hyperoxic gas on the developing airways.

Supervisors:

Harding, R (Joint), Sozo, F (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The effects of daily caffeine administration on the development of the immature brain: Short and long-term effects at escalating doses..

Supervisors:

De Matteo, R (Main), Harding, R (Associate), Tolcos, M (Associate).

Completed Supervision

Student:

Atik, A.

Program of Study:

The Effects of Nutrition and Growth on critical organ development after pre term birth. 2009.

Supervisors:

De Matteo, R (Main), Harding, R (Associate).

Student:

Brew, N.

Program of Study:

Mechanical ventilation of the very immature lung: mechanisms of injury and repair. (PHD) 2012.

Supervisors:

Harding, R (Joint-Co), Hooper, S (Joint).

Student:

Camm, E.

Program of Study:

THE EFFECTS OF PRENATAL HYPOXIA ON POSTNATAL COGNITIVE FUNCTION: A BEHAVIOURAL, PHARMACOLOGICAL AND STRUCTURAL STUDY. (PHD) 2002.

Supervisors:

Harding, R (Main), Gibbs, M (Associate).

Student:

Cvejic, L.

Program of Study:

Prevalence of laryngeal penetration and aspiration associated with swallowing in individuals with chronic obstructive pulmonary disease (COPD).. (Masters) 2004.

Supervisors:

Harding, R (Joint-Co).

Student:

Dalitz, P.

Program of Study:

Fetal neuropathology induced by acute prenatal alcohol exposure: characteristics and potential mechanisms. (PHD) 2006.

Supervisors:

Harding, R (Main), Cock, M (Joint-Co).

Student:

Davey, M.

Program of Study:

RESPITORY FUNCTION AND LUNG STRUCTURE IN LAMBS FOLLOWING IN UTERO TREATMENT OF LUNG HYPOPLASIA BY TRACHEAL OBSTRUCTION. (PHD) 2000.

Supervisors:

Harding, R (Main), Hooper, S (Associate).

Student:

Flecknoe, S.

Program of Study:

REGULATION OF THE ALVEOLAR EPITHELIAL CELL PHENOTYPES IN FETAL AND POSTNATAL SHEEP: EFFECTS OF PHYSICAL AND ENDOCRINE FACTORS. (PHD) 2004.

Supervisors:

Hooper, S (Main), Harding, R (Associate).

Student:

Goh, M.

Program of Study:

. 2008.

Supervisors:

Black, M (Main), Harding, R (Joint).

Student:

Goh, M.

Program of Study:

EFFECTS OF REPEATED ALCOHOL EXPOSURE DURING LATE GESTATION ON HTE DEVELOPMENT OF THE HEART. (Masters) 2010.

Supervisors:

Black, M (Main), Harding, R (Joint).

Student:

Joyce, B.

Program of Study:

ELASTIN SYNTHESIS IN THE FETAL SHEEP LUNG IN VIVO: EFFECTS OF PHYSICAL, METABOLIC AND ENDOCRINE FACTORS. (PHD) 2004.

Supervisors:

Harding, R (Main), Hooper, S (Associate).

Student:

Louey, S.

Program of Study:

THE EFFECTS OF INTRAUTERINE GROWTH RESTRICTION ON POSTNATAL GROWTH, ARTERIAL PRESSURE AND THE VASCULATURE. (PHD) 2003.

Supervisors:

Harding, R (Main), Parkington, H (Joint).

Student:

Mcgregor, H.

Program of Study:

VENTILATION AND METABOLISM IN THE NEONATAL GUINEA PIG FOLLOWING PRENATAL EXPOSURE TO NICOTINE AND/OR CARBON MONOXIDE. (PHD) 2002.

Supervisors:

Walker, D (Main), Harding, R (Associate).

Student:

O'Reilly, M.

Program of Study:

The effects of neonatal inhalation of hyperoxic gas on airway development and lung function in later life. (PHD) 2012.

Supervisors:

Harding, R (Joint-Co), Sozo, F (Joint).

Student:

Suzuki, K.

Program of Study:

EFFECTS OF LUNG HYPOPLASIA ON PULMONARY VASCULAR DEVELOPMENT IN FETAL SHEEP. (PHD) 2005.

Supervisors:

Harding, R (Joint-Co), Hooper, S (Joint).

Student:

Tuladhar, R.

Program of Study:

THE DEVELOPMENT OF AUTONOMIC CONTROL OF THE CARDIOVASCULAR SYSTEM DURING SLEEP IN INFANTS. (PHD) 2003.

Supervisors:

Horne, R (Main), Harding, R (Associate).

Student:

Wignarajah, D.

Program of Study:

MICROVASCULAR REMODELLING AND ANGIOGENIC FACTORS IN ASTHMA. (PHD) 2004.

Supervisors:

Thomson, N (Main), Harding, R (Associate), Walters, E (Associate).