Dr Stuart Ellem - Researcher Profile

Biography

Dr Stuart Ellem is an early career researcher whose work focuses on the role of estrogen in the prostate and prostate disease. In particular, his work has been important in dissecting the role of both estrogen receptors in the prostate, as well defining the link between aberrant estrogen exposure, inflammation, and the development of prostate cancer.

Dr Ellem’s work includes examination of steroid and steroid receptor function/expression, inflammation, tumour microenvironment, gene expression and localisation studies, and more. Underpinning all of this is the analysis of human tissue pathology, in-vitro cell culture and modelling, and the use of various animal models.

To pursue his research work, Dr Ellem has received a number of fellowships and grants from National and International funding bodies, including the NH&MRC (Fellowship and Project grants), United States Department of Defence, and the Prostate Cancer Foundation of Australia.

Qualifications

GRADUATE DIPLOMA IN INTELLECTUAL PROPERTY LAW

Institution: Melbourne University

Year awarded: 2010

PHD

Institution: Monash University

Year awarded: 2006

BACHELOR OF SCIENCE WITH HONOURS

Institution: Monash University

Year awarded: 2001

Publications

Book Chapters

Mcpherson, S.J., Ellem, S.J., Patchev, V., Fritzemeier, K., Risbridger, G.P., 2007, The Role of ER-Alpha and ER-Beta in the prostate: insights from genetic models and isoform-selective ligands, in Tissue-Specific Estrogen Action Novel Mechanisms, Novel Ligands, Novel Therapies?, eds K. S. Korach & T. Wintermantel, Springer, Germany, pp. 131-147.

Journal Articles

Toivanen, R., Taylor, R.A., Pook, D.W., Ellem, S.J., Risbridger, G.P., 2012, Breaking through a roadblock in prostate cancer research: An update on human model systems, Journal of Steroid Biochemistry and Molecular Biology [P], vol 131, issue 3-5, Pergamon, UK, pp. 122-131.

Hussain, S., Lawrence, M.G., Taylor, R.A., Lo, C.Y., APC BioResource, Frydenberg, M., Ellem, S.J., Furic, L., Risbridger, G.P., 2012, Estrogen Receptor beta Activation Impairs Prostatic Regeneration by Inducing Apoptosis in Murine and Human Stem/Progenitor Enriched Cell Populations, PLoS ONE [P], vol 7, issue 7, Public Library of Science, USA, pp. e40732-1-e40732-9.

Toivanen, R., Berman, D., Wang, H., Pedersen, J., Frydenberg, M., Meeker, A., Ellem, S., Risbridger, G., Taylor, R., 2011, Brief report: A bioassay to identify primary human prostate cancer repopulating cells, Stem Cells [P], vol 29, issue 8, Wiley-Blackwell, USA, pp. 1310-1314.

Ellem, S.J., Risbridger, G.P., 2010, Aromatase and regulating the estrogen: Androgen ratio in the prostate gland, Journal of Steroid Biochemistry and Molecular Biology [P], vol 118, issue 4-5, Pergamon, United Kingdom, pp. 246-251.

Ellem, S.J., Wang, H., Poutanen, M., Risbridger, G.P., 2009, Increased endogenous estrogen synthesis leads to the sequential induction of prostatic inflammation (prostatitis) and prostatic pre-malignancy, American Journal Of Pathology [P], vol 175, issue 3, American Society for Investigative Pathology, United States, pp. 1187-1199.

Mcpherson, S.J., Ellem, S.J., Risbridger, G.P., 2008, Estrogen-regulated development and differentiation of the prostate, Differentiation, vol 76, issue 6, Elsevier Ltd., UK, USA, pp. 660-670.

Mcpherson, S.J., Ellem, S.J., Simpson, E., Patchev, V., Fritzemeier, K., Risbridger, G.P., 2007, Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia, Endocrinology, vol 148, issue 2, Endocrine Society, USA, pp. 566-574.

Risbridger, G.P., Ellem, S.J., Mcpherson, S.J., 2007, Estrogen action on the prostate gland: A critical mix of endocrine and paracrine signaling, Journal of Molecular Endocrinology, vol 39, issue 3, Society for Endocrinology, UK, pp. 183-188.

Ellem, S.J., Risbridger, G.P., 2007, Treating prostate cancer: A rationale for targeting local oestrogens, Nature Reviews Cancer, vol 7, issue 8, Nature Publishing Group, UK, pp. 621-627.

Ellem, S.J., Risbridger, G.P., 2006, Aromatase and prostate cancer, Minerva Endocrinologica, vol 31, issue 1, Edizioni Minerva Medica, Italy, pp. 1-12.

Ellem, S.J., Schmidt, J.F., Pedersen, J.S., Frydenberg, M., Risbridger, G.P., 2004, Local Aromatase Expression in Human Prostate is altered in Malignancy, The Journal of Clinical Endocrinology & Metabolism, vol 89, issue 5, Endocrine Society, USA, pp. 2434-2441.

Risbridger, G.P., Bianco, J.J., Ellem, S.J., Mcpherson, S.J., 2003, Oestrogens and prostate cancer, Endocrine-Related Cancer, vol 10, issue 2, Society for Endocrinology, Bristol UK, pp. 187-191.

Other

Ellem, S.J., Risbridger, G.P., 2009, The dual, opposing roles of estrogen in the prostate, Annals of the New York Academy of Sciences [P], vol 1155, issue 1, Wiley-Blackwell Publishing, Inc., United States, pp. 174-186.

Teaching Commitment

DEV3990 Unit Coordinator

Grants

Title:

Aperio ScanScope CS (Digital slide scanner) with operating software and server.

Investigators:

Furic, L, Risbridger, G, Taylor, R, Ellem, S

Funding:

(2012 - 2015). Prostate Cancer Foundation of Australia.

Title:

Early origins of prostate cancer.

Investigators:

Risbridger, G, McPherson, S, Ellem, S

Funding:

(2006 - 2010). Cancer Council Victoria.

Title:

Estrogens in prostatitis and prostate cancer.

Investigators:

Ellem, S

Funding:

(2009 - 2013). Prostate Cancer Foundation of Australia.

(2010 - 2013). Prostate Cancer Foundation of Australia.

Title:

Linking Estrogen, postatitis, and prostate cancer.

Investigators:

Ellem, S

Funding:

(2008 - 2012). US Department of Defense.

(2009 - 2013). US Department of Defense.

Title:

Linking estrogens, prostatitis and prostate cancer.

Investigators:

Ellem, S

Funding:

(2008 - 2011). National Health & Medical Research Council (NHMRC).

(2009 - 2013). National Health & Medical Research Council (NHMRC).

Title:

The concerted actions of estrogen, ERa and mast cells in the development of prostatitis and prostate cancer.

Investigators:

Ellem, S

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).